메뉴 건너뛰기




Volumn 14, Issue 4, 2013, Pages 344-349

Power of metabolomics in biomarker discovery and mining mechanisms of obesity

Author keywords

Biomarkers; Early diagnosis; Metabolites; Metabolomics; Obesity

Indexed keywords

BIOLOGICAL MARKER;

EID: 84875050927     PISSN: 14677881     EISSN: 1467789X     Source Type: Journal    
DOI: 10.1111/obr.12011     Document Type: Article
Times cited : (104)

References (46)
  • 1
    • 77954941113 scopus 로고    scopus 로고
    • Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5
    • Choi JH, Banks AS, Estall JL etal. Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5. Nature 2010; 466: 451-456.
    • (2010) Nature , vol.466 , pp. 451-456
    • Choi, J.H.1    Banks, A.S.2    Estall, J.L.3
  • 2
    • 84856957894 scopus 로고    scopus 로고
    • Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
    • Henao-Mejia J, Elinav E, Jin C etal. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 2012; 482: 179-185.
    • (2012) Nature , vol.482 , pp. 179-185
    • Henao-Mejia, J.1    Elinav, E.2    Jin, C.3
  • 3
    • 84875055772 scopus 로고    scopus 로고
    • World Health Organization (WHO). Global Strategy on Diet, Physical Activity and Health. [WWW document]. URL (accessed 18 December 2012).
    • World Health Organization (WHO). Global Strategy on Diet, Physical Activity and Health. 2011. [WWW document]. URL http://www.who.int/dietphysicalactivity/childhood/en/ (accessed 18 December 2012).
    • (2011)
  • 4
    • 77954911499 scopus 로고    scopus 로고
    • Obesity: new life for antidiabetic drugs
    • Houtkooper RH, Auwerx J. Obesity: new life for antidiabetic drugs. Nature 2010; 466: 443-444.
    • (2010) Nature , vol.466 , pp. 443-444
    • Houtkooper, R.H.1    Auwerx, J.2
  • 5
    • 66249084497 scopus 로고    scopus 로고
    • Obesity: causes and control of excess body fat
    • Friedman JM. Obesity: causes and control of excess body fat. Nature 2009; 459: 340-342.
    • (2009) Nature , vol.459 , pp. 340-342
    • Friedman, J.M.1
  • 6
    • 84864828304 scopus 로고    scopus 로고
    • Urine metabolomics analysis for biomarker discovery and detection of jaundice syndrome in patients with liver disease
    • Wang X, Zhang A, Han Y etal. Urine metabolomics analysis for biomarker discovery and detection of jaundice syndrome in patients with liver disease. Mol Cell Proteomics 2012; 11: 370-380.
    • (2012) Mol Cell Proteomics , vol.11 , pp. 370-380
    • Wang, X.1    Zhang, A.2    Han, Y.3
  • 7
    • 84871784703 scopus 로고    scopus 로고
    • Saliva metabolomics opens door to biomarker discovery, disease diagnosis, and treatment
    • Zhang A, Sun H, Wang X. Saliva metabolomics opens door to biomarker discovery, disease diagnosis, and treatment. Appl Biochem Biotechnol 2012; 168: 1718-1727.
    • (2012) Appl Biochem Biotechnol , vol.168 , pp. 1718-1727
    • Zhang, A.1    Sun, H.2    Wang, X.3
  • 8
    • 84855392494 scopus 로고    scopus 로고
    • Pattern recognition approaches and computational systems tools for ultra performance liquid chromatography-mass spectrometry-based comprehensive metabolomic profiling and pathways analysis of biological data sets
    • Wang X, Yang B, Sun H, Zhang A. Pattern recognition approaches and computational systems tools for ultra performance liquid chromatography-mass spectrometry-based comprehensive metabolomic profiling and pathways analysis of biological data sets. Anal Chem 2012; 84: 428-439.
