-
1
-
-
63749125392
-
VEGFs and receptors involved in angiogenesis versus lymphangiogenesis
-
Lohela M, Bry M, Tammela T, Alitalo K (2009) VEGFs and receptors involved in angiogenesis versus lymphangiogenesis. Curr Opin Cell Biol, 21:154-165.
-
(2009)
Curr Opin Cell Biol
, vol.21
, pp. 154-165
-
-
Lohela, M.1
Bry, M.2
Tammela, T.3
Alitalo, K.4
-
2
-
-
33344474964
-
Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis
-
Shibuya M, Claesson-Welsh L (2006) Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis. Exp Cell Res, 312:549-560.
-
(2006)
Exp Cell Res
, vol.312
, pp. 549-560
-
-
Shibuya, M.1
Claesson-Welsh, L.2
-
3
-
-
0242624291
-
Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3
-
Mäkinen T, et al. (2001) Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3. EMBO J, 20:4762-4773.
-
(2001)
EMBO J
, vol.20
, pp. 4762-4773
-
-
Mäkinen, T.1
-
4
-
-
9144236286
-
Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
-
Kärkkäinen MJ, et al. (2004) Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nat Immunol, 5:74-80.
-
(2004)
Nat Immunol
, vol.5
, pp. 74-80
-
-
Kärkkäinen, M.J.1
-
5
-
-
42349095246
-
VEGF-C induced angiogenesis preferentially occurs at a distance from lymphangiogenesis
-
Benest AV, Harper SJ, Ylä-Herttuala SY, Alitalo K, Bates DO (2008) VEGF-C induced angiogenesis preferentially occurs at a distance from lymphangiogenesis. Cardiovasc Res, 78:315-323.
-
(2008)
Cardiovasc Res
, vol.78
, pp. 315-323
-
-
Benest, A.V.1
Harper, S.J.2
Ylä-Herttuala, S.Y.3
Alitalo, K.4
Bates, D.O.5
-
6
-
-
57149104377
-
Transgenic induction of vascular endothelial growth factor-C is strongly angiogenic in mouse embryos but leads to persistent lymphatic hyperplasia in adult tissues
-
Lohela M, Heloterä H, Haiko P, Dumont DJ, Alitalo K (2008) Transgenic induction of vascular endothelial growth factor-C is strongly angiogenic in mouse embryos but leads to persistent lymphatic hyperplasia in adult tissues. Am J Pathol, 173:1891-1901.
-
(2008)
Am J Pathol
, vol.173
, pp. 1891-1901
-
-
Lohela, M.1
Heloterä, H.2
Haiko, P.3
Dumont, D.J.4
Alitalo, K.5
-
7
-
-
67649871388
-
Activated forms of VEGF-C and VEGF-D provide improved vascular function in skeletal muscle
-
Anisimov A, et al. (2009) Activated forms of VEGF-C and VEGF-D provide improved vascular function in skeletal muscle. Circ Res, 104:1302-1312.
-
(2009)
Circ Res
, vol.104
, pp. 1302-1312
-
-
Anisimov, A.1
-
8
-
-
48349129069
-
Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
-
Tammela T, et al. (2008) Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature, 454:656-660.
-
(2008)
Nature
, vol.454
, pp. 656-660
-
-
Tammela, T.1
-
9
-
-
17044458971
-
Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites
-
Dixelius J, et al. (2003) Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites. J Biol Chem, 278:40973-40979.
-
(2003)
J Biol Chem
, vol.278
, pp. 40973-40979
-
-
Dixelius, J.1
-
10
-
-
33746503288
-
Functional interaction of VEGF-C and VEGF-D with neuropilin receptors
-
Kärpänen T, et al. (2006) Functional interaction of VEGF-C and VEGF-D with neuropilin receptors. FASEB J, 20:1462-1472.
