DHA supplementation: Current implications in pregnancy and childhood

Pharmacological Research

Volumn 70, Issue 1, 2013, Pages 13-19

  Rogers, Lynette K ^a,b   Valentine, Christina J ^c   Keim, Sarah A ^a,b  

^a THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN S HOSPITAL   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c Cincinnati Children's Hospital   (United States)

Author keywords

DHA; Lipids; Long chain fatty acids; Natural products; Omega 3

Indexed keywords

DOCOSAHEXAENOIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE;

ADAPTIVE IMMUNITY; ANTIINFLAMMATORY ACTIVITY; BLEEDING; CARCINOGENICITY; CARDIOVASCULAR DISEASE; CEREBROVASCULAR ACCIDENT; CHILD DEVELOPMENT; CHILD GROWTH; CHILDHOOD; COGNITION; DIET SUPPLEMENTATION; DIMERIZATION; DOPAMINERGIC SYSTEM; DRUG ACTIVITY; DRUG EFFICACY; GASTROINTESTINAL DISEASE; HUMAN; IMMUNE DEFICIENCY; INNATE IMMUNITY; LIPID RAFT; MEMBRANE FLUIDITY; MEMORY; MUTAGENICITY; NERVE CELL PLASTICITY; NEUROMODULATION; NEUROTRANSMISSION; NONHUMAN; PREGNANCY; PREMATURITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; REVIEW; SENSORIMOTOR INTEGRATION; SIDE EFFECT; SIGNAL TRANSDUCTION;

ANIMALS; CENTRAL NERVOUS SYSTEM; CHILD DEVELOPMENT; DIETARY SUPPLEMENTS; DOCOSAHEXAENOIC ACIDS; FEMALE; FETAL DEVELOPMENT; HUMANS; INFANT; ORGAN SIZE; PLACENTA; PREGNANCY; PREMATURE BIRTH; RETINA;

EID: 84875135461     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2012.12.003     Document Type: Review

References (114)

