메뉴 건너뛰기




Volumn 63, Issue 3, 2008, Pages 380-391

Mesenchymal stem cell and gene therapies for spinal fusion

Author keywords

Bone morphogenetic protein; Gene therapy; Mesenchymal stem cells; Osteogenesis; Spinal fusion

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 9; LIPOSOME; NAKED DNA; OSTEOGENIC PROTEIN 1;

EID: 65849212897     PISSN: 0148396X     EISSN: None     Source Type: Journal    
DOI: 10.1227/01.NEU.0000324990.04818.13     Document Type: Review
Times cited : (41)

References (93)
  • 1
    • 0037102489 scopus 로고    scopus 로고
    • Economic evaluation of bone morphogenetic protein versus autogenous iliac crest bone graft in single-level anterior lumbar fusion: An evidence-based modeling approach
    • Ackerman SJ, Mafilios MS, Polly DW Jr: Economic evaluation of bone morphogenetic protein versus autogenous iliac crest bone graft in single-level anterior lumbar fusion: An evidence-based modeling approach. Spine 27:S94-S99, 2002.
    • (2002) Spine , vol.27
    • Ackerman, S.J.1    Mafilios, M.S.2    Polly Jr, D.W.3
  • 4
    • 67650245129 scopus 로고    scopus 로고
    • Examination of soft tissue edema following implantation of rhBMP-2 on an absorbable collagen sponge in a rat ectopic model
    • Bae H, Badura J, Peckam S, McKay W: Examination of soft tissue edema following implantation of rhBMP-2 on an absorbable collagen sponge in a rat ectopic model. Spine J 7:15S-16S, 2007.
    • (2007) Spine J , vol.7
    • Bae, H.1    Badura, J.2    Peckam, S.3    McKay, W.4
  • 7
    • 0029621125 scopus 로고
    • Biologic enhancement of spinal fusion
    • Boden SD, Schimandle JH: Biologic enhancement of spinal fusion. Spine 20:113S-123S, 1995.
    • (1995) Spine , vol.20
    • Boden, S.D.1    Schimandle, J.H.2
  • 8
    • 18644363051 scopus 로고    scopus 로고
    • Comparison of Healos/bone marrow to INFUSE(rhBMP-2acs) with a collagen-ceramic sponge bulking agent as graft substitutes for lumbar spine fusion
    • Boden S, Kraiwattanapong C, Louis-Ugbo J, Barnes B, Hutton WC: Comparison of Healos/bone marrow to INFUSE(rhBMP-2acs) with a collagen-ceramic sponge bulking agent as graft substitutes for lumbar spine fusion. Spine 30:1001-1007, 2005.
    • (2005) Spine , vol.30 , pp. 1001-1007
    • Boden, S.1    Kraiwattanapong, C.2    Louis-Ugbo, J.3    Barnes, B.4    Hutton, W.C.5
  • 9
    • 0033557962 scopus 로고    scopus 로고
    • The use of coralline hydroxyapatite with bone marrow, autogenous bone graft, or osteoinductive bone protein extract for posterolateral lumbar spine fusion
    • Boden SD, Martin GJ Jr, Morone M, Ugbo JL, Titus L, Hutton WC: The use of coralline hydroxyapatite with bone marrow, autogenous bone graft, or osteoinductive bone protein extract for posterolateral lumbar spine fusion. Spine 24:320-327, 1999.
    • (1999) Spine , vol.24 , pp. 320-327
    • Boden, S.D.1    Martin Jr, G.J.2    Morone, M.3    Ugbo, J.L.4    Titus, L.5    Hutton, W.C.6
  • 10
    • 0029646085 scopus 로고
    • Volvo Award in basic sciences. The use of an osteoinductive growth factor for lumbar spinal fusion. Part II: Study of dose, carrier, and species
    • Boden SD, Schimandle JH, Hutton WC: 1995 Volvo Award in basic sciences. The use of an osteoinductive growth factor for lumbar spinal fusion. Part II: Study of dose, carrier, and species. Spine 20:2633-2644, 1995.
    • (1995) Spine , vol.20 , pp. 2633-2644
    • Boden, S.D.1    Schimandle, J.H.2    Hutton, W.C.3
  • 11
    • 0032238373 scopus 로고    scopus 로고
    • Lumbar spine fusion by local gene therapy with a cDNA encoding a novel osteoinductive protein (LMP-1)
    • Boden SD, Titus L, Hair G, Liu Y, Viggeswarapu M, Nanes MS, Baranowski C: Lumbar spine fusion by local gene therapy with a cDNA encoding a novel osteoinductive protein (LMP-1). Spine 23:2486-2492, 1998.
