Quality counts: New parameters in blood cell counting

International Journal of Laboratory Hematology

Volumn 31, Issue 3, 2009, Pages 277-297

  Briggs, C ^a   Mellors, I ^b   Roderick, A ^c   Ward, A ^d   O'Malley, C ^e   Barker, J ^f   De La Salle, B ^g   McTaggart, P ^g   Hyde, K ^g,h   MacHin, S J ^a  

^a UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

^b FREEMAN HOSPITAL   (United Kingdom)

^c UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

^d ROYAL HALLAMSHIRE HOSPITAL   (United Kingdom)

^e ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^f QUEEN ELIZABETH HOSPITAL   (United Kingdom)

^g UK NEQAS (H)   (United Kingdom)

^h MANCHESTER ROYAL INFIRMARY   (United Kingdom)

Author keywords

Blood cell analysers; External Quality Assessment; Functional iron deficiency; Immature granulocytes; Nucleated red blood cells

Indexed keywords

MONOCLONAL ANTIBODY;

ANALYZER; BLOOD CELL COUNT; CELLULAR DISTRIBUTION; CLINICAL DECISION MAKING; CONSENSUS; ERYTHROBLAST; ERYTHROCYTE; ERYTHROCYTE SEDIMENTATION RATE; FLOW CYTOMETRY; GRANULOCYTE; HEMATOLOGY; HUMAN; IRON DEFICIENCY; LEUKOCYTE; PARAMETER; PRIORITY JOURNAL; QUALITY CONTROL; RETICULOCYTE COUNT; REVIEW; THROMBOCYTE;

BLOOD CELL COUNT; FLOW CYTOMETRY; HUMANS; QUALITY CONTROL; REFERENCE VALUES;

EID: 65349101612     PISSN: 17515521     EISSN: 1751553X     Source Type: Journal    
DOI: 10.1111/j.1751-553X.2009.01160.x     Document Type: Review

References (91)