1. N. Kromann, and A. Green Epidemiological studies in the Upernavik district, Greenland. Incidence of some chronic diseases 1950-1974 Acta Medica Scandinavica 208 1980 401 406
2. D. Kromhout, E.B. Bosschieter, and C. de Lezenne Coulander The inverse relation between fish consumption and 20-year mortality from coronary heart disease New England Journal of Medicine 312 1985 1205 1209
3. J.L. Beare-Rogers, L. Gray, E.A. Nera, and O.L. Levin Nutritional properties of poppyseed oil relative to some other oils Nutrition and Metabolism 23 1979 335 346
4. R.B. Ervin, C.Y. Wang, J.D. Wright, and J. Kennedy-Stephenson Dietary intake of selected minerals for the United States population: 1999-2000 Advance Data 341 2004 1 5
5. J. Bradbury Docosahexaenoic acid (DHA): an ancient nutrient for the modern human brain Nutrients 3 2011 529 554
6. A.P. Simopoulos Evolutionary aspects of diet: the omega-6/omega-3 ratio and the brain Molecular Neurobiology 44 2011 203 215
7. P.M. Barnes, E. Powell-Griner, K. McFann, and R.L. Nahin Complementary and alternative medicine use among adults: United States, 2002 Advance Data 343 2004 1 19
8. P.C. Calder Immunomodulation by omega-3 fatty acids Prostaglandins Leukotrienes and Essential Fatty Acids 77 2007 327 335
9. S.E. Carlson Docosahexaenoic acid supplementation in pregnancy and lactation American Journal of Clinical Nutrition 89 2009 678S 684S
10. A.P. Simopoulos Omega-3 fatty acids in inflammation and autoimmune diseases Journal of the American College of Nutrition 21 2002 495 505
11. A. Beyerlein, M. Hadders-Algra, K. Kennedy, M. Fewtrell, A. Singhal, and E. Rosenfeld Infant formula supplementation with long-chain polyunsaturated fatty acids has no effect on Bayley developmental scores at 18 months of age-IPD meta-analysis of 4 large clinical trials Journal of Pediatric Gastroenterology and Nutrition 50 2010 79 84
12. M.F. Delgado-Noguera, J.A. Calvache, and X. Bonfill Cosp Supplementation with long chain polyunsaturated fatty acids (LCPUFA) to breastfeeding mothers for improving child growth and development Cochrane Database of Systematic Reviews 12 2010 CD007901
13. E. Yavin Versatile roles of docosahexaenoic acid in the prenatal brain: from pro- and anti-oxidant features to regulation of gene expression Prostaglandins, Leukotrienes and Essential Fatty Acids 75 2006 203 211
14. P.C. Calder The relationship between the fatty acid composition of immune cells and their function Prostaglandins, Leukotrienes and Essential Fatty Acids 79 2008 101 108
15. J. Himmelfarb, S. Phinney, T.A. Ikizler, J. Kane, E. McMonagle, and G. Miller Gamma-tocopherol and docosahexaenoic acid decrease inflammation in dialysis patients Journal of Renal Nutrition 17 2007 296 304
16. J.C. McCann, and B.N. Ames Is docosahexaenoic acid, an N-3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals American Journal of Clinical Nutrition 82 2005 281 295
17. J.Y. Lee, A. Plakidas, W.H. Lee, A. Heikkinen, P. Chanmugam, and G. Bray Differential modulation of toll-like receptors by fatty acids: preferential inhibition by N-3 polyunsaturated fatty acids Journal of Lipid Research 44 2003 479 486
18. D.Y. Oh, S. Talukdar, E.J. Bae, T. Imamura, H. Morinaga, and W. Fan Gpr120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects Cell 142 2010 687 698
19. H. Li, X.Z. Ruan, S.H. Powis, R. Fernando, W.Y. Mon, and D.C. Wheeler EPA and DHA reduce LPS-induced inflammation responses in HK-2 cells: evidence for a PPAR-gamma-dependent mechanism Kidney International 67 2005 867 874
20. S.M. Innis, and S. de La Presa Owens Dietary fatty acid composition in pregnancy alters neurite membrane fatty acids and dopamine in newborn rat brain Journal of Nutrition 131 2001 118 122
21. H.S. Bhatia, R. Agrawal, S. Sharma, Y.X. Huo, Z. Ying, and F. Gomez-Pinilla Omega-3 fatty acid deficiency during brain maturation reduces neuronal and behavioral plasticity in adulthood PLoS ONE 6 2011 e28451
