The sodium channel β-subunits SCN3b modulates the kinetics of SCN5a and is expressed heterogeneously in sheep heart

Journal of Physiology

Volumn 537, Issue 3, 2001, Pages 693-700

  Fahmi, Ahmed I ^a   Patel, Manoj ^b   Stevens, Edward B ^a,d   Fowden, Abigail L ^a   John III, James Edward ^b   Lee, Kevin ^a   Pinnock, Robert ^a   Morgan, Kevin ^a   Jackson, Antony P ^a   Vandenberg, Jamie I ^a,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^c VICTOR CHANG CARDIAC RESEARCH INSTITUTE   (Australia)

^d Cambridge Drug Discovery   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN SUBUNIT; SODIUM CHANNEL; SODIUM CHANNEL NAV1.5; VOLTAGE GATED SODIUM CHANNEL BETA 1 SUBUNIT; VOLTAGE GATED SODIUM CHANNEL BETA 3 SUBUNIT;

ALPHA CHAIN; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BETA CHAIN; CELL ACTIVATION; CELL MEMBRANE POTENTIAL; CELLULAR DISTRIBUTION; CHANNEL GATING; CONTROLLED STUDY; ELECTRIC ACTIVITY; HEART; HEART ATRIUM; HEART MUSCLE POTENTIAL; HEART VENTRICLE; NONHUMAN; NORTHERN BLOTTING; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN LOCALIZATION; PURKINJE FIBER; SHEEP; STEADY STATE; TISSUE DISTRIBUTION; TRANSPORT KINETICS; WESTERN BLOTTING; XENOPUS; ADULT; CELL MEMBRANE DEPOLARIZATION; EWE; FEMALE; HALF-ACTIVATION VOLTAGE; HALF-INACTIVATION VOLTAGE; PROTEIN FUNCTION; PROTEIN TARGETING;

ANIMALS; ELECTROPHYSIOLOGY; FEMALE; KINETICS; MYOCARDIUM; OOCYTES; SHEEP; SODIUM CHANNELS; XENOPUS;

EID: 0035893688     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2001.012691     Document Type: Article

References (27)

1. + channel activity through interactions between alpha- and beta1 -subunits
2. SCN5A mutation (T1620M) causing Brugada syndrome exhibits different phenotypes when expressed in Xenopus oocytes and mammalian cells
3. Assembly intermediates of the mouse muscle nicotinic acetylcholine receptor in stably transfected fibroblasts
4. Sudden death in high-risk family members: Brugada syndrome
5. From ionic currents to molecular mechanisms: The structure and function of voltage-gated sodium channels
6. Genetic basis and molecular mechanism for idiopathic ventricular fibrillation
7. Setting the standards: Quality control in the secretory pathway
8. Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel
9. Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel
10. Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif
11. Transmembrane sodium current is different in atrial from ventricular myocytes of guinea-pig heart
12. + channel beta 1 subunit mRNA expressed in adult human skeletal muscle, heart, and brain is encoded by a single gene
13. Characterization of sodium channel alpha- and beta-subunits in rat and mouse cardiac myocytes
14. Structure and function of voltage-gated sodium channels
15. Beta 3: An additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics
16. Functional association of the beta 1 subunit with human cardiac (hH1) and rat skeletal muscle (mu 1) sodium channel alpha subunits expressed in Xenopus oocytes
17. Sodium channel isoform-specific effects of halothane: Protein kinase C co-expression and slow inactivation gating
18. Long QT and Brugada syndromes: From genetics to clinical management
19. + channel expression in Xenopus oocytes by beta 1 subunits
20. Distribution of a persistent sodium current across the ventricular wall in guinea pigs
21. Cardiac conduction defects associate with mutations in SCN5A
22. Tissue distribution and functional expression of the human voltage-gated sodium channel beta 3 subunit
23. Beta 1 subunits of sodium channels. Studies with subunit-specific antibodies
24. +-channel beta1 subunit gene SCN1B
25. SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome
26. Ventricular action potentials, ventricular extracellular potentials, and the ECG of guinea pig
27. Molecular and functional distributions of chloride conductances in rabbit ventricle