Leptin and inflammation-associated cachexia in chronic kidney disease

Kidney International

Volumn 69, Issue 5, 2006, Pages 794-797

  Mak, R H ^a,b   Cheung, W ^a   Cone, R D ^b   Marks, D L ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Cachexia; Chronic kidney disease; Cytokines; Inflammation; Leptin; Melanocortin

Indexed keywords

AGOUTI RELATED PROTEIN; CYTOKINE; HORMONE RECEPTOR BLOCKING AGENT; LEPTIN; LEPTIN RECEPTOR; MELANOCORTIN; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR; PEPTIDE DERIVATIVE;

APPETITE; BASAL METABOLIC RATE; BODY COMPOSITION; CACHEXIA; CHRONIC KIDNEY DISEASE; CLINICAL FEATURE; DISEASE ASSOCIATION; DRUG MECHANISM; ENERGY; FOOD INTAKE; HOMEOSTASIS; HUMAN; HYPOTHALAMUS; INFLAMMATION; KNOCKOUT MOUSE; LEAN BODY WEIGHT; METABOLIC RATE; MOUSE STRAIN; NEPHRECTOMY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TRANSPORT; SHORT SURVEY; SIGNAL TRANSDUCTION; UREMIA; WEIGHT GAIN;

ANIMALS; APPETITE; CACHEXIA; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; KIDNEY FAILURE, CHRONIC; LEPTIN; MELANOCYTE-STIMULATING HORMONES; MICE; RECEPTORS, CELL SURFACE; RECEPTORS, MELANOCORTIN; SIGNAL TRANSDUCTION;

EID: 33644554532     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ki.5000182     Document Type: Short Survey

References (32)

1. Zhang Y, Procena R, Maffei M et al. Positional cloning of the mouse obese gene and its human homologues. Nature 1994; 372: 425-432.
2. Gaucher EA, Miyamoto MM, Benner SA. Evolutionary, structural and biochemical evidence for a new interaction site of the leptin obesity protein. Genetics 2003; 163: 1549-1553.
3. Targlia LA, Dembski M, Weng X et al. Identification and expression cloning of a leptin receptor OB-R. Cell 1995; 83: 1263-1271.
4. Lee GH, Proenca R, Montez JM et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996; 379: 632-635.
5. Lammert A, Kiess W, Bottner A et al. Soluble leptin receptor represents the main leptin binding activity in human blood. Biochem Biophy Res Commun 2001; 283: 982-988.
6. Zhang F, Chen Y, Heiman M, Dimarchi R. Leptin: structure, function and biology. Vitam Horm 2005; 71: 345-372.
7. Banks WA, Kastin AJ, Huang W et al. Leptin enters the brain by a saturable system independent of insulin. Peptides 1996; 17: 305-311.
8. Hileman SM, Tornoe J, Flier JS et al. Transcellular transport of leptin by the short leptin isoform ObRa in Madin-Darby Canine kidney cells. Distribution of leptin receptor rRNA isoforms in the rat brain. Endocrinology 2000; 141: 1955-1961.
9. Bryson JM. The future of leptin and leptin analogues in the treatment of obesity. Diabetes Obes Metabol 2000; 2: 83-89.
10. Halaas JL, Boozer C, Blair-West J et al. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc Natl Acad Sci USA 1997; 94: 8878-8883.
11. Takaya K, Ogawa Y, Hiradoka J et al. Nonsense mutation of leptin receptor in the obese spontaneously hypertensive Koletsky rat. Nat Genet 1996; 14: 130-131.
12. Schwartz MW, Morton GJ. Keeping hunger at bay. Nature 2002; 418: 595-597.
13. Horvath TL. The hardship of obesity: a soft-wired hypothalamus. Nature Neurosci 2005; 8: 561-565.
14. Cone RD. Anatomy and regulation of the central melanocortin system. Nature Neurosci 2005; 8: 571-578.
15. Cowley MA, Smart JL, Rubinstein M et al. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 2001; 411: 480-484.
16. Shamsuzzaman AS, Winnicki M, Wolk R et al. Independent association between plasma leptin and CRP in healthy humans. Circulation 2004; 109: 2181-2185.
17. Ble A, Windham G, Bandinelli S et al. Relation of plasma leptin to C-reactive protein in older adults. Am J Cardiol 2005; 96: 991-995.
18. Hukshorn CJ, Lindeman JH, Toet KH et al. Leptin and the proinflammatory state associated with human obesity. J Clin Endocrinol Metab 2004; 89: 1773-1778.
19. Dowidar NL, Dejong CHC, Fearson KCH et al. Effects of leptin on isolated human hepatocyte C reactive protein production. Eur J Gastroenterol Hepatol 2000; 12: A18.
20. Wang Y, Kuropetwinski KK, White DW et al. Leptin receptor action in hepatic cells. J Biol Chem 1997; 272: 16216-16223.
21. Cumin F, Baum HP, De Gasparo M, Levens N. Leptin is cleared from the circulation primarily by the kidney. Int J obes Relat Metab Disord 1997; 21: 495-504.
22. Sharma K, Considine RV, Michael B et al. Plasma leptin is partly cleared by the kidney and is elevated in hemodialysis patients. Kidney Int 1997; 51: 1980-1985.
23. Teta D, Bevington A, Brown J et al. Effect of acidosis on leptin secretion from 3T3 adipocytes and on serum leptin in the uraemic rat. Clin Sci 1999; 97: 363-368.
24. Nordfors L, Lonnqvist F, Heimburger O et al. Low leptin gene expression and hyperleptinemia in chronic renal failure. Kidney Int 1998; 54: 1267-1275.
25. Stenvinkel P, Lindholm B, Lonnqvist F et al. Increases in serum leptin levels during peritoneal dialysis are associated with inflammation and a decrease in lean body mass. J Am Soc Nephrol 2000; 11: 1303-1309.
26. Pecoits-Filho R, Nordfors L, Heimburger O et al. Soluble leptin receptors and serum leptin in end-stage renal disease: relationship with inflammation and body composition. Eur J Clin Invest 2002; 32: 811-817.
27. Voegeling S, Fantuzzi G. Regulation of free and bound leptin and soluble leptin receptors during inflammation in mice. Cytokine 2001; 14: 97-103.
28. Huang QH, Hruby VJ, Tatro JB. Role of central melanocortins in endotoxin-induced anorexia. Am J Physiol 1999; 276: R864-R871.
29. Marks DL, Ling N, Cone RD. Role of central melanocortin system in cachexia. Cancer Res 2001; 61: 1432-1438.
30. Cheung W, Yu PX, Little BM et al. Role of leptin and melanocortin signaling in uremia-associated cachexia. J Clin Invest 2005; 115: 1659-1665.
31. Madiehe AM, Mitchell TD, Harris RB. Hyperleptinemia and reduced TNF-alpha secretion cause resistance of db/db mice to endotoxin. Am J Physiol Regul Integr Comp Physiol 2003; 284: R763-R770.
32. Daschner M, Tonshoff B, Blum WF et al. Inappropriate elevate of serum leptin in children with chronic renal failure. European Study Group for Nutritional Treatment of Chronic Renal Failure in Childhood. J Am Soc Nephrol 1998; 9: 1074-1079.