22. S. Delion, S. Chalon, J. Herault, D. Guilloteau, J.C. Besnard, and G. Durand Chronic dietary alpha-linolenic acid deficiency alters dopaminergic and serotoninergic neurotransmission in rats Journal of Nutrition 124 1994 2466 2476
23. P.E. Wainwright Dietary essential fatty acids and brain function: a developmental perspective on mechanisms Proceedings of the Nutrition Society 61 2002 61 69
24. S.W. Wong, M.J. Kwon, A.M. Choi, H.P. Kim, K. Nakahira, and D.H. Hwang Fatty acids modulate toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner Journal of Biological Chemistry 284 2009 27384 27392
25. S. Malaeb, and O. Dammann Fetal inflammatory response and brain injury in the preterm newborn Journal of Child Neurology 24 2009 1119 1126
26. J.Y. Lee, J. Ye, Z. Gao, H.S. Youn, W.H. Lee, and L. Zhao Reciprocal modulation of toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids Journal of Biological Chemistry 278 2003 37041 37051
27. D.Y. Oh, and J.M. Olefsky Omega 3 fatty acids and GPR120 Cell Metabolism 15 2012 564 565
28. R.S. Chapkin, W. Kim, J.R. Lupton, and D.N. McMurray Dietary docosahexaenoic and eicosapentaenoic acid: emerging mediators of inflammation Prostaglandins Leukotrienes and Essential Fatty Acids 81 2009 187 191
29. J. Lengqvist, A. Mata De Urquiza, A.C. Bergman, T.M. Willson, J. Sjovall, and T. Perlmann Polyunsaturated fatty acids including docosahexaenoic and arachidonic acid bind to the retinoid × receptor alpha ligand-binding domain Molecular and Cellular Proteomics 3 2004 692 703
30. H. Tiesset, M. Pierre, J.L. Desseyn, B. Guery, C. Beermann, and C. Galabert Dietary (N-3) polyunsaturated fatty acids affect the kinetics of pro- and antiinflammatory responses in mice with pseudomonas aeruginosa lung infection Journal of Nutrition 139 2009 82 89
31. H.E. Xu, M.H. Lambert, V.G. Montana, D.J. Parks, S.G. Blanchard, and P.J. Brown Molecular recognition of fatty acids by peroxisome proliferator-activated receptors Molecular Cell 3 1999 397 403
32. R.L. Bradley, F.F. Fisher, and E. Maratos-Flier Dietary fatty acids differentially regulate production of TNF-alpha and IL-10 by murine 3T3-L1 adipocytes Obesity (Silver Spring) 16 2008 938 944
33. M. Akbar, F. Calderon, Z. Wen, and H.Y. Kim Docosahexaenoic acid: a positive modulator of AKT signaling in neuronal survival Proceedings of the National Academy of Sciences of the United States of America 102 2005 10858 10863
34. K. Simons, and E. Ikonen Functional rafts in cell membranes Nature 387 1997 569 572
35. S.R. Wassall, and W. Stillwell Polyunsaturated fatty acid-cholesterol interactions: domain formation in membranes Biochimica et Biophysica Acta 1788 2009 24 32
36. T. Huber, K. Rajamoorthi, V.F. Kurze, K. Beyer, and M.F. Brown Structure of docosahexaenoic acid-containing phospholipid bilayers as studied by (2)H NMR and molecular dynamics simulations Journal of the American Chemical Society 124 2002 298 309
37. S. Kew, T. Banerjee, A.M. Minihane, Y.E. Finnegan, C.M. Williams, and P.C. Calder Relation between the fatty acid composition of peripheral blood mononuclear cells and measures of immune cell function in healthy, free-living subjects aged 25-72 years American Journal of Clinical Nutrition 77 2003 1278 1286
38. D.A. Healy, F.A. Wallace, E.A. Miles, P.C. Calder, and P. Newsholm Effect of low-to-moderate amounts of dietary fish oil on neutrophil lipid composition and function Lipids 35 2000 763 768
39. S.M. Innis Perinatal biochemistry and physiology of long-chain polyunsaturated fatty acids Journal of Pediatrics 143 2003 S1 S8
40. F.J. van Kuijk, and P. Buck Fatty acid composition of the human macula and peripheral retina Investigative Ophthalmology and Visual Science 33 1992 3493 3496
