Microwave assisted synthesis of isothiazolo-, thiazolo-, imidazo-, and pyrimido-pyrimidinones as novel MCH1R antagonists

Tetrahedron Letters

Volumn 48, Issue 4, 2007, Pages 613-615

  Guo, Tao ^a   Hunter, Rachael C ^a   Zhang, Rui ^a   Greenlee, William J ^b  

^a PHARMACOPEIA INC   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Isothiazolo , thiazolo , imidazo , pyrimido pyrimidinones; MCH1R antagonist; Microwave assisted synthesis

Indexed keywords

IMIDAZOLE DERIVATIVE; ISOTHIAZOLE DERIVATIVE; MELANIN CONCENTRATING HORMONE; MELANIN CONCENTRATING HORMONE 1 RECEPTOR; PYRIMIDINONE DERIVATIVE; RECEPTOR BLOCKING AGENT; THIAZOLE DERIVATIVE;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; HEATING; HIGH TEMPERATURE; MICROWAVE RADIATION; POLYMERIZATION; REACTION ANALYSIS; STRUCTURE ANALYSIS; TEMPERATURE SENSITIVITY;

EID: 33845676684     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2006.11.120     Document Type: Article

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15. +].
16. i's represent the average of two or more determinations. The standard deviations were no greater than 30% from the mean.