Expression of a dominant-negative mutant of p21(ras) inhibits induction of nitric oxide synthase and activation of nuclear factor-κB in primary astrocytes

Journal of Neurochemistry

Volumn 74, Issue 6, 2000, Pages 2288-2295

  Pahan, Kalipada ^a   Liu, Xiaojuan ^a   McKinney, Michael J ^c   Wood, Charles ^b   Sheikh, Faruk G ^d   Raymond, John R ^e  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^c MAYO CLINIC   (United States)

^d WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^e MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Astrocytes; Cytokines; Inducible nitric oxide synthase; Lipopolysaccharides; Nuclear factor B; P21(ras)

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CHLORAMPHENICOL ACETYLTRANSFERASE; CYTOKINE; GAMMA INTERFERON; GUANOSINE TRIPHOSPHATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MUTANT PROTEIN; NITRIC OXIDE SYNTHASE; PROTEIN P21; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; ASTROCYTE; CONTROLLED STUDY; DNA BINDING; ENZYME ACTIVITY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ASTROCYTES; CELLS, CULTURED; CEREBRAL CORTEX; FETUS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, DOMINANT; HUMANS; INTERFERON TYPE II; INTERLEUKIN-1; LIPOPOLYSACCHARIDES; NEURITIS; NF-KAPPA B; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS P21(RAS); RATS; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 0034025512     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0742288.x     Document Type: Article

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