41. Y. Kishimoto, B.W. Agranoff, N.S. Radin, and R.M. Burton Comparison of the fatty acids of lipids of subcellular brain fractions Journal of Neurochemistry 16 1969 397 404
42. R.E. Anderson Lipids of ocular tissues. IV. A comparison of the phospholipids from the retina of six mammalian species Experimental Eye Research 10 1970 339 344
43. G.Y. Sun, and Y. Sun Phospholipids and acyl groups of synaptosomal and myelin membranes isolated from the cerebral cortex of squirrel monkey (Saimiri sciureus) Biochimica et Biophysica Acta 280 1972 306 315
44. P.C. Calder, J.A. Bond, D.J. Harvey, S. Gordon, and E.A. Newsholme Uptake and incorporation of saturated and unsaturated fatty acids into macrophage lipids and their effect upon macrophage adhesion and phagocytosis Biochemical Journal 269 1990 807 814
45. C.N. Serhan Novel eicosanoid and docosanoid mediators: resolvins, docosatrienes, and neuroprotectins Current Opinion in Clinical Nutrition and Metabolic Care 8 2005 115 121
46. C.N. Serhan, C.B. Clish, J. Brannon, S.P. Colgan, N. Chiang, and K. Gronert Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing Journal of Experimental Medicine 192 2000 1197 1204
47. C.N. Serhan Novel chemical mediators in the resolution of inflammation: resolvins and protectins Anesthesiology Clinics 24 2006 341 364
48. C.N. Serhan, K. Gotlinger, S. Hong, Y. Lu, J. Siegelman, and T. Baer Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes Journal of Immunology 176 2006 1848 1859
49. T.D. Niemoller, and N.G. Bazan Docosahexaenoic acid neurolipidomics Prostaglandins and Other Lipid Mediators 91 2010 85 89
50. H. Yin, W. Liu, K. Goleniewska, N.A. Porter, J.D. Morrow, and R.S. Peebles Jr. Dietary supplementation of omega-3 fatty acid-containing fish oil suppresses F2-isoprostanes but enhances inflammatory cytokine response in a mouse model of ovalbumin-induced allergic lung inflammation Free Radical Biology and Medicine 47 2009 622 628
51. G.C. Burdge, J. Powell, T. Dadd, D. Talbot, J. Civil, and P.C. Calder Acute consumption of fish oil improves postprandial VLDL profiles in healthy men aged 50-65 years British Journal of Nutrition 102 2009 160 165
52. G. Bannenberg, M. Arita, and C.N. Serhan Endogenous receptor agonists: resolving inflammation The Scientific World Journal 7 2007 1440 1462
53. M. Arita, T. Ohira, Y.P. Sun, S. Elangovan, N. Chiang, and C.N. Serhan Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation Journal of Immunology 178 2007 3912 3917
54. A. Ariel, and C.N. Serhan Resolvins and protectins in the termination program of acute inflammation Trends in Immunology 28 2007 176 183
55. J.M. Schwab, N. Chiang, M. Arita, and C.N. Serhan Resolvin E1 and protectin D1 activate inflammation-resolution programmes Nature 447 2007 869 874
56. L.M. Arterburn, E.B. Hall, and H. Oken Distribution, interconversion, and dose response of N-3 fatty acids in humans American Journal of Clinical Nutrition 83 2006 1467S 1476S
57. O.S. von Ehrenstein, G.I. Neta, W. Andrews, R. Goldenberg, A. Goepfert, and J. Zhang Child intellectual development in relation to cytokine levels in umbilical cord blood American Journal of Epidemiology 175 2012 1191 1199
58. B.H. Yoon, C.W. Park, and T. Chaiworapongsa Intrauterine infection and the development of cerebral palsy BJOG 110 Suppl. 20 2003 124 127
59. R. Pickler, L. Brown, J. McGrath, D. Lyon, D. Rattican, and C.Y. Cheng Integrated review of cytokines in maternal, cord, and newborn blood: Part II-associations with early infection and increased risk of neurologic damage in preterm infants Biological Research for Nursing 11 2010 377 386
60. R.H. Pickler, J.M. McGrath, B.A. Reyna, N. McCain, M. Lewis, and S. Cone A model of neurodevelopmental risk and protection for preterm infants Journal of Perinatal and Neonatal Nursing 24 2010 356 365
