McCollum Award Lecture, 1996: Protein-energy malnutrition in maintenance dialysis patients

American Journal of Clinical Nutrition

Volumn 65, Issue 5, 1997, Pages 1544-1557

  Kopple, Joel D ^a  

^a HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN GROWTH HORMONE; RECOMBINANT SOMATOMEDIN C;

CALORIC INTAKE; CHRONIC KIDNEY FAILURE; CONTINUOUS AMBULATORY PERITONEAL DIALYSIS; HEMODIALYSIS; HUMAN; NITROGEN BALANCE; NUTRITIONAL REQUIREMENT; NUTRITIONAL SUPPORT; PERITONEAL DIALYSIS; PROTEIN CALORIE MALNUTRITION; REVIEW; RISK ASSESSMENT; RISK FACTOR;

EID: 0030897465     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/65.5.1544     Document Type: Review

References (134)

1. Kopple JD. Dietary considerations in patients with advanced chronic renal failure, acute renal failure and transplantation. In: Schrier R, Gottschalk C, eds. Diseases of the kidney. 6th ed. Boston: Little Brown and Company, 1997:2913-62.
2. Kopple JD. Abnormal amino acid and protein metabolism in uremia. Kidney Int 1978;14:340-8.
3. Kluthe R, Lüttgen FM, Capetianu T, Heinze V, Katz N, Sudhoff A. Protein requirements in maintenance hemodialysis. Am J Clin Nutr 1978;31:1812-20.
4. Young GA, Oli HI, Davidson AM, Parsons FM. The effects of calorie and essential amino acid supplementation on plasma proteins in patients with chronic renal failure. Am J Clin Nutr 1978;31:1802-7.
5. Guarnieri G, Faccini L, Lipartiti T, et al. Simple methods for nutritional assessment in hemodialyzed patients. Am J Clin Nutr 1980;33:1598-607.
6. Schoenfeld PY, Henry RR, Laird NM, et al. Assessment of nutritional status of the National Cooperative Dialysis Study population. Kidney Int 1983;23 (suppl 13):S80-8.
7. Heide B, Pierratos A, Khanna R, et al. Nutritional status of patients undergoing continuous ambulatory peritoneal dialysis (CAPD). Perit Dial Bull 1983;3:138-41.
8. Blumenkrantz MJ, Kopple JD, Gutman RA, et al. Methods for assessing nutritional status of patients with renal failure. Am J Clin Nutr 1980;33:1567-85.
9. Wolfson M, Strong CJ, Minturn D, Gray DK, Kopple JD. Nutritional status and lymphocyte function in maintenance hemodialysis patients. Am J Clin Nutr 1984;39:547-55.
10. Salusky IB, Fine RN, Nelson P, Blumenkrantz MJ, Kopple JD. Nutritional status of children undergoing continuous ambulatory peritoneal dialysis. Am J Clin Nutr 1983;38:599-611.
11. Fenton SS, Johnston N, Delmore T, et al. Nutritional assessment of continuous ambulatory peritoneal dialysis patients. ASAIO Trans 1987;33:650-3.
12. Cano N, Fernandez JP, Lacombe P, et al. Statistical selection of nutritional parameters in hemodialyzed patients. Proceedings of the Fourth International Congress on Nutrition and Metabolism in Renal Disease. Kidney Int 1987;32 (suppl 22): S178-80.
13. Marckmann P. Nutritional status of patients on hemodialysis and peritoneal dialysis. Clin Nephrol 1988;29:75-8.
14. Bilbrey GL, Cohen TL. Identification and treatment of protein calorie malnutrition in chronic hemodialysis patients. Dial Transplant 1989; 18:669-77, 700.
15. Young GA, Kopple JD, Lindholm B, et al. Nutritional assessment of continuous ambulatory peritoneal dialysis patients: an international study. Am J Kidney Dis 1991;17:462-71.
