Engineered quorum sensing using pheromone-mediated cell-to-cell communication in saccharomyces cerevisiae

ACS Synthetic Biology

Volumn 2, Issue 3, 2013, Pages 136-149

  Williams, Thomas C ^a   Nielsen, Lars K ^a   Vickers, Claudia E ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

pheromone; cell to cell communication; dynamic control; quorum sensing; yeast

Indexed keywords

PHEROMONE;

ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; CELL COMMUNICATION; CONCENTRATION (PARAMETERS); CULTURE MEDIUM; GENETIC REGULATION; HAPLOIDY; MICROENVIRONMENT; NONHUMAN; POPULATION DENSITY DEPENDENCE; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ENGINEERING; PROTEIN EXPRESSION; QUORUM SENSING; SACCHAROMYCES CEREVISIAE; UPREGULATION;

AMINO ACIDS, AROMATIC; CELL COMMUNICATION; GENE EXPRESSION; PHEROMONES; PROMOTER REGIONS, GENETIC; QUORUM SENSING; SACCHAROMYCES CEREVISIAE; UP-REGULATION;

EID: 84875138991     PISSN: None     EISSN: 21615063     Source Type: Journal    
DOI: 10.1021/sb300110b     Document Type: Article

References (60)

1. Holtz, W. J. and Keasling, J. D. (2010) Engineering static and dynamic control of synthetic pathways Cell 140, 19-23
2. Nandagopal, N. and Elowitz, M. B. (2011) Synthetic biology: integrated gene circuits Science 333, 1244-1248
3. Purnick, P. E. M. and Weiss, R. (2009) The second wave of synthetic biology: from modules to systems Nat. Rev. Mol. Cell Biol. 10, 410-422
4. Smolke, C. D. and Silver, P. A. (2011) Informing biological design by integration of systems and synthetic biology Cell 144, 855-859
5. Nevoigt, E. (2008) Progress in metabolic engineering of Saccharomyces cerevisiae Microbiol. Mol. Biol. Rev. 72, 379-412
6. Chang, A. L., Wolf, J. J., and Smolke, C. D. (2012) Synthetic RNA switches as a tool for temporal and spatial control over gene expression Curr. Opin. Biotechnol. 23, 679-688
7. Khalil, A. S. and Collins, J. J. (2010) Synthetic biology: applications come of age Nat. Rev. Genet. 11, 367-379
8. Lu, T. K., Khalil, A. S., and Collins, J. J. (2009) Next-generation synthetic gene networks Nat. Biotechnol. 27, 1139-1150
9. Lee, S. K., Chou, H., Ham, T. S., Lee, T. S., and Keasling, J. D. (2008) Metabolic engineering of microorganisms for biofuels production: from bugs to synthetic biology to fuels Curr. Opin. Biotechnol. 19, 556-563
10. Anesiadis, N., Cluett, W. R., and Mahadevan, R. (2008) Dynamic metabolic engineering for increasing bioprocess productivity Metab. Eng. 10, 255-266
11. Gadkar, K. G., Doyle Iii, F. J., Edwards, J. S., and Mahadevan, R. (2005) Estimating optimal profiles of genetic alterations using constraint-based models Biotechnol. Bioeng. 89, 243-251
12. Keasling, J. D. (2008) Synthetic biology for synthetic chemistry ACS Chem. Biol. 3, 64-76 (Pubitemid 351227986)
13. Keasling, J. D. (2010) Manufacturing molecules through metabolic engineering Science 330, 1355-1358
14. Nevoigt, E., Fischer, C., Mucha, O., Matthäus, F., Stahl, U., and Stephanopoulos, G. (2007) Engineering promoter regulation Biotechnol. Bioeng. 96, 550-558 (Pubitemid 46232360)
15. Williams, P., Winzer, K., Chan, W. C., and Cámara, M. (2007) Look who's talking: communication and quorum sensing in the bacterial world Philos. Trans. R. Soc., B 362, 1119-1134 (Pubitemid 47075145)
16. Carter, K. K., Valdes, J. J., and Bentley, W. E. (2012) Pathway engineering via quorum sensing and sRNA riboregulators-interconnected networks and controllers Metab. Eng. 14, 281-288
17. Blount, B. A., Weenink, T., and Ellis, T. (2012) Construction of synthetic regulatory networks in yeast FEBS Lett. 586, 2112-2121
18. Chen, M.-T. and Weiss, R. (2005) Artificial cell-to-cell communication in yeast Saccharomyces cerevisiae using signaling elements from Arabidopsis thaliana Nat. Biotechnol. 23, 1551-1555 (Pubitemid 41752933)
19. Westfall, P. J., Pitera, D. J., Lenihan, J. R., Eng, D., Woolard, F. X., Regentin, R., Horning, T., Tsuruta, H., Melis, D. J., Owens, A., Fickes, S., Diola, D., Benjamin, K. R., Keasling, J. D., Leavell, M. D., McPhee, D. J., Renninger, N. S., Newman, J. D., and Paddon, C. J. (2012) Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin Proc. Natl. Acad. Sci. U.S.A. 10.1073/pnas.1110740109
