Frailty and protein-energy wasting in elderly patients with end stage kidney disease

Journal of the American Society of Nephrology

Volumn 24, Issue 3, 2013, Pages 337-351

  Kim, Jun Chul ^a,b   Kalantar Zadeh, Kamyar ^a,c,d,e   Kopple, Joel D ^a,d,e  

^a HARBOR UCLA MEDICAL CENTER   (United States)

^b CHA University   (South Korea)

^c Harold Simmons Center for Kidney Disease Research and Epidemiology   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANABOLIC AGENT; ANDROGEN; CARNITINE; GROWTH HORMONE; NANDROLONE DECANOATE; SOMATOMEDIN C; TESTOSTERONE;

ACIDEMIA; AGING; DYNAPENIA; EXERCISE; FRAIL ELDERLY; HUMAN; KIDNEY FAILURE; METABOLIC ACIDEMIA; MUSCLE ATROPHY; MUSCLE WEAKNESS; NUTRIENT LOADING; PHYSICAL DISABILITY; PREVALENCE; PRIORITY JOURNAL; PROTEIN CALORIE MALNUTRITION; PROTEIN ENERGY WASTING; REVIEW; WEAKNESS;

EID: 84874601140     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2012010047     Document Type: Review

References (229)

1. Oreopoulos DG, Dimkovic N: Geriatric nephrology is coming of age. J Am Soc Nephrol 14: 1099-1101, 2003 (Pubitemid 36359293)
2. Brown EA, Johansson L: Old age and frailty in the dialysis population. J Nephrol 23: 502-507, 2010
3. Cavalli A, Del Vecchio L, Locatelli F: Geriatric nephrology. J Nephrol 23[Suppl 15]: S11-S15, 2010
4. US Renal Data System: USRDS 2010 Annual Data Report: Atlas of Chronic KidneyDisease and End-Stage Renal Disease in the United States, Bethesda, MD, National Institute of Health, National Institute of Diabetes and Digestive And Kidney Disease, 2010
5. Jassal SV, Chiu E, Li M: Geriatric hemodialysis rehabilitation care. Adv Chronic Kidney Dis 15: 115-122, 2008 (Pubitemid 351343870)
6. Johansen KL, ChertowGM, Jin C, KutnerNG: Significance of frailty among dialysis patients. J Am Soc Nephrol 18: 2960-2967, 2007 (Pubitemid 350058404)
7. Lacquaniti A, Bolignano D, Campo S, Perrone C, Donato V, Fazio MR, Buemi A, Sturiale A, Buemi M: Malnutrition in the elderly patient on dialysis. Ren Fail 31: 239-245, 2009
8. Foley RN, Wang C, Ishani A, Collins AJ, Murray AM: Kidney function and sarcopenia in the United States general population: NHANES III. Am J Nephrol 27: 279-286, 2007 (Pubitemid 47164678)
9. Dukkipati R, Kopple JD: Causes and prevention of protein-energywasting in chronic kidney failure. Semin Nephrol 29: 39-49, 2009
10. Cook WL, Jassal SV: Functional dependencies among the elderly on hemodialysis. Kidney Int 73: 1289-1295, 2008 (Pubitemid 351693158)
11. Fried LP, Tangen CM, Walston J, Newman AB,Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, McBurnie MA; Cardiovascular Health Study Collaborative Research Group: Frailty in older adults: Evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56: M146-M156, 2001
12. Shlipak MG, Stehman-Breen C, Fried LF, Song X, Siscovick D, Fried LP, Psaty BM, NewmanAB: The presenceof frailty in elderly persons with chronic renal insufficiency. Am J Kidney Dis 43: 861-867, 2004 (Pubitemid 38529624)
13. Wilhelm-Leen ER, Hall YN, K Tamura M, Chertow GM: Frailty and chronic kidney disease: The Third National Health and Nutrition Evaluation Survey. Am JMed 122: 664-671, 2009
14. FouqueD, Kalantar-Zadeh K, Kopple J, Cano N, Chauveau P, Cuppari L, Franch H, GuarnieriG, Ikizler TA, KaysenG, LindholmB, Massy Z, Mitch W, Pineda E, Stenvinkel P, Treviño-Becerra A, Wanner C: A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease. Kidney Int 73: 391-398, 2008 (Pubitemid 351186278)
15. Kopple JD: McCollum Award Lecture, 1996: Protein-energy malnutrition in maintenance dialysis patients.AmJ ClinNutr 65: 1544-1557, 1997 (Pubitemid 27187771)
16. Warner HR, Sierra F, Thompson LV: Biology of aging. In: Brocklehurst's Textbook of Geriatric Medicine and Gerontology, 7th Ed., edited by Fillit HM, Rockwood K, Woodhouse K, Philadelphia, Saunders Elsevier, 2010, pp 30-37
17. Meng SJ, Yu LJ: Oxidative stress, molecular inflammation and sarcopenia. Int J Mol Sci 11: 1509-1526, 2010
18. Crowe AV, McArdle A, McArdle F, Pattwell DM, Bell GM, Kemp GJ, Bone JM, Griffiths RD, Jackson MJ: Markers of oxidative stress in the skeletal muscle of patients on haemodialysis. Nephrol Dial Transplant 22: 1177-1183, 2007 (Pubitemid 46523435)
19. Howard C, Ferrucci L, Sun K, Fried LP, Walston J, Varadhan R, Guralnik JM, Semba RD:Oxidative protein damage is associated with poor grip strength among older women living in the community. J Appl Physiol 103: 17-20, 2007 (Pubitemid 47092272)
20. Semba RD, Ferrucci L, Sun K, Walston J, Varadhan R, Guralnik JM, Fried LP: Oxidative stress and severe walking disability among older women.AmJMed 120: 1084-1089, 2007 (Pubitemid 350176564)
21. Rosenberg IH: Epidemiologic and methodologic problems in determining nutritional status of older persons. Proceedings of a conference. Albuquerque, New Mexico, October 19-21, 1988. Am J Clin Nutr 50 [Suppl]: 1121-1235, 1989
22. Rosenberg IH: Sarcopenia: Origins and clinical relevance. J Nutr 127[Suppl]: 990S-991S, 1997 (Pubitemid 27209486)
23. Clark BC, Manini TM: Sarcopenia =/= dynapenia. J Gerontol A Biol Sci Med Sci 63: 829-834, 2008
24. Morley JE, Abbatecola AM, Argiles JM, Baracos V, Bauer J, Bhasin S, Cederholm T, Coats AJ, Cummings SR, Evans WJ, Fearon K, Ferrucci L, Fielding RA, Guralnik JM, Harris TB, Inui A, Kalantar-Zadeh K, Kirwan BA, Mantovani G, Muscaritoli M, Newman AB, Rossi-Fanelli F, Rosano GM, Roubenoff R, Schambelan M, Sokol GH, Storer TW, Vellas B, von Haehling S, Yeh SS, Anker SD; Society on Sarcopenia, Cachexia and Wasting Disorders Trialist Workshop: Sarcopenia with limited mobility: An international consensus. J AmMedDir Assoc 12: 403-409, 2011
25. Frontera WR, Hughes VA, Fielding RA, Fiatarone MA, Evans WJ, Roubenoff R: Aging of skeletal muscle: A 12-yr longitudinal study. J Appl Physiol 88: 1321-1326, 2000 (Pubitemid 30217433)