16. Kawaguchi Y, Sugino N, Arai J, et al. Nutritional assessment of patients on continuous ambulatory peritoneal dialysis. Jpn J Nephrol 1993;37:843-51.
17. Cianciaruso B, Brunori G, Kopple JD, et al. Cross-sectional comparison of malnutrition in continuous ambulatory peritoneal dialysis and hemodialysis patients. Am J Kidney Dis 1995;26:475-86.
18. Dwyer JT, Kopple JD, Maroni BJ, et al. Dietary intake and nutritional status in the HEMO pilot study population. J Am Soc Nephrol 1995;6:576 (abstr).
19. Acchiardo SR, Moore LW, Latour PA. Malnutrition as the main factor in morbidity and mortality of hemodialysis patients. Kidney Int 1983;24 (suppl 16):S199-203.
20. Teehan BP, Schleifer CR, Brown JM, et al. Urea kinetic analysis and clinical outcome on CAPD. A five year longitudinal study. Adv Perit Dial 1990;6:181-5.
21. Lowrie EG, Lew NL. Death risk in hemodialysis patients: the predictive value of commonly measured variables and an evaluation of death rate differences between facilities. Am J Kidney Dis 1990;15:458-82.
22. Churchill DN, Taylor DW, Cook RJ, et al. Canadian hemodialysis morbidity study. Am J Kidney Dis 1992;19:214-34.
23. Davis SJ, Russell L, Bryan J, Phillips L, Russell GI. Comorbidity, urea kinetics, and appetite in continuous ambulatory peritoneal dialysis patients: their interrelationship and prediction of survival. Am J Kidney Dis 1995;26:353-61.
24. Lowrie EG, Lew NL, Huang WH. Race and diabetes as death risk predictors in hemodialysis patients. Kidney Int 1992;42 (suppl 38):S22-31.
25. Keane WF, Collins AJ. Influence of co-morbidity on mortality and morbidity in patients treated with hemodialysis. Am J Kidney Dis 1994;24:1010-8.
26. Kaysen GA, Rathore V, Shearer GC, Depner TA. Mechanisms of hypoalbuminemia in hemodialysis patients. Kidney Int 1995;48:510-6.
27. Docci D, Bilancioni R, Baldrati L, et al. Elevated acute phase reactants in hemodialysis patients. Clin Nephrol 1990;34:88-91.
28. Qureshi AR, Anderstam B, Danielsson A, et al. Predictors of malnutrition in maintenance hemodialysis (HD) patients. J Am Soc Nephrol 1995;6:586 (abstr).
29. Bologa RM, Levine DM, Parker TS, et al. High cytokine levels may mediate the high mortality of hemodialysis (HD) patients with low albumin and/or cholesterol (TC). J Am Soc Nephrol 1995;6:573 (abstr).
30. Capelli JP, Kushner H, Camiscioli TC, et al. Effect of intradialytic parenteral nutrition on mortality rates in end-stage renal disease care. Am J Kidney Dis 1994;23:808-16.
31. Chertow GM, Ling J, Lew NL, et al. The association of intradialytic parenteral nutrition administration with survival in hemodialysis patients. Am J Kidney Dis 1994;24:912-20.
32. Modification of Diet in Renal Disease (MDRD) Study Group, Kopple JD, Berg R, et al. Nutritional status of patients with different levels of chronic renal insufficiency. Kidney Int 1989;36 (suppl 27):S184-94.
33. Modification of Diet in Renal Disease (MDRD) Study Group, Kopple JD, Chumlea WC, et al. Relationship between GFR and nutritional status - results from the MDRD study. J Am Soc Nephrol 1994;5:335 (abstr).
34. Bergström J, Mamoun H, Anderstam B, Södersten P. Middle molecules (MM) isolated from uremic ultrafiltrate (UF) and normal urine induce dose-dependent inhibition of appetite in the rat. J Am Soc Nephrol 1994;5:488 (abstr).
