15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-β-induced suppressor of human gastrointestinal cancers

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 50, 2004, Pages 17468-17473

  Yan, Min ^a   Rerko, Ronald M ^b   Platzer, Petra ^a,b   Dawson, Dawn ^a   Willis, Joseph ^a   Tong, Min ^c   Lawrence, Earl ^a   Lutterbaugh, James ^a,b   Lu, Shilong ^a   Willson, James K V ^a   Luo, Guangbin ^a   Hensold, Jack ^a   Tai, Hsin Hsiung ^c   Wilson, Keith ^d   Markowitz, Sanford D ^a,b  

^a UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c University of Kentucky   (United States)

^d PROTEIN DESIGN LABS INC   (United States)

Author keywords

Colon; Gastric

Indexed keywords

15 HYDROPROSTAGLANDIN DEHYDROGENASE; CANCER GROWTH FACTOR; CANCER GROWTH FACTOR BETA; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; PROSTAGLANDIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOGENESIS; CANCER CELL; CANCER INHIBITION; COLON CANCER; COLON MUCOSA; CONTROLLED STUDY; DIGESTIVE SYSTEM CANCER; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME MECHANISM; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE DEFICIENCY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION;

CELL PROLIFERATION; CELLS, CULTURED; COLONIC NEOPLASMS; CYCLOOXYGENASE 2; HUMANS; HYDROXYPROSTAGLANDIN DEHYDROGENASES; IMMUNOHISTOCHEMISTRY; INTESTINAL MUCOSA; ISOENZYMES; KINETICS; MEMBRANE PROTEINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA;

EID: 10644274362     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0406142101     Document Type: Article

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