Quantitative spatiotemporal analysis of antibody fragment diffusion and endocytic consumption in tumor spheroids

Cancer Research

Volumn 68, Issue 9, 2008, Pages 3334-3341

  Thurber, Greg M ^a   Wittrup, K Dane ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER ANTIBODY; CARCINOEMBRYONIC ANTIGEN; IMMUNOGLOBULIN G; ANTIBODY; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; IMMUNOGLOBULIN FRAGMENT;

ANTIGEN BINDING; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TISSUE CULTURE; TUMOR SPHEROID; BIOLOGICAL MODEL; CELL CULTURE; COLON TUMOR; DIFFUSION; ENDOCYTOSIS; IMMUNOTHERAPY; METABOLISM; MULTICELLULAR SPHEROID; PATHOLOGY; PHYSIOLOGY; TIME; TISSUE DISTRIBUTION; VALIDATION STUDY;

ANTIBODIES; COLONIC NEOPLASMS; DIFFUSION; ENDOCYTOSIS; GREEN FLUORESCENT PROTEINS; HUMANS; IMMUNOGLOBULIN FRAGMENTS; IMMUNOTHERAPY; MODELS, BIOLOGICAL; RECOMBINANT FUSION PROTEINS; SPHEROIDS, CELLULAR; TIME FACTORS; TISSUE DISTRIBUTION; TUMOR CELLS, CULTURED;

EID: 44849135212     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-3018     Document Type: Article

References (23)

1. Jain RK. Transport of molecules, particles, and cells in solid tumors. Annu Rev Biomed Eng 1999;01:241-63.
2. Baxter L, Jain RK. Transport of fluid and macromolecules in tumors 1. Role of interstitial pressure and convection. Microvasc Res 1989;37:77-104.
3. Pluen A, Boucher Y, Ramanujan S, et al. Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors. Proc Natl Acad Sci U S A 2001;98:4628-33.
4. Rippe B, Haraldsson B. Fluid and protein fluxes across small and large pores in the microvasculature. application of two-pore equations. Acta Physiol Scand 1987;131:411-28.
5. Thurber GM, Zajic SC, Wittrup KD. Theoretic criteria for antibody penetration into solid tumors and micrometastases. J Nucl Med 2007;48:995-9.
6. Goldenberg DM, Sharkey RM, Paganelli G, Barbet J, Chatal JF. Antibody pretargeting advances cancer radioimmunodetection and radioimmunotherapy. J Clin Oncol 2006;24:823-34.
7. Fujimori K, Covell D, Fletcher J, Weinstein J. Modeling analysis of the global and microscopic distribution of immunoglobulin G, F(ab')2, and Fab in Tumors. Cancer Res 1989;49:5656-63.
8. Baxter L, Zhu H, Mackensen D, Jain RK. Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice. Cancer Res 1994;54:1517-28.
9. Graff CP, Wittrup KD. Theoretical analysis of antibody targeting of tumor spheroids: importance of dosage for penetration, and affinity for retention. Cancer Res 2003;63:1288-96.
10. Graff C, Chester K, Begent R, Wittrup KD. Directed evolution of an anti-carcinoembryonic antigen scFv with a four-day monovalent dissociation half-time at 37°C. Protein Eng Des Sel 2004;17:293-304.
11. Crank J. The Mathematics of Diffusion. 2nd ed. Oxford: Clarendon Press; 1975.
12. Kelm J, Timmins N, Brown C, Fussenegger M, Nielsen L. Method for generation of homogenous multicellular tumor spheroids applicable to a wide variety of cell types. Biotechnol Bioeng 2003;83:173-80.
13. Ballangrud AM, Yang WH, Charlton DE, et al. Response of LNCaP spheroids after treatment with an α-particle emitter (Bi-213)-labeled anti-prostate_specific membrane antigen antibody (J591). Cancer Res 2001;61:2008-14.
14. Lyng H, Haraldseth O, Rofstad EK. Measurement of cell density and necrotic fraction in human melanoma xenografts by diffusion weighted magnetic resonance imaging. Magn Reson Med 2000;43:828-36.
15. Berk DA, Yuan F, Leunig M, Jain RK. Direct in vivo measurement of targeted binding in a human tumor xenograft. Proc Natl Acad Sci U S A 1997;94:1785-90.
16. Krol A, Nagaraj S, Dewhirst M, Yuan F. Available volume fraction of macromolecules in tumor tissues. FASEB J 2000;14:A167-A.
17. Myrdal S, Foster M. Time-resolved confocal analysis of antibody penetration into living, solid tumor spheroids. Scanning 1994;16:155-67.
18. Brown EB, Boucher Y, Nasser S, Jain RK. Measurement of macromolecular diffusion coefficients in human tumors. Microvasc Res 2004;67:231-6.
19. Fujimori K, Covell DG, Fletcher JE, Weinstein JN. A modeling analysis of monoclonal antibody percolation through tumors: a binding-site barrier. J Nucl Med 1990;31:1191-8.
20. Adams G, Schier R, McCall A, et al. High affinity restricts the localization and tumor penetration of single-chain Fv antibody molecules. Cancer Res 2001;61:4750-5.
21. Thurber G, Schmidt M, Wittrup KD. Factors determining antibody distribution in tumors. Trends Pharmacol Sci 2008;29:57-61.
22. Yuan F, Dellian M, Fukumura D, et al. Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size. Cancer Res 1995;55:3752-6.
23. Mattes MJ, Griffiths G, Diril H, Goldenberg D, Ong G, Shih L. Processing of antibody-radioisotope conjugates after binding to the surface of tumor cells. Cancer 1994;73:787-93.