26. Noori N, Kopple JD, Kovesdy CP, Feroze U, Sim JJ, Murali SB, Luna A, Gomez M, Luna C, Bross R,Nissenson AR, Kalantar-Zadeh K: Mid-arm muscle circumference and quality of life and survival in maintenance hemodialysis patients. Clin J Am Soc Nephrol 5: 2258-2268, 2010
27. Kalantar-Zadeh K, Streja E, Kovesdy CP, Oreopoulos A, Noori N, Jing J, Nissenson AR, Krishnan M, Kopple JD, Mehrotra R, Anker SD: The obesity paradox and mortality associated with surrogates of body size and muscle mass in patients receiving hemodialysis. Mayo Clin Proc 85: 991-1001, 2010
28. Delmonico MJ, Harris TB, Visser M, Park SW, Conroy MB, Velasquez-Mieyer P, Boudreau R, Manini TM, NevittM, Newman AB, Goodpaster BH; Health, Aging, and Body: Longitudinal study of muscle strength, quality, and adipose tissue infiltration. Am J Clin Nutr 90: 1579-1585, 2009
29. Goodpaster BH, Park SW, Harris TB, Kritchevsky SB, Nevitt M, Schwartz AV, Simonsick EM, Tylavsky FA, Visser M, Newman AB: The loss of skeletal muscle strength, mass, and quality in older adults: The health, aging and body composition study. J Gerontol A Biol Sci Med Sci 61: 1059-1064, 2006 (Pubitemid 44727214)
30. Hughes VA, Frontera WR, Wood M, Evans WJ, Dallal GE, Roubenoff R, Fiatarone Singh MA: Longitudinal muscle strength changes in older adults: Influence of muscle mass, physical activity, and health. J Gerontol A Biol Sci Med Sci 56: B209-B217, 2001 (Pubitemid 32381799)
31. Storer TW, Casaburi R, Sawelson S, Kopple JD: Endurance exercise training during haemodialysis improves strength, power, fatigability and physical performance in maintenance haemodialysis patients. Nephrol Dial Transplant 20: 1429-1437, 2005 (Pubitemid 41430617)
32. VisserM, Deeg DJ, Lips P, Harris TB, Bouter LM: Skeletal muscle mass and muscle strength in relation to lower-extremity performance in older men and women. J Am Geriatr Soc 48: 381-386, 2000 (Pubitemid 30207761)
33. Newman AB, Kupelian V, Visser M, Simonsick EM, Goodpaster BH, Kritchevsky SB, Tylavsky FA, Rubin SM, Harris TB: Strength, but not muscle mass, is associated with mortality in the health, aging and body composition study cohort. J Gerontol A Biol Sci Med Sci 61: 72-77, 2006 (Pubitemid 43227803)
34. Cesari M, Pahor M, Lauretani F, Zamboni V, Bandinelli S, Bernabei R, Guralnik JM, Ferrucci L: Skeletal muscle and mortality results fromthe InCHIANTI Study. J Gerontol A Biol Sci Med Sci 64: 377-384, 2009
35. Baumgartner RN: Body composition in healthy aging. Ann N Y Acad Sci 904: 437-448, 2000 (Pubitemid 30389235)
36. Shaw KA, Srikanth VK, Fryer JL, Blizzard L, Dwyer T, Venn AJ: Dual energy X-ray absorptiometry body composition and aging in a population-based older cohort. Int J Obes (Lond) 31: 279-284, 2007 (Pubitemid 46183134)
37. Gallagher D, Ruts E, Visser M, Heshka S, Baumgartner RN, Wang J, Pierson RN, Pi-Sunyer FX, Heymsfield SB: Weight stability masks sarcopenia in elderly men and women. Am J Physiol Endocrinol Metab 279: E366-E375, 2000
38. Mehrotra R, Kopple JD: Nutritional management of maintenance dialysis patients: Why aren't we doing better? Annu Rev Nutr 21: 343-379, 2001 (Pubitemid 32695276)
39. Qureshi AR, Alvestrand A, Danielsson A, Divino-Filho JC, Gutierrez A, Lindholm B, Bergström J: Factors predicting malnutrition in hemodialysis patients: A cross-sectional study. Kidney Int 53: 773-782, 1998 (Pubitemid 28124295)
40. Biasioli S, Foroni R, Petrosino L, Cavallini L, Zambello A, Cavalcanti G, Talluri T: Effect of aging on the body composition of dialyzed subjects. Comparison with normal subjects. ASAIO J 39: M596-M601, 1993 (Pubitemid 23311768)
41. Kaizu Y, Ohkawa S, Odamaki M, Ikegaya N, Hibi I, Miyaji K, Kumagai H: Association between inflammatory mediators and muscle mass in long-term hemodialysis patients. AmJ Kidney Dis 42: 295-302, 2003 (Pubitemid 36944437)
42. McIntyre CW, Selby NM, Sigrist M, Pearce LE, Mercer TH, Naish PF: Patients receiving maintenance dialysis havemore severe functionally significant skeletal muscle wasting than patients with dialysis-independent chronic kidney disease. Nephrol Dial Transplant 21: 2210-2216, 2006 (Pubitemid 44295047)
43. Ohkawa S, Odamaki M, Ikegaya N, Hibi I, Miyaji K, Kumagai H: Association of age with muscle mass, fat mass and fat distribution in non-diabetic haemodialysis patients. Nephrol Dial Transplant 20: 945-951, 2005 (Pubitemid 40704031)
44. Odamaki M, Furuya R, Ohkawa S, Yoneyama T, Nishikino M, Hishida A, Kumagai H: Altered abdominal fat distribution and its association with the serum lipid profile in non-diabetic haemodialysis patients. NephrolDial Transplant 14: 2427-2432, 1999 (Pubitemid 29462482)
45. Woods NF, LaCroix AZ, Gray SL, Aragaki A, Cochrane BB, Brunner RL,Masaki K,Murray A, Newman AB; Women's Health Initiative: Frailty: Emergence and consequences in women aged 65 and older in the Women's Health Initiative Observational Study. J Am Geriatr Soc 53: 1321-1330, 2005 (Pubitemid 41602477)
46. Lang T, Streeper T, Cawthon P, Baldwin K, Taaffe DR, Harris TB: Sarcopenia: Etiology, clinical consequences, intervention, and assessment. Osteoporos Int 21: 543-559, 2010
47. Barzilai N, Gabriely I, Atzmon G, Suh Y, Rothenberg D, Bergman A: Genetic studies reveal the role of the endocrine and metabolic systems in aging. J Clin Endocrinol Metab 95: 4493-4500, 2010
48. Fedarko NS: The biology of aging and frailty. Clin Geriatr Med 27: 27-37, 2011
49. Papaconstantinou J: Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination. Mol Cell Endocrinol 299: 89-100, 2009
50. Berryman DE, Christiansen JS, Johannsson G, Thorner MO, Kopchick JJ: Role of the GH/IGF-1 axis in lifespan and healthspan: Lessons from animal models. Growth Horm IGF Res 18: 455-471, 2008
51. Rudman D, Feller AG,Nagraj HS, Gergans GA, Lalitha PY, Goldberg AF, Schlenker RA, Cohn L, Rudman IW, Mattson DE: Effects of human growth hormone in men over 60 years old. N Engl JMed 323: 1-6, 1990 (Pubitemid 20209464)
