Cardiac sodium channel NaV1.5 distribution in myocytes via interacting proteins: The multiple pool model

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1833, Issue 4, 2013, Pages 886-894

  Shy, Diana ^a   Gillet, Ludovic ^a   Abriel, Hugues ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Cardiac cells; Intercalated disk; Ion channels; Sodium channel

Indexed keywords

ALPHA ACTININ 2; ANKYRIN; ANKYRIN G; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALMODULIN; CALMODULIN KINASE II C; CAVEOLIN 3; DESMOGLEIN 2; DROSOPHILA DISKS LARGE TUMOR SUPPRESSOR PROTEIN; DYSTROPHIN; MOG1 PROTEIN; NEDD4 LIKE E3 UBIQUITIN LIGASE; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 3; PLAKOPHILIN; PLAKOPHILIN 2; PROTEIN 14 3 3; PROTEIN 14 3 3 ETA; PROTEIN TYROSINE PHOSPHATASE; PROTEIN ZO1; REGULATOR PROTEIN; SAP97 PROTEIN; SODIUM CHANNEL NAV1.5; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

BINDING SITE; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; EXTRACELLULAR SPACE; HEART MUSCLE CELL; INTRACELLULAR SPACE; IQ MOTIF; PDZ DOMAIN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PY MOTIF; REVIEW;

ACTION POTENTIALS; ANIMALS; CARDIOMYOPATHIES; EXCITATION CONTRACTION COUPLING; HUMANS; ION TRANSPORT; MODELS, BIOLOGICAL; MYOCARDIUM; MYOCYTES, CARDIAC; NAV1.5 VOLTAGE-GATED SODIUM CHANNEL; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN INTERACTION MAPPING; PROTEIN ISOFORMS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84875073626     PISSN: 01674889     EISSN: 18792596     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2012.10.026     Document Type: Review

References (83)

1. Abriel H. Cardiac sodium channel Na(v)1.5 and interacting proteins: physiology and pathophysiology. J. Mol. Cell. Cardiol. 2010, 48:2-11.
2. Abriel H., Kass R.S. Regulation of the voltage-gated cardiac sodium channel Nav1.5 by interacting proteins. Trends Cardiovasc. Med. 2005, 15:35-40.
3. Albesa M., Ogrodnik J., Rougier J.S., Abriel H. Regulation of the cardiac sodium channel Nav1.5 by utrophin in dystrophin-deficient mice. Cardiovasc. Res. 2011, 89:320-328.
4. Allouis M., Le B.F., Wilders R., Peroz D., Schott J.J., Noireaud J., Le M.H., Merot J., Escande D., Baro I. 14-3-3 is a regulator of the cardiac voltage-gated sodium channel Nav1.5. Circ. Res. 2006, 98:1538-1546.
5. Ashpole N.M., Herren A.W., Ginsburg K.S., Brogan J.D., Johnson D.E., Cummins T.R., Bers D.M., Hudmon A. Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites. J. Biol. Chem. 2012, 287:19856-19869.
6. Baba S., Dun W., Cabo C., Boyden P.A. Remodeling in cells from different regions of the reentrant circuit during ventricular tachycardia. Circulation 2005, 112:2386-2396.
7. Balse E., Steele D.F., Abriel H., Coulombe A., Fedida D., Hatem S.N. Dynamic of ion channel expression at the plasma membrane of cardiomyocytes. Physiol. Rev. 2012, 92:1317-1358.
8. Brackenbury W.J., Isom L.L. Na+ channel b subunits: overachievers of the ion channel family. Front. Pharmacol. 2011, 2.
9. Brette F., Orchard C. Resurgence of cardiac T-tubule research. Physiology 2007, 22:167-173.
10. Brette F., Orchard C.H. Density and sub-cellular distribution of cardiac and neuronal sodium channel isoforms in rat ventricular myocytes. Biochem. Biophys. Res. Commun. 2006, 348:1163-1166.
11. Cerrone M., Priori S.G. Genetics of sudden death: focus on inherited channelopathies. Eur. Heart J. 2011, 32:2109-2118.