20. Bardwell, L. (2005) A walk-through of the yeast mating pheromone response pathway Peptides 26, 339-350 (Pubitemid 40051432)
21. Bashor, C. J., Helman, N. C., Yan, S., and Lim, W. A. (2008) Using engineered scaffold interactions to reshape MAP kinase pathway signaling dynamics Science 319, 1539-1543 (Pubitemid 351398185)
22. Bhattacharyya, R. P., Reményi, A., Good, M. C., Bashor, C. J., Falick, A. M., and Lim, W. A. (2006) The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway Science 311, 822-826 (Pubitemid 43228840)
23. Ingolia, N. T. and Murray, A. W. (2007) Positive-feedback loops as a flexible biological module Curr. Biol. 17, 668-677 (Pubitemid 46552252)
24. Regot, S., Macia, J., Conde, N., Furukawa, K., Kjellen, J., Peeters, T., Hohmann, S., de Nadal, E., Posas, F., and Sole, R. (2011) Distributed biological computation with multicellular engineered networks Nature 469, 207-211
25. Wei, P., Wong, W. W., Park, J. S., Corcoran, E. E., Peisajovich, S. G., Onuffer, J. J., Weiss, A., and Lim, W. A. (2012) Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells Nature 488, 384-388
26. Whiteway, M., Hougan, L., and Thomas, D. Y. (1988) Expression of MFα1 in MATa cells supersensitive to α-factor leads to self-arrest Mol. Gen. Genet. 214, 85-88
27. Nakayama, N., Miyajima, A., and Arai, K. (1987) Common signal transduction system shared by STE2 and STE3 in haploid cells of Saccharomyces cerevisiae: autocrine cell-cycle arrest results from forced expression of STE2 EMBO J. 6, 249-254
28. Rivers, D. M. and Sprague, G. F. (2003) Autocrine activation of the pheromone response pathway in mata2-cells is attenuated by SST2- and ASG7-dependent mechanisms Mol. Genet. Genomics 270, 225-233 (Pubitemid 37518625)
29. Shah, N. A. and Sarkar, C. A. (2011) Robust network topologies for generating switch-like cellular responses PLoS Comput. Biol. 7, e1002085
30. van Dijken, J. P., Bauer, J., Brambilla, L., Duboc, P., Francois, J. M., Gancedo, C., Giuseppin, M. L. F., Heijnen, J. J., Hoare, M., Lange, H. C., Madden, E. A., Niederberger, P., Nielsen, J., Parrou, J. L., Petit, T., Porro, D., Reuss, M., van Riel, N., Rizzi, M., Steensma, H. Y., Verrips, C. T., Vindeløv, J., and Pronk, J. T. (2000) An interlaboratory comparison of physiological and genetic properties of four Saccharomyces cerevisiae strains Enzyme Microb. Technol. 26, 706-714 (Pubitemid 30345537)
31. Trueheart, J., Boeke, J., and Fink, G. (1987) Two genes required for cell fusion during yeast conjugation: evidence for a pheromone-induced surface protein Mol. Cell. Biol. 7, 2316-2328
32. Hagen, D. C., McCaffrey, G., and Sprague, G. F., Jr. (1991) Pheromone response elements are necessary and sufficient for basal and pheromone-induced transcription of the FUS1 gene of Saccharomyces cerevisiae Mol. Cell. Biol. 11, 2952-2961 (Pubitemid 21895680)
33. Singh, A., Chen, E. Y., Lugovoy, J. M., Chang, C. N., Hitzeman, R. A., and Seeburg, P. H. (1983) Saccharomyces cerevisiae contains two discrete genes coding for the Iî±-factor pheromone Nucleic Acids Res. 11, 4049-4063
34. Kemp, H. A., Sprague, J., and George, F. (2003) Far3 and five interacting proteins prevent premature recovery from pheromone arrest in the budding yeast Saccharomyces cerevisiae Mol. Cell. Biol. 23, 1750-1763 (Pubitemid 36246055)
35. Roberts, C. J., Nelson, B., Marton, M. J., Stoughton, R., Meyer, M. R., Bennett, H. A., He, Y. D., Dai, H., Walker, W. L., Hughes, T. R., Tyers, M., Boone, C., and Friend, S. H. (2000) Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profiles Science 287, 873-880 (Pubitemid 30084333)
36. Sprague, G. F. and Herskowitz, I. (1981) Control of yeast cell type by the mating type locus: I. Identification and control of expression of the a-specific gene BAR1 J. Mol. Biol. 153, 305-321 (Pubitemid 12083351)
37. Chasse, S. A., Flanary, P., Parnell, S. C., Hao, N., Cha, J. Y., Siderovski, D. P., and Dohlman, H. G. (2006) Genome-scale analysis reveals Sst2 as the principal regulator of mating pheromone signaling in the yeast Saccharomyces cerevisiae Eukaryotic Cell 5, 330-346 (Pubitemid 43262020)
38. Mateus, C. and Avery, S. V. (2000) Destabilized green fluorescent protein for monitoring dynamic changes in yeast gene expression with flow cytometry Yeast 16, 1313-1323
