Metabolomic profiling of fatty acid and amino acid metabolism in youth with obesity and type 2 diabetes: Evidence for enhanced mitochondrial oxidation

Diabetes Care

Volumn 35, Issue 3, 2012, Pages 605-611

  Mihalik, Stephanie J ^a   Michaliszyn, Sara F ^b   De Las Heras, Javier ^b,c   Bacha, Fida ^b   Lee, SoJung ^b   Chace, Donald H ^d   DeJesus, Victor R ^e   Vockley, Jerry ^b   Arslanian, Silva A ^b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^c HOSPITAL DE CRUCES   (Spain)

^d PEDIATRIX MEDICAL GROUP   (United States)

^e CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLCARNITINE; ALANINE; AMINO ACID; ARGININE; CITRULLINE; FATTY ACID; GLUCOSE; GLYCEROL; GLYCINE; HEMOGLOBIN A1C; HISTIDINE; INSULIN; ISOLEUCINE; LEUCINE; LONG CHAIN FATTY ACID; METHIONINE; PHENYLALANINE; SERINE; SHORT CHAIN FATTY ACID; TRYPTOPHAN; TYROSINE; VALINE; VERY LONG CHAIN FATTY ACID;

ADOLESCENT; AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; ARTICLE; BODY COMPOSITION; BODY MASS; CALORIMETRY; CHILD; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; ENZYME METABOLISM; ENZYME SUBSTRATE; FATTY ACID METABOLISM; FATTY ACID OXIDATION; FEMALE; GLUCOSE CLAMP TECHNIQUE; GLUCOSE OXIDATION; HUMAN; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; LIPOLYSIS; MAJOR CLINICAL STUDY; MALE; METABOLOMICS; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; OXYGEN CONSUMPTION; PRESCHOOL CHILD; RESPIRATORY QUOTIENT; SCHOOL CHILD; SUBCUTANEOUS FAT; TANDEM MASS SPECTROMETRY;

ABSORPTIOMETRY, PHOTON; ADOLESCENT; AMINO ACIDS; CARNITINE; DIABETES MELLITUS, TYPE 2; FASTING; FATTY ACIDS; FEMALE; HUMANS; MALE; OBESITY;

EID: 84859073302     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/DC11-1577     Document Type: Article

References (36)