35. Ikizler TA, Wingard RB, Hakim RM. Interventions to treat malnutrition in dialysis patients: the role of the dose of dialysis, intradialytic parenteral nutrition, and growth hormone. Am J Kidney Dis 1995;26:256-65.
36. Grodstein GP, Blumenkrantz MJ, Kopple JD. Nutritional and metabolic response to catabolic stress in chronic uremia. Am J Clin Nutr 1980;33:1411-6.
37. Renal Data System. USRDS 1995 Annual Data Report. Bethesda, MD: National Institute of Diabetes and Digestive and Kidney Diseases, 1995.
38. Memoli B, Libetta C, Rampino T, et al. Hemodialysis related induction of interleukin-6 production by peripheral blood mononuclear cells. Kidney Int 1992;42:320-6.
39. Macdonald C, Rush DN, Bernstein KN, McKenna RM. Production of tumor necrosis factor alpha and hemodialysis. Nephron 1993;65:273-7.
40. Heidland A, Horl WH, Heller N, et al. Proteolytic enzymes and catabolism: enhanced release of granulocyte proteinases in uremic intoxication and during hemodialysis. Kidney Int 1983;24 (suppl 16):S27-36.
41. Haag-Weber M, Hable M, Schollmeyer P, et al. Metabolic response of neutrophils to uremia and dialysis. Kidney Int 1989;36 (suppl 27):S293-8.
42. Bergstrom J. Protein catabolic factors in patients on renal replacement therapy. Contrib Nephrol 1990;77:86-95.
43. Parker TF III, Wingard RL, Husni L, et al. Effect of the membrane biocompatibility on nutritional parameters in chronic hemodialysis patients. Kidney Int 1996;49:551-6.
44. Giordano C, de Pascale C, DeCristofaro D, et al. Protein malnutrition in the treatment of chronic uremia. In: Berlyne GM, ed. Nutrition in renal disease. Baltimore: Williams & Wilkins, 1968:23.
45. Kopple JD, Swendseid ME, Shinaberger JH, Umezawa CY. The free and bound amino acids removed by hemodialysis. Trans Am Soc Artif Intern Organs 1973;19:309-13.
46. Wolfson M, Jones MR, Kopple JD. Amino acid losses during hemodialysis with infusion of amino acids and glucose. Kidney Int 1982;21:500-6.
47. Ikizler TA, Flakoll PJ, Parker RA, Hakim RM. Amino acid and albumin losses during hemodialysis. Kidney Int 1994;46:830-7.
48. Chazot C, Shahmir E, Matias B, Kopple JD. Provision of amino acids by dialysis during maintenance hemodialysis (MHD). J Am Soc Nephrol 1995;6:574 (abstr).
49. Kaplan AA, Halley SE, Lapkin RA, Graeber CW. Dialysate protein losses with bleach processed polysulphone dialyzers. Kidney Int 1995;47:573-8.
50. Grodstein GP, Blumenkrantz MJ, Kopple JD, et al. Glucose absorption during continuous ambulatory peritoneal dialysis. Kidney Int 1981;19:564-7.
51. Giordano C, DeSanto NG, Capodicasa G, et al. Amino acid losses during CAPD. Clin Nephrol 1980;14:230-2.
52. Kopple JD, Blumenkrantz MJ, Jones MR, Moran JK, Coburn JW. Plasma amino acid levels and amino acid losses during continuous ambulatory peritoneal dialysis. Am J Clin Nutr 1982;36:395-402.
53. Blumenkrantz MJ, Gahl GM, Kopple JD, et al. Protein losses during peritoneal dialysis. Kidney Int 1981;19:593-602.
54. Sullivan JF, Eisenstein AB, Mottola OM, Mittal AK. The effect of dialysis on plasma and tissue levels of vitamin C. Trans Am Soc Artif Intern Organs 1972;18:277-82.