52. Velloso CP: Regulation of muscle mass by growth hormone and IGF-I. Br J Pharmacol 154: 557-568, 2008 (Pubitemid 351744951)
53. Gibney J, Healy ML, Sönksen PH: The growth hormone/insulin-like growth factor-I axis in exercise and sport. Endocr Rev 28: 603-624, 2007 (Pubitemid 47610444)
54. Perrini S, Laviola L, CarreiraMC, Cignarelli A, Natalicchio A, Giorgino F: The GH/IGF1 axis and signaling pathways in the muscle and bone: Mechanisms underlying age-related skeletal muscle wasting and osteoporosis. J Endocrinol 205: 201-210, 2010
55. Hao CM, Haase VH: Sirtuins and their relevance to the kidney. J Am Soc Nephrol 21: 1620-1627, 2010
56. Weinberg JM: Mitochondrial biogenesis in kidney disease. J AmSocNephrol 22: 431-436, 2011
57. Wallace DC: A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: A dawn for evolutionary medicine. Annu Rev Genet 39: 359-407, 2005 (Pubitemid 43011120)
58. Dalle-Donne I, Rossi R, Giustarini D, Milzani A, Colombo R: Protein carbonyl groups as biomarkers of oxidative stress. Clin Chim Acta 329: 23-38, 2003 (Pubitemid 36187411)
59. Beal MF: Oxidatively modified proteins in aging and disease. Free Radic Biol Med 32: 797-803, 2002 (Pubitemid 34439250)
60. Salminen A, Ojala J, Kaarniranta K: Apoptosis and aging: Increased resistance to apoptosis enhances the aging process. Cell Mol Life Sci 68: 1021-1031, 2011
61. Salminen A, Kaarniranta K: Regulation of the aging process by autophagy. Trends Mol Med 15: 217-224, 2009
62. Sharpless NE, DePinho RA: How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol 8: 703-713, 2007 (Pubitemid 47312828)
63. Zhu H, Belcher M, van der Harst P: Healthy aging and disease: Role for telomere biology? Clin Sci (Lond) 120: 427-440, 2011
64. Wills LP, Schnellmann RG: Telomeres and telomerase in renal health. J Am Soc Nephrol 22: 39-41, 2011
65. Yang H, Fogo AB: Cell senescence in the aging kidney. J Am Soc Nephrol 21: 1436-1439, 2010
66. Giunta S: Is inflammaging an auto[innate] immunity subclinical syndrome? Immun Ageing 3: 12, 2006
67. Chung HY, KimHJ, KimKW, Choi JS, Yu BP: Molecular inflammation hypothesis of aging based on the anti-aging mechanism of calorie restriction. Microsc Res Tech 59: 264-272, 2002 (Pubitemid 35332944)
68. Chung HY, Cesari M, Anton S, Marzetti E, Giovannini S, Seo AY, Carter C, Yu BP, Leeuwenburgh C: Molecular inflammation: Underpinnings of aging and age-related diseases. Ageing Res Rev 8: 18-30, 2009
69. Holick MF: High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc 81: 353-373, 2006 (Pubitemid 43334631)
70. Need AG, Morris HA, Horowitz M, Nordin C: Effects of skin thickness, age, body fat, and sunlight on serum 25-hydroxyvitamin D. Am J Clin Nutr 58: 882-885, 1993 (Pubitemid 23353596)
71. Visser M, Deeg DJ, Lips P; Longitudinal Aging Study Amsterdam: Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia): The Longitudinal Aging Study Amsterdam. J Clin Endocrinol Metab 88: 5766-5772, 2003 (Pubitemid 38033048)
72. Dawson-Hughes B: Serum 25-hydroxyvitamin D and functional outcomes in the elderly. Am J Clin Nutr 88: 537S-540S, 2008
73. Sato Y, Iwamoto J, Kanoko T, Satoh K: Lowdose vitamin D prevents muscular atrophy and reduces falls and hip fractures in women after stroke: A randomized controlled trial. Cerebrovasc Dis 20: 187-192, 2005 (Pubitemid 41254180)
74. Gordon PL, Sakkas GK, Doyle JW, Shubert T, Johansen KL: Relationship between vitamin D and muscle size and strength in patients on hemodialysis. J Ren Nutr 17: 397-407, 2007 (Pubitemid 47633464)
75. Endo I, Inoue D, Mitsui T, Umaki Y, Akaike M, Yoshizawa T, Kato S, Matsumoto T: Deletion of vitamin D receptor gene in mice results in abnormal skeletal muscle development with deregulated expression of myoregulatory transcription factors. Endocrinology 144: 5138-5144, 2003 (Pubitemid 37476038)
76. Ceglia L: Vitamin D and its role in skeletal muscle. CurrOpin ClinNutr Metab Care 12: 628-633, 2009
77. DelbonoO: Neural control of aging skeletal muscle. Aging Cell 2: 21-29, 2003
78. Auyeung TW, Kwok T, Lee J, Leung PC, Leung J, Woo J: Functional decline in cognitive impairment -the relationship between physical and cognitive function. Neuroepidemiology 31: 167-173, 2008
79. Boyle PA, Buchman AS, Wilson RS, Leurgans SE, Bennett DA: Association of muscle strength with the risk of Alzheimer disease and the rate of cognitive decline in community-dwelling older persons. Arch Neurol 66: 1339-1344, 2009
80. Lexell J: Evidence for nervous system degeneration with advancing age. J Nutr 127 [Suppl]: 1011S-1013S, 1997 (Pubitemid 27209492)
81. Christie A, Kamen G: Doublet discharges in motoneurons of young and older adults. J Neurophysiol 95: 2787-2795, 2006
82. Lauretani F, Bandinelli S, Bartali B, Di Iorio A, Giacomini V, Corsi AM, Guralnik JM, Ferrucci L: Axonal degeneration affects muscle density in older men and women. Neurobiol Aging 27: 1145-1154, 2006 (Pubitemid 43850645)
83. Phillips T, Leeuwenburgh C: Muscle fiber specific apoptosis and TNF-alpha signaling in sarcopenia are attenuated by life-long calorie restriction. FASEB J 19: 668-670, 2005 (Pubitemid 40471280)
84. Kouidi E, AlbaniM, Natsis K,Megalopoulos A, Gigis P, Guiba-Tziampiri O, Tourkantonis A, Deligiannis A: The effects of exercise training onmuscle atrophy in haemodialysis patients. Nephrol Dial Transplant 13: 685-699, 1998 (Pubitemid 28119053)
85. Conboy IM, Conboy MJ, Smythe GM, Rando TA: Notch-mediated restoration of regenerative potential to aged muscle. Science 302: 1575-1577, 2003 (Pubitemid 37475703)
86. Verdijk LB, Koopman R, Schaart G, Meijer K, Savelberg HH, van Loon LJ: Satellite cell content is specifically reduced in type II skeletal muscle fibers in the elderly. Am J Physiol Endocrinol Metab 292: E151-E157, 2007 (Pubitemid 46052937)