    • (2012) Anal Chem , vol.84 , pp. 428-439
    • Wang, X.1    Yang, B.2    Sun, H.3    Zhang, A.4
  • 9
    • 84863077686 scopus 로고    scopus 로고
    • Metabolomics study on the toxicity of aconite root and its processed products using ultraperformance liquid-chromatography/electrospray-ionization synapt high-definition mass spectrometry coupled with pattern recognition approach and ingenuity pathways analysis
    • Wang X, Wang H, Zhang A etal. Metabolomics study on the toxicity of aconite root and its processed products using ultraperformance liquid-chromatography/electrospray-ionization synapt high-definition mass spectrometry coupled with pattern recognition approach and ingenuity pathways analysis. J Proteome Res 2012; 11: 1284-1301.
    • (2012) J Proteome Res , vol.11 , pp. 1284-1301
    • Wang, X.1    Wang, H.2    Zhang, A.3
  • 10
    • 84864989347 scopus 로고    scopus 로고
    • Exploratory urinary metabolic biomarkers and pathways using UPLC-Q-TOF-HDMS coupled with pattern recognition approach
    • Zhang A, Sun H, Han Y etal. Exploratory urinary metabolic biomarkers and pathways using UPLC-Q-TOF-HDMS coupled with pattern recognition approach. Analyst 2012; 137: 4200-4208.
    • (2012) Analyst , vol.137 , pp. 4200-4208
    • Zhang, A.1    Sun, H.2    Han, Y.3
  • 11
    • 84860352139 scopus 로고    scopus 로고
    • A positive/negative ion-switching, targeted mass spectrometry- basedmetabolomics platform for bodily fluids, cells, and fresh and fixed tissue
    • Yuan M, Breitkopf SB, Yang X, Asara JM. A positive/negative ion-switching, targeted mass spectrometry- basedmetabolomics platform for bodily fluids, cells, and fresh and fixed tissue. Nat Protoc 2012; 7: 872-881.
    • (2012) Nat Protoc , vol.7 , pp. 872-881
    • Yuan, M.1    Breitkopf, S.B.2    Yang, X.3    Asara, J.M.4
  • 12
    • 82255169467 scopus 로고    scopus 로고
    • Transplanted hypothalamic neurons restore leptin signaling and ameliorate obesity in db/db mice
    • Czupryn A, Zhou YD, Chen X etal. Transplanted hypothalamic neurons restore leptin signaling and ameliorate obesity in db/db mice. Science 2011; 334: 1133-1137.
    • (2011) Science , vol.334 , pp. 1133-1137
    • Czupryn, A.1    Zhou, Y.D.2    Chen, X.3
  • 13
    • 74549167737 scopus 로고    scopus 로고
    • Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression
    • Park EJ, Lee JH, Yu GY etal. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 2010; 140: 197-208.
    • (2010) Cell , vol.140 , pp. 197-208
    • Park, E.J.1    Lee, J.H.2    Yu, G.Y.3
  • 14
    • 84859646095 scopus 로고    scopus 로고
    • Circadian rhythms. Sleep study suggests triggers for diabetes and obesity
    • Leslie M. Circadian rhythms. Sleep study suggests triggers for diabetes and obesity. Science 2012; 336: 143.
    • (2012) Science , vol.336 , pp. 143
    • Leslie, M.1
  • 16
    • 84862683358 scopus 로고    scopus 로고
    • Obesidomics: contribution of adipose tissue secretome analysis to obesity research
    • Pardo M, Roca-Rivada A, Seoane LM, Casanueva FF. Obesidomics: contribution of adipose tissue secretome analysis to obesity research. Endocrine 2012; 41: 374-383.
    • (2012) Endocrine , vol.41 , pp. 374-383
    • Pardo, M.1    Roca-Rivada, A.2    Seoane, L.M.3    Casanueva, F.F.4
  • 18
    • 83455203337 scopus 로고    scopus 로고
    • Modern analytical techniques in metabolomics analysis
    • Zhang A, Sun H, Wang P, Han Y, Wang X. Modern analytical techniques in metabolomics analysis. Analyst 2012; 137: 293-300.