    • (1998) Spine , vol.23 , pp. 2486-2492
    • Boden, S.D.1    Titus, L.2    Hair, G.3    Liu, Y.4    Viggeswarapu, M.5    Nanes, M.S.6    Baranowski, C.7
  • 12
    • 33748338535 scopus 로고    scopus 로고
    • In vivo evaluation of plasmid DNA encoding OP-1 protein for spine fusion
    • Bright C, Park YS, Sieber AN, Kostuik J P, Leong KW: In vivo evaluation of plasmid DNA encoding OP-1 protein for spine fusion. Spine 31:2163-2172, 2006.
    • (2006) Spine , vol.31 , pp. 2163-2172
    • Bright, C.1    Park, Y.S.2    Sieber, A.N.3    Kostuik, J.P.4    Leong, K.W.5
  • 13
    • 0027973996 scopus 로고
    • Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy
    • Bruder S P, Fink DJ, Caplan AI: Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy. J Cell Biochem 56:283-294, 1994.
    • (1994) J Cell Biochem , vol.56 , pp. 283-294
    • Bruder, S.P.1    Fink, D.J.2    Caplan, A.I.3
  • 15
    • 0000680367 scopus 로고
    • Studies in the transplantation of bone. VII. The fresh composite homograft-autograft of cancellous bone; an analysis of factors leading to osteogenesis in marrow transplants and in marrow-containing bone grafts
    • Burwell RG: Studies in the transplantation of bone. VII. The fresh composite homograft-autograft of cancellous bone; an analysis of factors leading to osteogenesis in marrow transplants and in marrow-containing bone grafts. J Bone Joint Surg Br 46B:110-140, 1964.
    • (1964) J Bone Joint Surg Br , vol.46 B , pp. 110-140
    • Burwell, R.G.1
  • 16
    • 42749086517 scopus 로고    scopus 로고
    • Prospective nonrandomized comparison of an allograft with bone morphogenic protein versus an iliac-crest autograft in anterior cervical discectomy and fusion
    • Buttermann GR: Prospective nonrandomized comparison of an allograft with bone morphogenic protein versus an iliac-crest autograft in anterior cervical discectomy and fusion. Spine J 8:426-435, 2007.
    • (2007) Spine J , vol.8 , pp. 426-435
    • Buttermann, G.R.1
  • 17
    • 28244487461 scopus 로고    scopus 로고
    • Bone morphogenetic proteins for spinal fusion
    • Carlisle E, Fischgrund JS: Bone morphogenetic proteins for spinal fusion. Spine J 5:240S-249S, 2005.
    • (2005) Spine J , vol.5
    • Carlisle, E.1    Fischgrund, J.S.2
  • 18
    • 0041566591 scopus 로고    scopus 로고
    • Gene therapy applications for spine fusion
    • Cha CW, Boden SD: Gene therapy applications for spine fusion. Spine 28:S74-S84, 2003.
    • (2003) Spine , vol.28
    • Cha, C.W.1    Boden, S.D.2
  • 20
    • 0031734665 scopus 로고    scopus 로고
    • Clinical use of marrow osteoprogenitor cells to stimulate osteo-genesis
    • Connolly JF: Clinical use of marrow osteoprogenitor cells to stimulate osteo-genesis. Clin Orthop Relat Res 355 [Suppl]:S257-S266, 1998.
    • (1998) Clin Orthop Relat Res , vol.355 , Issue.SUPPL.
    • Connolly, J.F.1
  • 21
    • 0035500056 scopus 로고    scopus 로고
    • Comparison of lumbar spine fusion using mixed and cloned marrow cells
    • Cui Q, Ming Xiao Z, Balian G, Wang GJ: Comparison of lumbar spine fusion using mixed and cloned marrow cells. Spine 26:2305-2310, 2001.
    • (2001) Spine , vol.26 , pp. 2305-2310
    • Cui, Q.1    Ming Xiao, Z.2    Balian, G.3    Wang, G.J.4
  • 22
    • 34548398145 scopus 로고    scopus 로고
    • The incidence of donor site pain after bone graft harvesting from the posterior iliac crest may be overestimated: A study on spine fracture patients
    • Delawi D, Dhert WJ, Castelein RM, Verbout AJ, Oner FC: The incidence of donor site pain after bone graft harvesting from the posterior iliac crest may be overestimated: A study on spine fracture patients. Spine 32:1865-1868, 2007.
