Regulatory motifs in Chk1

Cell Cycle

Volumn 12, Issue 6, 2013, Pages 916-922

  Caparelli, Michael L ^a   O'Connell, Matthew J ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

checkpoint; Chk1; DNA damage; KA1 domain; Protein kinase

Indexed keywords

CHECKPOINT KINASE 1; SCHIZOSACCHAROMYCES POMBE PROTEIN;

ALLELE; ARTICLE; CAENORHABDITIS ELEGANS; CARBOXY TERMINAL SEQUENCE; CATALYSIS; DNA DAMAGE; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME REGULATION; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; NONHUMAN; PHYLOGENY; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN MOTIF; SCHIZOSACCHAROMYCES POMBE;

EID: 84875198769     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.23881     Document Type: Article

References (47)

1. O'Connell MJ, Walworth NC, Carr AM. The G2-phase DNA-damage checkpoint. Trends Cell Biol 2000; 10:296-303; PMID:10856933; http://dx.doi.org/10.1016/ S0962-8924(00)01773-6
2. O'Connell MJ, Cimprich KA. G2 damage checkpoints: what is the turn-on? J Cell Sci 2005; 118:1-6; PMID:15615778; http://dx.doi.org/10.1242/jcs.01626
3. Capasso H, Palermo C, Wan S, Rao H, John UP, O'Connell MJ, et al. Phosphorylation activates Chk1 and is required for checkpoint-mediated cell cycle arrest. J Cell Sci 2002; 115:4555-64; PMID:12415000; http://dx.doi.org/10. 1242/jcs.00133
4. Mochida S, Esashi F, Aono N, Tamai K, O'Connell MJ, Yanagida M. Regulation of checkpoint kinases through dynamic interaction with Crb2. EMBO J 2004; 23:418-28; PMID:14739927; http://dx.doi.org/10.1038/sj.emboj.7600018
5. Raleigh JM, O'Connell MJ. The G(2) DNA damage checkpoint targets both Wee1 and Cdc25. J Cell Sci 2000; 113:1727-36; PMID:10769204
6. Sørensen CS, Syljuasen RG. Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication. Nucleic Acids Res 2012; 40:477-86; PMID:21937510; http://dx.doi.org/10.1093/nar/gkr697
7. den Elzen NR, O'Connell MJ. Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1. EMBO J 2004; 23:908-18; PMID:14765108; http://dx.doi.org/10.1038/sj.emboj.7600105
8. Tapia-Alveal C, Calonge TM, O'Connell MJ. Regulation of chk1. Cell Div 2009; 4:8; PMID:19400965; http://dx.doi.org/10.1186/1747-1028-4-8
9. Chen P, Luo C, Deng Y, Ryan K, Register J, Margosiak S, et al. The 1.7 A crystal structure of human cell cycle checkpoint kinase Chk1: implications for Chk1 regulation. Cell 2000; 100:681-92; PMID:10761933; http://dx.doi.org/10. 1016/S0092-8674(00)80704-7
10. Katsuragi Y, Sagata N. Regulation of Chk1 kinase by autoinhibition and ATR-mediated phosphorylation. Mol Biol Cell 2004; 15:1680-9; PMID:14767054; http://dx.doi.org/10.1091/mbc.E03-12-0874
11. Wang SX, Dunphy WG. Activation of Xenopus Chk1 by mutagenesis of threonine-377. FEBS Lett 2000; 487:277-81; PMID:11150524; http://dx.doi.org/10. 1016/S0014-5793(00)02370-X
12. Pereira E, Chen Y, Sanchez Y. Conserved ATRMec1 phosphorylation- independent activation of Chk1 by single amino acid substitution in the GD domain. Cell Cycle 2009; 8:1788-93; PMID:19411848; http://dx.doi.org/10.4161/cc. 8.11.8737
13. Kosoy A, O'Connell MJ. Regulation of Chk1 by its C-terminal domain. Mol Biol Cell 2008; 19:4546-53; PMID:18716058; http://dx.doi.org/10.1091/mbc.E08-04- 0444
14. Chen Y, Caldwell JM, Pereira E, Baker RW, Sanchez Y. ATRMec1 phosphorylation-independent activation of Chk1 in vivo. J Biol Chem 2009; 284:182-90; PMID:18984588; http://dx.doi.org/10.1074/jbc.M806530200
