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Volumn 34, Issue 12, 2011, Pages 2624-2630

Emerging applications of metabolomic and genomic profiling in diabetic clinical medicine

Author keywords

[No Author keywords available]

Indexed keywords

CHROMATOGRAPHY; CLINICAL MEDICINE; DIABETES MELLITUS; EARLY DIAGNOSIS; ENVIRONMENTAL FACTOR; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE PHENOTYPE CORRELATION; GLYCEMIC CONTROL; HEREDITY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; LIFESTYLE MODIFICATION; MASS SPECTROMETRY; METABOLOMICS; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOGENESIS; POSITRON EMISSION TOMOGRAPHY; PROGNOSIS; QUALITY OF LIFE; REVIEW; SENSITIVITY AND SPECIFICITY; TWO DIMENSIONAL ELECTROPHORESIS; BLOOD; GENETIC PREDISPOSITION; GENETICS; GENOMICS; GLUCOSE BLOOD LEVEL; INFLAMMATION; METABOLIC SYNDROME X; METABOLISM; OXIDATIVE STRESS;

EID: 84858419687     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc11-0837     Document Type: Review
Times cited : (41)

References (60)
  • 1
    • 77956276702 scopus 로고    scopus 로고
    • Quantitative metabolomics by H-NMR and LC-MS/MS confirms altered metabolic pathways in diabetes
    • Lanza IR, Zhang S, Ward LE, Karakelides H, Raftery D, Nair KS. Quantitative metabolomics by H-NMR and LC-MS/MS confirms altered metabolic pathways in diabetes. PLoS ONE 2010;5:e10538
    • (2010) PLoS ONE , vol.5
    • Lanza, I.R.1    Zhang, S.2    Ward, L.E.3    Karakelides, H.4    Raftery, D.5    Nair, K.S.6
  • 4
    • 28244500484 scopus 로고    scopus 로고
    • Serum gamma-glutamyltransferase and risk of type 2 diabetes mellitus in men and women from the general population
    • DOI 10.1111/j.1365-2796.2005.01572.x
    • Meisinger C, Löwel H, HeierM, Schneider A, Thorand B; KORA Study Group. Serum gamma-glutamyltransferase and risk of type 2 diabetesmellitus inmen andwomen from the general population. J Intern Med 2005;258:527-535 (Pubitemid 41705393)
    • (2005) Journal of Internal Medicine , vol.258 , Issue.6 , pp. 527-535
    • Meisinger, C.1    Lowel, H.2    Heier, M.3    Schneider, A.4    Thorand, B.5
  • 5
    • 33750454286 scopus 로고    scopus 로고
    • Alanine aminotransferase as a marker of non-alcoholic fatty liver disease in relation to type 2 diabetes mellitus and cardiovascular disease
    • DOI 10.1002/dmrr.666
    • Schindhelm RK, Diamant M, Dekker JM, Tushuizen ME, Teerlink T, Heine RJ. Alanine aminotransferase as a marker of non-alcoholic fatty liver disease in relation to type 2 diabetes mellitus and cardiovascular disease. Diabetes Metab Res Rev 2006;22:437-443 (Pubitemid 44774047)
    • (2006) Diabetes/Metabolism Research and Reviews , vol.22 , Issue.6 , pp. 437-443
    • Schindhelm, R.K.1    Diamant, M.2    Dekker, J.M.3    Tushuizen, M.E.4    Teerlink, T.5    Heine, R.J.6
  • 6
    • 43049099344 scopus 로고    scopus 로고
    • Novel biochemical risk factors for type 2 diabetes: Pathogenic insights or prediction possibilities?