    • (2007) Spine , vol.32 , pp. 1865-1868
    • Delawi, D.1    Dhert, W.J.2    Castelein, R.M.3    Verbout, A.J.4    Oner, F.C.5
  • 23
    • 33750290922 scopus 로고    scopus 로고
    • Clinical outcomes and fusion success at 2 years of single-level instrumented posterolateral fusions with recombinant human bone morphogenetic protein-2/compression resistant matrix versus iliac crest bone graft
    • Dimar JR, Glassman SD, Burkus KJ, Carreon LY: Clinical outcomes and fusion success at 2 years of single-level instrumented posterolateral fusions with recombinant human bone morphogenetic protein-2/compression resistant matrix versus iliac crest bone graft. Spine 31:2534-2540, 2006.
    • (2006) Spine , vol.31 , pp. 2534-2540
    • Dimar, J.R.1    Glassman, S.D.2    Burkus, K.J.3    Carreon, L.Y.4
  • 24
    • 0036871171 scopus 로고    scopus 로고
    • Ex vivo bone morphogenetic protein-9 gene therapy using human mesenchymal stem cells induces spinal fusion in rodents
    • Dumont RJ, Dayoub H, Li JZ, Dumont AS, Kallmes DF, Hankins GR, Helm GA: Ex vivo bone morphogenetic protein-9 gene therapy using human mesenchymal stem cells induces spinal fusion in rodents. Neurosurgery 51:1239-1245, 2002.
    • (2002) Neurosurgery , vol.51 , pp. 1239-1245
    • Dumont, R.J.1    Dayoub, H.2    Li, J.Z.3    Dumont, A.S.4    Kallmes, D.F.5    Hankins, G.R.6    Helm, G.A.7
  • 25
    • 0014261390 scopus 로고
    • Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues
    • Friedenstein AJ, Petrakova K V, Kurolesova AI, Frolova GP: Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation 6:230-247, 1968.
    • (1968) Transplantation , vol.6 , pp. 230-247
    • Friedenstein, A.J.1    Petrakova, K.V.2    Kurolesova, A.I.3    Frolova, G.P.4
  • 26
    • 0029961204 scopus 로고    scopus 로고
    • The function of adipocytes in the bone marrow stroma: An update
    • Gimble JM, Robinson CE, Wu X, Kelly KA: The function of adipocytes in the bone marrow stroma: An update. Bone 19:421-428, 1996.
    • (1996) Bone , vol.19 , pp. 421-428
    • Gimble, J.M.1    Robinson, C.E.2    Wu, X.3    Kelly, K.A.4
  • 27
    • 33847617021 scopus 로고    scopus 로고
    • From the laboratory bench to the patient's bedside: An update on clinical trials with mesenchymal stem cells
    • Giordano A, Galderisi U, Marino IR: From the laboratory bench to the patient's bedside: An update on clinical trials with mesenchymal stem cells. J Cell Physiol 211:27-35, 2007.
    • (2007) J Cell Physiol , vol.211 , pp. 27-35
    • Giordano, A.1    Galderisi, U.2    Marino, I.R.3
  • 31
    • 0034433719 scopus 로고    scopus 로고
    • A randomized prospective study of an anterior cervical interbody fusion device with a minimum of 2 years of follow-up results
    • Hacker RJ: A randomized prospective study of an anterior cervical interbody fusion device with a minimum of 2 years of follow-up results. J Neurosurg 93:222-226, 2000.
    • (2000) J Neurosurg , vol.93 , pp. 222-226
    • Hacker, R.J.1
  • 32
    • 11144250305 scopus 로고    scopus 로고
    • Posterior lumbar inter-body fusion using recombinant human bone morphogenetic protein type-2 with cylindrical interbody cages
    • Haid RW Jr, Branch CL Jr, Alexander JT, Burkus JK: Posterior lumbar inter-body fusion using recombinant human bone morphogenetic protein type-2 with cylindrical interbody cages. Spine J 4:527-539, 2004.
    • (2004) Spine J , vol.4 , pp. 527-539
    • Haid Jr, R.W.1    Branch Jr, C.L.2    Alexander, J.T.3    Burkus, J.K.4
  • 33
    • 0033724704 scopus 로고    scopus 로고
    • Adipose-derived stromal cells - Their utility and potential in bone formation
    • Halvorsen YC, Wilkison WO, Gimble JM: Adipose-derived stromal cells - Their utility and potential in bone formation. Int J Obes Relat Metab Disord 24 [Suppl 4]:S41-S44, 2000.
