Sex hormones and frailty in older men: The osteoporotic fractures in men (MrOS) study

Journal of Clinical Endocrinology and Metabolism

Volumn 94, Issue 10, 2009, Pages 3806-3815

  Cawthon, Peggy M ^a   Ensrud, Kristine E ^b   Laughlin, Gail A ^c   Cauley, Jane A ^d   Dam, Thuy Tien L ^e   Barrett Connor, Elizabeth ^c   Fink, Howard A ^b,k   Hoffman, Andrew R ^f   Lau, Edith ^g   Lane, Nancy E ^h   Stefanick, Marcia L ⁱ   Cummings, Steven R ^a   Orwoll, Eric S ^j  

^a CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF PITTSBURGH   (United States)

^e Och Spine at New York Presbyterian Hospitals   (United States)

^f STANFORD UNIVERSITY MEDICAL CENTER   (United States)

^g Center for Health and Medical Research   (Hong Kong)

^h UNIVERSITY OF CALIFORNIA   (United States)

ⁱ STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^j OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^k VA MEDICAL CENTER   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ESTRADIOL; SEX HORMONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

AGED; ARTICLE; BIOAVAILABILITY; BODY SIZE; CONTROLLED STUDY; DISEASE ASSOCIATION; EXHAUSTION; FOLLOW UP; FRAGILITY FRACTURE; FRAIL ELDERLY; GAS CHROMATOGRAPHY; HEALTH STATUS; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MORTALITY; MUSCLE ATROPHY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SEX HORMONE DETERMINATION; TANDEM MASS SPECTROMETRY; WALKING SPEED; WEAKNESS;

EID: 70349918163     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-0417     Document Type: Article

References (35)