12. Chauhan V.S., Tuvia S., Buhusi M., Bennett V., Grant A.O. Abnormal cardiac Na(+) channel properties and QT heart rate adaptation in neonatal ankyrin(B) knockout mice. Circ. Res. 2000, 86:441-447.
13. Cheng J., Van Norstrand D.W., Medeiros-Domingo A., Valdivia C., Tan B.H., Ye B., Kroboth S., Vatta M., Tester D.J., January C.T., Makielski J.C., Ackerman M.J. {alpha}1-Syntrophin mutations identified in sudden infant death syndrome cause an increase in late cardiac sodium current. Circ. Arrhythm. Electrophysiol. 2009, 2:667-676.
14. Chin D., Means A.R. Calmodulin: a prototypical calcium sensor. Trends Cell Biol. 2000, 10:322-328.
15. Clatot J., Ziyadeh-Isleem A., Maugenre S., Denjoy I., Liu H., Dilanian G., Hatem S.N., Deschenes I., Coulombe A., Guicheney P., Neyroud N. Dominant-negative effect of SCN5A N-terminal mutations through the interaction of Nav1.5 alpha-subunits. Cardiovasc. Res. 2012, 96:53-63.
16. Cronk L.B., Ye B., Kaku T., Tester D.J., Vatta M., Makielski J.C., Ackerman M.J. Novel mechanism for sudden infant death syndrome: persistent late sodium current secondary to mutations in caveolin-3. Hear. Rhythm. 2007, 4:161-166.
17. Deschenes I., Neyroud N., DiSilvestre D., Marban E., Yue D.T., Tomaselli G.F. Isoform-specific modulation of voltage-gated Na(+) channels by calmodulin. Circ. Res. 2002, 90:E49-E57.
18. Desplantez T., McCain M., Beauchamp P., Rigoli G., Rothen-Rutishauser B., Parker K.K., Kleber A.G. Connexin 43 ablation in fetal atrial myocytes decreases electrical coupling, partner connexins and sodium current. Cardiovasc. Res. 2012, 94:58-65.
19. Dhar M.J., Chen C., Rivolta I., Abriel H., Malhotra R., Mattei L.N., Brosius F.C., Kass R.S., Isom L.L. Characterization of sodium channel alpha- and beta-subunits in rat and mouse cardiac myocytes. Circulation 2001, 103:1303-1310.
20. Doyle D.A., Lee A., Lewis J., Kim E., Sheng M., MacKinnon R. Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ. Cell 1996, 85:1067-1076.
21. Fahmi A.I., Patel M., Stevens E.B., Fowden A.L., John J.E., Lee K., Pinnock R., Morgan K., Jackson A.P., Vandenberg J.I. The sodium channel beta-subunit SCN3b modulates the kinetics of SCN5a and is expressed heterogeneously in sheep heart. J. Physiol. 2001, 537:693-700.
22. Faulkner G., Pallavicini A., Formentin E., Comelli A., Ievolella C., Trevisan S., Bortoletto G., Scannapieco P., Salamon M., Mouly V., Valle G., Lanfranchi G. ZASP: a new Z-band alternatively spliced PDZ-motif protein. J. Cell Biol. 1999, 146:465-475.
23. Fozzard H.A. Cardiac sodium and calcium channels: a history of excitatory currents. Cardiovasc. Res. 2002, 55:1-8.
24. Gavillet B., Rougier J.S., Domenighetti A.A., Behar R., Boixel C., Ruchat P., Lehr H.A., Pedrazzini T., Abriel H. Cardiac sodium channel Nav1.5 is regulated by a multiprotein complex composed of syntrophins and dystrophin. Circ. Res. 2006, 99:407-414.
25. Gee S.H., Madhavan R., Levinson S.R., Caldwell J.H., Sealock R., Froehner S.C. Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins. J. Neurosci. 1998, 18:128-137.