    • Sattar N, Wannamethee SG, Forouhi NG. Novel biochemical risk factors for type 2 diabetes: pathogenic insights or prediction possibilities? Diabetologia 2008;51:926-940
    • (2008) Diabetologia , vol.51 , pp. 926-940
    • Sattar, N.1    Wannamethee, S.G.2    Forouhi, N.G.3
  • 7
    • 67650070809 scopus 로고    scopus 로고
    • Development of a type 2 diabetes risk model from a panel of serum biomarkers from the Inter99 cohort
    • Kolberg JA, Jørgensen T, Gerwien RW, et al. Development of a type 2 diabetes risk model from a panel of serum biomarkers from the Inter99 cohort. Diabetes Care 2009;32:1207-1212
    • (2009) Diabetes Care , vol.32 , pp. 1207-1212
    • Kolberg, J.A.1    Jørgensen, T.2    Gerwien, R.W.3
  • 8
    • 77956336714 scopus 로고    scopus 로고
    • Thirty-one novel biomarkers as predictors for clinically incident diabetes
    • Salomaa V, Havulinna A, Saarela O, et al. Thirty-one novel biomarkers as predictors for clinically incident diabetes. PLoS ONE 2010;5:e10100
    • (2010) PLoS ONE , vol.5
    • Salomaa, V.1    Havulinna, A.2    Saarela, O.3
  • 9
    • 84863301040 scopus 로고    scopus 로고
    • Pancreatic polypeptide as target/marker of beta cell failure
    • US patent 2009/0215069.27 August
    • Christ A, Evers S, Krapfenbauer K, Sebokova E. Pancreatic polypeptide as target/marker of beta cell failure.US patent 2009/0215069.27 August 2009
    • (2009)
    • Christ, A.1    Evers, S.2    Krapfenbauer, K.3    Sebokova, E.4
  • 10
    • 84863333145 scopus 로고    scopus 로고
    • Fibronectin as target/marker for insulin resistance
    • International patent WO/2007/06278.7 June
    • Amrein K, Berndt P, Evers S, Foster S, Fountoulakis M, Sebokova E. Fibronectin as target/marker for insulin resistance. International patent WO/2007/06278.7 June 2007
    • (2007)
    • Amrein, K.1    Berndt, P.2    Evers, S.3    Foster, S.4    Fountoulakis, M.5    Sebokova, E.6
  • 11
    • 56649094538 scopus 로고    scopus 로고
    • Plasma fetuin-A levels and the risk of type 2 diabetes
    • Stefan N, Fritsche A, Weikert C, et al. Plasma fetuin-A levels and the risk of type 2 diabetes. Diabetes 2008;57:2762-2767
    • (2008) Diabetes , vol.57 , pp. 2762-2767
    • Stefan, N.1    Fritsche, A.2    Weikert, C.3
  • 12
    • 33644981693 scopus 로고    scopus 로고
    • Sex differences of endogenous sex hormones and risk of type 2 diabetes: A systematic review and meta-analysis
    • Ding EL, Song Y, Malik VS, Liu S. Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis. JAMA 2006;295:1288-1299
    • (2006) JAMA , vol.295 , pp. 1288-1299
    • Ding, E.L.1    Song, Y.2    Malik, V.S.3    Liu, S.4
  • 13
    • 21244481313 scopus 로고    scopus 로고
    • Insulin-like growth factor-I and risk of type 2 diabetes and coronary heart disease: Molecular epidemiology
    • Sandhu MS. Insulin-like growth factor-I and risk of type 2 diabetes and coronary heart disease: molecular epidemiology. Endocr Dev 2005;9:44-54
    • (2005) Endocr Dev , vol.9 , pp. 44-54
    • Sandhu, M.S.1
  • 14
    • 0023473996 scopus 로고
    • Fructosamine: Structure, analysis, and clinical usefulness
    • Armbruster DA. Fructosamine: structure, analysis, and clinical usefulness. Clin Chem 1987;33:2153-2163
    • (1987) Clin Chem , vol.33 , pp. 2153-2163
    • Armbruster, D.A.1
  • 15