    • (2012) Analyst , vol.137 , pp. 293-300
    • Zhang, A.1    Sun, H.2    Wang, P.3    Han, Y.4    Wang, X.5
  • 19
    • 84865593022 scopus 로고    scopus 로고
    • Serum metabolomics as a novel diagnostic approach for disease: a systematic review
    • Zhang A, Sun H, Wang X. Serum metabolomics as a novel diagnostic approach for disease: a systematic review. Anal Bioanal Chem 2012; 404: 1239-1245.
    • (2012) Anal Bioanal Chem , vol.404 , pp. 1239-1245
    • Zhang, A.1    Sun, H.2    Wang, X.3
  • 20
    • 84855870922 scopus 로고    scopus 로고
    • Potential drug targets on insomnia and intervention effects of Jujuboside A through metabolic pathway analysis as revealed by UPLC/ESI-SYNAPT-HDMS coupled with pattern recognition approach
    • Wang X, Yang B, Zhang A, Sun H, Yan G. Potential drug targets on insomnia and intervention effects of Jujuboside A through metabolic pathway analysis as revealed by UPLC/ESI-SYNAPT-HDMS coupled with pattern recognition approach. J Proteomics 2012; 75: 1411-1427.
    • (2012) J Proteomics , vol.75 , pp. 1411-1427
    • Wang, X.1    Yang, B.2    Zhang, A.3    Sun, H.4    Yan, G.5
  • 21
    • 84863895127 scopus 로고    scopus 로고
    • Future perspectives of Chinese medical formulae: chinmedomics as an effector
    • Wang X, Zhang A, Sun H. Future perspectives of Chinese medical formulae: chinmedomics as an effector. OMICS 2012; 16: 414-421.
    • (2012) OMICS , vol.16 , pp. 414-421
    • Wang, X.1    Zhang, A.2    Sun, H.3
  • 22
    • 84863258933 scopus 로고    scopus 로고
    • Ingenuity pathways analysis of urine metabolomics phenotypes toxicity of Chuanwu in Wistar rats by UPLC-Q-TOF-HDMS coupled with pattern recognition methods
    • Dong H, Zhang A, Sun H etal. Ingenuity pathways analysis of urine metabolomics phenotypes toxicity of Chuanwu in Wistar rats by UPLC-Q-TOF-HDMS coupled with pattern recognition methods. Mol Biosyst 2012; 8: 1206-1221.
    • (2012) Mol Biosyst , vol.8 , pp. 1206-1221
    • Dong, H.1    Zhang, A.2    Sun, H.3
  • 23
    • 84855883877 scopus 로고    scopus 로고
    • Recent and potential developments of biofluid analyses in metabolomics
    • Zhang A, Sun H, Wang P, Han Y, Wang X. Recent and potential developments of biofluid analyses in metabolomics. J Proteomics 2012; 75: 1079-1088.
    • (2012) J Proteomics , vol.75 , pp. 1079-1088
    • Zhang, A.1    Sun, H.2    Wang, P.3    Han, Y.4    Wang, X.5
  • 24
    • 66349124175 scopus 로고    scopus 로고
    • Impact of clock-associated Arabidopsis pseudo-response regulators in metabolic coordination
    • Fukushima A, Kusano M, Nakamichi N etal. Impact of clock-associated Arabidopsis pseudo-response regulators in metabolic coordination. Proc Natl Acad Sci U S A 2009; 106: 7251-7256.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 7251-7256
    • Fukushima, A.1    Kusano, M.2    Nakamichi, N.3
  • 25
    • 26444548613 scopus 로고    scopus 로고
    • Hierarchical metabolomics demonstrates substantial compositional similarity between genetically modified and conventional potato crops
    • Catchpole GS, Beckmann M, Enot DP etal. Hierarchical metabolomics demonstrates substantial compositional similarity between genetically modified and conventional potato crops. Proc Natl Acad Sci U S A 2009; 102: 14458-14462.