26. Gellens M.E., George A.L., Chen L.Q., Chahine M., Horn R., Barchi R.L., Kallen R.G. Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel. Proc. Natl. Acad. Sci. U. S. A. 1992, 89:554-558.
27. Goetz R., Dover K., Laezza F., Shtraizent N., Huang X., Tchetchik D., Eliseenkova A.V., Xu C.F., Neubert T.A., Ornitz D.M., Goldfarb M., Mohammadi M. Crystal structure of a fibroblast growth factor homologous factor (FHF) defines a conserved surface on FHFs for binding and modulation of voltage-gated sodium channels. J. Biol. Chem. 2009, 284:17883-17896.
28. Hund T.J., Koval O.M., Li J., Wright P.J., Qian L., Snyder J.S., Gudmundsson H., Kline C.F., Davidson N.P., Cardona N., Rasband M.N., Anderson M.E., Mohler P.J. A beta(IV)-spectrin/CaMKII signaling complex is essential for membrane excitability in mice. J. Clin. Invest. 2010, 120:3508-3519.
29. Jansen J.A., Noorman M., Musa H., Stein M., de J.S., van der Nagel R., Hund T.J., Mohler P.J., Vos M.A., van Veen T.A., de Bakker J.M., Delmar M., van Rijen H.V. Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current which accounts for arrhythmia vulnerability in conditional Cx43 knockout mice. Hear. Rhythm. 2012, 4:600-607.
30. Jespersen T., Gavillet B., van Bemmelen M.X., Cordonier S., Thomas M.A., Staub O., Abriel H. Cardiac sodium channel Na(v)1.5 interacts with and is regulated by the protein tyrosine phosphatase PTPH1. Biochem. Biophys. Res. Commun. 2006, 348:1455-1462.
31. Kaprielian R.R., Stevenson S., Rothery S.M., Cullen M.J., Severs N.J. Distinct patterns of dystrophin organization in myocyte sarcolemma and transverse tubules of normal and diseased human myocardium. Circulation 2000, 101:2586-2594.
32. Kim J., Ghosh S., Liu H., Tateyama M., Kass R.S., Pitt G.S. Calmodulin mediates Ca2+ sensitivity of sodium channels. J. Biol. Chem. 2004, 279:45004-45012.
33. Ko S.H., Lenkowski P.W., Lee H.C., Mounsey J.P., Patel M.K. Modulation of Na(v)1.5 by beta1- and beta3-subunit co-expression in mammalian cells. Pflugers Arch. 2005, 449:403-412.
34. Lemaillet G., Walker B., Lambert S. Identification of a conserved ankyrin-binding motif in the family of sodium channel alpha subunits. J. Biol. Chem. 2003, 278:27333-27339.
35. Leoni A.L., Gavillet B., Rougier J.S., Marionneau C., Probst V., Le S.S., Schott J.J., Demolombe S., Bruneval P., Huang C.L., Colledge W.H., Grace A.A., Le M.H., Wilde A.A., Mohler P.J., Escande D., Abriel H., Charpentier F. Variable Na(v)1.5 protein expression from the wild-type allele correlates with the penetrance of cardiac conduction disease in the Scn5a mouse model. PLoS One 2010, 5:e9298.
36. Li Z., Ai T., Samani K., Xi Y., Tzeng H.P., Xie M., Wu S., Ge S., Taylor M.D., Dong J.W., Cheng J., Ackerman M.J., Kimura A., Sinagra G., Brunelli L., Faulkner G., Vatta M. A ZASP missense mutation, S196L, leads to cytoskeletal and electrical abnormalities in a mouse model of cardiomyopathy. Circ. Arrhythm. Electrophysiol. 2010, 3:646-656.
37. Lin X., Liu N., Lu J., Zhang J., Anumonwo J.M., Isom L.L., Fishman G.I., Delmar M. Subcellular heterogeneity of sodium current properties in adult cardiac ventricular myocytes. Hear. Rhythm. 2011, 8:1923-1930.
38. Liu C.J., Dib-Hajj S.D., Renganathan M., Cummins T.R., Waxman S.G. Modulation of the cardiac sodium channel Nav1.5 by fibroblast growth factor homologous factor 1B. J. Biol. Chem. 2003, 278:1029-1036.