-
(2006)
FASEB J
, vol.20
, pp. 1462-1472
-
-
Kärpänen, T.1
-
11
-
-
33748479489
-
A VEGF-A splice variant defective for heparan sulfate and neuropilin-1 binding shows attenuated signaling through VEGFR-2
-
Cebe-Suarez S, et al. (2006) A VEGF-A splice variant defective for heparan sulfate and neuropilin-1 binding shows attenuated signaling through VEGFR-2. Cell Mol Life Sci, 63:2067-2077.
-
(2006)
Cell Mol Life Sci
, vol.63
, pp. 2067-2077
-
-
Cebe-Suarez, S.1
-
13
-
-
55749110742
-
Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization
-
Kawamura H, et al. (2008) Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization. Blood, 112:3638-3649.
-
(2008)
Blood
, vol.112
, pp. 3638-3649
-
-
Kawamura, H.1
-
14
-
-
48749088401
-
Orf virus VEGF-E NZ2 promotes paracellular NRP-1/VEGFR-2 coreceptor assembly via the peptide RPPR
-
Cebe-Suarez S, et al. (2008) Orf virus VEGF-E NZ2 promotes paracellular NRP-1/VEGFR-2 coreceptor assembly via the peptide RPPR. FASEB J, 22:3078-3086.
-
(2008)
FASEB J
, vol.22
, pp. 3078-3086
-
-
Cebe-Suarez, S.1
-
15
-
-
0035062394
-
The splice variants of vascular endothelial growth factor (VEGF) and their receptors
-
Robinson CJ, Stringer SE (2001) The splice variants of vascular endothelial growth factor (VEGF) and their receptors. J Cell Sci, 114:853-865.
-
(2001)
J Cell Sci
, vol.114
, pp. 853-865
-
-
Robinson, C.J.1
Stringer, S.E.2
-
16
-
-
0035010433
-
Evolution and classification of cystine knot-containing hormones and related extracellular signaling molecules
-
Vitt UA, Hsu SY, Hsueh AJ (2001) Evolution and classification of cystine knot-containing hormones and related extracellular signaling molecules. Mol Endocrinol, 15:681-694.
-
(2001)
Mol Endocrinol
, vol.15
, pp. 681-694
-
-
Vitt, U.A.1
Hsu, S.Y.2
Hsueh, A.J.3
-
17
-
-
0026744790
-
Crystal structure of human platelet-derived growth factor BB
-
Oefner C, D'Arcy A, Winkler FK, Eggimann B, Hosang M (1992) Crystal structure of human platelet-derived growth factor BB. EMBO J, 11:3921-3926.
-
(1992)
EMBO J
, vol.11
, pp. 3921-3926
-
-
Oefner, C.1
D'Arcy, A.2
Winkler, F.K.3
Eggimann, B.4
Hosang, M.5
-
18
-
-
0037931815
-
Platelet-derived growth factor (PDGF)-C, a PDGF family member with a vascular endothelial growth factor-like structure
-
Reigstad LJ, et al. (2003) Platelet-derived growth factor (PDGF)-C, a PDGF family member with a vascular endothelial growth factor-like structure. J Biol Chem, 278:17114-17120.
-
(2003)
J Biol Chem
, vol.278
, pp. 17114-17120
-
-
Reigstad, L.J.1
-
19
-
-
0037044749
-
The cystine knot promotes folding and not thermodynamic stability in vascular endothelial growth factor
-
Muller YA, Heiring C, Misselwitz R, Welfle K, Welfle H (2002) The cystine knot promotes folding and not thermodynamic stability in vascular endothelial growth factor. J Biol Chem, 277:43410-43416.
-
(2002)
J Biol Chem
, vol.277
, pp. 43410-43416
-
-
Muller, Y.A.1
Heiring, C.2
Misselwitz, R.3
Welfle, K.4
Welfle, H.5
-
20
-
-
0030118083
-
A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases
-
Joukov V, et al. (1996) A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. EMBO J, 15:290-298.
