Inhibitory effect of a tyrosine-fructose Maillard reaction product, 2,4-bis(p-hydroxyphenyl)-2-butenal on amyloid-β generation and inflammatory reactions via inhibition of NF-κB and STAT3 activation in cultured astrocytes and microglial BV-2 cells

Journal of Neuroinflammation

Volumn 8, Issue , 2011, Pages

  Lee, Young Jung ^a   Choi, Dong Young ^a   Choi, Im Seup ^a   Han, Jin Yi ^a   Jeong, Heon Sang ^a   Han, Sang Bae ^a   Oh, Ki Wan ^a   Hong, Jin Tae ^a  

^a Chungbuk National University   (South Korea)

Author keywords

2,4 bis(p hydroxyphenyl) 2 butenal; Amyloidogenesis; Neuroinflammation; Nf b; Stat3

Indexed keywords

2,4 BIS(PARA HYDROXYPHENYL) 2 BUTENAL; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; BETA SECRETASE; CROTONALDEHYDE; CYCLOOXYGENASE 2; GAMMA SECRETASE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PROTEIN P50; REACTIVE OXYGEN METABOLITE; SECRETASE; SMALL INTERFERING RNA; STAT3 PROTEIN; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 2-BUTENAL; ALDEHYDE; FRUCTOSE; NOS2 PROTEIN, MOUSE; PTGS2 PROTEIN, MOUSE; TYROSINE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ANTIAMYLOIDOGENIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTE; BINDING AFFINITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME REPRESSION; GEL MOBILITY SHIFT ASSAY; GENE CONTROL; GENETIC TRANSCRIPTION; GLYCATION; INFLAMMATION; MICROGLIA; NERVE CELL CULTURE; NEUROINFLAMMATION; NONHUMAN; PROTEIN DEGRADATION; PROTEIN TRANSPORT; RAT; ANIMAL; CELL LINE; CHEMISTRY; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HUMAN; METABOLISM; MOUSE;

ALDEHYDES; AMYLOID BETA-PEPTIDES; ANIMALS; ASTROCYTES; CELL LINE; CYCLOOXYGENASE 2; FRUCTOSE; HUMANS; INFLAMMATION; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MAILLARD REACTION; MICE; MICROGLIA; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; REACTIVE OXYGEN SPECIES; STAT3 TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR-ALPHA; TYROSINE;

EID: 80053602196     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-8-132     Document Type: Article

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