Synthesis and SAR study of pyrrolo[3,4-b]pyridin-7(6H)-one derivatives as melanin concentrating hormone receptor 1 (MCH-R1) antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 6, 2013, Pages 1736-1739

  Lim, Chae Jo ^a,b   Kim, Ji Young ^a   Lee, Byung Ho ^a   Oh, Kwang Seok ^a   Yi, Kyu Yang ^a,b  

^a Korea Research Institute of Chemical Technology   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

Author keywords

MCH R1 antagonists; Melanin concentrating hormone (MCH); Obesity; Pyrrolo 3,4 b pyridin 7(6H) one

Indexed keywords

MELANIN CONCENTRATING HORMONE RECEPTOR 1 ANTAGONIST; PYRIDINE DERIVATIVE; PYRROLO[3,4 B]PYRIDIN 7(6H) ONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SCREENING; DRUG STABILITY; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-OBESITY AGENTS; HALF-LIFE; HUMANS; OBESITY; PROTEIN BINDING; PYRIDINES; PYRIMIDINES; PYRROLES; PYRROLIDINONES; RATS; RECEPTORS, PITUITARY HORMONE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84874645827     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.01.053     Document Type: Article

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