    • 7644230144 scopus 로고    scopus 로고
    • Evaluation of an assay for serum 1,5-anhydroglucitol (GlycoMark) and determination of reference intervals on the Hitachi 917 analyzer
    • DOI 10.1016/j.cccn.2004.08.013, PII S000989810400419X
    • Nowatzke W, Sarno MJ, Birch NC, Stickle DF, Eden T, Cole TG. Evaluation of an assay for serum1,5-anhydroglucitol (GlycoMark) and determination of reference intervals on the Hitachi 917 analyzer. Clin Chim Acta 2004;350:201-209 (Pubitemid 39458264)
    • (2004) Clinica Chimica Acta , vol.350 , Issue.1-2 , pp. 201-209
    • Nowatzke, W.1    Sarno, M.J.2    Birch, N.C.3    Stickle, D.F.4    Eden, T.5    Cole, T.G.6
  • 16
    • 0036774115 scopus 로고    scopus 로고
    • An enzymatic method for the measurement of glycated albumin in biological samples
    • DOI 10.1016/S0009-8981(02)00207-3, PII S0009898102002073
    • Kouzuma T, Usami T, Yamakoshi M, Takahashi M, Imamura S. An enzymatic method for the measurement of glycated albumin in biological samples. Clin Chim Acta 2002;324:61-71 (Pubitemid 35245496)
    • (2002) Clinica Chimica Acta , vol.324 , Issue.1-2 , pp. 61-71
    • Kouzuma, T.1    Usami, T.2    Yamakoshi, M.3    Takahashi, M.4    Imamura, S.5
  • 17
    • 0037955886 scopus 로고    scopus 로고
    • Demonstration of increased concentrations of circulating glycated insulin in human Type 2 diabetes using a novel and specific radioimmunoassay
    • Lindsay JR, McKillop AM, Mooney MH, O'Harte FPM, Bell PM, Flatt PR. Demonstration of increased concentrations of circulating glycated insulin in human type 2 diabetes using a novel and specific radioimmunoassay. Diabetologia 2003;46:475-478 (Pubitemid 36577789)
    • (2003) Diabetologia , vol.46 , Issue.4 , pp. 475-478
    • Lindsay, J.R.1    McKillop, A.M.2    Mooney, M.H.3    O'Harte, F.P.M.4    Bell, P.M.5    Flatt, P.R.6
  • 18
    • 84863336954 scopus 로고    scopus 로고
    • Glycosylated amylins
    • International patent WO/1997/035600. 2 October
    • Rittenhouse J, Koda J, Fineman M, Percy A. Glycosylated amylins. International patent WO/1997/035600. 2 October 1997
    • (1997)
    • Rittenhouse, J.1    Koda, J.2    Fineman, M.3    Percy, A.4
  • 19
    • 84863321749 scopus 로고    scopus 로고
    • Monoclonal antibodies against glycated low density lipoprotein
    • US patent 5,494,791. 27 February
    • Cohen MP. Monoclonal antibodies against glycated low density lipoprotein. US patent 5,494,791. 27 February 1996
    • (1996)
    • Cohen, M.P.1
  • 21
    • 0034131346 scopus 로고    scopus 로고
    • Vitamin C and hyperglycemia in the European Prospective Investigation Into Cancer - Norfolk (EPIC-Norfolk) study
    • Sargeant LA, Wareham NJ, Bingham S, et al. Vitamin C and hyperglycemia in the European Prospective Investigation into Cancer - Norfolk (EPIC-Norfolk) study: a population-based study. Diabetes Care 2000;23:726-732 (Pubitemid 30414183)
    • (2000) Diabetes Care , vol.23 , Issue.6 , pp. 726-732
    • Sargeant, L.A.1    Wareham, N.J.2    Bingham, S.3    Day, N.E.4    Luben, R.N.5    Oakes, S.6    Welch, A.7    Khaw, K.-T.8
  • 22
    • 75149152979 scopus 로고    scopus 로고
    • Associations of serum concentrations of 25-hydroxyvitamin D and parathyroid hormone with surrogate markers of insulin resistance among U.S. adults without physician-diagnosed diabetes: NHANES, 2003-2006
