The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men

New England Journal of Medicine

Volumn 335, Issue 1, 1996, Pages 1-7

  Bhasin, Shalender ^a   Storer, Thomas W ^b   Berman, Nancy ^c   Callegari, Carlos ^a   Clevenger, Brenda ^a   Phillips, Jeffrey ^c   Bunnell, Thomas J ^b   Tricker, Ray ^d   Shirazi, Aida ^d   Casaburi, Richard ^c  

^a CHARLES R DREW UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^b El Camino College   (United States)

^c HARBOR UCLA MEDICAL CENTER   (United States)

^d OREGON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; TESTOSTERONE ENANTATE;

ADULT; ARTICLE; ATHLETE; CLINICAL ARTICLE; DRUG EFFECT; DRUG EFFICACY; DRUG MEGADOSE; EXERCISE; HORMONE RESPONSE; HUMAN; INTRAMUSCULAR DRUG ADMINISTRATION; MALE; MUSCLE LENGTH; MUSCLE MASS; MUSCLE STRENGTH; PRIORITY JOURNAL; STEROID THERAPY;

ADULT; AFFECT; ANGER; BEHAVIOR; BIOMECHANICS; BODY WEIGHT; DOUBLE-BLIND METHOD; GONADOTROPINS, PITUITARY; HUMANS; INJECTIONS, INTRAMUSCULAR; LIPIDS; MALE; MUSCLE, SKELETAL; SEX HORMONE-BINDING GLOBULIN; TESTOSTERONE; WEIGHT LIFTING;

EID: 8944233864     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199607043350101     Document Type: Article

References (40)