39. London B., Michalec M., Mehdi H., Zhu X., Kerchner L., Sanyal S., Viswanathan P.C., Pfahnl A.E., Shang L.L., Madhusudanan M., Baty C.J., Lagana S., Aleong R., Gutmann R., Ackerman M.J., McNamara D.M., Weiss R., Dudley S.C. Mutation in glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmias. Circulation 2007, 116:2260-2268.
40. Lou J.Y., Laezza F., Gerber B.R., Xiao M., Yamada K.A., Hartmann H., Craig A.M., Nerbonne J.M., Ornitz D.M. Fibroblast growth factor 14 is an intracellular modulator of voltage-gated sodium channels. J. Physiol. 2005, 569:179-193.
41. Maier S.K., Westenbroek R.E., McCormick K.A., Curtis R., Scheuer T., Catterall W.A. Distinct subcellular localization of different sodium channel alpha and beta subunits in single ventricular myocytes from mouse heart. Circulation 2004, 109:1421-1427.
42. Makita N., Bennett P.B., George A.L. Molecular determinants of beta 1 subunit-induced gating modulation in voltage-dependent Na+ channels. J. Neurosci. 1996, 16:7117-7127.
43. Mazzone A., Strege P.R., Tester D.J., Bernard C.E., Faulkner G., De G.R., Makielski J.C., Stanghellini V., Gibbons S.J., Ackerman M.J., Farrugia G. A mutation in telethonin alters Nav1.5 function. J. Biol. Chem. 2008, 283:16537-16544.
44. Medeiros-Domingo A., Kaku T., Tester D.J., Iturralde-Torres P., Itty A., Ye B., Valdivia C., Ueda K., Canizales-Quinteros S., Tusie-Luna M.T., Makielski J.C., Ackerman M.J. SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome. Circulation 2007, 116:134-142.
45. Milstein M.L., Musa H., Balbuena D.P., Anumonwo J.M., Auerbach D.S., Furspan P.B., Hou L., Hu B., Schumacher S.M., Vaidyanathan R., Martens J.R., Jalife J. Dynamic reciprocity of sodium and potassium channel expression in a macromolecular complex controls cardiac excitability and arrhythmia. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:E2134-E2143.
46. Mizusawa Y., Wilde A.A.M. Brugada syndrome. Circ. Arrhythm. Electrophysiol. 2012, 5:606-616.
47. Mohler P.J., Rivolta I., Napolitano C., Lemaillet G., Lambert S., Priori S.G., Bennett V. Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:17533-17538.
48. Mues A., van der Ven P.F., Young P., Furst D.O., Gautel M. Two immunoglobulin-like domains of the Z-disc portion of titin interact in a conformation-dependent way with telethonin. FEBS Lett. 1998, 428:111-114.
49. O'Brien J.E., Sharkey L.M., Vallianatos C.N., Han C., Blossom J.C., Yu T., Waxman S.G., Dib-Hajj S.D., Meisler M.H. Interaction of voltage-gated sodium channel Nav1.6 (SCN8A) with microtubule-associated protein Map1b. J. Biol. Chem. 2012, 287:18459-18466.
50. Olesen M.S., Jensen N.F., Holst A.G., Nielsen J.B., Tfelt-Hansen J., Jespersen T., Sajadieh A., Haunso S., Lund J.T., Calloe K., Schmitt N., Svendsen J.H. A novel nonsense variant in Nav1.5 cofactor MOG1 eliminates its sodium current increasing effect and may increase the risk of arrhythmias. Can. J. Cardiol. 2011, 27:523.
51. Ou Y., Strege P., Miller S.M., Makielski J., Ackerman M., Gibbons S.J., Farrugia G. Syntrophin gamma 2 regulates SCN5A gating by a PDZ domain-mediated interaction. J. Biol. Chem. 2003, 278:1915-1923.