    • Zhao G, Ford ES, Li C. Associations of serum concentrations of 25-hydroxyvitamin D and parathyroid hormone with surrogate markers of insulin resistance among U.S. adults without physician-diagnosed diabetes: NHANES, 2003-2006.DiabetesCare 2010;33:344-347
    • (2010) DiabetesCare , vol.33 , pp. 344-347
    • Zhao, G.1    Ford, E.S.2    Li, C.3
  • 23
    • 79953737332 scopus 로고    scopus 로고
    • Metabolite profiles and the risk of developing diabetes
    • Wang TJ, Larson MG, Vasan RS, et al. Metabolite profiles and the risk of developing diabetes. Nat Med 2011;17:448-453
    • (2011) Nat Med , vol.17 , pp. 448-453
    • Wang, T.J.1    Larson, M.G.2    Vasan, R.S.3
  • 24
    • 58149118771 scopus 로고    scopus 로고
    • Endogenous secretory RAGE as a novel biomarker for metabolic syndrome and cardiovascular diseases
    • Koyama H, Yamamoto H, Nishizawa Y. Endogenous secretory RAGE as a novel biomarker for metabolic syndrome and cardiovascular diseases. Biomark Insights 2007;2:331-339
    • (2007) Biomark Insights , vol.2 , pp. 331-339
    • Koyama, H.1    Yamamoto, H.2    Nishizawa, Y.3
  • 25
    • 77955904983 scopus 로고    scopus 로고
    • Associations between leptin and the leptin/adiponectin ratio and incident type 2 diabetes in middle-agedmen and women: Results from the MONICA/KORA Augsburg study 1984-2002
    • Thorand B, Zierer A, Baumert J, Meisinger C, Herder C, Koenig W. Associations between leptin and the leptin/adiponectin ratio and incident type 2 diabetes in middle-aged men and women: results from the MONICA/KORA Augsburg study 1984-2002. Diabet Med 2010;27:1004-1011
    • (2010) Diabet Med , vol.27 , pp. 1004-1011
    • Thorand, B.1    Zierer, A.2    Baumert, J.3    Meisinger, C.4    Herder, C.5    Koenig, W.6
  • 26
    • 0036312978 scopus 로고    scopus 로고
    • C-reactive protein is an independent predictor of risk for the development of diabetes in the west of Scotland coronary prevention study
    • Freeman DJ,Norrie J,Caslake MJ, et al.;West of Scotland Coronary Prevention Study. C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study. Diabetes 2002;51:1596-1600 (Pubitemid 34826630)
    • (2002) Diabetes , vol.51 , Issue.5 , pp. 1596-1600
    • Freeman, D.J.1    Norrie, J.2    Caslake, M.J.3    Gaw, A.4    Ford, I.5    Lowe, G.D.O.6    O'Reilly, D.S.J.7    Packard, C.J.8    Sattar, N.9
  • 27
    • 25844489169 scopus 로고    scopus 로고
    • Elevated levels of interleukin-18 predict the development of type 2 diabetes: Results from the MONICA/KORA Augsburg study, 1984-2002
    • DOI 10.2337/diabetes.54.10.2932
    • Thorand B, Kolb H, Baumert J, et al. Elevated levels of interleukin-18 predict the development of type 2 diabetes: results from the MONICA/KORA Augsburg Study, 1984-2002. Diabetes 2005;54:2932-2938 (Pubitemid 41401089)
    • (2005) Diabetes , vol.54 , Issue.10 , pp. 2932-2938
    • Thorand, B.1    Kolb, H.2    Baumert, J.3    Koenig, W.4    Chambless, L.5    Meisinger, C.6    Illig, T.7    Martin, S.8    Herder, C.9
  • 28
    • 64749095071 scopus 로고    scopus 로고
    • Elevated levels of the anti-inflammatory interleukin-1 receptor antagonist precede the onset of type 2 diabetes: TheWhitehall II study
    • Herder C, Brunner EJ, RathmannW, et al. Elevated levels of the anti-inflammatory interleukin-1 receptor antagonist precede the onset of type 2 diabetes: theWhitehall II study. Diabetes Care 2009;32:421-423