    • (2000) Int J Obes Relat Metab Disord , vol.24 , Issue.SUPPL. 4
    • Halvorsen, Y.C.1    Wilkison, W.O.2    Gimble, J.M.3
  • 34
    • 24944463395 scopus 로고    scopus 로고
    • Murine spinal fusion induced by engineered mesenchymal stem cells that conditionally express bone morphogenetic protein-2
    • Hasharoni A, Zilberman Y, Turgeman G, Helm GA, Liebergall M, Gazit D: Murine spinal fusion induced by engineered mesenchymal stem cells that conditionally express bone morphogenetic protein-2. J Neurosurg Spine 3:47-52, 2005.
    • (2005) J Neurosurg Spine , vol.3 , pp. 47-52
    • Hasharoni, A.1    Zilberman, Y.2    Turgeman, G.3    Helm, G.A.4    Liebergall, M.5    Gazit, D.6
  • 35
    • 33646687738 scopus 로고    scopus 로고
    • Future uses of mesenchymal stem cells in spine surgery
    • Helm GA, Gazit Z: Future uses of mesenchymal stem cells in spine surgery. Neurosurg Focus 19:E13, 2005.
    • (2005) Neurosurg Focus , vol.19
    • Helm, G.A.1    Gazit, Z.2
  • 37
    • 0141813683 scopus 로고    scopus 로고
    • Enhancement of spine fusion using combined gene therapy and tissue engineering BMP-7-expressing bone marrow cells and allograft bone
    • Hidaka C, Goshi K, Rawlins B, Boachie-Adjei O, Crystal RG: Enhancement of spine fusion using combined gene therapy and tissue engineering BMP-7-expressing bone marrow cells and allograft bone. Spine 28:2049-2057, 2003.
    • (2003) Spine , vol.28 , pp. 2049-2057
    • Hidaka, C.1    Goshi, K.2    Rawlins, B.3    Boachie-Adjei, O.4    Crystal, R.G.5
  • 38
    • 0037173116 scopus 로고    scopus 로고
    • Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone
    • Horwitz EM, Gordon PL, Koo WK, Marx JC, Neel MD, McNall RY, Muul L, Hofmann T: Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone. Proc Natl Acad Sci U S A 99:8932-8937, 2002.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 8932-8937
    • Horwitz, E.M.1    Gordon, P.L.2    Koo, W.K.3    Marx, J.C.4    Neel, M.D.5    McNall, R.Y.6    Muul, L.7    Hofmann, T.8
  • 39
    • 0031012411 scopus 로고    scopus 로고
    • Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro
    • Jaiswal N, Haynesworth SE, Caplan AI, Bruder SP: Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro. J Cell Biochem 64:295-312, 1997.
    • (1997) J Cell Biochem , vol.64 , pp. 295-312
    • Jaiswal, N.1    Haynesworth, S.E.2    Caplan, A.I.3    Bruder, S.P.4
  • 40
    • 39049119326 scopus 로고    scopus 로고
    • Heterotopic bone formation with the use of rhBMP2 in posterior minimal access interbody fusion
    • Joseph V, Rampersaud Y: Heterotopic bone formation with the use of rhBMP2 in posterior minimal access interbody fusion. Spine 32:2885-2890, 2007.
    • (2007) Spine , vol.32 , pp. 2885-2890
    • Joseph, V.1    Rampersaud, Y.2
  • 41
    • 0043076263 scopus 로고    scopus 로고
    • In vivo evaluation of bone marrow stromal-derived osteoblasts-porous calcium phosphate ceramic composites as bone graft substitute for lumbar intervertebral spinal fusion
    • Kai T, Shao-qing G, Geng-ting D: In vivo evaluation of bone marrow stromal-derived osteoblasts-porous calcium phosphate ceramic composites as bone graft substitute for lumbar intervertebral spinal fusion. Spine 28:1653-1658, 2003.
    • (2003) Spine , vol.28 , pp. 1653-1658
    • Kai, T.1    Shao-qing, G.2    Geng-ting, D.3
  • 42
    • 0345863388 scopus 로고    scopus 로고
    • Spinal fusion surgery: Animal models for tissue-engineered bone constructs
    • Khan S, Lane J: Spinal fusion surgery: Animal models for tissue-engineered bone constructs. Biomaterials 25:1475-1485, 2004.
    • (2004) Biomaterials , vol.25 , pp. 1475-1485
    • Khan, S.1    Lane, J.2
  • 43
    • 37349107086 scopus 로고    scopus 로고
    • Multilevel anterior cervical fusion using collagen-hydroxyapatite matrix with iliac crest bone marrow aspirate: An 18-month follow-up study
    • Khoueir P, Oh BC, DiRisio DJ, Wang MY: Multilevel anterior cervical fusion using collagen-hydroxyapatite matrix with iliac crest bone marrow aspirate: An 18-month follow-up study. Neurosurgery 61:963-971, 2007.
