Crystal structure of a fibroblast growth factor homologous factor (FHF) defines a conserved surface on FHFs for binding and modulation of voltage-gated sodium channels

Journal of Biological Chemistry

Volumn 284, Issue 26, 2009, Pages 17883-17896

  Goetz, Regina ^a   Dover, Katarzyna ^b   Laezza, Fernanda ^c   Shtraizent, Nataly ^b   Huang, Xiao ^b   Tchetchik, Dafna ^b   Eliseenkova, Anna V ^a   Xu, Chong Feng ^a   Neubert, Thomas A ^a   Ornitz, David M ^c   Goldfarb, Mitchell ^b,d   Mohammadi, Moosa ^a,d  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Washington University School of Medicine ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTION POTENTIALS; BINDING SURFACE; C-TERMINAL REGIONS; CRYSTAL PACKINGS; FIBROBLAST GROWTH FACTOR; HIPPOCAMPAL NEURONS; IN-VITRO; INITIATION AND PROPAGATION; ISOFORMS; MUSCLE CELL; NEURONAL CELL; SITE DIRECTED MUTAGENESIS; SODIUM CHANNEL; SODIUM CURRENT; STRUCTURAL FEATURE;

BINDING SITES; BIOACTIVITY; CELL CULTURE; ELECTRIC POTENTIAL; ENZYME ACTIVITY; FIBROBLASTS; MODULATION; PEPTIDES; SODIUM;

CRYSTAL STRUCTURE;

FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2A; FIBROBLAST GROWTH FACTOR HOMOLOGOUS FACTOR; GENE PRODUCT; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; GENE MUTATION; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN LOCALIZATION; RAT; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; CRYSTALLOGRAPHY, X-RAY; FIBROBLAST GROWTH FACTORS; HIPPOCAMPUS; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; NERVE TISSUE PROTEINS; NEURONS; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; RATS; SEQUENCE HOMOLOGY, AMINO ACID; SODIUM CHANNELS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 67650533766     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.001842     Document Type: Article

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