Saliva metabolomics opens door to biomarker discovery, disease diagnosis, and treatment

Applied Biochemistry and Biotechnology

Volumn 168, Issue 6, 2012, Pages 1718-1727

  Zhang, Aihua ^a,b   Sun, Hui ^a,b   Wang, Xijun ^a,b  

^a HEILONGJIANG UNIVERSITY OF CHINESE MEDICINE   (China)

^b Key Pharmacometabolomics Platform of Chinese Medicines   (China)

Author keywords

Biomarkers; Disease diagnostics; Metabolites; Metabolomics; Saliva analyses; System biology

Indexed keywords

BIO-MARKER DISCOVERY; BIOLOGICAL ORGANISMS; BIOLOGICAL SAMPLES; CHEMICAL FINGERPRINT; CLINICAL APPLICATION; CLINICAL DIAGNOSTICS; DIAGNOSTIC TOOLS; DIAGNOSTIC VALUE; DISEASE DETECTION; DISEASE DIAGNOSIS; DISEASE DIAGNOSTICS; DISEASE SURVEILLANCE; LARGE ARRAYS; LOW MOLECULAR WEIGHT; MEDICAL DIAGNOSTICS; METABOLITE PROFILES; METABOLOMES; METABOLOMIC ANALYSIS; METABOLOMICS; PROOF OF PRINCIPLES; SALIVA ANALYSES; SALIVARY BIOMARKERS; SYSTEM BIOLOGY; SYSTEMATIC STUDY;

BIOMARKERS; BIOMOLECULES; BODY FLUIDS; CHEMICAL ANALYSIS; DIAGNOSTIC PRODUCTS; METABOLITES; RESEARCH;

DIAGNOSIS;

4 AMINOBUTYRIC ACID; ALCOHOL DERIVATIVE; ALDEHYDE DERIVATIVE; AMIDE; AMINE; ARACHIDIC ACID; BIOLOGICAL MARKER; CARBOXYLIC ACID DERIVATIVE; ESTER DERIVATIVE; HYDROCARBON; KETONE DERIVATIVE; LACTIC ACID; LACTONE DERIVATIVE; PHENYLALANINE; VALINE; VOLATILE ORGANIC COMPOUND;

AREA UNDER THE CURVE; ARTICLE; CANCER MORTALITY; CANCER PROGNOSIS; CANCER SURVIVAL; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DISEASE COURSE; DISEASE PREDISPOSITION; FEASIBILITY STUDY; GAS CHROMATOGRAPHY; HEALTH PROMOTION; HEALTH STATUS; HIGH THROUGHPUT SCREENING; HUMAN; LEUKOPLAKIA; LICHEN PLANUS; METABOLOMICS; MORBIDITY; MOUTH SQUAMOUS CELL CARCINOMA; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PANCREAS CANCER; PERSONALIZED MEDICINE; PHENOTYPE; PRINCIPAL COMPONENT ANALYSIS; PUBLIC HEALTH; RELIABILITY; REPRODUCIBILITY; SALIVA; SENSITIVITY ANALYSIS; SYSTEMS BIOLOGY;

ANIMALS; BIOLOGICAL MARKERS; DIAGNOSIS; HUMANS; METABOLOMICS; SALIVA; THERAPEUTICS;

EID: 84871784703     PISSN: 02732289     EISSN: 15590291     Source Type: Journal    
DOI: 10.1007/s12010-012-9891-5     Document Type: Article

References (67)