87. Bigot A, Jacquemin V, Debacq-Chainiaux F, Butler-Browne GS, Toussaint O, Furling D, Mouly V: Replicative aging down-regulates the myogenic regulatory factors in human myoblasts. Biol Cell 100: 189-199, 2008 (Pubitemid 351372677)
88. Faulkner JA, Larkin LM, Claflin DR, Brooks SV: Age-related changes in the structure and function of skeletal muscles. Clin Exp Pharmacol Physiol 34: 1091-1096, 2007 (Pubitemid 47416362)
89. Campbell MJ, McComas AJ, Petito F: Physiological changes in ageing muscles. J Neurol Neurosurg Psychiatry 36: 174-182, 1973
90. Cuthbertson D, Smith K, Babraj J, Leese G, Waddell T, Atherton P, Wackerhage H, Taylor PM, Rennie MJ: Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle. FASEB J 19: 422-424, 2005 (Pubitemid 40316537)
91. Narici MV, Maganaris CN: Adaptability of elderly human muscles and tendons to increased loading.JAnat 208: 433-443, 2006
92. Murphey MD, Sartoris DJ, Quale JL, Pathria MN, Martin NL: Musculoskeletal manifestations of chronic renal insufficiency. Radiographics 13: 357-379, 1993
93. Thaunat M, Gaudin P, Naret C, Beaufils P, Thaunat O: Role of secondary hyperparathyroidism in spontaneous rupture of the quadriceps tendon complicating chronic renal failure. Rheumatology (Oxford) 45: 234-235, 2006 (Pubitemid 43160095)
94. Kalantar-Zadeh K, Singh K, Kleiner M, Jarrett MP, Luft FC: Nontraumatic bilateral rupture of patellar tendons in a diabetic dialysis patient with secondary hyperparathyroidism. Nephrol Dial Transplant 12: 1988-1990, 1997 (Pubitemid 27379479)
95. Jadoul M, Albert JM, Akiba T, Akizawa T, Arab L, Bragg-Gresham JL, Mason N, Prutz KG, Young EW, Pisoni RL: Incidence and risk factors for hip or other bone fractures among hemodialysis patients in the Dialysis Outcomes and Practice Patterns Study. Kidney Int 70: 1358-1366, 2006 (Pubitemid 44435190)
96. Jadoul M: Towards the prevention of bone fractures in dialysed patients? Nephrol Dial Transplant 22: 3377-3380, 2007 (Pubitemid 350212516)
97. Aparicio M, Cano N, Chauveau P, Azar R, Canaud B, Flory A, Laville M, Leverve X; French Study Group for Nutrition in Dialysis: Nutritional status of haemodialysis patients: A French national cooperative study. Nephrol Dial Transplant 14: 1679-1686, 1999 (Pubitemid 29313045)
98. Cotter KA, Lachman ME: No strain, no gain: Psychosocial predictors of physical activity across the adult lifespan. J Phys Act Health 7: 584-594, 2010
99. Johansen KL, Chertow GM, Ng AV, Mulligan K, Carey S, Schoenfeld PY, Kent-Braun JA: Physical activity levels in patients on hemodialysis and healthy sedentary controls. Kidney Int 57: 2564-2570, 2000 (Pubitemid 30340755)
100. Stack AG, Murthy B: Exercise and limitations in physical activity levels among new dialysis patients in the United States: An epidemiologic study. Ann Epidemiol 18: 880-888, 2008
101. Johansen KL, Chertow GM, Kutner NG, Dalrymple LS, Grimes BA, Kaysen GA: Low level of self-reported physical activity in ambulatory patients new to dialysis. Kidney Int 78: 1164-1170, 2010
102. Majchrzak KM, Pupim LB, Sundell M, Ikizler TA: Body composition and physical activity in end-stage renal disease. J Ren Nutr 17: 196-204, 2007 (Pubitemid 46617294)
103. Kutsuna T,Matsunaga A,Matsumoto T, Ishii A, Yamamoto K, Hotta K, Aiba N, Takagi Y, Yoshida A, Takahira N, Masuda T: Physical activity is necessary to prevent deterioration of the walking ability of patients undergoing maintenance hemodialysis. Ther Apher Dial 14: 193-200, 2010
104. Stack AG, Molony DA, Rives T, Tyson J, Murthy BV: Association of physical activity with mortality in the US dialysis population. Am J Kidney Dis 45: 690-701, 2005 (Pubitemid 40460757)
105. Bossola M, Tazza L, Giungi S, Luciani G: Anorexia in hemodialysis patients: An update. Kidney Int 70: 417-422, 2006 (Pubitemid 44141567)
106. Suri RS, Nesrallah GE, Mainra R, Garg AX, Lindsay RM, Greene T, Daugirdas JT: Daily hemodialysis: A systematic review. Clin J Am Soc Nephrol 1: 33-42, 2006
107. Rousset S, PatureauMirand P, Brandolini M, Martin JF, Boirie Y: Daily protein intakes and eating patterns in young and elderly French. Br J Nutr 90: 1107-1115, 2003 (Pubitemid 37553131)
108. Mekki K, RemaounM, Belleville J, Bouchenak M: Hemodialysis duration impairs food intake and nutritional parameters in chronic kidney disease patients. Int Urol Nephrol 44: 237-244, 2010
109. Raj DS, Sun Y, Tzamaloukas AH: Hypercatabolism in dialysis patients. Curr Opin Nephrol Hypertens 17: 589-594, 2008
110. Aguilera A, Codoceo R, Selgas R, Garcia P, Picornell M, Diaz C, Sanchez C, Bajo MA: Anorexigen (TNF-alpha, cholecystokinin) and orexigen (neuropeptide Y) plasma levels in peritoneal dialysis (PD) patients: Their relationship with nutritional parameters. Nephrol Dial Transplant 13: 1476-1483, 1998 (Pubitemid 28254323)
111. Mak RH, Cheung W, Cone RD, Marks DL: Leptin and inflammation-associated cachexia in chronic kidney disease. Kidney Int 69: 794-797, 2006
112. da Costa JA, Ikizler TA: Inflammation and insulin resistance as novel mechanisms of wasting in chronic dialysis patients. Semin Dial 22: 652-657, 2009
113. Utaka S, Avesani CM, Draibe SA, Kamimura MA, Andreoni S, Cuppari L: Inflammation is associated with increased energy expenditure in patients with chronic kidney disease. Am J Clin Nutr 82: 801-805, 2005 (Pubitemid 43779693)
114. Nicklas BJ, Brinkley TE: Exercise training as a treatment for chronic inflammation in the elderly. Exerc Sport Sci Rev 37: 165-170, 2009
115. Raj DS, Dominic EA, Pai A, Osman F, MorganM, Pickett G, Shah VO, Ferrando A, Moseley P: Skeletal muscle, cytokines, and oxidative stress in end-stage renal disease. Kidney Int 68: 2338-2344, 2005 (Pubitemid 43117813)
116. Dursun E, Ozben T, Suleymanlar G, Dursun B, Yakupoglu G: Effect of hemodialysis on the oxidative stress and antioxidants. Clin Chem Lab Med 40: 1009-1013, 2002 (Pubitemid 35356018)
117. Sanz A, Stefanatos RK: The mitochondrial free radical theory of aging: A critical view. Curr Aging Sci 1: 10-21, 2008