39. Iraqui, I., Vissers, S., Cartiaux, M., and Urrestarazu, A. (1998) Characterisation of Saccharomyces cerevisiae ARO8 and ARO9 genes encoding aromatic aminotransferases I and II reveals a new aminotransferase subfamily Mol. Gen. Genet. 257, 238-248
40. Iraqui, I., Vissers, S., Andre, B., and Urrestarazu, A. (1999) Transcriptional Induction by Aromatic Amino Acids in Saccharomyces cerevisiae Mol. Cell. Biol. 19, 3360-3371 (Pubitemid 29193796)
41. Chen, H. and Fink, G. R. (2006) Feedback control of morphogenesis in fungi by aromatic alcohols Genes Dev. 20, 1150-1161
42. Chan, R. K. and Otte, C. A. (1982) Physiological characterization of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and alpha factor pheromones Mol. Cell. Biol. 2, 21-29 (Pubitemid 12133003)
43. Dohlman, H. G., Song, J., Ma, D., Courchesne, W. E., and Thorner, J. (1996) Sst2, a negative regulator of pheromone signaling in the yeast Saccharomyces cerevisiae: expression, localization, and genetic interaction and physical association with Gpa1 (the G-protein alpha subunit) Mol. Cell. Biol. 16, 5194-5209 (Pubitemid 26272173)
44. Poritz, M. A., Malmstrom, S., Kim, M. K. H., Rossmeissl, P. J., and Kamb, A. (2001) Graded mode of transcriptional induction in yeast pheromone signalling revealed by single-cell analysis Yeast 18, 1331-1338 (Pubitemid 32998471)
45. Waters, C. M. and Bassler, B. L. (2005) Quorum sensing: cell-to-cell communication in bacteria Annu. Rev. Cell Dev. Biol. 21, 319-346 (Pubitemid 41740638)
46. Chang, F. and Herskowitz, I. (1990) Identification of a gene necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of a G1 cyclin, CLN2 Cell 63, 999-1011 (Pubitemid 120034941)
47. Siekhaus, D. E. and Drubin, D. G. (2003) Spontaneous receptor-independent heterotrimeric G-protein signalling in an RGS mutant Nat. Cell Biol. 5, 231-235 (Pubitemid 36322250)
48. Tan, C., Marguet, P., and You, L. (2009) Emergent bistability by a growth-modulating positive feedback circuit Nat. Chem. Biol. 5, 842-848
49. Mitrophanov, A. Y. and Groisman, E. A. (2008) Positive feedback in cellular control systems BioEssays 30, 542-555 (Pubitemid 351859411)
50. Paliwal, S., Iglesias, P. A., Campbell, K., Hilioti, Z., Groisman, A., and Levchenko, A. (2007) MAPK-mediated bimodal gene expression and adaptive gradient sensing in yeast Nature 446, 46-51 (Pubitemid 46348042)
51. McIsaac, R. S., Silverman, S. J., McClean, M. N., Gibney, P. A., Macinskas, J., Hickman, M. J., Petti, A. A., and Botstein, D. (2011) Fast-acting and nearly gratuitous induction of gene expression and protein depletion in Saccharomyces cerevisiae Mol. Biol. Cell 22, 4447-4459
52. Da Silva, N. A. and Srikrishnan, S. (2012) Introduction and expression of genes for metabolic engineering applications in Saccharomyces cerevisiae FEMS Yeast Res. 12, 197-214
53. Groß, A., Rödel, G., and Ostermann, K. (2011) Application of the yeast pheromone system for controlled cell-to-cell communication and signal amplification Lett. Appl. Microbiol. 52, 521-526
54. Moser, F., Broers, N. J., Hartmans, S., Tamsir, A., Kerkman, R., Roubos, J. A., Bovenberg, R., and Voigt, C. A. (2012) Genetic circuit performance under conditions relevant for industrial bioreactors ACS Synth. Biol. 1, 555-564
55. Sambrook, J. and Russell, D. W. (2001) Molecular Cloning, a Laboratory Manual, Cold Spring Harbour Laboratory Press, New York.
56. Daniel Gietz, R. and Woods, R. A. (2002) Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method, In Methods in Enzymology (Christine, G. and Gerald, R. F., Eds.), pp 87-96, Academic Press, New York. (Pubitemid 34619485)
57. Güldener, U., Heck, S., Fiedler, T., Beinhauer, J., and Hegemann, J. H. (1996) A new efficient gene disruption cassette for repeated use in budding yeast Nucleic Acids Res. 24, 2519-2524 (Pubitemid 26237149)
58. Sikorski, R. S. and Hieter, P. (1989) A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae Genetics 122, 19-27
59. Van Driessche, B., Tafforeau, L., Hentges, P., Carr, A. M., and Vandenhaute, J. (2005) Additional vectors for PCR-based gene tagging in Saccharomyces cerevisiae and Schizosaccharomyces pombe using nourseothricin resistance Yeast 22, 1061-1068 (Pubitemid 41582367)
60. Stansfield, I. and Stark, M. J. (2007) Yeast Gene Analysis, 2nd ed., Vol. 36, Elsevier, Amsterdam.