52. Petitprez S., Abriel H. Effects of heart failure on brain-type Na+ channels in rabbit ventricular myocytes. Europace 2008, 10:257-258.
53. Petitprez S., Zmoos A.F., Ogrodnik J., Balse E., Raad N., El-Haou S., Albesa M., Bittihn P., Luther S., Lehnart S.E., Hatem S.N., Coulombe A., Abriel H. SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes. Circ. Res. 2011, 108:294-304.
54. Poon W.Y., Malik-Hall M., Wood J.N., Okuse K. Identification of binding domains in the sodium channel Na(V)1.8 intracellular N-terminal region and annexin II light chain p11. FEBS Lett. 2004, 558:114-118.
55. Potet F., Chagot B., Anghelescu M., Viswanathan P.C., Stepanovic S.Z., Kupershmidt S., Chazin W.J., Balser J.R. Functional interactions between distinct sodium channel cytoplasmic domains through the action of calmodulin. J. Biol. Chem. 2009, 284:8846-8854.
56. Remme C.A. Connexin43 and Na(V)1.5: partners in crime?. Hear. Rhythm. 2012, 9:608-609.
57. Rizzo S., Lodder E.M., Verkerk A.O., Wolswinkel R., Beekman L., Pilichou K., Basso C., Remme C.A., Thiene G., Bezzina C.R. Intercalated disc abnormalities, reduced Na+ current density and conduction slowing in desmoglein-2 mutant mice prior to cardiomyopathic changes. Cardiovasc. Res. 2012, 95:409-418.
58. Rook M.B., Evers M.M., Vos M.A., Bierhuizen M.F. Biology of cardiac sodium channel Nav1.5 expression. Cardiovasc. Res. 2012, 93:12-23.
59. Rougier J.S., van Bemmelen M.X., Bruce M.C., Jespersen T., Gavillet B., Apotheloz F., Cordonier S., Staub O., Rotin D., Abriel H. Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins. Am. J. Physiol. Cell Physiol. 2005, 288:C692-C701.
60. Saras J., Heldin C.H. PDZ domains bind carboxy-terminal sequences of target proteins. Trends Biochem. Sci. 1996, 21:455-458.
61. Sarhan M.F., Van P.F., Ahern C.A. A double tyrosine motif in the cardiac sodium channel domain III-IV linker couples calcium-dependent calmodulin binding to inactivation gating. J. Biol. Chem. 2009, 284:33265-33274.
62. Sato P.Y., Coombs W., Lin X., Nekrasova O., Green K.J., Isom L.L., Taffet S.M., Delmar M. Interactions between ankyrin-G, Plakophilin-2, and Connexin43 at the cardiac intercalated disc. Circ. Res. 2011, 109:193-201.
63. Sato P.Y., Musa H., Coombs W., Guerrero-Serna G., Patino G.A., Taffet S.M., Isom L.L., Delmar M. Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes. Circ. Res. 2009, 105:523-526.
64. Stevenson S., Rothery S., Cullen M.J., Severs N.J. Dystrophin is not a specific component of the cardiac costamere. Circ. Res. 1997, 80:269-280.
65. Tan H.L., Kupershmidt S., Zhang R., Stepanovic S., Roden D.M., Wilde A.A., Anderson M.E., Balser J.R. A calcium sensor in the sodium channel modulates cardiac excitability. Nature 2002, 415:442-447.
66. Ueda K., Valdivia C., Medeiros-Domingo A., Tester D.J., Vatta M., Farrugia G., Ackerman M.J., Makielski J.C. Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex. PNAS 2008, 105:9355-9360.
67. Valdivia C.R., Medeiros-Domingo A., Ye B., Shen W.K., Algiers T.J., Ackerman M.J., Makielski J.C. Loss-of-function mutation of the SCN3B-encoded sodium channel {beta}3 subunit associated with a case of idiopathic ventricular fibrillation. Cardiovasc. Res. 2010, 86:392-400.
68. van Bemmelen M.X., Rougier J.S., Gavillet B., Apotheloz F., Daidie D., Tateyama M., Rivolta I., Thomas M.A., Kass R.S., Staub O., Abriel H. Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination. Circ. Res. 2004, 95:284-291.