118. Hekimi S, Lapointe J, Wen Y: Taking a "good" look at free radicals in the aging process. Trends Cell Biol 21: 569-576, 2011
119. Himmelfarb J, McMonagle E, McMenamin E: Plasma protein thiol oxidation and carbonyl formation in chronic renal failure. Kidney Int 58: 2571-2578, 2000
120. LindenE,CaiW, He JC,XueC, Li Z,Winston J, Vlassara H, Uribarri J: Endothelial dysfunction in patients with chronic kidney disease results from advanced glycation end products (AGE)-mediated inhibition of endothelial nitric oxide synthase through RAGE activation. Clin J Am Soc Nephrol 3: 691-698, 2008
121. Miyata T, Saito A, Kurokawa K, van Ypersele de Strihou C: Advanced glycation and lipoxidation end products: Reactive carbonyl compounds-related uraemic toxicity. Nephrol Dial Transplant 16[Suppl 4]: 8-11, 2001 (Pubitemid 32591152)
122. Satko SG, Sedor JR, Iyengar SK, Freedman BI: Familial clustering of chronic kidney disease. Semin Dial 20: 229-236, 2007
123. Lea JP, McClellan WM, Melcher C, Gladstone E, Hostetter T: CKD risk factors reported by primary care physicians: Do guidelines make a difference? Am J Kidney Dis 47: 72-77, 2006 (Pubitemid 41828268)
124. Stenvinkel P, Ekström TJ: Epigenetics -A helpful tool to better understand processes in clinical nephrology? Nephrol Dial Transplant 23: 1493-1496, 2008 (Pubitemid 351767797)
125. Salminen A, Kaarniranta K: Genetics vs. entropy: Longevity factors suppress the NF-kappaB-driven entropic aging process. Ageing Res Rev 9: 298-314, 2010
126. Sun DF, Zheng Z, Tummala P, Oh J, Schaefer F, Rabkin R: Chronic uremia attenuates growth hormone-induced signal transduction in skeletal muscle. J Am Soc Nephrol 15: 2630-2636, 2004 (Pubitemid 41103369)
127. Siew ED, Ikizler TA: Insulin resistance and protein energy metabolism in patients with advanced chronic kidney disease. Semin Dial 23: 378-382, 2010
128. Siew ED, Pupim LB,Majchrzak KM, Shintani A, Flakoll PJ, Ikizler TA: Insulin resistance is associated with skeletal muscle protein breakdown in non-diabetic chronic hemodialysis patients. Kidney Int 71: 146-152, 2007 (Pubitemid 46094688)
129. Workeneh BT, Mitch WE: Review of muscle wasting associated with chronic kidney disease. AmJ ClinNutr 91: 1128S-1132S, 2010
130. Pupim LB, Heimbürger O, Qureshi AR, Ikizler TA, Stenvinkel P: Accelerated lean body mass loss in incident chronic dialysis patients with diabetes mellitus. Kidney Int 68: 2368-2374, 2005 (Pubitemid 43117817)
131. Pupim LB, Flakoll PJ, Majchrzak KM, Aftab Guy DL, Stenvinkel P, Ikizler TA: Increased muscle protein breakdown in chronic hemodialysis patients with type 2 diabetes mellitus. Kidney Int 68: 1857-1865, 2005 (Pubitemid 43169932)
132. Park SW, Goodpaster BH, Strotmeyer ES, Kuller LH, Broudeau R, Kammerer C, de Rekeneire N, Harris TB, Schwartz AV, Tylavsky FA, Cho YW, Newman AB; Health, Aging, and Body Composition Study: Accelerated loss of skeletal muscle strength in older adults with type 2 diabetes: The health, aging, and body composition study. Diabetes Care 30: 1507-1512, 2007 (Pubitemid 46871162)
133. DingH,Gao XL, Hirschberg R, Vadgama JV, Kopple JD: Impaired actions of insulin-like growth factor 1 on protein Synthesis and degradation in skeletal muscle of rats with chronic renal failure. Evidence for a postreceptor defect. J Clin Invest 97: 1064-1075, 1996 (Pubitemid 26074153)
134. Kopple JD, Wang H, Casaburi R, Fournier M, Lewis MI, Taylor W, Storer TW: Exercise in maintenance hemodialysis patients induces transcriptional changes in genes favoring anabolic muscle. J Am Soc Nephrol 18: 2975-2986, 2007 (Pubitemid 350064083)
135. Wang H, Casaburi R, Taylor WE, Aboellail H, Storer TW, Kopple JD: Skeletal muscle mRNA for IGF-IEa, IGF-II, and IGF-I receptor is decreased in sedentary chronic hemodialysis patients. Kidney Int 68: 352-361, 2005 (Pubitemid 43181395)
136. Carrero JJ, Qureshi AR, Nakashima A, Arver S, Parini P, Lindholm B, Barany P, Heimburger O, Stenvinkel P: Prevalence and clinical implications of testosterone deficiency in men with end-stage renal disease. Nephrol Dial Transplant 26: 184-190, 2011
137. Feldman HA, Longcope C, Derby CA, Johannes CB, Araujo AB, Coviello AD, BremnerWJ,McKinlay JB: Age trends in the level of serum testosterone and other hormones in middle-aged men: Longitudinal results from the Massachusetts male aging study. J Clin Endocrinol Metab 87: 589-598, 2002 (Pubitemid 34158223)
138. Cawthon PM, Ensrud KE, Laughlin GA, Cauley JA, Dam TT, Barrett-Connor E, Fink HA, Hoffman AR, Lau E, Lane NE, Stefanick ML, Cummings SR, Orwoll ES; Osteoporotic Fractures in Men (MrOS) Research Group: Sex hormones and frailty in older men: The osteoporotic fractures in men (MrOS) study. J Clin Endocrinol Metab 94: 3806-3815, 2009
139. Bhasin S, Storer TW, BermanN, Callegari C, Clevenger B, Phillips J, Bunnell TJ, Tricker R, Shirazi A, Casaburi R: The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men. N Engl J Med 335: 1-7, 1996 (Pubitemid 26230806)
140. Rajan V, Mitch WE: Ubiquitin, proteasomes and proteolytic mechanisms activated by kidney disease. Biochim Biophys Acta 795-9: 2008, 1782
141. Mitch WE, Goldberg AL: Mechanisms of muscle wasting. The role of the ubiquitinproteasome pathway. N Engl J Med 335: 1897-1905, 1996 (Pubitemid 26419198)
142. Mehrotra R, Bross R, Wang H, Appell M, Tso L, Kopple JD: Effect of high-normal compared with low-normal arterial pH on protein balances in automated peritoneal dialysis patients. Am J Clin Nutr 90: 1532-1540, 2009
143. Kraut JA, Kurtz I:Metabolic acidosis ofCKD: Diagnosis, clinical characteristics, and treatment. Am J Kidney Dis 45: 978-993, 2005 (Pubitemid 40806510)
144. Wiederkehr MR, Kalogiros J, Krapf R: Correction of metabolic acidosis improves thyroid and growth hormone axes in haemodialysis patients. Nephrol Dial Transplant 19: 1190-1197, 2004 (Pubitemid 38628140)