    • (2009) Proc Natl Acad Sci U S A , vol.102 , pp. 14458-14462
    • Catchpole, G.S.1    Beckmann, M.2    Enot, D.P.3
  • 26
    • 84860901313 scopus 로고    scopus 로고
    • 'Omics'-driven discoveries in prevention and treatment of type 2 diabetes
    • Gjesing AP, Pedersen O. 'Omics'-driven discoveries in prevention and treatment of type 2 diabetes. Eur J Clin Invest 2012; 42: 579-588.
    • (2012) Eur J Clin Invest , vol.42 , pp. 579-588
    • Gjesing, A.P.1    Pedersen, O.2
  • 27
    • 84860463899 scopus 로고    scopus 로고
    • Metabolomic analysis of rat serum in streptozotocin-induced diabetes and after treatment with oral triethylenetetramine (TETA)
    • Ugarte M, Brown M, Hollywood KA, Cooper GJ, Bishop PN, Dunn WB. Metabolomic analysis of rat serum in streptozotocin-induced diabetes and after treatment with oral triethylenetetramine (TETA). Genome Med 2012; 4: 35.
    • (2012) Genome Med , vol.4 , pp. 35
    • Ugarte, M.1    Brown, M.2    Hollywood, K.A.3    Cooper, G.J.4    Bishop, P.N.5    Dunn, W.B.6
  • 28
    • 84859073302 scopus 로고    scopus 로고
    • Metabolomic profiling of fatty acid and amino acid metabolism in youth with obesity and type 2 diabetes: evidence for enhanced mitochondrial oxidation
    • Mihalik SJ, Michaliszyn SF, de las Heras J etal. Metabolomic profiling of fatty acid and amino acid metabolism in youth with obesity and type 2 diabetes: evidence for enhanced mitochondrial oxidation. Diabetes Care 2012; 35: 605-611.
    • (2012) Diabetes Care , vol.35 , pp. 605-611
    • Mihalik, S.J.1    Michaliszyn, S.F.2    de las Heras, J.3
  • 29
    • 84858419687 scopus 로고    scopus 로고
    • Emerging applications of metabolomic and genomic profiling in diabetic clinical medicine
    • McKillop AM, Flatt PR. Emerging applications of metabolomic and genomic profiling in diabetic clinical medicine. Diabetes Care 2011; 34: 2624-2630.
    • (2011) Diabetes Care , vol.34 , pp. 2624-2630
    • McKillop, A.M.1    Flatt, P.R.2
  • 30
    • 84856015478 scopus 로고    scopus 로고
    • Reconstruction of Arabidopsis metabolic network models accounting for subcellular compartmentalization and tissue-specificity
    • Mintz-Oron S, Meir S, Malitsky S, Ruppin E, Aharoni A, Shlomi T. Reconstruction of Arabidopsis metabolic network models accounting for subcellular compartmentalization and tissue-specificity. Proc Natl Acad Sci U S A 2012; 109: 339-344.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 339-344
    • Mintz-Oron, S.1    Meir, S.2    Malitsky, S.3    Ruppin, E.4    Aharoni, A.5    Shlomi, T.6
  • 31
    • 78049297452 scopus 로고    scopus 로고
    • Metabolic profiling of murine plasma reveals an unexpected biomarker in rofecoxib-mediated cardiovascular events
    • Liu JY, Li N, Yang J etal. Metabolic profiling of murine plasma reveals an unexpected biomarker in rofecoxib-mediated cardiovascular events. Proc Natl Acad Sci U S A 2010; 107: 17017-17022.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 17017-17022
    • Liu, J.Y.1    Li, N.2    Yang, J.3
  • 32
    • 77957061890 scopus 로고    scopus 로고
    • Prediction of metabolic fluxes by incorporating genomic context and flux-converging pattern analyses
    • Park JM, Kim TY, Lee SY. Prediction of metabolic fluxes by incorporating genomic context and flux-converging pattern analyses. Proc Natl Acad Sci U S A 2010; 107: 14931-14936.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 14931-14936
    • Park, J.M.1    Kim, T.Y.2    Lee, S.Y.3
  • 33
    • 84859812830 scopus 로고    scopus 로고
    • Urine metabolomics combined with the personalized diagnosis guided by Chinese medicine reveals subtypes of pre-diabetes
    • Wei H, Pasman W, Rubingh C etal. Urine metabolomics combined with the personalized diagnosis guided by Chinese medicine reveals subtypes of pre-diabetes. Mol Biosyst 2012; 8: 1482-1491.
