Estimating optimal profiles of genetic alterations using constraint-based models

Biotechnology and Bioengineering

Volumn 89, Issue 2, 2005, Pages 243-251

  Gadkar, Kapil G ^a   Doyle III, Francis J ^a   Edwards, Jeremy S ^b   Mahadevan, Radhakrishnan ^c,d  

^a University of California   (United States)

^b University of Delaware   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d GENOMATICA INC   (United States)

Author keywords

Bilevel optimization; Constraint based modeling; Ethanol overproduction; Flux balance analysis; Metabolic engineering

Indexed keywords

DNA; ENZYMES; ESCHERICHIA COLI; FERMENTATION; MATHEMATICAL MODELS; METABOLISM; PARAMETER ESTIMATION; PRODUCTIVITY;

GENETIC ALTERATIONS; GLYCEROL KINASE; METABOLIC NETWORKS; TEMPORAL FLUX;

GENETIC ENGINEERING;

1,3 PROPANEDIOL; ALCOHOL; GLYCEROL KINASE;

AEROBIC BACTERIUM; ALCOHOL PRODUCTION; ARTICLE; BACTERIUM CULTURE; BATCH FERMENTATION; ESCHERICHIA COLI; GROWTH INHIBITION; METABOLIC ENGINEERING; MODEL; MUTATION; NONHUMAN;

ALGORITHMS; COMPUTER SIMULATION; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; ETHANOL; GENE EXPRESSION REGULATION, BACTERIAL; GENETIC ENGINEERING; GENETIC ENHANCEMENT; GLYCEROL; MODELS, GENETIC; SIGNAL TRANSDUCTION;

ESCHERICHIA COLI;

EID: 12544260062     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.20349     Document Type: Article

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