69. Van Norstrand D.W., Valdivia C.R., Tester D.J., Ueda K., London B., Makielski J.C., Ackerman M.J. Molecular and functional characterization of novel glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) mutations in sudden infant death syndrome. Circulation 2007, 116:2253-2259.
70. Vatta M., Ackerman M.J., Ye B., Makielski J.C., Ughanze E.E., Taylor E.W., Tester D.J., Balijepalli R.C., Foell J.D., Li Z., Kamp T.J., Towbin J.A. Mutant caveolin-3 induces persistent late sodium current and is associated with long-QT syndrome. Circulation 2006, 114:2104-2112.
71. Verkerk A.O., van Ginneken A.C., van Veen T.A., Tan H.L. Effects of heart failure on brain-type Na+ channels in rabbit ventricular myocytes. Europace 2007, 9:571-577.
72. Wagner S., Dybkova N., Rasenack E.C., Jacobshagen C., Fabritz L., Kirchhof P., Maier S.K., Zhang T., Hasenfuss G., Brown J.H., Bers D.M., Maier L.S. Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels. J. Clin. Invest. 2006, 116:3127-3138.
73. Wang C., Hennessey J.A., Kirkton R.D., Wang C., Graham V., Puranam R.S., Rosenberg P.B., Bursac N., Pitt G.S. Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts. Circ. Res. 2011, 109:775-782.
74. Watanabe H., Yang T., Stroud D.M., Lowe J.S., Harris L., Atack T.C., Wang D.W., Hipkens S.B., Leake B., Hall L., Kupershmidt S., Chopra N., Magnuson M.A., Tanabe N., Knollmann B.C., George A.L., Roden D.M. Striking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro. Circulation 2011, 124:1001-1011.
75. Wilde A.A.M., Brugada R. Phenotypical manifestations of mutations in the genes encoding subunits of the cardiac sodium channel. Circ. Res. 2011, 108:884-897.
76. Williams T.M., Lisanti M.P. The Caveolin genes: from cell biology to medicine. Ann. Med. 2004, 36:584-595.
77. Wu L., Yong S.L., Fan C., Ni Y., Yoo S., Zhang T., Zhang X., Obejero-Paz C.A., Rho H.J., Ke T., Szafranski P., Jones S.W., Chen Q., Wang Q.K. Identification of a new co-factor, MOG1, required for the full function of cardiac sodium channel Nav 1.5. J. Biol. Chem. 2008, 283:6968-6978.
78. Yarbrough T.L., Lu T., Lee H.C., Shibata E.F. Localization of cardiac sodium channels in caveolin-rich membrane domains: regulation of sodium current amplitude. Circ. Res. 2002, 90:443-449.
79. Yoon J.Y., Ho W.K., Kim S.T., Cho H. Constitutive CaMKII activity regulates Na+ channel in rat ventricular myocytes. J. Mol. Cell. Cardiol. 2009, 47:475-484.
80. Young K.A., Caldwell J.H. Modulation of skeletal and cardiac voltage-gated sodium channels by calmodulin. J. Physiol. 2005, 565:349-370.
81. Yu F.H., Westenbroek R.E., Silos-Santiago I., McCormick K.A., Lawson D., Ge P., Ferriera H., Lilly J., DiStefano P.S., Catterall W.A., Scheuer T., Curtis R. Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2. J. Neurosci. 2003, 23:7577-7585.
82. Zhou Q., Ruiz-Lozano P., Martone M.E., Chen J. Cypher, a striated muscle-restricted PDZ and LIM domain-containing protein, binds to alpha-actinin-2 and protein kinase C. J. Biol. Chem. 1999, 274:19807-19813.
83. Ziane R., Huang H., Moghadaszadeh B., Beggs A.H., Levesque G., Chahine M. Cell membrane expression of cardiac sodium channel Na(v)1.5 is modulated by alpha-actinin-2 interaction. Biochemistry 2010, 49:166-178.