-
(1996)
EMBO J
, vol.15
, pp. 290-298
-
-
Joukov, V.1
-
21
-
-
33744951970
-
Vascular endothelial growth factor (VEGF)/VEGF-C mosaic molecules reveal specificity determinants and feature novel receptor binding patterns
-
Jeltsch M, et al. (2006) Vascular endothelial growth factor (VEGF)/VEGF-C mosaic molecules reveal specificity determinants and feature novel receptor binding patterns. J Biol Chem, 281:12187-12195.
-
(2006)
J Biol Chem
, vol.281
, pp. 12187-12195
-
-
Jeltsch, M.1
-
22
-
-
0031011529
-
Proteolytic processing regulates receptor specificity and activity of VEGF-C
-
Joukov V, et al. (1997) Proteolytic processing regulates receptor specificity and activity of VEGF-C. EMBO J, 16:3898-3911.
-
(1997)
EMBO J
, vol.16
, pp. 3898-3911
-
-
Joukov, V.1
-
23
-
-
0027979253
-
Homologs of vascular endothelial growth factor are encoded by the poxvirus orf virus
-
Lyttle DJ, Fraser KM, Fleming SB, Mercer AA, Robinson AJ (1994) Homologs of vascular endothelial growth factor are encoded by the poxvirus orf virus. J Virol, 68:84-92.
-
(1994)
J Virol
, vol.68
, pp. 84-92
-
-
Lyttle, D.J.1
Fraser, K.M.2
Fleming, S.B.3
Mercer, A.A.4
Robinson, A.J.5
-
24
-
-
0141621049
-
Viral vascular endothelial growth factors vary extensively in amino acid sequence, receptor-binding specificities, and the ability to induce vascular permeability yet are uniformly active mitogens
-
Wise LM, et al. (2003) Viral vascular endothelial growth factors vary extensively in amino acid sequence, receptor-binding specificities, and the ability to induce vascular permeability yet are uniformly active mitogens. J Biol Chem, 278:38004-38014.
-
(2003)
J Biol Chem
, vol.278
, pp. 38004-38014
-
-
Wise, L.M.1
-
25
-
-
18644374839
-
Vascular endothelial growth factors encoded by Orf virus show surprising sequence variation but have a conserved, functionally relevant structure
-
Mercer AA, et al. (2002) Vascular endothelial growth factors encoded by Orf virus show surprising sequence variation but have a conserved, functionally relevant structure. J Gen Virol, 83:2845-2855.
-
(2002)
J Gen Virol
, vol.83
, pp. 2845-2855
-
-
Mercer, A.A.1
-
26
-
-
0030795733
-
Vascular endothelial growth factor: Crystal structure and functional mapping of the kinase domain receptor binding site
-
Muller YA, et al. (1997) Vascular endothelial growth factor: Crystal structure and functional mapping of the kinase domain receptor binding site. Proc Natl Acad Sci USA, 94:7192-7197.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 7192-7197
-
-
Muller, Y.A.1
-
27
-
-
0035853679
-
The crystal structure of human placenta growth factor-1 (PlGF-1), an angiogenic protein, at 2.0 A resolution
-
Iyer S, et al. (2001) The crystal structure of human placenta growth factor-1 (PlGF-1), an angiogenic protein, at 2.0 A resolution. J Biol Chem, 276:12153-12161.
-
(2001)
J Biol Chem
, vol.276
, pp. 12153-12161
-
-
Iyer, S.1
-
28
-
-
33646185640
-
Crystal structure of human vascular endothelial growth factor-B: Identification of amino acids important for receptor binding
-
Iyer S, Scotney PD, Nash AD, Ravi Acharya K (2006) Crystal structure of human vascular endothelial growth factor-B: Identification of amino acids important for receptor binding. J Mol Biol, 359:76-85.
-
(2006)
J Mol Biol
, vol.359
, pp. 76-85
-
-
Iyer, S.1
Scotney, P.D.2
Nash, A.D.3
Ravi Acharya, K.4
-
29
-
-
33745860020
-
Crystal structure of the Orf virus NZ2 variant of vascular endothelial growth factor-E. Implications for receptor specificity
-
Pieren M, et al. (2006) Crystal structure of the Orf virus NZ2 variant of vascular endothelial growth factor-E. Implications for receptor specificity. J Biol Chem, 281:19578-19587.
