Anemia is common in heart failure and is associated with poor outcomes: Insights from a cohort of 12 065 patients with new-onset heart failure

Circulation

Volumn 107, Issue 2, 2003, Pages 223-225

  Ezekowitz, Justin A ^a   McAlister, Finlay A ^a   Armstrong, Paul W ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Anemia; Epidemiology; Heart failure

Indexed keywords

ADULT; AGED; ANEMIA; ARTICLE; CANADA; CHRONIC KIDNEY FAILURE; COMORBIDITY; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; PROGNOSIS; SEX DIFFERENCE;

AGED; ALBERTA; ANEMIA; CHRONIC DISEASE; COHORT STUDIES; COMORBIDITY; FEMALE; HEART FAILURE, CONGESTIVE; HUMANS; LOGISTIC MODELS; MALE; ODDS RATIO; PREVALENCE; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; SURVIVAL ANALYSIS;

EID: 0037458095     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000052622.51963.FC     Document Type: Article

References (11)

1. Al Ahmad A, Rand WM, Manjunath G, et al. Reduced kidney function and anemia as risk factors for mortality in patients with left ventricular dysfunction. J Am Coll Cardiol. 2001;38:955-962.
2. Horwich TB, Fonarow GC, Hamilton MA, et al. Anemia is associated with worse symptoms, greater impairment in functional capacity and a significant increase in mortality in patients with advanced heart failure. J Am Coll Cardiol. 2002;39:1780-1786.
3. McClellan WM, Flanders WD, Langston RD, et al. Anemia and renal insufficiency are independent risk factors for death among patients with congestive heart' failure admitted to community hospitals: a population-based study. J Am Soc Nephrol. 2002;13:1928-1936.
4. Silverberg DS, Wexler D, Blum M, et al. The use of subcutaneous erythropoietin and intravenous iron for the treatment of the anemia of severe, resistant congestive heart failure improves cardiac and renal function and functional cardiac class, and markedly reduces hospitalizations. J Am Coll Cardiol. 2000;35:1737-1744.
5. Sin D, McAlister FA. The impact of beta-blockers on morbidity and mortality in a population-based cohort of 11 942 elderly patients with congestive heart failure. Am J Med. In press.
6. Goff DC Jr, Pandey DK, Chan FA, et al. Congestive heart failure in the United States: is there more than meets the I (CD code)? The Corpus Christi Heart Project. Arch Intern Med. 2000;160:197-202.
7. Iversen PO, Woldbaek PR, Tonnessen T, et al. Decreased hematopoiesis in bone marrow of mice with congestive heart failure. Am J Physiol Regul Integr Comp Physiol. 2002;282:R166-R172.
8. Macdougall IC. The role of ACE inhibitors and angiotensin II receptor blockers in the response to epoetin. Nephrol Dial Transplant. 1999;14:1836-1841.
9. Levine B, Kalman J, Mayer L, et al. Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N Engl J Med. 1990;323:236-241.
10. Wen SW, Hernandez R, Naylor CD. Pitfalls in nonrandomized outcomes studies: the case of incidental appendectomy with open cholecystectomy. JAMA. 1995;274:1687-1691.
11. Silverberg DS, Wexler D, Sheps D, et al. The effect of correction of mild anemia in severe, resistant congestive heart failure using subcutaneous erythropoietin and intravenous iron: a randomized controlled study. J Am Coll Cardiol. 2001;37:1775-1780.