55. Hemmeloff Anderson KE. Folic acid status of patients with chronic renal failure maintained by dialysis. Clin Nephrol 1977;8:510-3.
56. Chazot C, Kopple JD. Vitamin metabolism and requirements in renal disease and renal failure. In: Kopple JD, Massry SG, eds. Nutritional management of renal disease. Baltimore: Williams and Wilkins, 1997;415-77.
57. Linton AL, Clark WF, Driedger AA, et al. Correctable factors contributing to the anemia of dialysis patients. Nephron 1977;19:95-8.
58. Rosenblatt SG, Drake S, Fadem S, et al. Gastrointestinal blood loss in patients with chronic renal failure. Am J Kidney Dis 1982;1:232-6.
59. De Fronzo RA, Tobin JD, Rowe JW, Andres R. Glucose intolerance in uremia: quantification of pancreatic beta cell sensitivity to glucose and tissue sensitivity to insulin. J Clin Invest 1978;62:425-35.
60. Phillips LS, Kopple JD. Circulating somatomedin activity and sulfate levels in adults with normal and impaired kidney function. Metabolism 1981;30:1091-5.
61. Fouque D, Peng SC, Kopple JD. Impaired metabolic response to recombinant insulin-like growth factor 1 in dialysis patients. Kidney Int 1995;47:876-83.
62. Sherwin RS, Bastl C, Finkelstein FO, et al. Influence of uremia and hemodialysis on the turnover and metabolic effects of glucagon. J Clin Invest 1976;57:722-31.
63. Moxley MA, Bell NH, Wagle SR, et al. Parathyroid hormone stimulation of glucose and urea production in isolated liver cells. Am J Physiol 1974;227:1058-61.
64. Birge SJ, Haddad JG. 25-Hydroxycholecalciferol stimulation of muscle metabolism. J Clin Invest 1975;56:1100-7.
65. Kopple JD. Products of nitrogen metabolism and their toxicity. In: Massry SG, Glassock RJ, eds. Textbook of nephrology. Vol 2. 3rd ed. Baltimore: Williams and Wilkins, 1995:1317-24.
66. Bergström J. Uremic toxicity. In: Kopple JD, Massry SG, eds. Nutritional management of renal disease. Baltimore: Williams and Wilkins, 1997:97-190.
67. Reaich D, Channon SM, Scrimgeour CM, Goodship TN. Ammonium chloride-induced acidosis increases protein breakdown and amino acid oxidation in humans. Am J Physiol 1992;263:E735-9.
68. Ballmer PE, McNurlan MA, Hulter HN, et al. Chronic metabolic acidosis decreases albumin synthesis and induces negative nitrogen balance in humans. J Clin Invest 1995;95:39-45.
69. Schoolwerth AC, Drewnowska K. Renal cell metabolism. In: Massry SG, Glassock RJ, eds. Massry & Glassock's textbook of nephrology. Vol 1. 3rd ed. Baltimore: Williams and Wilkins 1995:123-37.
70. Drueke TB, Lacour B, Touam M, et al. Effect of aluminum on hematopoiesis. Kidney Int 1986;29 (suppl 18):S45-8.
71. Coburn JW, Alfrey AC. Aluminum toxicity. In: Massry SG, Glassock RJ, eds. Massry & Glassock's textbook of nephrology. Vol 2. 3rd ed. Baltimore: Williams and Wilkins, 1995:1303-17.
72. Salusky IB, Fine RN, Nelson P, Kopple JD. Growth and nutritional status in children receiving CAPD. Kidney Int 1983;23:159 (abstr).
73. Kopple JD. Nutrition in renal failure. Causes of catabolism and wasting in acute or chronic renal failure. In: Robinson RR, ed. Nephrology. Vol 2. Proceedings of the IXth International Congress of Nephrology. New York: Springer-Verlag, 1984:1498-515.