61. S.T. Bland, J.T. Beckley, S. Young, V. Tsang, L.R. Watkins, and S.F. Maier Enduring consequences of early-life infection on glial and neural cell genesis within cognitive regions of the brain Brain, Behavior, and Immunity 24 2010 329 338
62. M. Huleihel, H. Golan, and M. Hallak Intrauterine infection/inflammation during pregnancy and offspring brain damages: possible mechanisms involved Reproductive Biology and Endocrinology 2 2004 17
63. G.E. Caughey, E. Mantzioris, R.A. Gibson, L.G. Cleland, and M.J. James The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in N-3 fatty acids from vegetable oil or fish oil American Journal of Clinical Nutrition 63 1996 116 122
64. E. Kawakita, M. Hashimoto, and O. Shido Docosahexaenoic acid promotes neurogenesis in vitro and in vivo Neuroscience 139 2006 991 997
65. S.E. Carlson Docosahexaenoic acid and arachidonic acid in infant development Seminars in Neonatology 6 2001 437 449
66. S.M. Innis Essential fatty acid transfer and fetal development Placenta 26 Suppl. A 2005 S70 S75
67. M.T. Clandinin, J.E. Chappell, S. Leong, T. Heim, P.R. Swyer, and G.W. Chance Intrauterine fatty acid accretion rates in human brain: implications for fatty acid requirements Early Human Development 4 1980 121 129
68. C. Henriksen, K. Haugholt, M. Lindgren, A.K. Aurvag, A. Ronnestad, and M. Gronn Improved cognitive development among preterm infants attributable to early supplementation of human milk with docosahexaenoic acid and arachidonic acid Pediatrics 121 2008 1137 1145
69. M.V. Dhobale, N. Wadhwani, S.S. Mehendale, H.R. Pisal, and S.R. Joshi Reduced levels of placental long chain polyunsaturated fatty acids in preterm deliveries Prostaglandins, Leukotrienes, and Essential Fatty Acids 85 2011 149 153
70. R.K. McNamara, and S.E. Carlson Role of omega-3 fatty acids in brain development and function: potential implications for the pathogenesis and prevention of psychopathology Prostaglandins Leukotrienes and Essential Fatty Acids 75 2006 329 349
71. L. Lauritzen, and S.E. Carlson Maternal fatty acid status during pregnancy and lactation and relation to newborn and infant status Maternal and Child Nutrition 7 Suppl. 2 2011 41 58
72. R.G. Jordan Prenatal omega-3 fatty acids: review and recommendations Journal of Midwifery and Women's Health 55 2010 520 528
73. J.A. Dunstan, L.R. Mitoulas, G. Dixon, D.A. Doherty, P.E. Hartmann, and K. Simmer The effects of fish oil supplementation in pregnancy on breast milk fatty acid composition over the course of lactation: a randomized controlled trial Pediatric Research 62 2007 689 694
74. L. Lauritzen, M.H. Jorgensen, T.B. Mikkelsen, M. Skovgaard, E.M. Straarup, and S.F. Olsen Maternal fish oil supplementation in lactation: effect on visual acuity and N-3 fatty acid content of infant erythrocytes Lipids 39 2004 195 206
75. S.J. Meldrum, N. D'Vaz, K. Simmer, J.A. Dunstan, K. Hird, and S.L. Prescott Effects of high-dose fish oil supplementation during early infancy on neurodevelopment and language: a randomised controlled trial British Journal of Nutrition 108 2012 1 12
76. C. Furuhjelm, K. Warstedt, M. Fageras, K. Falth-Magnusson, J. Larsson, and M. Fredriksson Allergic disease in infants up to 2 years of age in relation to plasma omega-3 fatty acids and maternal fish oil supplementation in pregnancy and lactation Pediatric Allergy and Immunology 22 2011 505 514
77. P.S. Noakes, M. Vlachava, L.S. Kremmyda, N.D. Diaper, E.A. Miles, and M. Erlewyn-Lajeunesse Increased intake of oily fish in pregnancy: effects on neonatal immune responses and on clinical outcomes in infants at 6 months American Journal of Clinical Nutrition 95 2012 395 404
78. J.D. Salvig, and R.F. Lamont Evidence regarding an effect of marine N-3 fatty acids on preterm birth: a systematic review and meta-analysis Acta Obstetricia et Gynecologica Scandinavica 90 2011 825 838