1. Fried LP, Walston J 1998 Frailty and failure to thrive. In: Hazzard WR, Blass JP, Ettinger WHJ, Halter JB, Ouslander J, eds. Principles of geriatric medicine and gerontology. 4th ed. New York: McGraw Hill; 1387-1402
2. Walston J, Hadley EC, Ferrucci L, Guralnik JM, Newman AB, Studenski SA, Ershler WB, Harris T, Fried LP 2006 Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc 54:991-1001 (Pubitemid 43847040)
3. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, McBurnie MA 2001 Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56:M146-156 (Pubitemid 32187141)
4. Bandeen-Roche K, Xue QL, Ferrucci L, Walston J, Guralnik JM, Chaves P, Zeger SL, Fried LP 2006 Phenotype of frailty: characterization in the women's health and aging studies. J Gerontol A Biol Sci Med Sci 61:262-266
5. Blaum CS, Xue QL, Michelon E, Semba RD, Fried LP 2005 The association between obesity and the frailty syndrome in older women: the Women's Health and Aging Studies. J Am Geriatr Soc 53: 927-934 (Pubitemid 41647587)
6. Ensrud KE, Ewing SK, Taylor BC, Fink HA, Stone KL, Cauley JA, Tracy JK, Hochberg MC, Rodondi N, Cawthon PM 2007 Frailty and risk of falls, fracture and mortality in older women: the study of osteoporotic fractures. J Gerontol A Biol Sci Med Sci 62:744-751 (Pubitemid 350143606)
7. Woods NF, LaCroix AZ, Gray SL, Aragaki A, Cochrane BB, Brunner RL, Masaki K, Murray A, Newman AB 2005 Frailty: emergence and consequences in women aged 65 and older in the Women's Health Initiative Observational Study. J Am Geriatr Soc 53:1321-1330 (Pubitemid 41602477)
8. Cawthon PM, Marshall LM, Michael Y, Dam TT, Ensrud KE, Barrett-Connor E, Orwoll ES 2007 Frailty in older men: prevalence, progression and relation to mortality. J Am Geriatr Soc 55:1216-1223
9. Kaufman JM, Vermeulen A 2005 The decline of androgen levels in elderly men and its clinical and therapeutic implications. Endocr Rev 26:833-876 (Pubitemid 41428540)
10. Bylow K, Mohile SG, Stadler WM, Dale W 2007 Does androgen-deprivation therapy accelerate the development of frailty in older men with prostate cancer? A conceptual review. Cancer 110:2604-2613 (Pubitemid 350250329)
11. Mohr BA, Bhasin S, Kupelian V, Araujo AB, O'Donnell AB, McKinlay JB 2007 Testosterone, sex hormone-binding globulin, and frailty in older men. J Am Geriatr Soc 55:548-555 (Pubitemid 46496587)
12. Blank JB, Cawthon PM, Carrion-Petersen ML, Harper L, Johnson JP, Mitson E, Delay RR 2005 Overview of recruitment for the osteoporotic fractures in men study (MrOS). Contemp Clin Trials 26:557-568 (Pubitemid 41242401)
13. Orwoll E, Blank JB, Barrett-Connor E, Cauley J, Cummings S, Ensrud K, Lewis C, Cawthon PM, Marcus R, Marshall LM, McGowan J, Phipps K, Sherman S, Stefanick ML, Stone K 2005 Design and baseline characteristics of the osteoporotic fractures in men (MrOS) study - a large observational study of the determinants of fracture in older men. Contemp Clin Trials 26:569-585 (Pubitemid 41242402)
14. Washburn RA, Smith KW, Jette AM, Janney CA 1993 The Physical Activity Scale for the Elderly (PASE): development and evaluation. J Clin Epidemiol 46:153-162
15. Ware J, Kosinski M, Keller S 1998 SF-12: How to score the SF-12 Physical and Mental Health Summary Scores. 3rd ed. Lincoln, RI: Quality Metric Incorporated
16. Pahor M, Chrischilles EA, Guralnik JM, Brown SL, Wallace RB, Carbonin P 1994 Drug data coding and analysis in epidemiologic studies. Eur J Epidemiol 10:405-411 (Pubitemid 24339205)
17. Södergård R, Bäckström T, Shanbhag V, Carstensen H 1982 Calculation of free and bound fractions of testosterone and estradiol-17 β to human plasma proteins at body temperature. J Steroid Biochem 16:801-810 (Pubitemid 13228095)
18. Vermeulen A, Verdonck L, Kaufman JM 1999 A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 84:3666-3672 (Pubitemid 30645223)
19. Institute of Medicine 2004 Testosterone and aging: clinical research directions. In: Liverman CT, Blazer DG, eds. Washington, DC: National Academies Press
20. Scott SC, Goldberg MS, Mayo NE 1997 Statistical assessment of ordinal outcomes in comparative studies. J Clin Epidemiol 50:45-55 (Pubitemid 27089206)
21. Matsumoto AM, Bremner WJ 2004 Serum testosterone assays - accuracy matters. J Clin Endocrinol Metab 89:520-524
22. Taieb J, Mathian B, Millot F, Patricot MC, Mathieu E, Queyrel N, Lacroix I, Somma-Delpero C, Boudou P 2003 Testosterone measured by 10 immunoassays and by isotope-dilution gas chromatography- mass spectrometry in sera from 116 men, women, and children. Clin Chem 49:1381-1395 (Pubitemid 36900626)
23. Wang C, Catlin DH, Demers LM, Starcevic B, Swerdloff RS 2004 Measurement of total serum testosterone in adult men: comparison of current laboratory methods versus liquid chromatography-tandem mass spectrometry. J Clin Endocrinol Metab 89:534-543 (Pubitemid 38269854)
24. Ensrud KE, Ewing SK, Taylor BC, Fink HA, Cawthon PM, Stone KL, Hillier TA, Cauley JA, Hochberg MC, Rodondi N, Tracy JK, Cummings SR 2008 Comparison of 2 frailty indexes for prediction of falls, disability, fractures, and death in older women. Arch Intern Med 168:382-389 (Pubitemid 351347130)
25. Ensrud KE, Ewing SK, Cawthon PM, Fink HA, Taylor BC, Cauley JA, Dam TT, Marshall LM, Orwoll ES, Cummings SR 2009 A comparison of frailty indexes for the prediction of falls, disability, fractures and mortality in older men. J Am Geriatr Soc 57:492-498
26. Mitnitski AB, Song X, Rockwood K 2004 The estimation of relative fitness and frailty in community-dwelling older adults using self-report data. J Gerontol A Biol Sci Med Sci 59:M627-M632 (Pubitemid 38869131)
27. Rockwood K, Howlett SE, MacKnight C, Beattie BL, Bergman H, Hébert R, Hogan DB, Wolfson C, McDowell I 2004 Prevalence, attributes, and outcomes of fitness and frailty in community-dwelling older adults: report from the Canadian study of health and aging. J Gerontol A Biol Sci Med Sci 59:1310-1317 (Pubitemid 40209418)
28. Studenski S, Hayes RP, Leibowitz RQ, Bode R, Lavery L, Walston J, Duncan P, Perera S 2004 Clinical global impression of change in physical frailty: development of a measure based on clinical judgment. J Am Geriatr Soc 52:1560-1566 (Pubitemid 39209608)
29. Muller M, Grobbee DE, Thijssen JH, van den Beld AW, van der Schouw YT 2003 Sex hormones and male health: effects on components of the frailty syndrome. Trends Endocrinol Metab 14:289-296 (Pubitemid 36988442)
30. Kilbourne EJ, Moore WJ, Freedman LP, Nagpal S 2007 Selective androgen receptor modulators for frailty and osteoporosis. Curr Opin Investig Drugs 8:821-829 (Pubitemid 47511879)
31. Ferrando AA, Sheffield-Moore M, Yeckel CW, Gilkison C, Jiang J, Achacosa A, Lieberman SA, Tipton K, Wolfe RR, Urban RJ 2002 Testosterone administration to older men improves muscle function: molecular and physiological mechanisms. Am J Physiol Endocrinol Metab 282:E601-E607 (Pubitemid 34654776)
32. Maggio M, Basaria S, Ble A, Lauretani F, Bandinelli S, Ceda GP, Valenti G, Ling SM, Ferrucci L 2006 Correlation between testosterone and the inflammatory marker soluble interleukin-6 receptor in older men. J Clin Endocrinol Metab 91:345-347 (Pubitemid 43069161)
33. Maggio M, Basaria S, Ceda GP, Ble A, Ling SM, Bandinelli S, Valenti G, Ferrucci L 2005 The relationship between testosterone and molecular markers of inflammation in older men. J Endocrinol Invest 28:116-119
34. Cesari M, Penninx BW, Pahor M, Lauretani F, Corsi AM, Rhys Williams G, Guralnik JM, Ferrucci L 2004 Inflammatory markers and physical performance in older persons: the In CHIANTI study. J Gerontol A Biol Sci Med Sci 59:242-248 (Pubitemid 38375337)
35. Hubbard RE, O'Mahony MS, Savva GM, Calver BL, Woodhouse KW6 March 2009 Inflammation and frailty measures in older people. J Cell Mol Med 10.1111/j.1582-4934.2009.00733.x