1. Nicholson, J. K., & Lindon, J. C. (2008). Metabonomics Nature, 455, 1054-1056.
2. Arakaki, A. K., Skolnick, J., & McDonald, J. F. (2008). Nature, 456, 443.
3. Park, C., Yun, S., Lee, S. Y., Park, K., & Lee, J. (2012). Applied Biochemistry and Biotechnology, 167(3), 425-438.
4. Yu, F. M., Qiao, B., Zhu, F., Wu, J. C., & Yuan, Y. J. (2006). Applied Biochemistry and Biotechnology, 135(2), 145-158.
5. Wang, X., Yang, B., Sun, H., & Zhang, A. (2012). Analytical Chemistry, 84, 428-439.
6. Zhang, A., Sun, H., Wang, P., Han, Y., & Wang, X. (2012). Journal of Proteomics, 75, 1079-1088.
7. Wang, X., Wang, H., Zhang, A., Lu, X., Sun, H., Dong, H., & Wang, P. (2012). Journal of Proteome Research, 11, 1284-1301.
8. Wang, X., Zhang, A., Han, Y., Wang, P., Sun, H., Song, G., Dong, T., Yuan, Y., Yuan, X., Zhang, M., Ning, X., Zhang, H., Dong, H., & Dong, W. (2012). Molecular & Cellular Proteomics, 11(8), 370-380.
9. Spielmann, N., & Wong, D. T. (2011). Oral Diseases, 17(4), 345-354.
10. Bertram, H. C., Eggers, N., & Eller, N. (2009). Analytical Chemistry, 81(21), 9188-9193.
11. Giannobile,W. V., McDevitt, J. T., Niedbala, R. S., & Malamud, D. (2011). Advances in Dental Research, 23(4), 375-380.
12. Miller, C. S., Foley, J. D., Bailey, A. L., Campell, C. L., Humphries, R. L., Christodoulides, N., Floriano, P. N., Simmons, G., Bhagwandin, B., Jacobson, J. W., Redding, S. W., Ebersole, J. L., & McDevitt, J. T. (2010). Biomarkers in Medicine, 4(1), 171-189.
13. Yan, W., Apweiler, R., Balgley, B. M., Boontheung, P., Bundy, J. L., Cargile, B. J., Cole, S., Fang, X., Gonzalez-Begne, M., Griffin, T. J., Hagen, F., Hu, S., Wolinsky, L. E., Lee, C. S., Malamud, D., Melvin, J. E., Menon, R., Mueller, M., Qiao, R., Rhodus, N. L., Sevinsky, J. R., States, D., Stephenson, J. L., Than, S., Yates, J. R., Yu, W., Xie, H., Xie, Y., Omenn, G. S., Loo, J. A., & Wong, D. T. (2009). Proteomics. Clinical Applications, 3(1), 116-134.
14. Hu, S., Yen, Y., Ann, D., & Wong, D. T. (2007). Drug Discovery Today, 12(21-22), 911-916.
15. Baum, B. J., Yates, J. R., 3rd, Srivastava, S., Wong, D. T., & Melvin, J. E. (2011). Advances in Dental Research, 23(4), 360-368.
16. Thomadaki, K., Helmerhorst, E. J., Tian, N., Sun, X., Siqueira, W. L., Walt, D. R., & Oppenheim, F. G. (2011). Journal of Dental Research, 90(11), 1325-1330.
17. Yeh, C. K., Christodoulides, N. J., Floriano, P. N., Miller, C. S., Ebersole, J. L., Weigum, S. E., McDevitt, J., & Redding, S. W. (2010). Texas Dental Journal, 127(7), 651-661.
18. Bigler, L. R., Streckfus, C. F., & Dubinsky, W. P. (2009). Clinics in Laboratory Medicine, 29(1), 71-85.
19. Wong, D. T. (2006). Journal of the California Dental Association, 34(4), 303-308.
20. Samaranayake, L. (2007). International Dental Journal, 57(5), 295-299.
21. Jarai, T., Maasz, G., Burian, A., Bona, A., Jambor, E., Gerlinger, I., & Mark, L. (2012). Pathology and Oncology Research, 18(3), 623-628.
22. Streckfus, C. F., Brown, R. E., & Bull, J. M. (2010). International Journal of Hyperthermia, 26(7), 649-661.
23. McMurray, H. R., Sampson, E. R., Compitello, G., Kinsey, C., Newman, L., Smith, B., Chen, S. R., Klebanov, L., Salzman, P., Yakovlev, A., & Land, H. (2008). Nature, 453(7198), 1112-1116.
24. Ma, Y., Zhang, P., Wang, F., Liu, W., Yang, J., & Qin, H. (2012). Annals of Surgery, 255, 720-730.