1. Ault K.A., Rinder H.M., Mitchell J.G., Carmody M.B., Vary C.P.H. Hillman R.S. (1992) The significance of platelets with increased RNA content (reticulated platelets): a measure of the rate of thrombopoiesis. American Journal of Clinical Pathology 98, 637 646.
2. Bain B.J. (1983) Some influences on the ESR and fibrinogen level in healthy subjects. Clinical Laboratory Heamtology 5, 45 54.
3. Banno S., Ito Y., Tanaka C., Hori T., Fujimoto K., Suzuki T., Hashimoto T., Ueda R. Mizokami M. (2002) Quantification of red blood cell fragmentation by the automated hematology analyzer XE-2100 in patients with living donor liver transplantation. Clinical Laboratory Haematology 27, 292 296.
4. Bowles K.M., Cooke L.J., Richards E.M. Baglin T. (2005) Platelet size has diagnostic predictive value in patients with thrombocytopenia. Clinical and Laboratory Haematology 27, 370 373.
5. Briggs C., Grant D. Machin S.J. (2001) Comparison of the automated reticulocyte counts and immature reticulocyte fraction measurements obtained with the ABX Pentra 120 Retic blood cell analyzer and the Sysmex XE-2100 automated haematology analyzer. Laboratory Hematology 7, 1 6.
6. Briggs C., Rogers R., Thompson B. Machin S.J. (2001) New red cell parameters on the Sysmex XE-2100 as potential markers of functional iron deficiency. Infusion Therapy and Transfusion Medicine 28, 256 262.
7. Briggs C., Kunka S., Fuijimoto H., Hamaguchi Y., Davies B. Machin S.J. (2003) Evaluation of the immature granulocyte counts by the XE-IG Master: upgraded software for the XE-2100 automated hematology analyser. Laboratory Hematology 9, 117 124.
8. Briggs C., Kunka S., Hart D., Oguni S. Machin S.J. (2004) Assessment of an immature platelet fraction (IPF) in peripheral thrombocytopenia. British Journal of Haematology 126, 93 99.
9. Briggs C., Da Costa A., Freeman L., Aucamp I., Ngubeni B. Machin S.J. (2006) Development of an automated malaria discriminant factor using VCS technology. American Journal of Clinical Pathology 126, 691 698.
10. Brugnara C. (1998) Use of reticulocyte cellular indices in the diagnosis and treatment of haematological disorders. International Journal of Clinical and Laboratory Research 28, 1 11.
11. Brugnara C., Laufer M.R., Friedman A.J., Bridges K. Platt O. (1994) Reticulocyte hemoglobin content (CHr): early indicator of iron deficiency and response to therapy. Blood 83, 3100 3101.
12. BS EN 14136 (2004) Use of External Quality Assessment Schemes in the Assessment of the Performance of In Vitro Diagnostic Examination Procedures. British Standards Institute, London.
13. Burns E.R., Lou Y. Pathak A. (2004) Morphological diagnosis of thrombotic thrombocytopenia purpura. American Journal of Hematolgy 75, 18 21.
14. Buttarello M., Bulian P., Farina G., Petris M.G., Temporin V. Toffolo L. (2002) Five fully automated methods for performing immature reticulocyte fraction: comparison in diagnosis of bone marrow aplasia. American Journal of Clinical Pathology 117, 871 879.
15. Chaoui D., Chakroun T., Robert F., Rio B., Belhocine R., Legrand O., Salanoubat C., Lecrubier C., Casadevall N., Marie J.P. Elalamy I. (2005) Reticulated platelets: a reliable measure to reduce prophylactic platelet transfusions after intensive chemotherapy. Transfusion 45, 766 772.
16. Chaves F., Tierno B. Xu D. (2005) Quantitative determination of neutrophil VCS parameters by the Coulter automated hematology analyzer: new and reliable indicators for acute bacterial infection. American Journal of Clinical Pathology 124, 440 444.
17. Cho Y.G., Lee J.H., Kim D.S., Lee H.S. Choi S.I. (2007) Clinical usefulness of the simple technique to diagnose thrombocytopenia using immature platelet fraction. Korean Journal of Laboratory Medicine 27, 1 6.
18. Chuang C.L., Liu R.S., Wei Y.H., Huang T.P. Tarng D.C. (2003) Early prediction of response to intravenous iron supplementation by reticulocyte haemoglobin content and high-fluorescence reticulocyte count in haemodialysis patients. Nephrology, Dialysis Transplantation 18, 370 377.