74. Walser M. Does prolonged protein restriction preceding dialysis lead to protein malnutrition at the onset of dialysis? Kidney Int 1993;44:1139-44.
75. Ginn HE, Frost A, Lacy WW. Nitrogen balance in hemodialysis patients. Am J Clin Nutr 1968;21:385-93.
76. Kopple JD, Shinaberger JH, Coburn JW, et al. Optimal dietary protein treatment during chronic hemodialysis. Trans Am Soc Artif Intern Organs 1969;15:302-8.
77. Borah M, Schoenfeld PY, Gotch FA, et al. Nitrogen balance during intermittent hemodialysis therapy of uremia. Kidney Int 1978;14:491-500.
78. Giordano C, DeSanto NG, Pluvio M, et al. Protein requirement of patients on CAPD: a study on nitrogen balance. Int J Artif Organs 1980;3:11-4.
79. Lindholm B, Alvestrand A, Furst P, et al. Metabolic effects of continuous ambulatory peritoneal dialysis. Proc Eur Dial Transplant Assoc 1980;17:283-90.
80. Bergström J, Fürst P, Alvestrand A, Lindholm B. Protein and energy intake, nitrogen balance and nitrogen losses in patients treated with continuous ambulatory peritoneal dialysis. Kidney Int 1993;44:1048-57.
81. Blumenkrantz MJ, Kopple JD, Moran JK, Coburn JW. Metabolic balance studies and dietary protein requirements in patients undergoing continuous ambulatory peritoneal dialysis. Kidney Int 1982;21:849-61.
82. Slomowitz LA, Monteon FJ, Grosvenor M, et al. Effect of energy intake on nutritional status in maintenance hemodialysis patients. Kidney Int 1989;35:704-11.
83. Baeyer HV, Gahl GM, Riedinger H, et al. Unexpected alteration of nutritional habits in patients undergoing CAPD. In: Gahl GM, Kessel M, Nolph KD, eds. Advances in peritoneal dialysis. Amsterdam: Excerpta Medica, 1981:408-12.
84. Lindholm B, Bergström J. Nutritional aspects of peritoneal dialysis. Kidney Int 1993;42 (suppl 38):165-71.
85. Monteon FJ, Laidlaw SA, Shaib JK, Kopple JD. Energy expenditure in patients with chronic renal failure. Kidney Int 1986;30:741-7.
86. Schneeweiss B, Graninger W, Stockenhuber F, et al. Energy metabolism in acute and chronic renal failure. Am J Clin Nutr 1990;52:596-601.
87. Kopple JD, Monteon FJ, Shaib JK. Effect of energy intake on nitrogen metabolism in nondialyzed patients with chronic renal failure. Kidney Int 1986;29:734-42.
88. National Research Council. Recommended dietary allowances. 10th ed. Washington, DC: National Academy Press, 1989.
89. Moore LW, Fedje L. Diet plans and oral and enteral nutritional supplements for acute and chronic renal failure. In: Kopple JD, Massry SG, eds. Nutritional management of renal disease. Baltimore: Williams and Wilkins, 1997:857-76.
90. Hecking E, Köhler H, Zobel R, et al. Treatment with essential amino acids in patients on chronic hemodialysis: a double blind cross-over study. Am J Clin Nutr 1978;31:1821-6.
91. Phillips ME, Havard J, Howard JP. Oral essential amino acid supplementation in patients on maintenance hemodialysis. Clin Nephrol 1978;9:241-8.
92. Allman MA, Stewart PM, Tiller DJ, Horvath JS, Duggin GG, Truswell AS. Energy supplementation and the nutritional status of hemodialysis patients. Am J Clin Nutr 1990;51:558-62.
93. Kohaut EC, CAPD in infants. In: Fine RN, ed. Chronic ambulatory peritoneal dialysis and chronic cycling peritoneal dialysis in children. Boston: Martinus Nijhoff, 1987:77.