    • (2012) Mol Biosyst , vol.8 , pp. 1482-1491
    • Wei, H.1    Pasman, W.2    Rubingh, C.3
  • 34
    • 77956276702 scopus 로고    scopus 로고
    • Quantitative metabolomics by H-NMR and LC-MS/MS confirms altered metabolic pathways in diabetes
    • Lanza IR, Zhang S, Ward LE, Karakelides H, Raftery D, Nair KS. Quantitative metabolomics by H-NMR and LC-MS/MS confirms altered metabolic pathways in diabetes. PLoS ONE 2010; 5: e10538.
    • (2010) PLoS ONE , vol.5
    • Lanza, I.R.1    Zhang, S.2    Ward, L.E.3    Karakelides, H.4    Raftery, D.5    Nair, K.S.6
  • 35
    • 79960766855 scopus 로고    scopus 로고
    • Differentiating short- and long-term effects of diet in the obese mouse using (1) H-nuclear magnetic resonance metabolomics
    • Duggan GE, Hittel DS, Hughey CC, Weljie A, Vogel HJ, Shearer J. Differentiating short- and long-term effects of diet in the obese mouse using (1) H-nuclear magnetic resonance metabolomics. Diabetes Obes Metab 2011; 13: 859-862.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 859-862
    • Duggan, G.E.1    Hittel, D.S.2    Hughey, C.C.3    Weljie, A.4    Vogel, H.J.5    Shearer, J.6
  • 36
    • 79955033733 scopus 로고    scopus 로고
    • Biomarker discovery in biological specimens (plasma, hair, liver and kidney) of diabetic mice based upon metabolite profiling using ultra-performance liquid chromatography with electrospray ionization time-of-flight mass spectrometry
    • Tsutsui H, Maeda T, Min JZ etal. Biomarker discovery in biological specimens (plasma, hair, liver and kidney) of diabetic mice based upon metabolite profiling using ultra-performance liquid chromatography with electrospray ionization time-of-flight mass spectrometry. Clin Chim Acta 2011; 412: 861-872.
    • (2011) Clin Chim Acta , vol.412 , pp. 861-872
    • Tsutsui, H.1    Maeda, T.2    Min, J.Z.3
  • 37
    • 84868268623 scopus 로고    scopus 로고
    • The relationship between BMI and metabolomic profiles: a focus on amino acids
    • Morris C, O'Grada C, Ryan M etal. The relationship between BMI and metabolomic profiles: a focus on amino acids. Proc Nutr Soc 2012; 71: 634-638.
    • (2012) Proc Nutr Soc , vol.71 , pp. 634-638
    • Morris, C.1    O'Grada, C.2    Ryan, M.3
  • 38
    • 80053921608 scopus 로고    scopus 로고
    • Combined proteomic and metabolomic profiling of serum reveals association of the complement system with obesity and identifies novel markers of body fat mass changes
    • Oberbach A, Blüher M, Wirth H etal. Combined proteomic and metabolomic profiling of serum reveals association of the complement system with obesity and identifies novel markers of body fat mass changes. J Proteome Res 2011; 10: 4769-4788.
    • (2011) J Proteome Res , vol.10 , pp. 4769-4788
    • Oberbach, A.1    Blüher, M.2    Wirth, H.3
  • 39
    • 79955433960 scopus 로고    scopus 로고
    • Metabolomic analysis of livers and serum from high-fat diet induced obese mice
    • Kim HJ, Kim JH, Noh S etal. Metabolomic analysis of livers and serum from high-fat diet induced obese mice. J Proteome Res 2011; 10: 722-731.
