α1-Syntrophin mutations identified in sudden infant death syndrome cause an increase in late cardiac sodium current

Circulation: Arrhythmia and Electrophysiology

Volumn 2, Issue 6, 2009, Pages 667-676

  Ackerman, Michael J ^b   Cheng, Jianding ^a   Van Norstrand, David W ^b   Medeiros Domingo, Argelia ^b   Valdivia, Carmen ^a   Tan, Bi Hua ^a   Ye, Bin ^a   Kroboth, Stacie ^a   Vatta, Matteo ^c   Tester, David J ^b   January, Craig T ^a   Makielski, Jonathan C ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

^c TEXAS CHILDREN S HOSPITAL   (United States)

Author keywords

Death; Genetics; Ion channels; Long QT syndrome; Nitric oxide synthase; Sudden

Indexed keywords

ALPHA1 SYNTROPHIN; GENE PRODUCT; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PROTEIN PMCA4B; SODIUM CHANNEL NAV1.5; SYNTROPHIN; UNCLASSIFIED DRUG; CALCIUM BINDING PROTEIN; ENZYME INHIBITOR; MEMBRANE PROTEIN; MUSCLE PROTEIN; NITRIC OXIDE SYNTHASE; NOS1 PROTEIN, RAT; PLASMA MEMBRANE CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SCN5A PROTEIN, HUMAN; SODIUM; SODIUM CHANNEL; SYNTROPHIN ALPHA1;

ALLELE; ARTICLE; CELL STRAIN HEK293; CHANNELOPATHY; DEPOLARIZATION; DNA SEQUENCE; FEMALE; GENE; GENE MUTATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PATHOGENESIS; PHENOTYPE; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL; SNTA1 GENE; SODIUM CURRENT; SUDDEN INFANT DEATH SYNDROME; ANIMAL; CELL LINE; CELL MEMBRANE POTENTIAL; CHANNEL GATING; DRUG ANTAGONISM; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; GENOTYPE; HEART MUSCLE; INFANT; LONG QT SYNDROME; METABOLISM; MOUSE; NEWBORN; PATCH CLAMP; RAT; TIME;

ANIMALS; CALCIUM-BINDING PROTEINS; CELL LINE; DNA MUTATIONAL ANALYSIS; ENZYME INHIBITORS; FEMALE; GENOTYPE; HUMANS; INFANT; INFANT, NEWBORN; ION CHANNEL GATING; LONG QT SYNDROME; MALE; MEMBRANE POTENTIALS; MEMBRANE PROTEINS; MICE; MUSCLE PROTEINS; MUTATION, MISSENSE; MYOCARDIUM; NITRIC OXIDE SYNTHASE; OPEN READING FRAMES; PATCH-CLAMP TECHNIQUES; PHENOTYPE; PLASMA MEMBRANE CALCIUM-TRANSPORTING ATPASES; RATS; SODIUM; SODIUM CHANNELS; SUDDEN INFANT DEATH; TIME FACTORS; TRANSFECTION;

EID: 73949159312     PISSN: 19413149     EISSN: 19413084     Source Type: Journal    
DOI: 10.1161/CIRCEP.109.891440     Document Type: Article

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