Natural flavone jaceosidin is a neuroinflammation inhibitor

Phytotherapy Research

Volumn 27, Issue 3, 2013, Pages 404-411

  Nam, Youngpyo ^a   Choi, Mijung ^a   Hwang, Heehong ^a   Lee, Maan Gee ^a   Kwon, Byoung Mog ^b   Lee, Won Ha ^c   Suk, Kyoungho ^a  

^a Kyungpook National University School of Medicine   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c Kyungpook National University   (South Korea)

Author keywords

flavone; jaceosidin; microglia; neuroinflammation; nitric oxide

Indexed keywords

ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; FLAVONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; JACEOSIDIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; STAT PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ENZYME PHOSPHORYLATION; FEMALE; GENE EXPRESSION; IC 50; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; INTRACELLULAR SIGNALING; MICROGLIA; MOUSE; NERVE CELL INHIBITION; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PROTEIN EXPRESSION; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTEMISIA; CELL LINE; COCULTURE TECHNIQUES; CYTOKINES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; FLAVONOIDS; INFLAMMATION; MICE; MICE, INBRED C57BL; MICROGLIA; NITRIC OXIDE; RATS;

ARTEMISIA;

EID: 84874936875     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.4737     Document Type: Article

References (47)

1. Basso DM, Beattie MS, Bresnahan JC,. 1996. Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp Neurol 139: 244-256. (Pubitemid 26228093)
2. Block ML, Zecca L, Hong JS,. 2007. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci 8: 57-69. (Pubitemid 46011999)
3. Bocchini V, Mazzolla R, Barluzzi R, Blasi E, Sick P, Kettenmann H,. 1992. An immortalized cell line expresses properties of activated microglial cells. J Neurosci Res 31: 616-621.
4. Cheepsunthorn P, Radov L, Menzies S, Reid J, Connor JR,. 2001. Characterization of a novel brain-derived microglial cell line isolated from neonatal rat brain. Glia 35: 53-62. (Pubitemid 32656753)
5. Chen JC, Ho FM, Pei-Dawn Lee C, et al,. 2005. Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia. Eur J Pharmacol 521: 9-20.
6. Choi DK, Koppula S, Suk K,. 2011. Inhibitors of microglial neurotoxicity: focus on natural products. Molecules 16: 1021-1043.
7. Gao HM, Liu B, Zhang W, Hong JS,. 2003. Novel anti-inflammatory therapy for Parkinson's disease. Trends Pharmacol Sci 24: 395-401. (Pubitemid 36952555)
8. Hanisch UK, Kettenmann H,. 2007. Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci 10: 1387-1394. (Pubitemid 350014685)
9. Hewett JA, Hewett SJ,. 2012. Induction of nitric oxide synthase-2 expression and measurement of nitric oxide production in enriched primary cortical astrocyte cultures. Methods Mol Biol 814: 251-263.
10. Hommes DW, Peppelenbosch MP, van Deventer SJ,. 2003. Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets. Gut 52: 144-151. (Pubitemid 36020783)
11. Hwang J, Zheng LT, Ock J, et al,. 2008. Inhibition of glial inflammatory activation and neurotoxicity by tricyclic antidepressants. Neuropharmacology 55: 826-834.
12. Hwang J, Hwang H, Lee HW, Suk K,. 2010. Microglia signaling as a target of donepezil. Neuropharmacology 58: 1122-1129.
13. Hwang H, Jeon H, Ock J, et al,. 2011. 2'-Hydroxycinnamaldehyde targets low-density lipoprotein receptor-related protein-1 to inhibit lipopolysaccharide-induced microglial activation. J Neuroimmunol 230: 52-64.
14. Jager AK, Saaby L,. 2011. Flavonoids and the CNS. Molecules 16: 1471-1485.
15. Ji HY, Kim SY, Kim DK, Jeong JH, Lee HS,. 2010. Effects of eupatilin and jaceosidin on cytochrome p450 enzyme activities in human liver microsomes. Molecules 15: 6466-6475.
16. Jin GH, Ha SK, Park HM, et al,. 2008. Synthesis of azaisoflavones and their inhibitory activities of NO production in activated microglia. Bioorg Med Chem Lett 18: 4092-4094.
17. Kavvadias D, Sand P, Youdim KA, et al,. 2004. The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects. Br J Pharmacol 142: 811-820. (Pubitemid 38998095)
18. Kettenmann H, Hanisch UK, Noda M, Verkhratsky A,. 2011. Physiology of microglia. Physiol Rev 91: 461-553.
19. Kim MJ, Kim DH, Lee KW, Yoon DY, Surh YJ,. 2007. Jaceosidin induces apoptosis in ras-transformed human breast epithelial cells through generation of reactive oxygen species. Ann N Y Acad Sci 1095: 483-495.
20. Kim MJ, Han JM, Jin YY, et al,. 2008. In vitro antioxidant and anti-inflammatory activities of Jaceosidin from Artemisia princeps Pampanini cv. Sajabal. Arch Pharm Res 31: 429-437.
21. Kim JH, Lee HW, Hwang J, et al,. 2012. Microglia-inhibiting activity of Parkinson's disease drug amantadine. Neurobiol Aging. http://dx.doi.org/10.1016/ j.neurobiolaging.2011.08.011
