Isolation and characterization of dermal lymphatic and blood endothelial cells reveal stable and functionally specialized cell lineages

Journal of Experimental Medicine

Volumn 194, Issue 6, 2001, Pages 797-808

  Kriehuber, E ^a   Breiteneder Geleff, S ^a   Groeger, M ^a   Soleiman, A ^a   Schoppmann, S F ^a   Stingl, G ^a   Kerjaschki, D ^a   Maurer, D ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

Chemokines; Endothelial cell lineages; Endothelial cell tube formation; Podoplanin; Vascular endothelial cell growth factors

Indexed keywords

CADHERIN; CD31 ANTIGEN; CD34 ANTIGEN; CHEMOKINE RECEPTOR; CHEMOTACTIC FACTOR; MACROPHAGE INFLAMMATORY PROTEIN; MUCOPROTEIN; PODOCALYXIN; PROTEIN TYROSINE KINASE; RNA; VASCULOTROPIN RECEPTOR; VON WILLEBRAND FACTOR;

AMINO ACID SEQUENCE; ARTICLE; BLOOD; CELL ISOLATION; CELL LINEAGE; DERMIS; ENDOTHELIUM CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; LYMPHATIC SYSTEM; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

ADULT; ANIMALS; ANTIGENS, CD44; BIOLOGICAL MARKERS; CELL LINEAGE; CELL SEPARATION; CELLS, CULTURED; DERMIS; ENDOTHELIUM, VASCULAR; EXTRACELLULAR MATRIX PROTEINS; GLYCOPROTEINS; HUMANS; INTERCELLULAR JUNCTIONS; LYMPHATIC SYSTEM; MEMBRANE GLYCOPROTEINS; MUCOPROTEINS; RABBITS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, TIE-2; RECEPTORS, CELL SURFACE; RECEPTORS, GROWTH FACTOR; RECEPTORS, TIE; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3;

EID: 0035903330     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.194.6.797     Document Type: Article

References (42)

1. Structure, function, and molecular control of the skin lymphatic system
2. Lymphangiogenesis: Mechanisms, significance, and clinical implication
3. Structure and function of lymphatics
4. Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: Podoplanin as a specific marker for lymphatic endothelium
5. + precursor cells develop into Langerhans cells in a TGF-beta-1-dependent manner
6. Immunoelectron microscopic characterization of human dermal lymphatic microvascular endothelial cells. Differential expression of CD31, CD34, and type IV collagen with lymphatic endothelial cells vs blood capillary endothelial cells in normal human skin, lymphangioma, and hemangioma in situ
7. Phenotype of normal cutaneous microvasculature. Immunoelectron microscopic observations with emphasis on the differences between blood vessels and lymphatics
8. The peripheral blood fibrocyte is a potent antigen-presenting cell capable of priming naive T cells in situ
9. CD34 expression is regulated reciprocally with adhesion molecules in vascular endothelial cells in vitro
10. LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan
11. Expression of the fins-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development
12. VEGFR-3 and its ligand VEGF-C are associated with angiogenesis in breast cancer
13. VEGF-C and VEGF-D expression in neuroendocrine cells and their receptor, VEGFR-3, in fenestrated blood vessels in human tissues
14. Expression of vascular endothelial growth factor receptor 3 in blood and lymphatic vessels of lung adenocarcinoma
15. Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors
16. Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures
17. Growth factors: Formation of endothelial cell networks
18. Angiogenesis in cancer and other diseases
19. Vascular-specific growth factors and blood vessel formation
20. T-cell function and migration. Two sides of the same coin
21. Podoplanin, a novel 43-kd membrane protein of glomerular epithelial cells, is down-regulated in puromycin nephrosis
22. Characterization and cloning of the E11 antigen, a marker expressed by rat osteoblasts and osteocytes
23. Cloning, characterization, and development expression of a rat lung alveolar type I cell gene in embryonic endodermal and neural derivatives
24. Mouse LYVE-1 is an endocytic receptor for hyaluronan in lymphatic endothelium
25. Lymphatic endothelial tumors induced by intraperitoneal injection of incomplete Freund's adjuvant
26. Expression of vascular endothelial growth factor receptor-3 and podoplanin suggests a lymphatic endothelial cell origin of Kaposi's sarcoma tumor cells
27. Hyperplasia of lymphatic vessels in VEGF-C transgenic mice
28. VEGF-C-mediated lymphangiogenesis promotes tumour metastasis
29. Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis
30. Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis
31. VEGF-D promotes the metastatic spread of tumor cells via the lymphatics
32. Human cutaneous dendritic cells migrate through dermal lymphatic vessels in a skin organ culture model
33. Inhibition of functional T cell priming and contact hypersensitivity responses by treatment with anti-secondary lymphoid chemokine antibody during hapten sensitization
34. Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization
35. The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3β, ELC)-dependent mobilization of dendritic cells to lymph nodes
36. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
37. Macrophage inflammatory protein 3α is involved in the constitutive trafficking of epidermal Langerhans cells
38. Involvement of chemokine receptors in breast cancer metastasis
39. Gene duplications at the chemokine locus on mouse chromosome 4: Multiple strainspecific haplotypes and the deletion of secondary lymphoidorgan chemokine and EBI-1 ligand chemokine genes in the plt mutation
40. Mice lacking expression of the chemokines CCL21-Ser and CCL19 (plt mice) demonstrate delayed but enhanced T cell immune responses
41. The CC chemokine thymus-derived chemotactic agent 4 (TCA-4, secondary lymphoid tissue chemokine, 6Ckine, exodus-2) triggers lymphocyte function-associated antigen 1-mediated arrest of rolling T lymphocytes in peripheral lymph node high endothelial venules
42. Prox1 function is required for the development of the murine lymphatic system