    • (2007) Neurosurgery , vol.61 , pp. 963-971
    • Khoueir, P.1    Oh, B.C.2    DiRisio, D.J.3    Wang, M.Y.4
  • 44
    • 34250886203 scopus 로고    scopus 로고
    • Review: Gene- and stem cell-based therapeutics for bone regeneration and repair
    • Kimelman N, Pelled G, Helm GA, Huard J, Schwarz EM, Gazit D: Review: Gene- and stem cell-based therapeutics for bone regeneration and repair. Tissue Eng 13:1135-1150, 2007.
    • (2007) Tissue Eng , vol.13 , pp. 1135-1150
    • Kimelman, N.1    Pelled, G.2    Helm, G.A.3    Huard, J.4    Schwarz, E.M.5    Gazit, D.6
  • 45
    • 26844434929 scopus 로고    scopus 로고
    • Techniques for aspirating bone marrow for use in spinal surgery
    • Kitchel SH, Wang MY, Lauryssen CL: Techniques for aspirating bone marrow for use in spinal surgery. Neurosurgery 57:286-289, 2005.
    • (2005) Neurosurgery , vol.57 , pp. 286-289
    • Kitchel, S.H.1    Wang, M.Y.2    Lauryssen, C.L.3
  • 46
    • 18644363051 scopus 로고    scopus 로고
    • Comparison of Healos/bone marrow to INFUSE(rhBMP-2/ACS) with a collagen-ceramic sponge bulking agent as graft substitutes for lumbar spine fusion
    • Kraiwattanapong C, Boden SD, Louis-Ugbo J, Attallah E, Barnes B, Hutton WC: Comparison of Healos/bone marrow to INFUSE(rhBMP-2/ACS) with a collagen-ceramic sponge bulking agent as graft substitutes for lumbar spine fusion. Spine 30:1001-1007, 2005.
    • (2005) Spine , vol.30 , pp. 1001-1007
    • Kraiwattanapong, C.1    Boden, S.D.2    Louis-Ugbo, J.3    Attallah, E.4    Barnes, B.5    Hutton, W.C.6
  • 47
    • 28244495581 scopus 로고    scopus 로고
    • Carrier materials for spinal fusion
    • Kwon B, Jenis LG: Carrier materials for spinal fusion. Spine J 5:224S-230S, 2005.
    • (2005) Spine J , vol.5
    • Kwon, B.1    Jenis, L.G.2
  • 49
    • 32244449372 scopus 로고    scopus 로고
    • Bone morphogenetic protein gene therapy using a fibrin scaffold for a rabbit spinal-fusion experiment
    • Lee TC, Ho JT, Hung KS, Chen WF, Chung YH, Yang YL: Bone morphogenetic protein gene therapy using a fibrin scaffold for a rabbit spinal-fusion experiment. Neurosurgery 58:373-380, 2006.
    • (2006) Neurosurgery , vol.58 , pp. 373-380
    • Lee, T.C.1    Ho, J.T.2    Hung, K.S.3    Chen, W.F.4    Chung, Y.H.5    Yang, Y.L.6
  • 50
    • 34748922901 scopus 로고    scopus 로고
    • Vertebral osteolysis after posterior interbody lumbar fusion with recombinant human bone morphogenetic protein 2: A report of five cases
    • Lewandrowski KU, Nanson C, Calderon R: Vertebral osteolysis after posterior interbody lumbar fusion with recombinant human bone morphogenetic protein 2: A report of five cases. Spine J 7:609-614, 2007.
    • (2007) Spine J , vol.7 , pp. 609-614
    • Lewandrowski, K.U.1    Nanson, C.2    Calderon, R.3
  • 53
    • 0000844225 scopus 로고    scopus 로고
    • Osteoinductive bone graft substitutes
    • Ludwig SC, Kowalski JM, Boden SD: Osteoinductive bone graft substitutes. Eur Spine J 9 [Suppl 1]:S119-S125, 2000.
    • (2000) Eur Spine J , vol.9 , Issue.SUPPL. 1
    • Ludwig, S.C.1    Kowalski, J.M.2    Boden, S.D.3
  • 54
    • 0028346280 scopus 로고
    • Cellular expression of bone-related proteins during in vitro osteogenesis in rat bone marrow stromal cell cultures
    • Malaval L, Modrowski D, Gupta AK, Aubin JE: Cellular expression of bone-related proteins during in vitro osteogenesis in rat bone marrow stromal cell cultures. J Cell Physiol 158:555-572, 1994.