1. Hannon TS, Rao G, Arslanian SA. Childhood obesity and type 2 diabetes mellitus. Pediatrics 2005;116:473-480 (Pubitemid 44161477)
2. Levy-Marchal C, Arslanian S, Cutfield W, et al.; ESPE-LWPES-ISPAD-APPES- APEG-SLEP-JSPE; Insulin Resistance in Children Consensus Conference Group. Insulin resistance in children: consensus, perspective, and future directions. J Clin Endocrinol Metab 2010;95:5189-5198
3. Newgard CB, An J, Bain JR, et al. A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab 2009;9:311-326
4. Huffman KM, Shah SH, Stevens RD, et al. Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women. Diabetes Care 2009;32:1678-1683
5. Tai ES, Tan ML, Stevens RD, et al. Insulin resistance isassociated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men. Diabetologia 2010;53:757-767
6. Adams SH, Hoppel CL, Lok KH, et al. Plasma acylcarnitine profiles suggest incomplete long-chain fatty acid beta-oxidation and altered tricarboxylic acid cycle activity in type 2 diabetic African-American women. J Nutr 2009;139:1073-1081
7. Mihalik SJ, Goodpaster BH, Kelley DE, et al. Increased levels of plasma acylcarnitines in obesity and type 2 diabetes and identification of a marker of glucolipotoxicity. Obesity (Silver Spring) 2010;18:1695-1700
8. Fiehn O, Garvey WT, Newman JW, Lok KH, Hoppel CL, Adams SH. Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women. PLoS ONE 2010;5:e15234
9. Kim JY, Park JY, Kim OY, et al. Metabolic profiling of plasma in overweight/obese and lean men using ultra performance liquid chromatography and Q-TOF mass spectrometry (UPLC-Q-TOF MS). J Proteome Res 2010;9:4368-4375
10. George L, Bacha F, Lee S, Tfayli H, Andreatta E, Arslanian S. Surrogate estimates of insulin sensitivity in obese youth along the spectrum of glucose tolerance from normal to prediabetes to diabetes. J Clin Endocrinol Metab 2011;96:2136-2145
11. Tfayli H, Bacha F, Gungor N, Arslanian S. Islet cell antibody-positive versus -negative phenotypic type 2 diabetes in youth: does the oral glucose tolerance test distinguish between the two? Diabetes Care 2010;33:632-638
12. Bacha F, Gungor N, Lee S, Arslanian SA. In vivo insulin sensitivity and secretion in obese youth: what are the differences between normal glucose tolerance, impaired glucose tolerance, and type 2 diabetes? Diabetes Care 2009;32:100-105
13. Tanner JM. Growth and maturation during adolescence. Nutr Rev 1981;39:43-55
14. Arslanian SA, Kalhan SC. Correlations between fatty acid and glucose metabolism. Potential explanation of insulin resistance of puberty. Diabetes 1994;43:908-914
15. Arslanian S, Suprasongsin C. Testosterone treatment inadolescents with delayed puberty: changes in body composition, protein, fat, and glucose metabolism. J Clin Endocrinol Metab 1997;82:3213-3220 (Pubitemid 27419059)
16. Burns SF, Lee S, Arslanian SA. In vivo insulin sensitivity and lipoprotein particle size and concentration in black and white children. Diabetes Care 2009;32:2087-2093
17. Tfayli H, Bacha F, Gungor N, Arslanian S. Phenotypic type 2diabetes in obese youth: insulin sensitivity and secretion in islet cell antibody-negative versus -positive patients. Diabetes 2009;58:738-744
18. Chace DH, Kalas TA, Naylor EW. Use of tandem mass spectrometry for multi-analyte screening of dried blood specimens from newborns. Clin Chem 2003;49:1797-1817 (Pubitemid 37340314)
19. Lee S, Kuk JL, Hannon TS, Arslanian SA. Race and gender differences in the relationships between anthropometrics and abdominal fat in youth. Obesity (Silver Spring) 2008;16:1066-1071 (Pubitemid 351620458)
20. Danadian K, Balasekaran G, Lewy V, Meza MP, Robertson R, Arslanian SA. Insulin sensitivity in African-American children with and without family history of type 2 diabetes. Diabetes Care 1999;22:1325-1329 (Pubitemid 29350244)
21. Gungor N, Bacha F, Saad R, Janosky J, Arslanian S. Youth type 2diabetes: insulin resistance, beta-cell failure, or both? Diabetes Care 2005;28:638-644
22. Danadian K, Lewy V, Janosky JJ, Arslanian S. Lipolysis in African-American children: is it ametabolic risk factor predisposing to obesity? J Clin Endocrinol Metab 2001;86:3022-3026 (Pubitemid 32673460)
23. Frayn KN. Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol 1983;55:628-634 (Pubitemid 13044099)
24. Nurjhan N, Consoli A, Gerich J. Increased lipolysis and its consequences on gluconeogenesis in non-insulin-dependent diabetes mellitus. J Clin Invest 1992;89:169-175
25. Arslanian SA, Kalhan SC. Protein turnover during puberty in normal children. Am J Physiol 1996;270:E79-E84
26. Herman MA, She P, Peroni OD, Lynch CJ, Kahn BB. Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels. J Biol Chem 2010;285:11348-11356
27. Lenaers E, De Feyter HM, Hoeks J, et al. Adaptations in mitochondrial function parallel, but fail to rescue, the transition to severe hyperglycemia and hyperinsulinemia: a study in Zucker diabetic fatty rats. Obesity (Silver Spring) 2010;18:1100-1107
28. Boyle KE, Canham JP, Consitt LA, et al. A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals. J Clin Endocrinol Metab 2011;96:775-781
29. Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med 2004;350:664-671 (Pubitemid 38364625)
30. Kelley DE, He J, Menshikova EV, Ritov VB. Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 2002;51:2944-2950
31. Maffeis C, Pinelli L, Schutz Y. Increased fat oxidation inprepubertal obese children: a metabolic defense against further weight gain? J Pediatr 1995;126:15-20
32. Molnár D, Schutz Y. Fat oxidation innonobese and obese adolescents: effect of body composition and pubertal development. J Pediatr 1998;132:98-104 (Pubitemid 28082539)
33. Koves TR, Ussher JR, Noland RC, et al. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab 2008;7:45-56
34. Bonnard C, Durand A, Peyrol S, et al. Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice. J Clin Invest 2008;118:789-800 (Pubitemid 351206566)
35. Randle PJ, Priestman DA, Mistry SC, Halsall A. Glucose fatty acid interactions and the regulation of glucose disposal. J Cell Biochem 1994;55(Suppl.):1-11 (Pubitemid 24199280)
36. Arslanian S, Suprasongsin C. Glucose-fatty acid interactions inprepubertal and pubertal children: effects of lipid infusion. Am J Physiol 1997;272:E523-E529