    • (2011) J Proteome Res , vol.10 , pp. 722-731
    • Kim, H.J.1    Kim, J.H.2    Noh, S.3
  • 40
    • 77956299196 scopus 로고    scopus 로고
    • Metabolic profiling of plasma in overweight/obese and lean men using ultra performance liquid chromatography and Q-TOF mass spectrometry (UPLC-Q-TOF MS)
    • Kim JY, Park JY, Kim OY etal. Metabolic profiling of plasma in overweight/obese and lean men using ultra performance liquid chromatography and Q-TOF mass spectrometry (UPLC-Q-TOF MS). J Proteome Res 2010; 9: 4368-4375.
    • (2010) J Proteome Res , vol.9 , pp. 4368-4375
    • Kim, J.Y.1    Park, J.Y.2    Kim, O.Y.3
  • 41
    • 84855477382 scopus 로고    scopus 로고
    • Comparison of serum metabolite compositions between obese and lean growing pigs using an NMR-based metabonomic approach
    • He Q, Ren P, Kong X etal. Comparison of serum metabolite compositions between obese and lean growing pigs using an NMR-based metabonomic approach. J Nutr Biochem 2012; 23: 133-139.
    • (2012) J Nutr Biochem , vol.23 , pp. 133-139
    • He, Q.1    Ren, P.2    Kong, X.3
  • 42
    • 84867900785 scopus 로고    scopus 로고
    • Childhood obesity is associated with changes in the serum metabolite profile
    • Wahl S, Yu Z, Kleber M etal. Childhood obesity is associated with changes in the serum metabolite profile. Obes Facts 2012; 5: 660-670.
    • (2012) Obes Facts , vol.5 , pp. 660-670
    • Wahl, S.1    Yu, Z.2    Kleber, M.3
  • 43
    • 84866596616 scopus 로고    scopus 로고
    • 1H NMR-based metabolite profiling of diet-induced obesity in a mouse mode
    • Jung JY, Kim IY, Kim YN etal. 1H NMR-based metabolite profiling of diet-induced obesity in a mouse mode. BMB Rep 2012; 45: 419-424.
    • (2012) BMB Rep , vol.45 , pp. 419-424
    • Jung, J.Y.1    Kim, I.Y.2    Kim, Y.N.3
  • 44
    • 70349759319 scopus 로고    scopus 로고
    • 1H-nuclear magnetic resonance spectroscopy-based metabolic assessment in a rat model of obesity induced by a high-fat diet
    • Kim SH, Yang SO, Kim HS, Kim Y, Park T, Choi HK. 1H-nuclear magnetic resonance spectroscopy-based metabolic assessment in a rat model of obesity induced by a high-fat diet. Anal Bioanal Chem 2009; 395: 1117-1124.
    • (2009) Anal Bioanal Chem , vol.395 , pp. 1117-1124
    • Kim, S.H.1    Yang, S.O.2    Kim, H.S.3    Kim, Y.4    Park, T.5    Choi, H.K.6
  • 45
    • 77953611756 scopus 로고    scopus 로고
    • Gut microbiome-derived metabolites characterize a peculiar obese urinary metabotype
    • Calvani R, Miccheli A, Capuani G etal. Gut microbiome-derived metabolites characterize a peculiar obese urinary metabotype. Int J Obes (Lond) 2010; 34: 1095-1098.
    • (2010) Int J Obes (Lond) , vol.34 , pp. 1095-1098
    • Calvani, R.1    Miccheli, A.2    Capuani, G.3
  • 46
    • 84867217128 scopus 로고    scopus 로고
    • Candy at the cash register-a risk factor for obesity and chronic disease
    • Cohen DA, Babey SH. Candy at the cash register-a risk factor for obesity and chronic disease. N Engl J Med 2012; 367: 1381-1383.
    • (2012) N Engl J Med , vol.367 , pp. 1381-1383
    • Cohen, D.A.1    Babey, S.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.