    • (1994) J Cell Physiol , vol.158 , pp. 555-572
    • Malaval, L.1    Modrowski, D.2    Gupta, A.K.3    Aubin, J.E.4
  • 55
    • 28544453297 scopus 로고    scopus 로고
    • Aspiration of osteoprogen-itor cells for augmenting spinal fusion: Comparison of progenitor cell concentrations from the vertebral body and iliac crest
    • McLain RF, Fleming JE, Boehm CA, Muschler GF: Aspiration of osteoprogen-itor cells for augmenting spinal fusion: Comparison of progenitor cell concentrations from the vertebral body and iliac crest. J Bone Joint Surg Am 87A:2655-2661, 2005.
    • (2005) J Bone Joint Surg Am , vol.87 A , pp. 2655-2661
    • McLain, R.F.1    Fleming, J.E.2    Boehm, C.A.3    Muschler, G.F.4
  • 56
    • 18844440475 scopus 로고    scopus 로고
    • The use of cultured bone marrow cells in type I collagen gel and porous hydroxyapatite for posterolateral lumbar spine fusion
    • Minamide A, Yoshida M, Kawakami M, Yamasaki S, Kojima H, Hashizume H, Boden SD: The use of cultured bone marrow cells in type I collagen gel and porous hydroxyapatite for posterolateral lumbar spine fusion. Spine 30:1134-1138, 2005.
    • (2005) Spine , vol.30 , pp. 1134-1138
    • Minamide, A.1    Yoshida, M.2    Kawakami, M.3    Yamasaki, S.4    Kojima, H.5    Hashizume, H.6    Boden, S.D.7
  • 57
    • 0030702126 scopus 로고    scopus 로고
    • Aspiration to obtain osteoblast progenitor cells from human bone marrow: The influence of aspiration volume
    • Muschler GF, Boehm C, Easley K: Aspiration to obtain osteoblast progenitor cells from human bone marrow: The influence of aspiration volume. J Bone Joint Surg Am 79A:1699-1709, 1997.
    • (1997) J Bone Joint Surg Am , vol.79 A , pp. 1699-1709
    • Muschler, G.F.1    Boehm, C.2    Easley, K.3
  • 60
    • 0032904745 scopus 로고    scopus 로고
    • Adenovirus-mediated direct gene therapy with bone morphogenetic protein-2 produces bone
    • Musgrave DS, Bosch P, Ghivizzani S, Robbins PD, Evans CH, Huard J: Adenovirus-mediated direct gene therapy with bone morphogenetic protein-2 produces bone. Bone 24:541-547, 1999.
    • (1999) Bone , vol.24 , pp. 541-547
    • Musgrave, D.S.1    Bosch, P.2    Ghivizzani, S.3    Robbins, P.D.4    Evans, C.H.5    Huard, J.6
  • 61
    • 34147100125 scopus 로고    scopus 로고
    • Bone morphogenetic proteins and bone defects: A systematic review
    • Mussano F, Ciccone G, Ceccarelli M, Baldi I, Bassi F: Bone morphogenetic proteins and bone defects: A systematic review. Spine 32:824-830, 2007.
    • (2007) Spine , vol.32 , pp. 824-830
    • Mussano, F.1    Ciccone, G.2    Ceccarelli, M.3    Baldi, I.4    Bassi, F.5
  • 62
    • 37349027968 scopus 로고    scopus 로고
    • Evaluation of posterolateral spinal fusion using mesenchymal stem cells: Differences with or without osteogenic differentiation
    • Nakajima T, Iizuka H, Tsutsumi S, Kayakabe M, Takagishi K: Evaluation of posterolateral spinal fusion using mesenchymal stem cells: Differences with or without osteogenic differentiation. Spine 32:2432-2436, 2007.
    • (2007) Spine , vol.32 , pp. 2432-2436
    • Nakajima, T.1    Iizuka, H.2    Tsutsumi, S.3    Kayakabe, M.4    Takagishi, K.5
  • 63
    • 33747364474 scopus 로고    scopus 로고
    • Healos and bone marrow aspirate used for lumbar spine fusion: A case controlled study comparing Healos with autograft
    • Neen D, Noyes D, Shaw M, Gwilym S, Fairlie N, Birch N: Healos and bone marrow aspirate used for lumbar spine fusion: A case controlled study comparing Healos with autograft. Spine 31:E636-E640, 2006.
    • (2006) Spine , vol.31
    • Neen, D.1    Noyes, D.2    Shaw, M.3    Gwilym, S.4    Fairlie, N.5    Birch, N.6
  • 64
    • 0034656696 scopus 로고    scopus 로고
    • Spine update: Potential applications of gene therapy to the treatment of spinal disorders
    • Nishida K, Gilbertson LG, Evans CH, Kang JD: Spine update: Potential applications of gene therapy to the treatment of spinal disorders. Spine 25:1308-1314, 2000.
