The impact of new onset anaemia on morbidity and mortality in chronic heart failure: Results from COMET

European Heart Journal

Volumn 27, Issue 12, 2006, Pages 1440-1446

  Komajda, Michel ^a   Anker, Stefan D ^b,c   Charlesworth, Andrew ^d   Okonko, Darlington ^c   Metra, Marco ^e   Di Lenarda, Andrea ^f   Remme, Willem ^g   Moullet, Christine ^h   Swedberg, Karl ⁱ   Cleland, John G F ^j   Poole Wilson, Philip A ^c  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^d Nottingham Clinical Research Group   (United Kingdom)

^e UNIVERSITY OF BRESCIA   (Italy)

^f UNIVERSITY OF TRIESTE   (Italy)

^g Sticares Cardiovascular Research Foundation   (Netherlands)

^h F HOFFMANN LA ROCHE LTD   (Switzerland)

ⁱ SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^j UNIVERSITY OF HULL   (United Kingdom)

more..

Author keywords

Anaemia; Beta blockers; Heart failure; Prognosis

Indexed keywords

ACETYLSALICYLIC ACID; ALDOSTERONE ANTAGONIST; ANTICOAGULANT AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARVEDILOL; CREATININE; DIGITALIS; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; FUROSEMIDE; HEMOGLOBIN; METOPROLOL TARTRATE; NITRATE; POTASSIUM; SODIUM; STATINE DERIVATIVE;

ADULT; AGED; AGING; AMBULATORY CARE; ANEMIA; ARTICLE; BODY MASS; CAUSE OF DEATH; CLINICAL TRIAL; COMORBIDITY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DRUG MEGADOSE; FEMALE; FOLLOW UP; HEART FAILURE; HEMOGLOBIN DETERMINATION; HOSPITALIZATION; HUMAN; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MORTALITY; POTASSIUM BLOOD LEVEL; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL; SEX DIFFERENCE; SODIUM BLOOD LEVEL;

AGED; ANEMIA; CHRONIC DISEASE; EPIDEMIOLOGIC METHODS; FEMALE; FOLLOW-UP STUDIES; HEART FAILURE; HEART FAILURE, CONGESTIVE; HEMOGLOBINS; HOSPITALIZATION; HUMANS; MALE; MIDDLE AGED; PROGNOSIS;

EID: 33745697922     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehl012     Document Type: Article

References (18)

1. Kalra PR, Bolger AP, Francis DP, Genth-Zotz S, Sharma R, Ponikowski PP, Poole-Wilson PA, Coats AJ, Anker SD. Effect of anemia on exercise tolerance in chronic heart failure in men. Am J Cardiol 2003;91:888-891.
2. Ezekowitz JA, McALister FA, Armstrong PW. Anemia is common in heart failure and is associated with poor outcomes. Insights form a cohort of 12 065 patients with new-onset heart failure. Circulation 2003;107:294-299.
3. Anand IS, Kuskowski MA, Rector TS, Florea VG, Glazer RD, Hester A, Chiang YT, Aknay N, Maggioni AP, Opasich C, Latini R, Cohn JN. Anemia and change in hemoglobin over time related to mortality and morbidity in patients with chronic heart failure: results from Val-HeFT. Circulation 2005;112:1121-1127.
4. Sharma R, Francis DP, Pitt B, Poole-Wilson PA, Coats AJ, Anker SD. Haemoglobin predicts survival in patients with chronic heart failure: a substudy of the ELITE II trial. Eur Heart J 2004;25:1021-1028.
5. Horwich TB, Fonarow GC, Hamilton MA, Maclellan WR, Borenstein J. Anemia is associated with worse symptoms, greater impairment in functional capacity and a significant increase in mortality in patients with advance heart failure. J Am Coll Cardiol 2002;39:1780-1786.
6. Mozaffarian D, Nye R, Levy WC. Anemia predicts mortality in severe heart failure. The prospective randomized amlodipine survival evaluation (PRAISE). J Am Coll Cardiol 2003;41:1933-1939.
7. Anand I, McMurray JV, Whitmore J, Warren M, Pham A, McCamish MA, Burton P BJ. Anemia and its relationship to clinical outcome in heart failure. Circulation 2004;110:149-154.
8. Komajda M. Prevalence of anemia in patients with chronic heart failure and their clinical characteristics. J Card Fail 2004;10:S1-S4.
9. Poole-Wilson PA, Swedberg K, Cleland JG, Di Lenarda A, Hanrath P, Komajda M, Lubsen J, Lutiger B, Metra M, Remme WJ, Torp-Pedersen C, Scherhag A, Skene A, Carvedilol Or Metoprolol European Trial Investigators. Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomized controlled trial. Lancet 2003;362:7-13.
10. Izaks GJ, Westendorp RG, Knook DL. The definition of anemia in older persons. JAMA 1999;281:1714-1717.
11. Opasich C, Cazzola M, Scelsi L, De Feo S, Bosimini E, Lagioia R, Febo O, Ferrari R, Fucili A, Moratti R, Tramarin R, Tavazzi L. Blunted erythropoietin production and defective iron supply for erythropoiesis as major causes of anaemia in patients with chronic heart failure. Eur Heart J 2005;26:2232-2237.
12. Ishani A, Weinhandl E, Zhao Z, Gilbertson DT, Collins AJ, Yusuf S, Herzog CA. Angiotensin-converting enzyme inhibitor as a risk factor for the development of anemia, and the impact of incident anemia on mortality in patients with left ventricular dysfunction. J Am Coll Cardiol 2005; 3:391-399.
13. Okonko DO, Anker SD. Anemia in chronic heart failure: pathogenetic mechanisms. J Card Fail 2004;10(suppl.):S5-S9.
14. Cole J, Ertoy D, Lin H, Sutliff RL, Ezan E, Guyene TT, Capecchi M, Corvol P, Bernstein KE. Lack of angiotensin II-facilitated erythropoiesis causes anemia in angiotensin-converting enzyme-deficient mice. J Clin Invest 2000;106:1391-1398.
15. Lefkowitz R, Limbird L, Mukhergee C, Caron M. The beta-adrenergic receptor and adenylate cyclase. Biochimi Biophys Acta 1976;457:1-39.
16. Feldman S, Rachmilewitz, Izak G. The effect of central nervous system stimulation on erythropoiesis in rats with chronically implanted electrodes. J Lab Clin Medl 1966;67:713-725.
17. Przala F, Gross DM, Beckman B, Fisher JW. Influence of albuterol on erythropoïetin production and erythroid progenitor cell activation. Am J Physiol 1979;236:H422-H426.
18. Mladenovic J, Adamson JW. Adrenergic modulation of erythropoiesis: in vitro studies of colony-forming cells in normal and polycythaemic man. Br J Haematol 1984;56:323-332.