15. Giono LE, Manfredi JJ. The p53 tumor suppressor participates in multiple cell cycle checkpoints. J Cell Physiol 2006; 209:13-20; PMID:16741928; http://dx.doi.org/10.1002/jcp.20689
16. Koniaras K, Cuddihy AR, Christopoulos H, Hogg A, O'Connell MJ. Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells. Oncogene 2001; 20:7453-63; PMID:11709716; http://dx.doi.org/10.1038/sj. onc.1204942
17. Kuntz K, O'Connell MJ. The G(2) DNA damage checkpoint: could this ancient regulator be the Achilles heel of cancer? Cancer Biol Ther 2009; 8:1433-9; PMID:19574738; http://dx.doi.org/10.4161/cbt.8.15.9081
18. Dent P, Tang Y, Yacoub A, Dai Y, Fisher PB, Grant S. CHK1 inhibitors in combination chemotherapy: thinking beyond the cell cycle. Mol Interv 2011; 11:133-40; PMID:21540473; http://dx.doi.org/10.1124/mi.11.2.11
19. Garrett MD, Collins I. Anticancer therapy with checkpoint inhibitors: what, where and when? Trends Pharmacol Sci 2011; 32:308-16; PMID:21458083; http://dx.doi.org/10.1016/j.tips.2011.02.014
20. Saka Y, Esashi F, Matsusaka T, Mochida S, Yanagida M. Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1. Genes Dev 1997; 11:3387-400; PMID:9407031; http://dx.doi.org/10.1101/gad.11.24.3387
21. Wang B, Matsuoka S, Carpenter PB, Elledge SJ. 53BP1, a mediator of the DNA damage checkpoint. Science 2002; 298:1435-8; PMID:12364621; http://dx.doi.org/10.1126/science.1076182
22. Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ. MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature 2003; 421:961-6; PMID:12607005; http://dx.doi.org/10.1038/nature01446
23. Goldberg M, Stucki M, Falck J, D'Amours D, Rahman D, Pappin D, et al. MDC1 is required for the intra-S-phase DNA damage checkpoint. Nature 2003; 421:952-6; PMID:12607003; http://dx.doi.org/10.1038/nature01445
24. Lou Z, Minter-Dykhouse K, Wu X, Chen J. MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways. Nature 2003; 421:957-61; PMID:12607004; http://dx.doi.org/10.1038/nature01447
25. Chini CC, Chen J. Human claspin is required for replication checkpoint control. J Biol Chem 2003; 278:30057-62; PMID:12766152; http://dx.doi.org/10. 1074/jbc.M301136200
26. Kumagai A, Dunphy WG. Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. Mol Cell 2000; 6:839-49; PMID:11090622; http://dx.doi.org/10.1016/ S1097-2765(05)00092-4
27. Lee J, Kumagai A, Dunphy WG. Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17. Mol Cell 2003; 11:329-40; PMID:12620222; http://dx.doi.org/10.1016/S1097-2765(03)00045-5
28. Kai M, Wang TS. Checkpoint responses to replication stalling: inducing tolerance and preventing mutagenesis. Mutat Res 2003; 532:59-73; PMID:14643429; http://dx.doi.org/10.1016/j.mrfmmm.2003.08.010
29. Dahlen M, Olsson T, Kanter-Smoler G, Ramne A, Sunnerhagen P. Regulation of telomere length by checkpoint genes in Schizosaccharomyces pombe. Mol Biol Cell 1998; 9:611-21; PMID:9487130
30. Lindsay HD, Griffiths DJF, Edwards RJ, Christensen PU, Murray JM, Osman F, et al. S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe. Genes Dev 1998; 12:382-95; PMID:9450932; http://dx.doi.org/10.1101/gad.12.3.382
31. Ohta M, Guo Y, Halfter U, Zhu JK. A novel domain in the protein kinase SOS2 mediates interaction with the protein phosphatase 2C ABI2. Proc Natl Acad Sci USA 2003; 100:11771-6; PMID:14504388; http://dx.doi.org/10.1073/pnas. 2034853100