94. Brewer E. Supplemental enteral tube feeding in infants undergoing dialysis-indications and outcome. Semin Dial 1994;7:429-34.
95. Warady BA, Weis L, Johnson L. Nasogastric tube feeding in infants on peritoneal dialysis. Perit Dial Int (in press).
96. Heidland A, Kult J. Long-term effects of essential amino acids supplementation in patients on regular dialysis treatment. Clin Nephrol 1975;3:234-9.
97. Thunberg B, Jain VK, Patterson PG, et al. Nutritional measurements and urea kinetics to guide intradialytic hyperalimentation. Proc Clin Dial Transplant Forum 1980;10:22-8.
98. Piraino AJ, Firpo JJ, Powers DV. Prolonged hyperalimentation in catabolic chronic dialysis therapy patients. JPEN J Parenter Enteral Nutr 1981;5:463-77.
99. R (amino acid injection) formulated for renal failure. In: Kinney JM, Brown PR, eds. Perspectives in clinical nutrition. Baltimore: Urban & Schwarzenberg, 1989:191-205.
100. Olshan A, Bruce J, Schwartz A. Intradialytic parenteral nutrition administration during outpatient hemodialysis. Dial Transplant 1987;16:495-6.
101. Bilbrey GL. Is intradialytic parenteral nutrition of benefit in hemodialysis patients? In: Lazarus JM, ed. Semin Dial 1993;6:168-70.
102. Cano N, Labastie-Coeyrehourq J, Lacombe P, et al. Perdialytic parenteral nutrition with lipids and amino acids in malnourished hemodialysis patients. Am J Clin Nutr 1990;52:726-30.
103. Madigan KM, Olshan A, Yingling DJ. Effectiveness of intradialytic parenteral nutrition in diabetic patients with end-stage renal disease. J Am Diet Assoc 1990;90:861-3.
104. Snyder S, Bergen C, Sigler MH, Teehan BP. Intradialytic parenteral nutrition in chronic hemodialysis patients. ASAIO Trans 1991;37:M373-5.
105. Schulman G, Wingard RL, Hutchison RL, et al. The effects of recombinant human growth hormone and intradialytic parenteral nutrition in malnourished hemodialysis patients. Am J Kidney Dis 1993;21:527-34.
106. Ruggian JC, Fishbane S, Frei GL. Effect of intradialytic parenteral nutrition (IDPN) on hypoalbuminemic hemodialysis (HD) patients. J Am Soc Nephrol 1994;5:502 (abstr).
107. Chan A, Cochran C, Harbert G, et al. Use of intradialytic parenteral nutrition: an end-stage renal disease network perspective. J Renal Nutr 1994;4:11-4.
108. Foulks CJ. Intradialytic parenteral nutrition. In: Kopple JD, Massry SG, eds. Nutritional management of renal disease. Baltimore: Williams and Wilkins, 1997:601-18.
109. Feinstein EI, Collins JF, Blumenkrantz MJ, et al. Nutritional hemodialysis. Prog Artif Organs 1983;1:421-6.
110. Oreopoulos DG, Marliss E, Anderson GH, et al. Nutritional aspects of CAPD and the potential use of amino acid containing dialysis solutions. Perit Dial Bull 1983; (suppl 3):S10-2.
111. Young GA, Dibble JB, Hobson SM, et al. The use of an amino-acid based CAPD fluid over 12 weeks. Nephrol Dial Transplant 1989;4:285-92.
112. Jones MR, Martis L, Algrim CE, et al. Amino acid solutions for CAPD: rationale and clinical experience. Miner Electrolyte Metab 1992;18:309-15.
113. Kopple JD, Bernard D, Swartz R, et al. Treatment of malnourished CAPD patients with an amino acid based dialysate. Kidney Int 1995;47:1148-57.