22. Koistinaho M, Koistinaho J,. 2002. Role of p38 and p44/42 mitogen-activated protein kinases in microglia. Glia 40: 175-183. (Pubitemid 35337375)
23. Kreutzberg GW,. 1996. Microglia: a sensor for pathological events in the CNS. Trends Neurosci 19: 312-318. (Pubitemid 26349059)
24. Lee H, Kim YO, Kim H, et al,. 2003. Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia. FASEB J 17: 1943-1944.
25. Lee SH, Bae EA, Park EK, et al,. 2007. Inhibitory effect of eupatilin and jaceosidin isolated from Artemisia princeps in IgE-induced hypersensitivity. Int Immunopharmacol 7: 1678-1684. (Pubitemid 350054929)
26. Lee S, Park JY, Lee WH, et al,. 2009. Lipocalin-2 is an autocrine mediator of reactive astrocytosis. J Neurosci 29: 234-249.
27. Lee YJ, Choi DY, Choi IS, et al,. 2011. Inhibitory effect of a tyrosine-fructose Maillard reaction product, 2,4-bis(p-hydroxyphenyl)-2-butenal on amyloid-beta generation and inflammatory reactions via inhibition of NF-kappaB and STAT3 activation in cultured astrocytes and microglial BV-2 cells. J Neuroinflammation 8: 132.
28. Li R, Huang YG, Fang D, Le WD,. 2004. (-)-Epigallocatechin gallate inhibits lipopolysaccharide-induced microglial activation and protects against inflammation-mediated dopaminergic neuronal injury. J Neurosci Res 78: 723-731. (Pubitemid 39657589)
29. Lv W, Sheng X, Chen T, Xu Q, Xie X,. 2008. Jaceosidin induces apoptosis in human ovary cancer cells through mitochondrial pathway. J Biomed Biotechnol 2008: 394802.
30. Manner CK, Nicholson B, MacLeod CL,. 2003. CAT2 arginine transporter deficiency significantly reduces iNOS-mediated NO production in astrocytes. J Neurochem 85: 476-482. (Pubitemid 36438343)
31. McCarthy KD, de Vellis J,. 1980. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J Cell Biol 85: 890-902. (Pubitemid 10007455)
32. McGeer EG, McGeer PL,. 2007. The role of anti-inflammatory agents in Parkinson's disease. CNS Drugs 21: 789-797. (Pubitemid 47443301)
33. Min SW, Kim NJ, Baek NI, Kim DH,. 2009. Inhibitory effect of eupatilin and jaceosidin isolated from Artemisia princeps on carrageenan-induced inflammation in mice. J Ethnopharmacol 125: 497-500.
34. Moscatelli V, Hnatyszyn O, Acevedo C, Megias J, Alcaraz MJ, Ferraro G,. 2006. Flavonoids from Artemisia copa with anti-inflammatory activity. Planta Med 72: 72-74. (Pubitemid 43241597)
35. Nakasugi T, Nakashima M, Komai K,. 2000. Antimutagens in gaiyou (Artemisia argyi levl. et vant.). J Agric Food Chem 48: 3256-3266.
36. Noh HJ, Sohn MJ, Yu HE, Yoo ID, Kim WG,. 2007. Cyclo(Dehydrohistidyl-L- tryptophyl), an inhibitor of nitric oxide production from a fungal strain, Fb956. J Microbiol Biotechnol 17: 1717-1720.
37. Ock J, Han HS, Hong SH, et al,. 2010a. Obovatol attenuates microglia-mediated neuroinflammation by modulating redox regulation. Br J Pharmacol 159: 1646-1662.
38. Ock J, Kim S, Yi KY, et al,. 2010b. A novel anti-neuroinflammatory pyridylimidazole compound KR-31360. Biochem Pharmacol 79: 596-609.
39. Pahan K, Liu X, McKinney MJ, Wood C, Sheikh FG, Raymond JR,. 2000. Expression of a dominant-negative mutant of p21(ras) inhibits induction of nitric oxide synthase and activation of nuclear factor-kappaB in primary astrocytes. J Neurochem 74: 2288-2295. (Pubitemid 30314203)
40. Saura J, Tusell JM, Serratosa J,. 2003. High-yield isolation of murine microglia by mild trypsinization. Glia 44: 183-189. (Pubitemid 37484470)
41. Schubert D, Heinemann S, Carlisle W, et al,. 1974. Clonal cell lines from the rat central nervous system. Nature 249: 224-227.
42. Suk K,. 2005. Regulation of neuroinflammation by herbal medicine and its implications for neurodegenerative diseases. A focus on traditional medicines and flavonoids. Neurosignals 14: 23-33. (Pubitemid 40868981)
43. Suk K, Ock J,. 2012. Chemical genetics of neuroinflammation: natural and synthetic compounds as microglial inhibitors. Inflammopharmacology 20: 151-158.
44. Wang YH, Shen YC, Liao JF, et al,. 2008. Anti-inflammatory effects of dimemorfan on inflammatory cells and LPS-induced endotoxin shock in mice. Br J Pharmacol 154: 1327-1338.
45. Weng JR, Tsao LT, Yen MH, Wang JP, Lin CN,. 2003. Anti-inflammatory constituents and new pterocarpanoid of Crotalaria pallida. J Nat Prod 66: 404-407.
46. Yin Y, Sun Y, Gu L, et al,. 2011. Jaceosidin inhibits contact hypersensitivity in mice via down-regulating IFN-gamma/STAT1/T-bet signaling in T cells. Eur J Pharmacol 651: 205-211.
47. Youdim KA, Qaiser MZ, Begley DJ, Rice-Evans CA, Abbott NJ,. 2004. Flavonoid permeability across an in situ model of the blood-brain barrier. Free Radic Biol Med 36: 592-604. (Pubitemid 38230176)