    • (2000) Spine , vol.25 , pp. 1308-1314
    • Nishida, K.1    Gilbertson, L.G.2    Evans, C.H.3    Kang, J.D.4
  • 67
    • 33847041526 scopus 로고    scopus 로고
    • Adverse swelling associated with use of rh-BMP-2 in anterior cervical discectomy and fusion: A case study
    • Perri B, Cooper M, Lauryssen C, Anand N: Adverse swelling associated with use of rh-BMP-2 in anterior cervical discectomy and fusion: A case study. Spine J 7:235-239, 2007.
    • (2007) Spine J , vol.7 , pp. 235-239
    • Perri, B.1    Cooper, M.2    Lauryssen, C.3    Anand, N.4
  • 68
    • 13444268948 scopus 로고    scopus 로고
    • Genetically modified human derived bone marrow cells for posterolateral lumbar spine fusion in athymic rats: Beyond conventional autologous bone grafting
    • Peterson B, Iglesias R, Zhang J, Wang JC, Lieberman JR: Genetically modified human derived bone marrow cells for posterolateral lumbar spine fusion in athymic rats: Beyond conventional autologous bone grafting. Spine 30:283-290, 2005.
    • (2005) Spine , vol.30 , pp. 283-290
    • Peterson, B.1    Iglesias, R.2    Zhang, J.3    Wang, J.C.4    Lieberman, J.R.5
  • 72
  • 73
    • 0031685274 scopus 로고    scopus 로고
    • Induction of bone formation using a recombinant adenoviral vector carrying the human BMP-2 gene in a rabbit spinal fusion model
    • Riew KD, Wright NM, Cheng S, Avioli LV, Lou J: Induction of bone formation using a recombinant adenoviral vector carrying the human BMP-2 gene in a rabbit spinal fusion model. Calcif Tissue Int 63:357-360, 1998.
    • (1998) Calcif Tissue Int , vol.63 , pp. 357-360
    • Riew, K.D.1    Wright, N.M.2    Cheng, S.3    Avioli, L.V.4    Lou, J.5
  • 75
    • 0035398051 scopus 로고    scopus 로고
    • Natural history of posterior iliac crest bone graft donation for spinal surgery: A prospective analysis of morbidity
    • Robertson PA, Wray AC: Natural history of posterior iliac crest bone graft donation for spinal surgery: A prospective analysis of morbidity. Spine 26:1473-1476, 2001.
    • (2001) Spine , vol.26 , pp. 1473-1476
    • Robertson, P.A.1    Wray, A.C.2
  • 77
  • 79
    • 19944377827 scopus 로고    scopus 로고
    • Spine Interbody Research Group: Iliac crest bone graft donor site pain after anterior lumbar interbody fusion: A prospective patient satisfaction outcome assessment
    • Sasso RC, LeHuec JC, Shaffrey C; Spine Interbody Research Group: Iliac crest bone graft donor site pain after anterior lumbar interbody fusion: A prospective patient satisfaction outcome assessment. J Spinal Disord Tech 18 [Suppl]: S77-S81, 2005.
    • (2005) J Spinal Disord Tech , vol.18 , Issue.SUPPL.
    • Sasso, R.C.1    LeHuec, J.C.2    Shaffrey, C.3
  • 80
    • 0031882790 scopus 로고    scopus 로고
    • A comparative analysis of fusion rates and donor-site morbidity for autogeneic rib and iliac crest bone grafts in posterior cervical fusions
    • Sawin PD, Traynelis VC, Menezes AH: A comparative analysis of fusion rates and donor-site morbidity for autogeneic rib and iliac crest bone grafts in posterior cervical fusions. J Neurosurg 88:255-265, 1998.
    • (1998) J Neurosurg , vol.88 , pp. 255-265
    • Sawin, P.D.1    Traynelis, V.C.2    Menezes, A.H.3
  • 81
    • 28244436501 scopus 로고    scopus 로고
    • Cell technologies for spinal fusion
    • Shen FH, Samartzis D, An HS: Cell technologies for spinal fusion. Spine J 5:231S-239S, 2005.
    • (2005) Spine J , vol.5
    • Shen, F.H.1    Samartzis, D.2    An, H.S.3
  • 82
    • 33645508135 scopus 로고    scopus 로고
    • Adverse effects associated with high-dose recombinant human bone morphogenetic protein-2 use in anterior cervical spine fusion
    • Shields LB, Raque GH, Glassman SD, Campbell M, Vitaz T, Harpring J, Shields CB: Adverse effects associated with high-dose recombinant human bone morphogenetic protein-2 use in anterior cervical spine fusion. Spine 31:542-547, 2006.