19. Clinical Pathology Accreditation (UK) Ltd (2008) Standards for the medical laboratory. http://www.cpa-uk.co.uk.
20. Cornbleet P.J. Novak R.W. (1994) Classifying segmented and band neutrophils. CAP Today 8, 37 41.
21. Cullen P., Söffker J., Höpfl M., Bremer C., Schlaghecken R., Mehrens T., Assmann G. Schaefer R.M. (1999) Hypochromic red cells and reticulocyte haemoglobin content as markers of iron-deficient erythropoiesis in patients undergoing chronic haemodialysis. Nephrology Dialysis Transplantation 14, 659 565.
22. Cymbalista F. (2007) Usefulness of NEUT-X Determination in Routine Diagnostic Procedures: Application to Myelodysplastic Syndromes (l Lecture). Proceeding of the Sysmex European Haematology Symposium, Lisbon, Portugal June 13-14.
23. D'Erasmo E., Aliberti G., Celi F.S., Romagnoli E., Vecci E. Mazzuoli G.F. (1990) Platelet count, mean platelet volume and their relation to prognosis in cerebral infarction. Journal of Internal Medicine 227, 11 14.
24. D'Onofrio G., Chirillo R., Zini G., Caenaro G., Tommasi M. Micciulli G. (1995) Simultaneous measurement of reticulocyte and red blood cell indices in healthy subjects and patients with microcytic and macrocytic anemia. Blood 85, 818 823.
25. Daliphard S., Bizet M., Callet M.P., Beufe S., Latouche J.B., Soufiani H. Monconduit M. (1993) Evaluation of reticulocyte subtype distribution in myelodysplastic syndromes. American Journal of Hematology 44, 210 220.
26. Davies B.H. (1996) Immature reticulocyte fraction (IRF): By any name, a useful clinical parameter. Laboratory Hematology 2, 2 8.
27. Dutcher T.F. (1984) Leukocyte differentials are they worth the effort? Clinics in Laboratory Medicine 4, 71 87.
28. Fishbane S., Galgaano C., Langley R.C., Canfield W. Maesaka J.K. (1997) Reticulocyte haemoglobin content in the evaluation of iron status of hemodialysis patients. Kidney International 52, 217 222.
29. Fishbane S., Shaprio W., Duka P., Valenzuela O.F. Faubert J. (2001) A randomized trial of iron deficiency testing strategies in hemodialysis patients. Kidney International 60, 2406 2411.
30. Fitzsimons E.J. Brock J.H. (2001) The anaemia of chronic disease. British Medical Journal 322, 811 8112.
31. Foerster J. (1999) Red cell fragmentation syndromes. In : Clinical Hematology (eds R. Lee, J. Foerster, J. Lukens, F. Paraskevas, J.P. Greer G.M. Rodgers 10th edn, 1305 1328. Lippincott Williams & Wilkins, Philadelphia.
32. Gill J.E., Davis K.A., Cowart W.J., Napacena F.U. Kim Y.R. (2000) A rapid and accurate closed tube immunoassay for platelets on an automated haematology analyzer. American Journal of Clinical Pathology 114, 47 56.
33. Grotto H.Z.W., Vigoritto A.C., Noronha J.F.A. Lima G.A.L.M. (1999) Immature reticulocyte fraction as a criterion for marrow engraftment. Evaluation of a semi-automated reticulocyte counting method. Clinical and Laboratory Haematology 23, 285 287.
34. Harrison P. (1997) Variables affecting flow cytometric analysis of platelets. Laboratory Hematology 3, 167.
35. Horl W.H., Cavill I., McDougall C., Schaefer R.M. Sunder-Plassmann G. (1996) How to diagnose and correct iron-deficiency during rhuEpo therapy - a consensus report. Nephrology, Dialysis, Transplant 11, 246 250.
36. Houwen B. (2001) The differential cell count. Laboratory Hematology 7, 89 100.
37. Ingram M. Coopersmith A. (1969) Reticulated platelets following acute blood loss. British Journal of Haematology 17, 225 229.
38. International Council for Standardization in Haematology (1988) Guidelines on the selection of laboratory tests for monitoring the acute phase response. Journal of Clinical Pathology 41, 1203 1212.
39. International Council for Standardization in Haematology (1993) Recommendations for measurement of erythrocyte sedimentation rate. Journal of Clinical Pathology 46, 198 203.