    • (2009) Diabetes Care , vol.32 , pp. 421-423
    • Herder, C.1    Brunner, E.J.2    Rathmann, W.3
  • 29
    • 0036230414 scopus 로고    scopus 로고
    • Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes: The insulin resistance atherosclerosis study
    • Festa A, D'Agostino R Jr, Tracy RP, Haffner SM; Insulin Resistance Atherosclerosis Study. Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes: the insulin resistance atherosclerosis study. Diabetes 2002;51:1131-1137 (Pubitemid 34438360)
    • (2002) Diabetes , vol.51 , Issue.4 , pp. 1131-1137
    • Festa, A.1    D'Agostino Jr., R.2    Tracy, R.P.3    Haffner, S.M.4
  • 31
    • 48649098600 scopus 로고    scopus 로고
    • Tissue plasminogen activator, von Willebrand factor, and risk of type 2 diabetes in older men
    • Wannamethee SG, Sattar N, Rumley A, Whincup PH, Lennon L, Lowe GD. Tissue plasminogen activator, von Willebrand factor, and risk of type 2 diabetes in older men. Diabetes Care 2008;31:995-1000
    • (2008) Diabetes Care , vol.31 , pp. 995-1000
    • Wannamethee, S.G.1    Sattar, N.2    Rumley, A.3    Whincup, P.H.4    Lennon, L.5    Lowe, G.D.6
  • 32
    • 77954143522 scopus 로고    scopus 로고
    • Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
    • MAGIC investigators; GIANT Consortium
    • Voight BF, Scott LJ, Steinthorsdottir V, et al.; MAGIC investigators; GIANT Consortium. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 2010;42:579-589
    • (2010) Nat Genet , vol.42 , pp. 579-589
    • Voight, B.F.1    Scott, L.J.2    Steinthorsdottir, V.3
  • 33
    • 32544451924 scopus 로고    scopus 로고
    • Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
    • Grant SF, Thorleifsson G, Reynisdottir I, et al. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 2006;38:320-323
    • (2006) Nat Genet , vol.38 , pp. 320-323
    • Grant, S.F.1    Thorleifsson, G.2    Reynisdottir, I.3
  • 37
    • 42349106044 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    • DOI 10.1038/ng.120, PII NG120
    • Zeggini E, Scott LJ, Saxena R, et al.; Wellcome Trust Case Control Consortium. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 2008;40:638-645 (Pubitemid 351601209)
    • (2008) Nature Genetics , vol.40 , Issue.5 , pp. 638-645
    • Zeggini, E.1    Scott, L.J.2    Saxena, R.3    Voight, B.F.4
  • 38
    • 75749091912 scopus 로고    scopus 로고
    • Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
    • GIANT consortium; MAGIC investigators
    • Saxena R, Hivert MF, Langenberg C, et al; GIANT consortium; MAGIC investigators. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet 2010;42:142-148
    • (2010) Nat Genet , vol.42 , pp. 142-148
    • Saxena, R.1    Hivert, M.F.2    Langenberg, C.3
  • 41
    • 70349557826 scopus 로고    scopus 로고
    • Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia
    • Rung J, Cauchi S, Albrechtsen A, et al. Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nat Genet 2009;41:1110-1115
    • (2009) Nat Genet , vol.41 , pp. 1110-1115
    • Rung, J.1    Cauchi, S.2    Albrechtsen, A.3
  • 42
    • 78649461131 scopus 로고    scopus 로고
    • Common variants at 10 genomic loci influence hemoglobin A1c levels via glycemic and nonglycemic pathways
    • WTCCC.