145. Kopple JD, Kalantar-Zadeh K, Mehrotra R: Risks of chronic metabolic acidosis in patients with chronic kidney disease. Kidney Int Suppl 95: S21-S27, 2005 (Pubitemid 43361552)
146. Jamal SA, Leiter RE, Jassal V, Hamilton CJ, Bauer DC: Impaired muscle strength is associated with fractures in hemodialysis patients. Osteoporos Int 17: 1390-1397, 2006 (Pubitemid 44127326)
147. Cheema B, Abas H, Smith B, O'Sullivan AJ, Chan M, Patwardhan A, Kelly J, Gillin A, Pang G, Lloyd B, Berger K, Baune BT, Singh MF: Investigation of skeletal muscle quantity and quality in end-stage renal disease. Nephrology (Carlton) 15: 454-463, 2010
148. Johansen KL, Shubert T, Doyle J, Soher B, Sakkas GK, Kent-Braun JA:Muscle atrophy in patients receiving hemodialysis: Effects on muscle strength, muscle quality, and physical function. Kidney Int 63: 291-297, 2003 (Pubitemid 35463933)
149. Kaysen GA, Larive B, Painter P, Craig A, Lindsay RM, Rocco MV, Daugirdas JT, Schulman G, Chertow GM, Group FHNT: Baseline physical performance, health, and functioning of participants in the Frequent Hemodialysis Network (FHN) trial. Am J Kidney Dis 57: 101-112, 2011
150. Sterky E, Stegmayr BG: Elderly patients on haemodialysis have 50% less functional capacity than gender-and age-matched healthy subjects. Scand J Urol Nephrol 39: 423-430, 2005 (Pubitemid 41666028)
151. Buchman AS, Boyle PA, Wilson RS, Tang Y, Bennett DA: Frailty is associated with incident Alzheimer's disease and cognitive decline in the elderly. Psychosom Med 69: 483-489, 2007 (Pubitemid 46987892)
152. Bouchard DR, Janssen I: Dynapenic-obesity and physical function in older adults. J Gerontol A Biol Sci Med Sci 65: 71-77, 2010
153. Bouchard DR, Beliaeff S, Dionne IJ, Brochu M: Fat mass but not fat-free mass is related to physical capacity in well-functioning older individuals: Nutrition as a determinant of successful aging (NuAge) -the Quebec Longitudinal Study. J Gerontol A Biol Sci Med Sci 62: 1382-1388, 2007 (Pubitemid 351158366)
154. Pijnappels M, van der Burg PJ, Reeves ND, van Dieën JH: Identification of elderly fallers bymuscle strengthmeasures. Eur JAppl Physiol 102: 585-592, 2008
155. Cook WL, Jassal SV: Prevalence of falls among seniors maintained on
156. Cook WL, Tomlinson G, Donaldson M, Markowitz SN, Naglie G, Sobolev B, Jassal SV: Falls and fall-related injuries in older dialysis patients. Clin J Am Soc Nephrol 1: 1197-1204, 2006
157. Desmet C, Beguin C, Swine C, Jadoul M; Universite Catholique de Louvain Collaborative: Falls in hemodialysis patients: Prospective study of incidence, risk factors, and complications. Am J Kidney Dis 45: 148-153, 2005 (Pubitemid 40038055)
158. Li M, Tomlinson G, Naglie G, Cook WL, Jassal SV: Geriatric comorbidities, such as falls, confer an independent mortality risk to elderly dialysis patients. Nephrol Dial Transplant 23: 1396-1400, 2008 (Pubitemid 351767499)
159. Danese MD, Kim J, Doan QV, Dylan M, Griffiths R, Chertow GM: PTH and the risks for hip, vertebral, and pelvic fractures among patients on dialysis.AmJKidneyDis 47: 149-156, 2006 (Pubitemid 41828277)
160. Kalantar-Zadeh K: Causes and consequences of the reverse epidemiology of body mass index in dialysis patients. J Ren Nutr 15: 142-147, 2005 (Pubitemid 40093699)
161. Chazot C, Gassia JP, Di Benedetto A, Cesare S, Ponce P, Marcelli D: Is there any survival advantage of obesity in Southern European haemodialysis patients? Nephrol Dial Transplant 24: 2871-2876, 2009
162. Kalantar-Zadeh K, BlockG,HumphreysMH, Kopple JD: Reverse epidemiology of cardiovascular risk factors in maintenance dialysis patients. Kidney Int 63: 793-808, 2003 (Pubitemid 36315558)
163. Beddhu S, Pappas LM, Ramkumar N, Samore M: Effects of body size and body composition on survival in hemodialysis patients.J AmSocNephrol 14: 2366-2372, 2003 (Pubitemid 37069205)
164. Ramkumar N, Pappas LM, Beddhu S: Effect of body size and body composition on survival in peritoneal dialysis patients. Perit Dial Int 25: 461-469, 2005 (Pubitemid 41448401)
165. Kalantar-Zadeh K, Abbott KC, Salahudeen AK, Kilpatrick RD, Horwich TB: Survival advantages of obesity in dialysis patients. Am J Clin Nutr 81: 543-554, 2005
166. Kalantar-Zadeh K, Kopple JD: Obesity paradox in patients on maintenance dialysis. Contrib Nephrol 151: 57-69, 2006 (Pubitemid 44298224)
167. Kalantar-Zadeh K, Kuwae N, Wu DY, Shantouf RS, Fouque D, Anker SD, Block G, Kopple JD: Associations of body fat and its changes over time with quality of life and prospective mortality in hemodialysis patients. Am J Clin Nutr 83: 202-210, 2006 (Pubitemid 44713179)
168. Antunes AA, Delatim Vannini F, de Arruda Silveira LV, Martin LC, Barretti P, Caramori JC: Influence of protein intake and muscle mass on survival in chronic dialysis patients. Ren Fail 32: 1055-1059, 2010
169. Honda H, Qureshi AR, Axelsson J, Heimburger O, Suliman ME, Barany P, Stenvinkel P, Lindholm B: Obese sarcopenia in patients with end-stage renal disease is associated with inflammation and increased mortality. Am J Clin Nutr 86: 633-638, 2007 (Pubitemid 47435829)
170. Cordeiro AC, Qureshi AR, Stenvinkel P, Heimbürger O, Axelsson J, Bárány P, Lindholm B, Carrero JJ: Abdominal fat deposition is associated with increased inflammation, protein-energy wasting and worse outcome in patients undergoing haemodialysis. Nephrol Dial Transplant 25: 562-568, 2010
171. Chung SH, LindholmB, LeeHB: Influence of initial nutritional status on continuous ambulatory peritoneal dialysis patient survival. Peritoneal dialysis international: journal of the International Society for Peritoneal Dialysis 20: 19-26, 2000 (Pubitemid 30184766)
172. Iseki K, Uehara H, Nishime K, Tokuyama K, Yoshihara K, Kinjo K, Shiohira Y, Fukiyama K: Impact of the initial levels of laboratory variables on survival in chronic dialysis patients. Am J Kidney Dis 28: 541-548, 1996 (Pubitemid 26337593)