1. Wilson JD. Androgen abuse by athletes. Endocr Rev 1988;9:181-99.
2. Strauss RH, Yesalis CE. Anabolic steroids in the athlete. Annu Rev Med 1991;42:449-57.
3. Haupt HA, Rovere GD. Anabolic steroids: a review of the literature. Am J Sports Med 1984;12:469-84.
4. Cowart V. Steroids in sports: after four decades, time to return these genies to bottle? JAMA 1987;257:421-3.
5. Elashoff JD, Jacknow AD, Shain SG, Braunstein GD. Effects of anabolic-androgenic steroids on muscular strength. Ann Intern Med 1991;115: 387-93.
6. Wade N. Anabolic steroids: doctors denounce them, but athletes aren't listening. Science 1972;176:1399-403.
7. Buckley WE, Yesalis CE III, Friedl KE, Anderson WA, Streit AL, Wright JE. Estimated prevalence of anabolic steroid use among male high school seniors. JAMA 1988;260:3441-5.
8. Casaburi R, Storer T, Bhasin S. Androgen effects on body composition and muscle performance. In: Bhasin S, Gabelnick HL, Spieler JM, Swerdloff RS, Wang C, eds. Pharmacology, biology, and clinical applications of androgens: current status and future prospects. New York: Wiley-Liss, 1996:283-8.
9. American College of Sports Medicine. Position stand on the use of anabolic-androgenic steroids in sports. Med Sci Sports Exerc 1987;19:534-9.
10. Mooradian AD, Morley JE, Korenman SG. Biological actions of androgens. Endocr Rev 1987;8:1-28.
11. Kochakian CD. Comparison of protein anabolic property of various androgens in the castrated rat. Am J Physiol 1950;160:53-67.
12. Kenyon AT, Knowlton K, Sandiford I, Koch FC, Lotwin G. A comparative study of the metabolic effects of testosterone propionate in normal men and women and in eunuchoidism. Endocrinology 1940;26:26-45.
13. Bhasin S, Casaburi R, Berman N, et al. Replacement doses of testosterone increase lean body mass, muscle size and strength in hypogonadal men. Presented at the American Society of Andrology Meeting, Springfield, III., April 4-6, 1994. abstract.
14. Katznelson L, Finkelstein J, Baressi C, Klibanski A. Increase in trabecular bone density and altered body composition in androgen replaced hypogonadal men. In: Program and abstracts of the 76th Annual Meeting of the Endocrine Society, Anaheim, Calif, June 15-18, 1994. Bethesda, Md.: Endocrine Society Press, 1994:581. abstract.
15. Griggs RC, Kingston W, Jozefowicz RF, Herr BE, Forbes G, Halliday D. Effect of testosterone on muscle mass and muscle protein synthesis. J Appl Physiol 1989;66:498-503.
16. Ward P. The effect of an anabolic steroid on strength and lean body mass. Med Sci Sports 1973;5:277-82.
17. Johnson LC, Fisher G, Silvester LJ, Hofheins CC. Anabolic steroid: effects on strength, body weight, oxygen uptake, and spermatogenesis upon mature males. Med Sci Sports 1972;4:43-5.
18. Ariel G. The effect of anabolic steroid upon skeletal muscle contractile force. J Sports Med Phys Fitness 1973;13:187-90.
19. Hervey GR, Knibbs AV, Burkinshaw L, et al. Effects of methandienone on the performance and body composition of men undergoing athletic training. Clin Sci 1981;60:457-61.
20. Stamford BA, Moffatt R. Anabolic steroid: effectiveness as an ergogenic aid to experienced weight trainers. J Sports Med Phys Fitness 1974;14: 191-7
21. Win-May M, Mya-Tu M. The effect of anabolic steroids on physical fitness. J Sports Med Phys Fitness 1975;15:266-71.
22. Tahmindjis AJ. The use of anabolic steroids by athletes to increase body weight and strength. Med J Aust 1976;1:991-3.
23. Freed DLJ, Banks AJ, Longson D, Burley DM. Anabolic steroids in athletics: crossover double-blind trial on weightlifters. BMJ 1975; 2:471-3.
24. Johnson LC, O'Shea JP. Anabolic steroid: effects on strength development. Science 1969;164:957-9.
25. Bowers RW, Reardon JP. Effects of methandostenolone (Dianabol) on strength development and aerobic capacity. Med Sci Sports 1972;4:54. abstract.
26. Golding LA, Freydinger JE, Fishel SS. Weight, size, and strength - unchanged with steroids. Physician Sports Med 1974;2(6):39-43.
27. Stromme SB, Meen HD, Aakvaag A. Effects of an androgenic-anabolic steroid on strength development and plasma testosterone levels in normal males. Med Sci Sports 1974;6:203-8.
28. Fahey TD, Brown CH. The effects of an anabolic steroid on the strength, body composition, and endurance of college males when accompanied by a weight training program. Med Sci Sports 1973;5:272-6.
29. Casner SW Jr, Early RG, Carlson BR. Anabolic steroid effects on body composition in normal young men. J Sports Med Phys Fitness 1971;11:98-103.
30. Samuels LT, Henschel AF, Keys A. Influence of methyl testosterone on muscular work and creatine metabolism in normal young men. J Clin Endocrinol 1942;2:649-54.
31. Loughton SJ, Ruhling RO. Human strength and endurance responses to anabolic steroid and training. J Sports Med Phys Fitness 1977;17:285-96.
32. Crist DM, Stackpole PJ, Peake GT. Effects of androgenic-anabolic steroids on neuromuscular power and body composition. J Appl Physiol 1983; 54:366-70.
33. O'Shea JP, Winkler W. Biochemical and physical effects of an anabolic steroid in competitive swimmers and weightlifters. Nutr Rep Int 1970;2: 351-62.
34. Matsumoto AM. Is high dosage testosterone an effective male contraceptive agent? Fertil Steril 1988;50:324-8.
35. Practical testing and progress evaluation. In: Stone MH, O'Bryant HS. Weight training: a scientific approach. Edina, Minn.: Burgess International Group, 1987.
36. Tom L, Bhasin S, Salameh W, et al. Male contraception: induction of azoospermia in normal men with combined gonadotropin-releasing hormone antagonist and testosterone enanthate. J Clin Endocrinol Metab 1992;75:476-83.
37. Bhasin S, Swerdloff RS, Steiner BS, et al. A biodegradable testosterone microcapsule formulation provides uniform cugonadal levels of testosterone for 10-11 weeks in hypogonadal men. J Clin Endocrinol Metab 1992; 74:75-83.
38. Siegel JM. The Multidimensional Anger Inventory. J Pers Soc Psychol 1986;51:191-200.
39. Forbes GB. The effect of anabolic steroids on lean body mass: the dose response curve. Metabolism 1985;34:571-3.
40. Byerley LO, Lee WP, Buena F, et al. Effect of modulating serum testosterone in the normal male range on protein dynamics, carbohydrate and lipid metabolism. Endocr J 1993;1:253-9.