    • (2006) Spine , vol.31 , pp. 542-547
    • Shields, L.B.1    Raque, G.H.2    Glassman, S.D.3    Campbell, M.4    Vitaz, T.5    Harpring, J.6    Shields, C.B.7
  • 84
    • 33751109482 scopus 로고    scopus 로고
    • Increased swelling complications associated with off-label usage of rhBMP-2 in the anterior cervical spine
    • Smucker JD, Rhee JM, Singh K, Yoon ST, Heller JG: Increased swelling complications associated with off-label usage of rhBMP-2 in the anterior cervical spine. Spine 31:2813-2819, 2006.
    • (2006) Spine , vol.31 , pp. 2813-2819
    • Smucker, J.D.1    Rhee, J.M.2    Singh, K.3    Yoon, S.T.4    Heller, J.G.5
  • 86
    • 35348887265 scopus 로고    scopus 로고
    • Complications of anterior cervical discectomy and fusion using recombinant human bone mor-phogenetic protein-2
    • Vaidya R, Carp J, Sethi A, Bartol S, Craig J, Les CM: Complications of anterior cervical discectomy and fusion using recombinant human bone mor-phogenetic protein-2. Eur Spine J 16:1257-1265, 2007.
    • (2007) Eur Spine J , vol.16 , pp. 1257-1265
    • Vaidya, R.1    Carp, J.2    Sethi, A.3    Bartol, S.4    Craig, J.5    Les, C.M.6
  • 87
    • 34147186878 scopus 로고    scopus 로고
    • Interbody fusion with allograft and rhBMP-2 leads to consistent fusion but early subsidence
    • Vaidya R, Weir R, Sethi A, Meisterling S, Hakeos W, Wybo CD: Interbody fusion with allograft and rhBMP-2 leads to consistent fusion but early subsidence. J Bone Joint Surg Br 89B:342-345, 2007.
    • (2007) J Bone Joint Surg Br , vol.89 B , pp. 342-345
    • Vaidya, R.1    Weir, R.2    Sethi, A.3    Meisterling, S.4    Hakeos, W.5    Wybo, C.D.6
  • 89
    • 24944504397 scopus 로고    scopus 로고
    • Evaluation of autologous bone marrow mesenchymal stem cell-calcium phosphate ceramic composite for lumbar fusion in rhesus monkey interbody fusion model
    • Wang T, Dang G, Guo Z, Yang M: Evaluation of autologous bone marrow mesenchymal stem cell-calcium phosphate ceramic composite for lumbar fusion in rhesus monkey interbody fusion model. Tissue Eng 11:1159-1167, 2005.
    • (2005) Tissue Eng , vol.11 , pp. 1159-1167
    • Wang, T.1    Dang, G.2    Guo, Z.3    Yang, M.4
  • 90
    • 0038333622 scopus 로고    scopus 로고
    • Effect of regional gene therapy with bone morphogenetic protein-2-producing bone marrow cells on spinal fusion in rats
    • Wang JC, Kanim LE, Yoo S, Campbell PA, Berk AJ, Lieberman JR: Effect of regional gene therapy with bone morphogenetic protein-2-producing bone marrow cells on spinal fusion in rats. J Bone Joint Surg Am 85A:905-911, 2003.
    • (2003) J Bone Joint Surg Am , vol.85 A , pp. 905-911
    • Wang, J.C.1    Kanim, L.E.2    Yoo, S.3    Campbell, P.A.4    Berk, A.J.5    Lieberman, J.R.6
  • 91
    • 67650260412 scopus 로고    scopus 로고
    • Wong DA, Kumar A, Jatana S, Ghiselli G, Wong K: Neurologic impairment from ectopic bone in the lumbar canal: A potential complication of off-label PLIF/TLIF use of bone morphogenetic protein-2 (BMP-2). Spine J EPub 11/26/2007.
    • Wong DA, Kumar A, Jatana S, Ghiselli G, Wong K: Neurologic impairment from ectopic bone in the lumbar canal: A potential complication of off-label PLIF/TLIF use of bone morphogenetic protein-2 (BMP-2). Spine J EPub 11/26/2007.
  • 92
    • 1342327562 scopus 로고    scopus 로고
    • Spine fusion by gene therapy
    • Yoon ST, Boden SD: Spine fusion by gene therapy. Gene Ther 11:360-367, 2004.
    • (2004) Gene Ther , vol.11 , pp. 360-367
    • Yoon, S.T.1    Boden, S.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.