40. International Council for Standardization in Haematology Expert Panel on Cytometry; International Society of Laboratory Hematology Task Force on Platelet Counting (2001) Platelet counting by the RBC/platelet ratio method. A reference method. American Journal of Clinical Pathology 115, 460 464.
41. Jiang M., Saigo K., Kumagai S., Imoto S., Kosaka Y., Matsumoto H. Fujimoto K. (2001) Quantification of red blood cell fragmentation by automated haematology anayzer XE-2100. Clinical and Laboratory Haematology 23, 167 172.
42. Johannessen B., Roemer B., Flatmoen L., Just T., Aarsand A.K. Scott C.S. (2006) Implementation of monoclonal antibody fluorescence on the Abbott CELL-DYN Sapphire haematology analyser: evaluation of lymphoid, myeloid and platelet markers. Clinical Laboratory Haematology 28, 84 96.
43. Kaito K., Otsubo H., Usui N., Yoshida M., Tanno J., Kurihara E., Matsumoto K., Hirata R., Domitsu K. Kobayashi M. (2005) Platelet size deviation width, platelet large cell ratio, and mean platelet volume have sufficient sensitivity and specificity in the diagnosis of immune thrombocytopenia. British Journal of Haematology 128, 698 702.
44. Khandekar M.M., Khurana A.S., Deshmukh S.D., Kakrani A.L., Katdare A.D. Inamdar A.K. (2006) Platelet volume indices in patients with coronary artery disease and acute myocardial infarction: an Indian scenario. Journal of Clinical Pathology 59, 146 149.
45. Kim Y.R., Kanzor J., Landayan M., Kihara J., Bearden J. Sheehan E. (1997) A rapid and sensitive reticulocyte method on a high throughput haematology instrument. Laboratory Hematology 3, 19 26.
46. Kopelman R.C., Smith L., Peoples L., Biesecker R. Rizkala A.R. (2007) Functional iron deficiency in hemodialysis patients with high ferritin. Hemodialysis International 2, 238 246.
47. Kratz A., Maloum K., O'Malley C., Zini G., Rocco V., Zelmanovic D. Kling G. (2006) Enumeration of nucleated red blood cells with the ADVIA 2120 hematology system: an international multicenter clinical trial. Laboratory Hematology 12, 63 70.
48. Lesesve J.F., Salignac S., Alla F., Defente M., Benbih M., Bordigoni P. Lecompte T. (2004) Comparative evaluation of schistocyte counting by an automated method and by microscopic determination. American Journal of Clinical Pathology 121, 739 745.
49. Lewis S.M., Bain B.J. Bates I. (2006) Dacie & Lewis Practical Haematology, 10th edn, pp. 595 600. Elsvier Science Limited, Churchill Livingstone.
50. Lewis S.M. Burgess B.J. (1969) Report of interlaboratory trials in Britain. British Medical Journal 4, 253 256.
51. Lin C.K., Lin J.S., Chen S.Y., Jiang M.L. Chiu C.F. (1992) Comparison of hemoglobin and red blood cell distribution width in the differential diagnosis of microcytic anemia. Archives of Pathology and Laboratory Medicine 116, 1030 1032.
52. Linssen J., Jennissen V., Hildmann J., Reisinger E., Schindler J., Malchau G., Nierhaus A. Wielckens K. (2007) Identification and quantification of high fluorescence-stained lymphocytes as antibody synthesizing/secreting cells using the automated routine hematology analyzer XE-2100. Cytometry, Part B, Clinical Cytometry 72, 157 166.
53. Little B.H., Robson R., Roemer B. Scott C.S. (2005) Immunocytometric quantitation of foeto-maternal haemorrhage with the Abbott Cell-Dyn CD4000 haematology analyser. Clinical Laboratory Haematology 27, 21 31.
54. + T-cell populations on the Cell-Dyn 4000 hematology analyzer. Laboratory Hematology 6, 137 143.
55. Mast A.E., Blinder M.A., Lu Q., Flax S. Dietzen D.J. (2002) Clinical utility of the reticulocyte hemoglobin content in the diagnosis of iron deficiency. Blood 99, 1489 1491.
56. Miguel A., Orero M., Simon R., Collado R., Perez P.L., Pacios A., Iglesias R., Martinez A. Carbonell F. (2007) Automated neutrophil morphology and its utility in the assessment of neutrophil dysplasia. Laboratory Haematology 13, 98 102.
57. Mittman N., Sreedhara R., Mushick R., Chattopadhyay J., Zelmanovic D., Vaseghi M. Avram M.M. (1997) Reticulocyte hemoglobin content predicts functional iron deficiency in hemodialysis patients receiving rHuEPO. American Journal of Kidney Disease 30, 912 922.
