Ingenuity pathways analysis of urine metabolomics phenotypes toxicity of Chuanwu in Wistar rats by UPLC-Q-TOF-HDMS coupled with pattern recognition methods

Molecular BioSystems

Volumn 8, Issue 4, 2012, Pages 1206-1221

  Dong, Hui ^a   Zhang, Aihua ^a   Sun, Hui ^a   Wang, Huiyu ^a   Lu, Xin ^a   Wang, Mo ^a   Ni, Bei ^a   Wang, Xijun ^a  

^a HEILONGJIANG UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; HERBACEOUS AGENT; PLANT EXTRACT;

ACONITE; ANIMAL; ARTICLE; BODY FLUID; CHEMISTRY; DRUG EFFECT; HEART; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER; MALE; MASS SPECTROMETRY; METABOLOME; METABOLOMICS; METHODOLOGY; PATHOLOGY; PATHOPHYSIOLOGY; PHENOTYPE; PLANT ROOT; PRINCIPAL COMPONENT ANALYSIS; RAT; URINE; WISTAR RAT;

ACONITUM; ANIMALS; BIOLOGICAL MARKERS; BODY FLUIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; HEART; LIVER; MALE; MASS SPECTROMETRY; METABOLOME; METABOLOMICS; PHENOTYPE; PLANT EXTRACTS; PLANT ROOTS; PRINCIPAL COMPONENT ANALYSIS; RATS; RATS, WISTAR;

ACONITUM CARMICHAELII; RATTUS NORVEGICUS;

EID: 84863258933     PISSN: 1742206X     EISSN: 17422051     Source Type: Journal    
DOI: 10.1039/c1mb05366c     Document Type: Article

References (32)