-
(2006)
J Biol Chem
, vol.281
, pp. 19578-19587
-
-
Pieren, M.1
-
30
-
-
0030782410
-
Crystal structure at 1.7 Å resolution of VEGF in complex with domain 2 of the Flt-1 receptor
-
Wiesmann C, et al. (1997) Crystal structure at 1.7 Å resolution of VEGF in complex with domain 2 of the Flt-1 receptor. Cell, 91:695-704.
-
(1997)
Cell
, vol.91
, pp. 695-704
-
-
Wiesmann, C.1
-
31
-
-
1642297115
-
The crystal structure of placental growth factor in complex with domain 2 of vascular endothelial growth factor receptor-1
-
Christinger HW, Fuh G, de Vos AM, Wiesmann C (2004) The crystal structure of placental growth factor in complex with domain 2 of vascular endothelial growth factor receptor-1. J Biol Chem, 279:10382-10388.
-
(2004)
J Biol Chem
, vol.279
, pp. 10382-10388
-
-
Christinger, H.W.1
Fuh, G.2
de Vos, A.M.3
Wiesmann, C.4
-
32
-
-
0032488966
-
Mapping the charged residues in the second immunoglobulin-like domain of the vascular endothelial growth factor/placenta growth factor receptor Flt-1 required for binding and structural stability
-
Davis-Smyth T, Presta LG, Ferrara N (1998) Mapping the charged residues in the second immunoglobulin-like domain of the vascular endothelial growth factor/placenta growth factor receptor Flt-1 required for binding and structural stability. J Biol Chem, 273:3216-3222.
-
(1998)
J Biol Chem
, vol.273
, pp. 3216-3222
-
-
Davis-Smyth, T.1
Presta, L.G.2
Ferrara, N.3
-
33
-
-
0032080310
-
Requirements for binding and signaling of the kinase domain receptor for vascular endothelial growth factor
-
Fuh G, Li B, Crowley C, Cunningham B, Wells JA (1998) Requirements for binding and signaling of the kinase domain receptor for vascular endothelial growth factor. J Biol Chem, 273:11197-11204.
-
(1998)
J Biol Chem
, vol.273
, pp. 11197-11204
-
-
Fuh, G.1
Li, B.2
Crowley, C.3
Cunningham, B.4
Wells, J.A.5
-
34
-
-
33847630758
-
Structure of a VEGF-VEGF receptor complex determined by electron microscopy
-
Ruch C, Skiniotis G, Steinmetz MO, Walz T, Ballmer-Hofer K (2007) Structure of a VEGF-VEGF receptor complex determined by electron microscopy. Nat Struct Mol Biol, 14:249-250.
-
(2007)
Nat Struct Mol Biol
, vol.14
, pp. 249-250
-
-
Ruch, C.1
Skiniotis, G.2
Steinmetz, M.O.3
Walz, T.4
Ballmer-Hofer, K.5
-
35
-
-
0028361540
-
Many of the immunoglobulin superfamily domains in cell adhesion molecules and surface receptors belong to a new structural set which is close to that containing variable domains
-
Harpaz Y, Chothia C (1994) Many of the immunoglobulin superfamily domains in cell adhesion molecules and surface receptors belong to a new structural set which is close to that containing variable domains. J Mol Biol, 238:528-539.
-
(1994)
J Mol Biol
, vol.238
, pp. 528-539
-
-
Harpaz, Y.1
Chothia, C.2
-
36
-
-
34447531743
-
Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor
-
Yuzawa S, et al. (2007) Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor. Cell, 130:323-334.