25. Chen, F., Xue, J., Zhou, L., Wu, S., & Chen, Z. (2011). Analytical and Bioanalytical Chemistry, 401, 1899-1904.
26. Tan, Y., Yin, P., Tang, L., Xing,W., Huang, Q., Cao, D., Zhao, X.,Wang,W., Lu, X., Xu, Z.,Wang, H., & Xu, G. (2012). Molecular & Cellular Proteomics, 11, M111.010694.
27. Bertini, I., Cacciatore, S., Jensen, B. V., Schou, J. V., Johansen, J. S., Kruhøffer, M., Luchinat, C., Nielsen, D. L., & Turano, P. (2012). Cancer Research, 72, 356-364.
28. Hori, S., Nishiumi, S., Kobayashi, K., Shinohara, M., Hatakeyama, Y., Kotani, Y., Hatano, N., Maniwa, Y., Nishio, W., Bamba, T., Fukusaki, E., Azuma, T., Takenawa, T., Nishimura, Y., & Yoshida, M. (2011). Lung Cancer, 74, 284-292.
29. Lin, L., Huang, Z., Gao, Y., Yan, X., Xing, J., & Hang, W. (2011). Journal of Proteome Research, 10, 1396-1405.
30. Liu, J. Y., Li, N., Yang, J., Li, N., Qiu, H., Ai, D., Chiamvimonvat, N., Zhu, Y., & Hammock, B. D. (2010). Proceedings of the National Academy of Sciences of the United States of America, 107, 17017-17022.
31. Beckwith-Hall, B. M., Thompson, N. A., Nicholson, J. K., Lindon, J. C., & Holmes, E. (2003). Analyst, 128, 814-818.
32. Soga, T., Sugimoto, M., Honma, M., Mori, M., Igarashi, K., Kashikura, K., Ikeda, S., Hirayama, A., Yamamoto, T., Yoshida, H., Otsuka, M., Tsuji, S., Yatomi, Y., Sakuragawa, T., Watanabe, H., Nihei, K., Saito, T., Kawata, S., Suzuki, H., Tomita, M., & Suematsu, M. (2011). Journal of Hepatology, 55, 896-905.
33. Tiziani, S., Lopes, V., & Günther, U. L. (2009). Neoplasia, 11, 269-276.
34. Denery, J. R., Nunes, A. A., Hixon, M. S., Dickerson, T. J., & Janda, K. D. (2010). PLoS Neglected Tropical Diseases, 4, e834.
35. Chen, J., Zhang, X., Cao, R., Lu, X., Zhao, S., Fekete, A., Huang, Q., Schmitt-Kopplin, P., Wang, Y., Xu, Z., Wan, X., Wu, X., Zhao, N., Xu, C., & Xu, G. (2011). Journal of Proteome Research, 10, 2625-2632.
36. Bathe, O. F., Shaykhutdinov, R., Kopciuk, K., Weljie, A. M., McKay, A., Sutherland, F. R., Dixon, E., Dunse, N., Sotiropoulos, D., & Vogel, H. J. (2011). Cancer Epidemiology, Biomarkers & Prevention, 20, 140-147.
37. Sysi-Aho, M., Ermolov, A., Gopalacharyulu, P. V., Tripathi, A., Seppänen-Laakso, T., Maukonen, J., Mattila, I., Ruohonen, S. T., Vähätalo, L., Yetukuri, L., Härkönen, T., Lindfors, E., Nikkilä, J., Ilonen, J., Simell, O., Saarela, M., Knip, M., Kaski, S., Savontaus, E., & Orešič, M. (2011). PLoS Computational Biology, 7, e1002257.
38. Prince, E. K., & Pohnert, G. (2010). Analytical and Bioanalytical Chemistry, 396, 193-197.
39. Zhang, A., Sun, H., Wang, P., Han, Y., & Wang, X. (2012). Pharmazie, 67(2), 99-105.
40. Lee, R., West, D., Phillips, S. M., & Britz-McKibbin, P. (2010). Analytical Chemistry, 82, 2959-2968.
41. Zhou, L., Wang, Q., Yin, P., Xing, W., Wu, Z., Chen, S., Lu, X., Zhang, Y., Lin, X., & Xu, G. (2012). Analytical and Bioanalytical Chemistry, 403(1), 203-213.
42. Wu, H., Xue, R., Tang, Z., Deng, C., Liu, T., Zeng, H., Sun, Y., & Shen, X. (2010). Analytical and Bioanalytical Chemistry, 396(4), 1385-1395.
43. Sreekumar, A., Poisson, L. M., Rajendiran, T. M., Khan, A. P., Cao, Q., Yu, J., Laxman, B., Mehra, R., Lonigro, R. J., Li, Y., Nyati, M. K., Ahsan, A., Kalyana-Sundaram, S., Han, B., Cao, X., Byun, J., Omenn, G. S., Ghosh, D., Pennathur, S., Alexander, D. C., Berger, A., Shuster, J. R., Wei, J. T., Varambally, S., Beecher, C., & Chinnaiyan, A. M. (2009). Nature, 457, 910-914.
