The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects

British Journal of Pharmacology

Volumn 142, Issue 5, 2004, Pages 811-820

  Kavvadias, Dominique ^a   Sand, Philipp ^a,e   Youdim, Kuresh A ^b   Qaiser, M Zeeshan ^b   Rice Evans, Catherine ^b   Baur, Roland ^c   Sigel, Erwin ^c   Rausch, Wolf Dieter ^d   Riederer, Peter ^a   Schreier, Peter ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF BERN   (Switzerland)

^d UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^e UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Blood brain barrier; Caco 2; Epilepsy; GABA A receptor; Hispidulin; Partial positive allosteric modulator

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BENZODIAZEPINE RECEPTOR STIMULATING AGENT; CARBON 14; DIAZEPAM; DRUG METABOLITE; HISPIDULIN; RECEPTOR SUBTYPE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CELL STRAIN CACO 2; CHLORIDE CURRENT; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; DRUG PENETRATION; DRUG SYNTHESIS; DRUG UPTAKE; EPILEPSY; EXPERIMENTAL ANIMAL; EXPERIMENTAL MODEL; EXPERIMENTAL RAT; GERBIL; HUMAN; HUMAN CELL; ISOTOPE LABELING; MALE; MEASUREMENT; MONOLAYER CULTURE; NONHUMAN; OOCYTE; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEIZURE; XENOPUS LAEVIS;

ANIMALS; ANTICONVULSANTS; APIGENIN; BLOOD-BRAIN BARRIER; BRAIN; CACO-2 CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTROPHYSIOLOGY; FLAVONES; GABA MODULATORS; GERBILLINAE; HUMANS; INDICATORS AND REAGENTS; ISOTOPE LABELING; KINETICS; LIGANDS; MALE; OOCYTES; PERFUSION; RATS; RECEPTORS, GABA-A; SEIZURES; XENOPUS LAEVIS;

EID: 3242875643     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705828     Document Type: Article

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