32. Tochio N, Koshiba S, Kobayashi N, Inoue M, Yabuki T, Aoki M, et al. Solution structure of the kinaseassociated domain 1 of mouse microtubule-associated protein/microtubule affinity-regulating kinase 3. Protein Sci 2006; 15:2534-43; PMID:17075132; http://dx.doi.org/10.1110/ps.062391106
33. Moravcevic K, Mendrola JM, Schmitz KR, Wang YH, Slochower D, Janmey PA, et al. Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids. Cell 2010; 143:966-77; PMID:21145462; http://dx.doi.org/10.1016/j.cell.2010.11.028
34. Beullens M, Vancauwenbergh S, Morrice N, Derua R, Ceulemans H, Waelkens E, et al. Substrate specificity and activity regulation of protein kinase MELK. J Biol Chem 2005; 280:40003-11; PMID:16216881; http://dx.doi.org/10.1074/jbc. M507274200
35. Elbert M, Rossi G, Brennwald P. The yeast par-1 homologs kin1 and kin2 show genetic and physical interactions with components of the exocytic machinery. Mol Biol Cell 2005; 16:532-49; PMID:15563607; http://dx.doi.org/10. 1091/mbc.E04-07-0549
36. Akaboshi M, Hashimoto H, Ishida H, Saijo S, Koizumi N, Sato M, et al. The crystal structure of plant-specific calcium-binding protein AtCBL2 in complex with the regulatory domain of AtCIPK14. J Mol Biol 2008; 377:246-57; PMID:18237745; http://dx.doi.org/10.1016/j.jmb.2008.01.006
37. den Elzen N, Kosoy A, Christopoulos H, O'Connell MJ. Resisting arrest: recovery from checkpoint arrest through dephosphorylation of Chk1 by PP1. Cell Cycle 2004; 3:529-33; PMID:15020842
38. Calonge TM, O'Connell MJ. Turning off the G2 DNA damage checkpoint. DNA Repair (Amst) 2008; 7:136-40; PMID:17851138; http://dx.doi.org/10.1016/j.dnarep. 2007.07.017
39. Zou L, Elledge SJ. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 2003; 300:1542-8; PMID:12791985; http://dx.doi.org/10.1126/science.1083430
40. Saka Y, Esashi F, Matsusaka T, Mochida S, Yanagida M. Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1. Genes Dev 1997; 11:3387-400; PMID:9407031; http://dx.doi.org/10.1101/gad.11.24.3387
41. Maundrell K. Thiamine-repressible expression vectors pREP and pRIP for fission yeast. Gene 1993; 123:127-30; PMID:8422996; http://dx.doi.org/10.1016/ 0378-1119(93)90551-D
42. Sickmeier M, Hamilton JA, LeGall T, Vacic V, Cortese MS, Tantos A, et al. DisProt: the Database of Disordered Proteins. Nucleic Acids Res 2007; 35(Database issue):D786-93; PMID:17145717; http://dx.doi.org/10.1093/nar/gkl893
43. Buchan DW, Ward SM, Lobley AE, Nugent TC, Bryson K, Jones DT. Protein annotation and modelling servers at University College London. Nucleic Acids Res 2010; 38(Web Server issue):W563-8; PMID:20507913; http://dx.doi.org/10.1093/ nar/gkq427
44. Calonge TM, Eshaghi M, Liu J, Ronai Z, O'Connell MJ. Transformation/ transcription domain-associated protein (TRRAP)-mediated regulation of Wee1. Genetics 2010; 185:81-93; PMID:20194963; http://dx.doi.org/10.1534/genetics.110. 114769
45. Calonge TM, O'Connell MJ. Antagonism of Chk1 signaling in the G2 DNA damage checkpoint by dominant alleles of Cdr1. Genetics 2006; 174:113-23; PMID:16816416; http://dx.doi.org/10.1534/genetics.106.060970
46. Kunkel TA, Roberts JD, Zakour RA. Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol 1987; 154:367-82; PMID:3323813; http://dx.doi.org/10.1016/0076-6879(87)54085-X
47. Tapia-Alveal C, O'Connell MJ. Methods for studying checkpoint kinases -Chk1. Methods Mol Biol 2011; 782:171-9; PMID:21870291; http://dx.doi.org/10. 1007/978-1-61779-273-1-12