44. Catchpole, G. S., Beckmann, M., Enot, D. P., Mondhe, M., Zywicki, B., Taylor, J., Hardy, N., Smith, A., King, R. D., Kell, D. B., Fiehn, O., & Draper, J. (2009). Proceedings of the National Academy of Science U S A, 102, 14458-14462.
45. Xu, J., Zhang, J., Cai, S., Dong, J., Yang, J. Y., & Chen, Z. (2009). Analytical and Bioanalytical Chemistry, 393(6-7), 1657-1668.
46. Kuhara, T., Ohse, M., Inoue, Y., & Cooper, A. J. (2011). Analytical and Bioanalytical Chemistry, 400(7), 1881-1894.
47. Wang, X., Sun, H., Zhang, A., Sun, W., Wang, P., & Wang, Z. (2010). Journal of Pharmaceutical and Biomedical Analysis, 55, 859-868.
48. Zhang, A., Sun, H., Wang, Z., Sun, W., Wang, P., & Wang, X. (2010). Planta Medica, 76, 2026-2035.
49. Sun H, Zhang A, Wang X (2012). Phytother Res doi: 10.1002/ptr.4613.
50. Zhang, A., Sun, H., Wang, P., Han, Y., & Wang, X. (2012). Analyst, 137, 293-300.
51. Zhang, A., Sun, H., Wang, P., Han, Y., & Wang, X. (2012). Complement Therapies Medical, 20, 93-99.
52. Winder, C. L., Cornmell, R., Schuler, S., Jarvis, R. M., Stephens, G. M., & Goodacre, R. (2011). Analytical and Bioanalytical Chemistry, 399, 387-401.
53. Yang, B., Zhang, A., Sun, H., Dong, W., Yan, G., Li, T., & Wang, X. (2012). Journal of Pharmaceutical and Biomedical Analysis, 58, 113-124.
54. Wang, X., Sun, H., Zhang, A., Sun, W., Wang, P., & Wang, Z. (2011). Journal of Pharmaceutical and Biomedical Analysis, 55, 859-868.
55. Psychogios, N., Hau, D. D., Peng, J., Guo, A. C., Mandal, R., Bouatra, S., Sinelnikov, I., Krishnamurthy, R., Eisner, R., Gautam, B., Young, N., Xia, J., Knox, C., Dong, E., Huang, P., Hollander, Z., Pedersen, T. L., Smith, S. R., Bamforth, F., Greiner, R., McManus, B., Newman, J. W., Goodfriend, T., & Wishart, D. S. (2011). PLoS One, 6(2), e16957.
56. Amantonico, A., Urban, P. L., & Zenobi, R. (2010). Analytical and Bioanalytical Chemistry, 398, 2493-2504.
57. Zhang, L., Xiao, H., & Wong, D. T. (2009). Molecular Diagnosis & Therapy, 13(4), 245-259.
58. Lee, J. M., Garon, E., & Wong, D. T. (2009). Orthodontics & Craniofacial Research, 12(3), 206-211.
59. Segal, A., & Wong, D. T. (2008). European Journal of Dental Education, 12(Suppl 1), 22-29.
60. Giovane, A., Balestrieri, A., & Napoli, C. (2008). Journal of Cellular Biochemistry, 105(3), 648-654.
61. Zhang, A., Sun, H., Han, Y., Yuan, Y., Wang, P., Song, G., Yuan, X., Zhang, M., Xie, N., & Wang, X. (2012). Analyst, 137(18), 4200-4208.
62. Soini, H. A., Klouckova, I., Wiesler, D., Oberzaucher, E., Grammer, K., Dixon, S. J., Xu, Y., Brereton, R. G., Penn, D. J., & Novotny, M. V. (2010). Journal of Chemical Ecology, 36(9), 1035-1042.
63. Hamada, S., & Shimosegawa, T. (2011). Pancreatology, 11(Suppl 2), 14-19.
64. Zhang A, Sun H, Wang X. Anal Bioanal Chem. 2012,PMID: 22648167
65. Yan, S. K., Wei, B. J., Lin, Z. Y., Yang, Y., Zhou, Z. T., & Zhang, W. D. (2008). Oral Oncology, 44(5), 477-483.
66. Sugimoto, M., Wong, D. T., Hirayama, A., Soga, T., & Tomita, M. (2010). Metabolomics, 6(1), 78-95.
67. OuYang, D., Xu, J., Huang, H., & Chen, Z. (2011). Applied Biochemistry and Biotechnology, 165(1), 148-154.