    • Soranzo N, Sanna S, Wheeler E, et al.; WTCCC. Common variants at 10 genomic loci influence hemoglobin A1c levels via glycemic and nonglycemic pathways. Diabetes 2010;59:3229-3239
    • (2010) Diabetes , vol.59 , pp. 3229-3239
    • Soranzo, N.1    Sanna, S.2    Wheeler, E.3
  • 43
    • 73949102958 scopus 로고    scopus 로고
    • Lack of significant effects of the type 2 diabetes susceptibility loci JAZF1, CDC123/CAMK1D,NOTCH2, ADAMTS9, THADA, and TSPAN8/LGR5 on diabetes and quantitative metabolic traits
    • Schleinitz D, Tönjes A, Böttcher Y, et al. Lack of significant effects of the type 2 diabetes susceptibility loci JAZF1, CDC123/CAMK1D,NOTCH2, ADAMTS9, THADA, and TSPAN8/LGR5 on diabetes and quantitative metabolic traits. Horm Metab Res 2010;42:14-22
    • (2010) Horm Metab Res , vol.42 , pp. 14-22
    • Schleinitz, D.1    Tönjes, A.2    Böttcher, Y.3
  • 44
    • 77951819019 scopus 로고    scopus 로고
    • Large-scale association analysis of TNF/LTA gene region polymorphisms in type 2 diabetes
    • Boraska V, Rayner NW, Groves CJ, et al. Large-scale association analysis of TNF/LTA gene region polymorphisms in type 2 diabetes. BMC Med Genet 2010;11:69
    • (2010) BMC Med Genet , vol.11 , pp. 69
    • Boraska, V.1    Rayner, N.W.2    Groves, C.J.3
  • 45
    • 79960565557 scopus 로고    scopus 로고
    • Genetic polymorphisms of innate immunity-related inflammatory pathways and their association with factors related to type 2 diabetes
    • Arora P, Garcia-Bailo B, Dastani Z, et al. Genetic polymorphisms of innate immunity-related inflammatory pathways and their association with factors related to type 2 diabetes. BMC Med Genet 2011;12:95
    • (2011) BMC Med Genet , vol.12 , pp. 95
    • Arora, P.1    Garcia-Bailo, B.2    Dastani, Z.3
  • 48
    • 42449144715 scopus 로고    scopus 로고
    • HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: Analysis of the type 1 diabetes genetics consortium families
    • Type 1 Diabetes Genetics Consortium.
    • Erlich H, Valdes AM, Noble J, et al.; Type 1 Diabetes Genetics Consortium. HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes 2008;57:1084-1092
    • (2008) Diabetes , vol.57 , pp. 1084-1092
    • Erlich, H.1    Valdes, A.M.2    Noble, J.3
  • 49
    • 77955389016 scopus 로고    scopus 로고
    • Type 1 Diabetes Genetics Consortium. HLA DPA1, DPB1 alleles and haplotypes contribute to the risk associated with type 1 diabetes: Analysis of the type 1 diabetes genetics consortium families
    • Varney MD, Valdes AM, Carlson JA, et al.; Type 1 Diabetes Genetics Consortium. HLA DPA1, DPB1 alleles and haplotypes contribute to the risk associated with type 1 diabetes: analysis of the type 1 diabetes genetics consortium families. Diabetes 2010;59:2055-2062
    • (2010) Diabetes , vol.59 , pp. 2055-2062
    • Varney, M.D.1    Valdes, A.M.2    Carlson, J.A.3
  • 50
    • 0028989040 scopus 로고
    • HLA-DQB1*0602 is associated with dominant protection from diabetes even among islet cell antibody-positive first-degree relatives of patientswith IDDM
    • Pugliese A, Gianani R, Moromisato R, et al. HLA-DQB1*0602 is associated with dominant protection from diabetes even among islet cell antibody-positive first-degree relatives of patientswith IDDM. Diabetes 1995;44:608-613
    • (1995) Diabetes , vol.44 , pp. 608-613
    • Pugliese, A.1    Gianani, R.2    Moromisato, R.3
  • 51
    • 79952384694 scopus 로고    scopus 로고
    • Stepwise or linear decrease in penetrance of type 1 diabetes with lower-risk HLA genotypes over the past 40 years
    • Type 1 Diabetes Genetics Consortium.