173. Goldwasser P, Kaldas AI, Barth RH: Rise in serumalbumin and creatinine in the first half year on hemodialysis. Kidney Int 56: 2260-2268, 1999 (Pubitemid 30004757)
174. Mehrotra R, Berman N, Alistwani A, Kopple JD: Improvement of nutritional status after initiation of maintenance hemodialysis. Am J Kidney Dis 40: 133-142, 2002 (Pubitemid 34701221)
175. Schulman G: Nutrition in daily hemodialysis. Am J Kidney Dis 41[Suppl 1]: S112-S115, 2003 (Pubitemid 36278359)
176. Coombes JS, Fassett RG: Antioxidant therapy in hemodialysis patients: A systematic review. Kidney Int 81: 233-246,2011
177. Iglesias P, Diez JJ: Peroxisome proliferatoractivated receptor gamma agonists in renal disease. Eur J Endocrinol 154: 613-621, 2006 (Pubitemid 43810845)
178. Kumar S, Raftery M, Yaqoob M, Fan SL: Anti-inflammatory effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors (statins) in peritoneal dialysis patients. Perit Dial Int 27: 283-287, 2007 (Pubitemid 47054604)
179. Boaz M, Smetana S,Weinstein T, Matas Z, Gafter U, Iaina A, Knecht A, Weissgarten Y, Brunner D, Fainaru M, Green MS: Secondary prevention with antioxidants of cardiovascular disease in endstage renal disease (SPACE): Randomised placebocontrolled trial. Lancet 356: 1213-1218, 2000
180. TepelM, van derGietM, Statz M, Jankowski J, Zidek W: The antioxidant acetylcysteine reduces cardiovascular events in patients with end-stage renal failure: A randomized, controlled trial. Circulation 107: 992-995, 2003 (Pubitemid 36258722)
181. Kidney Disease Outcomes Quality Initiative (K/DOQI): K/DOQI clinical practice guidelines for nutrition in chronic renal failure.Am J Kidney Dis 35: S38-S39, 2000
182. Dukkipati R, Noori N, Feroze U, Kopple JD: Dietary protein intake in patients with advanced chronic kidney disease and on dialysis. Semin Dial 23: 365-372, 2010
183. Kovesdy CP, Shinaberger CS, Kalantar-Zadeh K: Epidemiology of dietary nutrient intake in ESRD. Semin Dial 23: 353-358, 2010
184. Paddon-Jones D, Short KR, Campbell WW, Volpi E,Wolfe RR: Role of dietary protein in the sarcopenia of aging. Am J Clin Nutr 87: 1562S-1566S, 2008 (Pubitemid 351679811)
185. Volpi E, Kobayashi H, Sheffield-Moore M, Mittendorfer B, Wolfe RR: Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults. Am J Clin Nutr 78: 250-258, 2003 (Pubitemid 39655228)
186. Rieu I, Balage M, Sornet C, Giraudet C, Pujos E, Grizard J, Mosoni L, Dardevet D: Leucine supplementation improves muscle protein synthesis in elderly men independently of hyperaminoacidaemia. J Physiol 575: 305-315, 2006 (Pubitemid 44182713)
187. Paddon-Jones D, Rasmussen BB: Dietary protein recommendations and the prevention of sarcopenia. Curr Opin Clin Nutr Metab Care 12: 86-90, 2009
188. Stratton RJ, Bircher G, Fouque D, Stenvinkel P, de Mutsert R, Engfer M, Elia M:Multinutrient oral supplements and tube feeding in maintenance dialysis: A systematic review and meta-analysis. Am J Kidney Dis 46: 387-405, 2005 (Pubitemid 41208174)
189. Pupim LB, Flakoll PJ, Brouillette JR, Levenhagen DK, Hakim RM, Ikizler TA: Intradialytic parenteral nutrition improves protein and energy homeostasis in chronic hemodialysis patients. J Clin Invest 110: 483-492, 2002 (Pubitemid 34919702)
190. Dong J, Ikizler TA: Newinsights into the role of anabolic interventions in dialysis patients with protein energy wasting. Curr Opin Nephrol Hypertens 18: 469-475, 2009
191. Dukkipati R, Kalantar-Zadeh K, Kopple JD: Is there a role for intradialytic parenteral nutrition? A review of the evidence. Am J Kidney Dis 55: 352-364, 2010
192. KDOQI: K/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease.AmJ Kidney Dis 42: S129-S130, 2003
193. Szeto CC, Wong TY, Chow KM, Leung CB, Li PK: Oral sodium bicarbonate for the treatment of metabolic acidosis in peritoneal dialysis patients: A randomized placebo-control trial. JAmSocNephrol 14: 2119-2126, 2003 (Pubitemid 36909920)
194. de Brito-Ashurst I, Varagunam M, Raftery MJ, Yaqoob MM: Bicarbonate supplementation slows progression of CKD and improves nutritional status. J Am Soc Nephrol 20: 2075-2084, 2009
195. Shah SN, Abramowitz M, Hostetter TH, Melamed ML: Serum bicarbonate levels and the progression of kidney disease: A cohort study. Am J Kidney Dis 54: 270-277, 2009
196. Phisitkul S, Khanna A, Simoni J, Broglio K, Sheather S, Rajab MH, Wesson DE: Amelioration of metabolic acidosis in patients with low GFR reduced kidney endothelin production and kidney injury, and better preserved GFR. Kidney Int 77: 617-623, 2010
197. Gadola L, Noboa O, Márquez MN, Rodriguez MJ, Nin N, Boggia J, Ferreiro A, García S, Ortega V, Musto ML, Ponte P, Sesser P, Pizarrosa C, Ravaglio S, Vallega A: Calciumcitrate ameliorates the progression of chronic renal injury. Kidney Int 65: 1224-1230, 2004 (Pubitemid 38406960)
198. Gjorup S, Thaysen JH: Anabolic steroids in treatment of uraemia. Lancet 2: 886-887, 1958
199. Snyder D, Brest AN: Chronic renal insufficiency treated with anabolic steroids: Effects on acid-base balance, protein metabolism and hematopoiesis. J Am Geriatr Soc 14: 21-32, 1966
200. Lindner A, Tenckhoff H: Influence of anabolic steroids on nitrogen balance in chronic peritoneal dialysis. Nephron 9: 77-85, 1972
201. LindnerA, TenckhoffH: Nitrogen balance in patients on maintenance peritoneal dialysis. Trans Am Soc Artif Intern Organs 16: 255-259, 1970
202. Johansen KL, Mulligan K, Schambelan M: Anabolic effects of nandrolone decanoate in patients receiving dialysis: A randomized controlled trial. JAMA 281: 1275-1281, 1999 (Pubitemid 29174478)
203. Johansen KL: Testosterone metabolism and replacement therapy in patients with end-stage renal disease. Semin Dial 17: 202-208, 2004 (Pubitemid 38824501)
204. Ottenbacher KJ, Ottenbacher ME, Ottenbacher AJ, Acha AA, Ostir GV: Androgen treatment and muscle strength in elderly men: A meta-analysis. J Am Geriatr Soc 54: 1666-1673, 2006 (Pubitemid 44665204)