79. R.S. Kuipers, M.F. Luxwolda, P.J. Offringa, E.R. Boersma, D.A. Dijck-Brouwer, and F.A. Muskiet Fetal intrauterine whole body linoleic, arachidonic and docosahexaenoic acid contents and accretion rates Prostaglandins, Leukotrienes, and Essential Fatty Acids 86 2012 13 20
80. C.J. Valentine Maternal dietary DHA supplementation to improve inflammatory outcomes in the preterm infant Advanced Nutrients 3 2012 370 376
81. H. Szajewska, and M. Makrides Is early nutrition related to short-term health and long-term outcome? Annals of Nutrition and Metabolism 58 Suppl. 1 2011 38 48
82. C.J. Valentine, G. Morrow, S. Fernandez, P. Gulati, D. Bartholomew, and D. Long Docosahexaenoic acid and amino acid content in pastuerized donor milk are low for preterm infants Journal of Pediatrics 157 2010 906 910
83. C.J. Valentine, G. Morrow, M. Pennell, A.L. Morrow, A. Hodge, and A. Haban-Bartz Randomized controlled trial of docosahexaenoic acid supplementation in midwestern U.S. Human milk donors Breastfeeding Medicine 2012 epub ahead of print
84. J.T. Brenna, B. Varamini, R.G. Jensen, D.A. Diersen-Schade, J.A. Boettcher, and L.M. Arterburn Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide American Journal of Clinical Nutrition 85 2007 1457 1464
85. R.L. Goldenberg, M.B. DuBard, S.P. Cliver, K.G. Nelson, K. Blankson, and S.L. Ramey Pregnancy outcome and intelligence at age five years American Journal of Obstetrics and Gynecology 175 1996 1511 1515
86. K.N. Wharton, H. Pinar, B.S. Stonestreet, R. Tucker, K.R. McLean, and M. Wallach Severe umbilical cord inflammation-a predictor of periventricular leukomalacia in very low birth weight infants Early Human Development 77 2004 77 87
87. M. Martinez Tissue levels of polyunsaturated fatty acids during early human development Journal of Pediatrics 120 1992 S129 S138
88. N.G. Bazan, M.F. Molina, and W.C. Gordon Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer's, and other neurodegenerative diseases Annual Review of Nutrition 31 2011 321 351
89. M. Hadders-Algra The role of long-chain polyunsaturated fatty acids (LCPUFA) in growth and development Advances in Experimental Medicine and Biology 569 2005 80 94
90. M. Hadders-Algra, H. Bouwstra, S.A. van Goor, D.A. Dijck-Brouwer, and F.A. Muskiet Prenatal and early postnatal fatty acid status and neurodevelopmental outcome Journal of Perinatal Medicine 35 Suppl. 1 2007 S28 S34
91. G.Y. Diau, A.T. Hsieh, E.A. Sarkadi-Nagy, V. Wijendran, P.W. Nathanielsz, and J.T. Brenna The influence of long chain polyunsaturate supplementation on docosahexaenoic acid and arachidonic acid in baboon neonate central nervous system BMC Medicine 3 2005 11
92. S. Favreliere, L. Barrier, G. Durand, S. Chalon, and C. Tallineau Chronic dietary N-3 polyunsaturated fatty acids deficiency affects the fatty acid composition of plasmenylethanolamine and phosphatidylethanolamine differently in rat frontal cortex, striatum, and cerebellum Lipids 33 1998 401 407
93. J.M. Bourre, G. Pascal, G. Durand, M. Masson, O. Dumont, and M. Piciotti Alterations in the fatty acid composition of rat brain cells (neurons, astrocytes, and oligodendrocytes) and of subcellular fractions (myelin and synaptosomes) induced by a diet devoid of N-3 fatty acids Journal of Neurochemistry 43 1984 342 348
94. L. Lauritzen, H.S. Hansen, M.H. Jorgensen, and K.F. Michaelsen The essentiality of long chain N-3 fatty acids in relation to development and function of the brain and retina Progress in Lipid Research 40 2001 1 94
95. J.C. Martin, P. Bougnoux, A. Fignon, V. Theret, J.M. Antoine, and F. Lamisse Dependence of human milk essential fatty acids on adipose stores during lactation American Journal of Clinical Nutrition 58 1993 653 659
96. M.T. Clandinin, J.E. Van Aerde, K.L. Merkel, C.L. Harris, M.A. Springer, and J.W. Hansen Growth and development of preterm infants fed infant formulas containing docosahexaenoic acid and arachidonic acid Journal of Pediatrics 146 2005 461 468