58. Molero T., Roemer B., Perera Alvarez Mdel M., Lemes A., Iñigo Sde L., Palacios G. Scott CS. (2005) Analysis and enumeration of T cells, B cells and NK cells using the monoclonal antibody fluorescence capability of a routine haematology analyser (Cell-Dyn CD4000). Clinical Laboratory Haematology 27, 224 234.
59. Molina J.R., Sanchez-Garcia J., Torres A., Alvarez M.A., Serrano J., Casaño J., Gomez P., Martinez F., Rodriguez A. Martin C. (2007) Reticulocyte maturation parameters are reliable early predictors of hematopoietic engraftment after allogeneic stem cell transplantation. Biology of Blood Marrow Transplantation 13, 172 182.
60. Nemeth E. Ganz T. (2006) Regulation of iron metabolism by hepcidin. Annual Review of Nutrition 26, 323 342.
61. O'Malley C.J., Rasko J.E., Basser R.L., McGrath K.M., Cebon J., Grigg A.P., Hopkins W., Cohen B., O'Byrne J., Green M.D., Fox R.M., Berndt M.C. Begley C.G. (1996) Administration of pegylated recombinant human megakaryocyte growth factor to humans stimulates the production of functional platelets that show no evidence of in vivo activation. Blood 88, 3288 3298.
62. Ogura M., Yasuno M., Kobayashi Y. Tsukada T. (1995) Clinical significance of platelet volume indices estimated by automated blood cell analyzer. Rinsho Byori. 43, 385 390.
63. Patterson K. (1997) Platelet parameters generated by automated blood counters. CME Bull Haematology 1, 13 16.
64. Peebles D. (1981) Analysis of manual reticulocyte counting. American Journal of Clinical Pathology 76, 713 717.
65. Richards E.M. Baglin T.P. (1995) Quantitation of reticulated platelets: methodology and clinical application. British Journal of Haematology 91, 445 451.
66. Richards E.M., Jestice H.K., Mahendra P., Scott M.A., Marcus R.E. Baglin T.P. (1996) Measurement of reticulated platelets following peripheral blood progenitor cell and bone marrow transplantation: implications for marrow reconstitution and the use of thrombopoietin. Bone Marrow Transplantation 17, 1029 1033.
67. Rinder H.M., Munz U.J., Ault K.A., Bonan J.L. Smith B.R. (1993) Reticulated platelets in the evaluation of thrombopoietic disorders. Archives of Pathology & Laboratory Medicine 117, 606 610.
68. Roberts G.T. Badawi S.B. (1985) Red blood cell distribution width index in some hematologic diseases. American Journal of Clinical Pathology 83, 222.
69. Robinson M.S.C., Mackie I.J., Khair K., Liesner R., Goodall A.H., Savidge G.F., Machin S.J. Harrison P. (1998) Flow cytometric analysis of reticulated platelets: evidence for a large proportion of non-specific labelling of dense granules by fluorescent dyes. British Journal of Haematology 100, 351 357.
70. Rowan M. (1983) Blood Cell Volume Analysis - A New Screening Technology for the Haematologist. Albert Clarke and Company Limited, London.
71. Roy C.N., Mak H.H., Akpan C., Losyev G., Zurakowski D. Andrews N.C. (2007) Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation. Blood 109, 4038 4044.
72. Rumke C.L. (1979) The statistically expected variability in differential leukocyte counting. In : Differential Leukocyte Counting (ed. J.A. Koepke 39 45. College of American Pathologists, St. Louis, USA.
73. Ruutu T., Barosi G., Benjamin R., Clark R., George J., Gratwohl A., Holler E., Lacobelli M., Kentouch K., Lammle B., Noake J., Richardson P., Socie G., Zeigler Z., Niederwieser D. Barbuni T. (2007) Diagnostic criteria for hematopoietic stem cell transplant-associated microangiopathy: results of a consensus process by an International Working Group. Haematologica 92, 95 100.
74. Schaefer R.M. Schaefer L. (1995) The Hypochromic red cell - a new parameter for monitoring of iron supplementation during rhuEpo therapy. Journal of Perinatal Medicine 23, 83 88.
75. Schimenti K., Lacerna K., Wamble A., Maston L., Laffaldano C., Straight M., Rabinovitch A., Lazarus H. Jacobberger J. (1992) Reticulocyte quantification by flow cytometry, image analysis and manual counting. Cytometry 13, 853 862.
