G-protein coupled receptor resensitization - appreciating the balancing act of receptor function

Current Molecular Pharmacology

Volumn 5, Issue 3, 2012, Pages 350-361

  Mohan, Maradumane L ^a   Vasudevan, Neelakantan T ^a   Gupta, Manveen K ^a   Martelli, Elizabeth E ^a   Prasad, Sathyamangla V Naga ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

adrenergic receptors; arrestin; Desensitization; G protein coupled receptor kinases; G protein coupled receptors; Inhibitor of protein phosphatase 2A (I2PP2A); Internalization; Phosphoinositide 3 kinase; Protein phosphatase 2A; Recycling

Indexed keywords

BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ARRESTIN; CHOLECYSTOKININ RECEPTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE 2; G PROTEIN COUPLED RECEPTOR KINASE 3; G PROTEIN COUPLED RECEPTOR KINASE 5; G PROTEIN COUPLED RECEPTOR KINASE 6; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; UBIQUITIN PROTEIN LIGASE E3;

ACIDIFICATION; ADENOSINE DIPHOSPHATE RIBOSYLATION; ASTHMA; COLORECTAL CANCER; DEPHOSPHORYLATION; ENDOCYTOSIS; ENZYME ACTIVITY; ENZYME SPECIFICITY; HEART FAILURE; HEART VENTRICLE HYPERTROPHY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; NONHUMAN; OLIGOMERIZATION; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DEPHOSPHORYLATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; REVIEW; SIGNAL TRANSDUCTION; UBIQUITINATION;

EID: 84874869611     PISSN: 18744672     EISSN: 18744702     Source Type: Journal    
DOI: 10.2174/1874467211205030004     Document Type: Review

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