97. M. Hadders-Algra Prenatal long-chain polyunsaturated fatty acid status: the importance of a balanced intake of docosahexaenoic acid and arachidonic acid Journal of Perinatal Medicine 36 2008 101 109
98. B. Koletzko, C. Agostoni, S.E. Carlson, T. Clandinin, G. Hornstra, and M. Neuringer Long chain polyunsaturated fatty acids (LC-PUFA) and perinatal development Acta Paediatrica 90 2001 460 464
99. E.E. Birch, D.G. Birch, D.R. Hoffman, and R. Uauy Dietary essential fatty acid supply and visual acuity development Investigative Ophthalmology and Visual Science 33 1992 3242 3253
100. S.J. Meldrum, M.A. Smith, S.L. Prescott, K. Hird, and K. Simmer Achieving definitive results in long-chain polyunsaturated fatty acid supplementation trials of term infants: factors for consideration Nutrition Reviews 69 2011 205 214
101. M. Makrides, L.G. Smithers, and R.A. Gibson Role of long-chain polyunsaturated fatty acids in neurodevelopment and growth Nestle Nutrition Workshop Series: Pediatric Program 65 2010 123 133 [discussion 133-126]
102. S.M. Schulzke, S.K. Patole, and K. Simmer Longchain polyunsaturated fatty acid supplementation in preterm infants Cochrane Database of Systematic Reviews 2011 CD000375
103. K. Simmer, S.K. Patole, and S.C. Rao Longchain polyunsaturated fatty acid supplementation in infants born at term Cochrane Database of Systematic Reviews 12 2011 CD000376
104. National Immunization Survey, Provisional Data. U.S. Centers for Disease Control and Prevention, 2008.
105. J. Belsky, and M. de Haan Annual research review: parenting and children's brain development: the end of the beginning Journal of Child Psychology and Psychiatry and Allied Disciplines 52 2011 409 428
106. M. Makrides, R.A. Gibson, T. Udell, and K. Ried Supplementation of infant formula with long-chain polyunsaturated fatty acids does not influence the growth of term infants American Journal of Clinical Nutrition 81 2005 1094 1101
107. M. Lagarde, C. Calzada, M. Guichardant, and E. Vericel Dose-effect and metabolism of docosahexaenoic acid: pathophysiological relevance in blood platelets Prostaglandins Leukotrienes and Essential Fatty Acids 2012 epub ahead of print
108. N. Guillot, E. Caillet, M. Laville, C. Calzada, M. Lagarde, and E. Vericel Increasing intakes of the long-chain omega-3 docosahexaenoic acid: effects on platelet functions and redox status in healthy men FASEB Journal 23 2009 2909 2916
109. M. Phang, M.L. Garg, and A.J. Sinclair Inhibition of platelet aggregation by omega-3 polyunsaturated fatty acids is gender specific-redefining platelet response to fish oils Prostaglandins Leukotrienes and Essential Fatty Acids 81 2009 35 40
110. T.W. Rice, A.P. Wheeler, B.T. Thompson, B.P. DeBoisblanc, J. Steingrub, and P. Rock Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury JAMA: The Journal of the American Medical Association 306 2011 1574 1581
111. S. Serini, E. Fasano, E. Piccioni, A.R. Cittadini, and G. Calviello Dietary N-3 polyunsaturated fatty acids and the paradox of their health benefits and potential harmful effects Chemical Research in Toxicology 24 2011 2093 2105
112. H. Grundt, D.W. Nilsen, M.A. Mansoor, and A. Nordoy Increased lipid peroxidation during long-term intervention with high doses of N-3 fatty acids (PUFAS) following an acute myocardial infarction European Journal of Clinical Nutrition 57 2003 793 800
113. P. Palozza, E. Sgarlata, C. Luberto, E. Piccioni, M. Anti, and G. Marra N-3 fatty acids induce oxidative modifications in human erythrocytes depending on dose and duration of dietary supplementation American Journal of Clinical Nutrition 64 1996 297 304
114. A. Taneja, and H. Singh Challenges for the delivery of long-chain N-3 fatty acids in functional foods Annual Review of Food Science and Technology 3 2012 105 123