-
(2007)
Cell
, vol.130
, pp. 323-334
-
-
Yuzawa, S.1
-
37
-
-
57449106861
-
Structure of macrophage colony stimulating factor bound to FMS: Diverse signaling assemblies of class III receptor tyrosine kinases
-
Chen X, Liu H, Focia PJ, Shim AH, He X (2008) Structure of macrophage colony stimulating factor bound to FMS: Diverse signaling assemblies of class III receptor tyrosine kinases. Proc Natl Acad Sci USA, 105:18267-18272.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 18267-18272
-
-
Chen, X.1
Liu, H.2
Focia, P.J.3
Shim, A.H.4
He, X.5
-
38
-
-
0032549572
-
A recombinant mutant vascular endothelial growth factor-C that has lost vascular endothelial growth factor receptor-2 binding, activation, and vascular permeability activities
-
Joukov V, et al. (1998) A recombinant mutant vascular endothelial growth factor-C that has lost vascular endothelial growth factor receptor-2 binding, activation, and vascular permeability activities. J Biol Chem, 273:6599-6602.
-
(1998)
J Biol Chem
, vol.273
, pp. 6599-6602
-
-
Joukov, V.1
-
39
-
-
0035377195
-
The specificity of receptor binding by vascular endothelial growth factor-d is different in mouse and man
-
Baldwin ME, et al. (2001) The specificity of receptor binding by vascular endothelial growth factor-d is different in mouse and man. J Biol Chem, 276:19166-19171.
-
(2001)
J Biol Chem
, vol.276
, pp. 19166-19171
-
-
Baldwin, M.E.1
-
40
-
-
67650156457
-
Novel vascular endothelial growth factor D variants with increased biological activity
-
Toivanen PI, et al. (2009) Novel vascular endothelial growth factor D variants with increased biological activity. J Biol Chem, 284:16037-16048.
-
(2009)
J Biol Chem
, vol.284
, pp. 16037-16048
-
-
Toivanen, P.I.1
-
41
-
-
0037631338
-
A set of loop-1 and -3 structures in the novel vascular endothelial growth factor (VEGF) family member, VEGF-ENZ-7, is essential for the activation of VEGFR-2 signaling
-
Kiba A, Yabana N, Shibuya M (2003) A set of loop-1 and -3 structures in the novel vascular endothelial growth factor (VEGF) family member, VEGF-ENZ-7, is essential for the activation of VEGFR-2 signaling. J Biol Chem, 278:13453-13461.
-
(2003)
J Biol Chem
, vol.278
, pp. 13453-13461
-
-
Kiba, A.1
Yabana, N.2
Shibuya, M.3
-
42
-
-
75149176738
-
-
Dell'Era Dosch D, Ballmer-Hofer K (2010) Transmembrane domain-mediated orientation of receptor monomers in active VEGFR-2 dimers. FASEB J, 24:32-38.
-
Dell'Era Dosch D, Ballmer-Hofer K (2010) Transmembrane domain-mediated orientation of receptor monomers in active VEGFR-2 dimers. FASEB J, 24:32-38.
-
-
-
-
43
-
-
45549109855
-
Contacts between membrane proximal regions of the PDGF receptor ectodomain are required for receptor activation but not for receptor dimerization
-
Yang Y, Yuzawa S, Schlessinger J (2008) Contacts between membrane proximal regions of the PDGF receptor ectodomain are required for receptor activation but not for receptor dimerization. Proc Natl Acad Sci USA, 105:7681-7686.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 7681-7686
-
-
Yang, Y.1
Yuzawa, S.2
Schlessinger, J.3
-
44
-
-
50249158577
-
Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex
-
Skiniotis G, Lupardus PJ, Martick M, Walz T, Garcia KC (2008) Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex. Mol Cell, 31:737-748.
-
(2008)
Mol Cell
, vol.31
, pp. 737-748
-
-
Skiniotis, G.1
Lupardus, P.J.2
Martick, M.3
Walz, T.4
Garcia, K.C.5
-
45
-
-
34249689753
-
Molecular regulation of angiogenesis and lymphangiogenesis
-
Alitalo K, Adams RH (2007) Molecular regulation of angiogenesis and lymphangiogenesis. Nat Rev Mol Cell Biol, 8:464-478.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 464-478
-
-
Alitalo, K.1
Adams, R.H.2
|