Variable Nav1.5 protein expression from the wild-type allele correlates with the penetrance of cardiac conduction disease in the Scn5a +/- mouse model

PLoS ONE

Volumn 5, Issue 2, 2010, Pages

  Leoni, Anne Laure ^a,c   Gavillet, Bruno ⁱ   Rougier, Jean Sébastien ^d   Marionneau, Céline ^a,c   Probst, Vincent ^a,b,c   Le Scouarnec, Solena ^a,b,c   Schott, Jean Jacques ^a,b,c   Demolombe, Sophie ^a,b,c   Bruneval, Patrick ^e   Huang, Christopher L H ^g   Colledge, William H ^g   Grace, Andrew A ^g   Le Marec, Hervé ^a,b,c   Wilde, Arthur A ^f   Mohler, Peter J ^h   Escande, Denis ^a,c   Abriel, Hugues ^d   Charpentier, Flavien ^a,b,c  

^a L INSTITUT DU THORAX   (France)

^b CNRS   (France)

^c UNIVERSITÉ DE NANTES   (France)

^d UNIVERSITY OF BERN   (Switzerland)

^e INSERM   (France)

^f ACADEMIC MEDICAL CENTER   (Netherlands)

^g UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^h UNIVERSITY OF IOWA   (United States)

ⁱ UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AJMALINE; MESSENGER RNA; SODIUM CHANNEL NAV1.5; VOLTAGE GATED SODIUM CHANNEL; SODIUM CHANNEL; VOLTAGE GATED NA+ CHANNEL NA(V)1.5A; VOLTAGE-GATED NA+ CHANNEL NA(V)1.5A;

ACTION POTENTIAL; AGING; ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ELECTROCARDIOGRAPHY; FEMALE; GENETIC CORRELATION; HEART MUSCLE CONDUCTION DISTURBANCE; HEART MUSCLE FIBROSIS; HEART VENTRICLE CONDUCTION; HEART VENTRICLE TACHYCARDIA; LOSS OF FUNCTION MUTATION; MALE; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; QRS COMPLEX; WILD TYPE; ADOLESCENT; ADULT; ANIMAL; BRUGADA SYNDROME; CHILD; CYTOLOGY; DISEASE MODEL; GENE EXPRESSION; GENETICS; GENOTYPE; HEART ARRHYTHMIA; HEART MUSCLE CELL; HUMAN; METABOLISM; MIDDLE AGED; MOUSE MUTANT; MOUSE STRAIN; MUTATION; PATCH CLAMP; PATHOLOGY; PATHOPHYSIOLOGY; PENETRANCE; PHYSIOLOGY; WESTERN BLOTTING;

MUS;

ADOLESCENT; ADULT; ALLELES; ANIMALS; ARRHYTHMIAS, CARDIAC; BLOTTING, WESTERN; BRUGADA SYNDROME; CHILD; DISEASE MODELS, ANIMAL; ELECTROCARDIOGRAPHY; FEMALE; GENE EXPRESSION; GENOTYPE; HUMANS; MALE; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; MIDDLE AGED; MUTATION; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; PENETRANCE; SODIUM CHANNELS; YOUNG ADULT;

EID: 77949508337     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0009298     Document Type: Article

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