76. Scott C.S., Van Zyl D., Ho E., Meyersfeld D., Ruivo L., Mendelow B.V. Coetzer T.L. (2002) Automated detection of malaria-associated intraleucocytic haemozin by Cell-Dyn CD4000 depolarisation analysis. Clinical and Laboratory Haematology 25, 77 86.
77. Segal H., Briggs C., Kunka S., Casbard A., Harrison P., Machin S.J. Murphy M. (2005) Accuracy of platelet counting haematology analysers in severe thrombocytopenia and potential impact on platelet transfusion. British Journal of Haematology 128, 520 525.
78. Silva M., Fourcade C., Fartoukh C., Lenormand B., Buchonnet G., Callat M.P., Leclerc C., Basuyau J.P. Vasse M. (2006) Lymphocyte volume and conductivity indices of the haematology analyser Coulter GEN.STM in lymphoproliferative disorders and viral diseases. Clinical and Laboratory Haematology 28, 1 28.
79. Takami A., Shibayama M., Orito M., Omote M., Okumura H., Yamashita T., Shimadoi S., Yoshida T., Nakao S. Asakura H. (2007) Immature platelet fraction for prediction of platelet engraftment after allogeneic stem cell transplantation. Bone Marrow Transplantation 39, 501 507.
80. Thomas L., Franck S., Messinger M., Linssen J., Thomé M. Thomas C. (2005) Reticulocyte hemoglobin measurement - comparison of two methods in the diagnosis of iron-restricted erythropoiesis. Clinical Chemistry and Laboratory Medicine 43, 1193 1202.
81. Thomas C., Kirschbaum A., Boehm D. Thomas L. (2006) The diagnostic plot: a concept for identifying different states of iron deficiency and monitoring the response to erythropoetin therapy. Medical Onocology 23, 23 36.
82. Thompson C.B., Eaton K.A., Princiotta S.M., Rushin C.A. Valeri C.R. (1982) size dependent platelet subpopulations: relationship of platelet volume to ultrastructure, enzymatic activity, and function. British Journal of Haematology 50, 509 519.
83. Thompson C.B., Jakubowski J.A., Quinn P.G., Deykin D. Valeri C.R. (1984) Platelet size and age determine platelet function independently. Blood 63, 1372 1375.
84. Trowbridge E.A., Reardon D.M., Hutchinson D. Pickering C. (1985) The routine measurement of platelet volume: a comparison of light-scattering and aperture-impedance technologies. Clinical Physics and Physiological Measurements 6, 221 238.
85. Tsuchiya K., Okano H., Teramura M., Iwamoto Y., Yamashita N., Suda A., Shimada K., Nihei H. Ando M. (2003) Content of reticulocyte hemoglobin is a reliable tool for determining iron deficiency in dialysis patients. Clinical Nephrology 59, 115 123.
86. Urrechaga E. (2008) Clinical utility of the Beckman Coulter parameter red blood cell size factor in the study of erythropoiesis. International Journal of Laboratory Hematology, 7.
87. Watanabe K., Kawai Y., Takeuchi K., Shimizu N., Iri H., Ikeda Y. Houwen B. (1994) Reticulocyte maturity as an indicator for estimating qualitative abnormality of erythropoiesis. Journal of Clinical Pathology 47, 736 739.
88. Wever P.C., Henskens Y.M., Kager P.A., Dankert J. Gool T. (2002) Detection of imported malaria with the Cell-Dyn 4000 hematology analyser. Journal of Clinical Microbiology 40, 4729 4731.
89. WHO/LAB (1998) Laboratory Services for Primary Health Care: Requirements for Essential Clinical Laboratory Tests. WHO/LAB/98.1;1998. World Health Organization, Geneva.
90. Zini G., Machin S., Briggs C., Preloznik-Zupan I., Junca J., Romero S., Beerenhout C., Garzia M., Pintado-Cros T., Junior E., Reis A., Solenthaler M., Goetgheluck Q., Simon R., Qian C. Huo Z. (2006) Multicenter evaluation of Coulter MCH and the new derived LHD% parameters versus CHr and %hypo for the assessment of iron metabolism disturbances. Laboratory Hematology 12, 184 185.
91. Zucker M.L., Murphy C.A., Rachel J.M., Martinez G.A., Abhyankar S., McGuirk J.P., Reid K.J. Plapp F.V. (2006) Immature platelet fraction as a predictor of platelet recovery following hematopoietic progenitor cell transplantation. Laboratory Hematology 2, 125 130.