114. Jones M, Hagen T, Vonesh E, et al. Use of a 1.1% amino-acid (AA) dialysis solution to treat malnutrition in peritoneal dialysis (PD) patients. J Am Soc Nephrol 1995;6:580 (abstr).
115. von Roenn JH, Murphy RL, Weber KM, et al. Megestrol acetate for treatment of cachexia associated with human immunodeficiency virus (HIV) infection. Ann Intern Med 1988;109:840-1.
116. Loprinzi CL, Ellison NH, Schaid DJ, et al. Controlled trial of megestrol acetate for the treatment of cancer anorexia and cachexia. J Natl Cancer Inst 1990;82:1127-32.
117. Lindner A, Tenckhoff H. Nitrogen balance in patients on maintenance peritoneal dialysis. Trans Am Soc Artif Intern Organs 1970;16:255-9.
118. Lindner A, Tenckhoff H. Influence of anabolic steroids on nitrogen balance in chronic peritoneal dialysis. Nephron 1972;9:77-85.
119. Langsford KS, Miell JP. The insulin-like growth factor-1/binding protein axis: physiology, pathophysiology and therapeutic manipulation. Eur J Clin Invest 1993;23:503-16.
120. Strobl JS, Thomas MJ. Human growth hormone. Pharmacol Rev 1994;46:1-34.
121. Feld S, Hirschberg R. Growth hormone, the IGF-system and the kidney. Endocrinol Rev 1996;17:423-80.
122. Hokken-Koelega ACS, Stijnen T, de Muinck Keizer-Schrama SMPF, et al. Placebo-controlled, double-blind, cross-over trial of growth hormone treatment in prepubertal children with chronic renal failure. Lancet 1991;338:585-90.
123. Fine RN, Kohaut EC, Brown D, Perlman AJ. Growth after recombinant human growth hormone treatment in children with chronic renal failure: report of a multicenter randomized double-blind placebo-controlled study. J Pediatr 1994;124:374-82.
124. Broyer M, Guest G, Crosnier H, Berard E. Recombinant growth hormone in children after renal transplantation. Lancet 1994;343:539-40.
125. Jiang Z-M, He G-Z, Zhang S-Y, et al. Low-dose growth hormone and hypocaloric nutrition attenuate the protein-catabolic response after major operation. Ann Surg 1989;210:513-25.
126. Ponting GA, Halliday D, Teale JD, Sim AJW. Postoperative positive nitrogen balance with intravenous hyponutrition and growth hormone. Lancet 1988;1:438-40.
127. Wilmore DW. Catabolic illness. Strategies for enhancing recovery. N Engl J Med 1991;325:695-702.
128. Saito H, Taniwaka K, Hiramatu T, Morioka Y. Growth hormone treatment enhances immune function in surgically stressed rats. JPEN J Parenter Enteral Nutr 1990;14:105 (abstr).
129. Belcher HJCR, Mercer D, Judkins KC, et al. Biosynthetic human growth hormone in burned patients: a pilot study. Burns 1989;15:99-107.
130. Dahn MS, Lange P, Jacobs LA. Insulin-like growth factor-1 production is inhibited in human sepsis. Arch Surg 1988;123:1409-14.
131. Clemmons DR, Underwood LE. Nutritional regulation of IGF-1 and IGF binding proteins. Annu Rev Nutr 1991;11:393-412.
132. Ziegler TR, Lazarus JM, Young LS, et al. Effects of recombinant human growth hormone in adults receiving maintenance hemodialysis. J Am Soc Nephrol 1991;2:1130-5.
133. Kopple JD. The rationale for the use of growth hormone or insulin-like growth factor 1 in adult patients with renal failure. Miner Electrolyte Metab 1992;18:269-75.
134. Shahmir E, Peng S, Fouque D, Kopple JD. Effect of insulin-like growth factor 1 (IGF-1) on nitrogen balance in malnourished CAPD patient. J Am Soc Nephrol 1995;6:587 (abstr).