205. Johansen KL, Painter PL, Sakkas GK, Gordon P, Doyle J, Shubert T: Effects of resistance exercise training and nandrolone decanoate on body composition and muscle function among patients who receive hemodialysis: A randomized, controlled trial. J Am Soc Nephrol 17: 2307-2314, 2006 (Pubitemid 44141922)
206. Kopple JD, Qing D: Effect of L-carnitine on nitrogen balance in CAPD patient. J Am Soc Nephrol 10: 264A, 1999
207. Garibotto G, Barreca A, Russo R, Sofia A, Araghi P, Cesarone A, Malaspina M, Fiorini F, Minuto F, Tizianello A: Effects of recombinant human growth hormone on muscle protein turnover in malnourished hemodialysis patients. J Clin Invest 99: 97-105, 1997 (Pubitemid 27058299)
208. Ziegler TR, Lazarus JM, Young LS, Hakim R, Wilmore DW: Effects of recombinant human growth hormone in adults receiving maintenance hemodialysis. J Am Soc Nephrol 2: 1130-1135, 1991
209. Schulman G, Wingard RL, Hutchison RL, Lawrence P, Hakim RM: The effects of recombinant human growth hormone and intradialytic parenteral nutrition in malnourished hemodialysis patients. Am J Kidney Dis 21: 527-534, 1993 (Pubitemid 23160514)
210. Kopple JD, Brunori G, Leiserowitz M, Fouque D: Growth hormone induces anabolism in malnourished maintenance haemodialysis patients. Nephrol Dial Transplant 20: 952-958, 2005 (Pubitemid 40704032)
211. Guebre-Egziabher F, Juillard L, Boirie Y, Laville M, Beaufrère B, Fouque D: Shortterm administration of a combination of recombinant growth hormone and insulinlike growth factor-I induces anabolism in maintenance hemodialysis. J Clin Endocrinol Metab 94: 2299-2305, 2009
212. Feldt-Rasmussen B, Lange M, Sulowicz W, Gafter U, Lai KN, Wiedemann J, Christiansen JS, El Nahas M; APCD Study Group: Growth hormone treatment during hemodialysis in a randomized trial improves nutrition, quality of life, and cardiovascular risk. J Am Soc Nephrol 18: 2161-2171, 2007 (Pubitemid 47041081)
213. Hansen TB, Gram J, Jensen PB, Kristiansen JH, Ekelund B, Christiansen JS, Pedersen FB: Influence of growth hormone on whole body and regional soft tissue composition in adult patients on hemodialysis. A doubleblind, randomized, placebo-controlled study. Clin Nephrol 53: 99-107, 2000 (Pubitemid 30082243)
214. Kopple JD, Cheung AK, Christiansen JS, Djurhuus CB, El Nahas M, Feldt-Rasmussen B,MitchWE,Wanner C,GothbergM, Ikizler TA: OPPORTUNITY™: A large-scale randomized clinical trial of growth hormone in hemodialysis patients. Nephrol Dial Transplant 26: 4095-4103, 2011
215. Langbakke IH, Nielsen JN, Skettrup MP, Harper A, Klitgaard T,Weil A, Engelhardt E, Lange M: Pharmacokinetics and pharmacodynamics of growth hormone in patients on chronic haemodialysis compared with matched healthy subjects: An open, nonrandomized, parallel-group trial. Clin Endocrinol (Oxf) 67: 776-783, 2007 (Pubitemid 47620446)
216. Kotzmann H, Yilmaz N, Lercher P, Riedl M, Schmidt A, Schuster E, Kreuzer S, Geyer G, Frisch H, Hörl WH, Mayer G, Luger A: Differential effects of growth hormone therapy in malnourished hemodialysis patients. Kidney Int 60: 1578-1585, 2001 (Pubitemid 32960055)
217. Johannsson G, Bengtsson BA, Ahlmén J: Double-blind, placebo-controlled study of growth hormone treatment in elderly patients undergoing chronic hemodialysis: Anabolic effect and functional improvement. Am J Kidney Dis 33: 709-717, 1999 (Pubitemid 29159937)
218. Blake PG: Growth hormone and malnutrition in dialysis patients. Perit Dial Int 15: 210-216, 1995
219. Messi ML, Delbono O: Target-derived trophic effect on skeletal muscle innervation in senescentmice. JNeurosci 23: 1351-1359, 2003 (Pubitemid 36258913)
220. Schertzer JD, van der Poel C, Shavlakadze T, Grounds MD, Lynch GS: Muscle-specific overexpression of IGF-I improves E-C coupling in skeletal muscle fibers from dystrophic mdx mice. Am J Physiol Cell Physiol 294: C161-C168, 2008
221. Fouque D, Peng SC, Shamir E, Kopple JD: Recombinant human insulin-like growth factor-1 induces an anabolic response in malnourished CAPD patients. Kidney Int 57: 646-654, 2000 (Pubitemid 30430658)
222. Fouque D, Tayek JA, Kopple JD: Altered mental function during intravenous infusion of recombinant human insulin-like growth factor 1. JPEN J Parenter Enteral Nutr 19: 231-233, 1995
223. O'Shea MH, Miller SB, Hammerman MR: Effects of IGF-I on renal function in patients with chronic renal failure. Am J Physiol 264: F917-F922, 1993 (Pubitemid 23149723)
224. Kopple JD, Storer T, Casburi R: Impaired exercise capacity and exercise training in maintenance hemodialysis patients. J Ren Nutr 15: 44-48, 2005 (Pubitemid 40103551)
225. Painter P, Carlson L, Carey S, Paul SM, Myll J: Low-functioning hemodialysis patients improve with exercise training.AmJ Kidney Dis 36: 600-608, 2000
226. Castaneda C, Gordon PL, Parker RC, Uhlin KL, Roubenoff R, Levey AS: Resistance training to reduce the malnutrition-inflammation complex syndrome of chronic kidney disease. Am J Kidney Dis 43: 607-616, 2004 (Pubitemid 38401875)
227. Cheema B, Abas H, Smith B, O'Sullivan A, Chan M, Patwardhan A, Kelly J, Gillin A, Pang G, Lloyd B, Singh MF: Progressive exercise for anabolism in kidney disease (PEAK): A randomized, controlled trial of resistance training during hemodialysis. J Am Soc Nephrol 18: 1594-1601, 2007 (Pubitemid 46729199)
228. Heiwe S, Tollbäck A, Clyne N: Twelveweeks of exercise training increases muscle function and walking capacity in elderly predialysis patients and healthy subjects. Nephron 88: 48-56, 2001 (Pubitemid 32429703)
229. Chen JL, Godfrey S, Ng TT, Moorthi R, Liangos O, Ruthazer R, Jaber BL, Levey AS, Castaneda-Sceppa C: Effect of intradialytic, low-intensity strength training on functional capacity in adult haemodialysis patients: A randomized pilot trial. Nephrol Dial Transplant 25: 1936-1943, 2010