    • Steck AK, Armstrong TK, Babu SR, Eisenbarth GS; Type 1 Diabetes Genetics Consortium. Stepwise or linear decrease in penetrance of type 1 diabetes with lower-risk HLA genotypes over the past 40 years. Diabetes 2011;60:1045-1049
    • (2011) Diabetes , vol.60 , pp. 1045-1049
    • Steck, A.K.1    Armstrong, T.K.2    Babu, S.R.3    Eisenbarth, G.S.4
  • 52
    • 43649103659 scopus 로고    scopus 로고
    • Type 1 diabetes risk for human leukocyte antigen (HLA)-DR3 haplotypes depends on genotypic context: Association of DPB1 and HLA class I loci among DR3- And DR4-matched Italian patients and controls
    • Noble JA, Martin A, Valdes AM, et al. Type 1 diabetes risk for human leukocyte antigen (HLA)-DR3 haplotypes depends on genotypic context: association of DPB1 and HLA class I loci among DR3- and DR4-matched Italian patients and controls. Hum Immunol 2008;69:291-300
    • (2008) Hum Immunol , vol.69 , pp. 291-300
    • Noble, J.A.1    Martin, A.2    Valdes, A.M.3
  • 53
    • 15444367789 scopus 로고    scopus 로고
    • Human leukocyte antigen class I B and C loci contribute to Type 1 Diabetes (T1D) susceptibility and age at T1D onset
    • DOI 10.1016/j.humimm.2004.12.001
    • Valdes AM, Erlich HA, Noble JA. Human leukocyte antigen class I B and C loci contribute to Type 1 Diabetes (T1D) susceptibility and age at T1D onset. Hum Immunol 2005;66:301-313 (Pubitemid 40395251)
    • (2005) Human Immunology , vol.66 , Issue.3 , pp. 301-313
    • Valdes, A.M.1    Erlich, H.A.2    Noble, J.A.3
  • 54
    • 79551469699 scopus 로고    scopus 로고
    • Genetics of type 1 diabetes
    • Steck AK, Rewers MJ. Genetics of type 1 diabetes. Clin Chem 2011;57:176-185
    • (2011) Clin Chem , vol.57 , pp. 176-185
    • Steck, A.K.1    Rewers, M.J.2
  • 55
    • 0021343570 scopus 로고
    • A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus
    • Bell GI, Horita S, Karam JH. A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus. Diabetes 1984;33:176-183 (Pubitemid 14184705)
    • (1984) Diabetes , vol.33 , Issue.2 , pp. 176-183
    • Bell, G.I.1    Horita, S.2    Karam, J.H.3
  • 56
    • 64649096894 scopus 로고    scopus 로고
    • Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium
    • Type 1 Diabetes Genetics Consortium
    • Concannon P, Chen WM, Julier C, et al.; Type 1 Diabetes Genetics Consortium. Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium. Diabetes 2009;58:1018-1022
    • (2009) Diabetes , vol.58 , pp. 1018-1022
    • Concannon, P.1    Chen, W.M.2    Julier, C.3
  • 58
    • 67349199566 scopus 로고    scopus 로고
    • Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
    • Barrett JC, Clayton DG, Concannon P, et al. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet 2009;41:703-707
    • (2009) Nat Genet , vol.41 , pp. 703-707
    • Barrett, J.C.1    Clayton, D.G.2    Concannon, P.3
  • 59
    • 58149090841 scopus 로고    scopus 로고
    • A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3
    • Type 1 Diabetes Genetics Consortium
    • Concannon P, Onengut-Gumuscu S, Todd JA, et al.; Type 1 Diabetes Genetics Consortium. A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3. Diabetes 2008;57:2858-2861
    • (2008) Diabetes , vol.57 , pp. 2858-2861
    • Concannon, P.1    Onengut-Gumuscu, S.2    Todd, J.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.