1. T. Ma C. Tan H. Zhang M. Wang W. Ding S. Li Bridging the gap between traditional Chinese medicine and systems biology: the connection of Cold Syndrome and NEI network Mol. BioSyst. 2010 6 613 619
2. S. Yan B. Wu Z. Lin H. Jin J. Huang Y. Yang X. Zhang Z. Shen W. Zhang Metabonomic characterization of aging and investigation on the anti-aging effects of total flavones of Epimedium Mol. BioSyst. 2009 5 1204 1213
3. K. C. Chen K. W. Chang H. Y. Chen C. Y. Chen Traditional Chinese medicine, a solution for reducing dual stroke risk factors at once? Mol. BioSyst. 2011 7 2711 2719
4. J. Singhuber M. Zhu S. Prinz B. Kopp Aconitum in traditional Chinese medicine: a valuable drug or an unpredictable risk? J. Ethnopharmacol. 2009 126 18 30
5. L. Tang L. Ye C. Lv Z. Zheng Y. Gong Z. Liu Toxicol Lett. Involvement of CYP3A4/5 and CYP2D6 in the metabolism of aconitine using human liver microsomes and recombinant CYP450 enzymes 2011 202 47 54
6. G. Lu Z. Dong Q. Wang G. Qian W. Huang Z. Jiang K. S. Leung Z. Zhao Toxicity assessment of nine types of decoction pieces from the daughter root of Aconitum carmichaeli (Fuzi) based on the chemical analysis of their diester diterpenoid alkaloids Planta Med. 2010 76 825 830
7. B. Sun L. Li S. Wu Q. Zhang H. Li H. Chen F. Li F. Dong X. Yan Metabolomic analysis of biofluids from rats treated with Aconitum alkaloids using nuclear magnetic resonance and gas chromatography/time-of-flight mass spectrometry Anal. Biochem. 2009 395 125 133
8. + ions J. Physiol. 2002 538 759 771 (Pubitemid 35190070)
9. P. Jiang W. Dai S. Yan Z. Chen R. Xu J. Ding L. Xiang S. Wang R. Liu W. Zhang Potential biomarkers in the urine of myocardial infarction rats: a metabolomic method and its application Mol. BioSyst. 2011 7 3 824 31
10. X. Wang H. Sun A. Zhang W. Sun P. Wang Z. Wang Potential role of metabolomics apporoaches in the area of traditional Chinese medicine: as pillars of the bridge between Chinese and Western medicine J. Pharm. Biomed. Anal. 2011 55 859 868
11. A. Zhang H. Sun Z. Wang W. Sun P. Wang X. Wang Metabolomics: towards understanding traditional Chinese medicine Planta Med. 2010 76 2026 2035
12. Z. Wang E. Klipfell B. J. Bennett R. Koeth B. S. Levison B. Dugar A. E. Feldstein E. B. Britt X. Fu Y. M. Chung Y. Wu P. Schauer J. D. Smith H. Allayee W. H. Tang J. A. DiDonato A. J. Lusis S. L. Hazen Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease Nature 2011 472 57 63
13. B. Yang A. Zhang H. Sun W. Dong G. Yan T. Li X. Wang Metabolomic study of insomnia and intervention effects of Suanzaoren decoction using ultra-performance liquid-chromatography/electrospray-ionization synapt high-definition mass spectrometry J. Pharm. Biomed. Anal. 2012 58 113 124
14. X. Li X. Luo X. Lu J. Duan G. Xu Metabolomics study of diabetic retinopathy using gas chromatography-mass spectrometry: a comparison of stages and subtypes diagnosed by Western and Chinese medicine Mol. BioSyst. 2011 7 2228 2237
15. Y. G. Kim A. C. Lou A. Saghatelian A metabolomics strategy for detecting protein-metabolite interactions to identify natural nuclear receptor ligands Mol. BioSyst. 2011 7 1046 1049
16. T. Ooga H. Sato A. Nagashima K. Sasaki M. Tomita T. Soga Y. Ohashi Metabolomic anatomy of an animal model revealing homeostatic imbalances in dyslipidaemia Mol. BioSyst. 2011 7 1217 1223
17. S. Giri K. W. Krausz J. R. Idle F. J. Gonzalez The metabolomics of (±)-arecoline 1-oxide in the mouse and its formation by human flavin-containing monooxygenases Biochem. Pharmacol. 2007 73 561 573 (Pubitemid 46038850)
18. M. R. Beyranvand M. K. Khalafi V. D. Roshan S. Choobineh S. A. Parsa M. A. Piranfar Effect of taurine supplementation on exercise capacity of patients with heart failure J. Cardiol. 2011 57 333 337
19. P. Guidetti R. Schwarcz 3-Hydroxykynurenine potentiates quinolinate but not NMDA toxicity in the rat striatum Eur. J. Neurosci. 1999 11 3857 3863 (Pubitemid 29537565)
20. J. Li J. Cao M. Li Y. Yu Y. Yang X. Xiao Z. Wu L. Wang Y. Tu H. Chen Collagen triple helix repeat containing-1 inhibits transforming growth factor-b1-induced collagen type I expression in keloid Br. J. Dermatol. 2011 164 1030 1036
21. D. MacKenna S. R. Summerour F. J. Villarreal Role of mechanical factors in modulating cardiac fibroblast function and extracellular matrix synthesis Cardiovasc. Res. 2000 46 257 263 (Pubitemid 30204597)
22. L. Z. Yang J. Kockskämper S. Khan J. Suarez S. Walther B. Doleschal G. Unterer M. Khafaga H. Mächler F. R. Heinzel W. H. Dillmann B. Pieske J. Spiess cAMP- and Ca2(+)/calmodulin-dependent protein kinases mediate inotropic, lusitropic and arrhythmogenic effects of urocortin 2 in mouse ventricular myocytes Br. J. Pharmacol. 2011 162 544 556
23. P. A. Insel L. Zhang F. Murray H. Yokouchi A. C. Zambon Cyclic AMP is both a pro-apoptotic and anti-apoptotic second messenger Acta Physiol. (Oxf.). 2011 10.1111/j.1748-1716
24. K. Noda E. Miyoshi J. Gu C. X. Gao S. Nakahara T. Kitada K. Honke K. Suzuki H. Yoshihara K. Yoshikawa K. Kawano M. Tonetti A. Kasahara M. Hori N. Hayashi N. Taniguchi Relationship between elevated FX expression and increased production of GDP-l-fucose, a common donor substrate for fucosylation in human hepatocellular carcinoma and hepatoma cell lines Cancer Res. 2003 63 6282 6289 (Pubitemid 37255175)
25. K. A. Kang R. Zhang M. J. Piao K. H. Lee B. J. Kim S. Y. Kim H. S. Kim D. H. Kim H. J. You J. W. Hyun Inhibitory effects of glycitein on hydrogen peroxide induced cell damage by scavenging reactive oxygen species and inhibiting c-Jun N-terminal kinase Free Radical Res. 2007 41 720 729 (Pubitemid 46845593)
26. B. C. Sallustio L. Sabordo A. M. Evans R. L. Nation Hepatic disposition of electrophilic acyl glucuronide conjugates Curr. Drug Metab. 2000 1 163 180
27. S. Almagro-Moreno E. F. Boyd Bacterial catabolism of nonulosonic (sialic) acid and fitness in the gut Gut Microbes 2010 1 45 50
28. M. Ganzera Recent advancements and applications in the analysis of traditional Chinese medicines Planta Med. 2009 75 776 783
29. J. Y. Liu N. Li J. Yang N. Li H. Qiu D. Ai N. Chiamvimonvat Y. Zhu B. D. Hammock Metabolic profiling of murine plasma reveals an unexpected biomarker in rofecoxib-mediated cardiovascular events Proc. Natl. Acad. Sci. U. S. A. 2010 107 17017 17022
30. J. L. Ward J. M. Baker A. M. Llewellyn N. D. Hawkins M. H. Beale Metabolomic analysis of Arabidopsis reveals hemiterpenoid glycosides as products of a nitrate ion-regulated Proc. Natl. Acad. Sci. U. S. A. 2011 108 10762 10767
31. A. M. Aura I. Mattila T. Hyötyläinen P. Gopalacharyulu C. Bounsaythip M. OreŠi K. M. Oksman-Caldentey Drug metabolome of the simvastatin formed by human intestinal microbiota in vitro Mol. BioSyst. 2011 7 437 446
32. J. K. Ellis T. J. Athersuch R. Cavill R. Radford C. Slattery P. Jennings T. McMorrow M. P. Ryan T. M. Ebbels H. C. Keun Metabolic response to low-level toxicant exposure in a novel renal tubule epithelial cell system Mol. BioSyst. 2011 7 247 257