Inflammation and insulin resistance as novel mechanisms of wasting in chronic dialysis patients

Seminars in Dialysis

Volumn 22, Issue 6, 2009, Pages 652-657

  Da Costa, José Abrão Cardeal ^a   Alp Ikizler, T ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHRONIC KIDNEY FAILURE; ENERGY METABOLISM; HUMAN; INFLAMMATION; INSULIN RESISTANCE; PATHOPHYSIOLOGY; PREVALENCE; PROTEIN CALORIE MALNUTRITION; RENAL REPLACEMENT THERAPY; RISK FACTOR;

ENERGY METABOLISM; HUMANS; INFLAMMATION; INSULIN RESISTANCE; KIDNEY FAILURE, CHRONIC; PREVALENCE; PROTEIN-ENERGY MALNUTRITION; RENAL DIALYSIS; RISK FACTORS;

EID: 71549152286     PISSN: 08940959     EISSN: 1525139X     Source Type: Journal    
DOI: 10.1111/j.1525-139X.2009.00664.x     Document Type: Article

References (45)

1. Collins AJ, Foley R, Herzog C, Chavers B, Gilbertson D, Ishani A, Kasiske B, Liu J, Mau LW, McBean M, Murray A, St Peter W, Xue J, Fan Q, Guo H, Li Q, Li S, Peng Y, Qiu Y, Roberts T, Skeans M, Snyder J, Solid C, Wang C, Weinhandl E, Zaun D, Zhang R, Arko C, Chen SC, Dalleska F, Daniels F, Dunning S, Ebben J, Frazier E, Hanzlik C, Johnson R, Sheets D, Wang X, Forrest B, Constantini E, Everson S, Eggers P, Agodoa L : Excerpts from the United States Renal Data System 2007 annual data report. Am J Kidney Dis 51 : S1 S320, 2008
2. Pupim LB, Cuppari L, Ikizler TA : Nutrition and metabolism in kidney disease. Semin Nephrol 26 : 134 157, 2006
3. Fouque D, Kalantar-Zadeh K, Kopple J, Cano N, Chauveau P, Cuppari L, Franch H, Guarnieri G, Ikizler TA, Kaysen G, Lindholm B, Massy Z, Mitch W, Pineda E, Stenvinkel P, Trevinho-Becerra A, Wanner C : A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease. Kidney Int 73 : 391 398, 2008
4. Ikizler TA, Hakim RM : Nutrition in end-stage renal disease. Kidney Int 50 : 343 357, 1996
5. Ikizler TA, Wingard RL, Harvell J, Shyr Y, Hakim RM : Association of morbidity with markers of nutrition and inflammation in chronic hemodialysis patients: a prospective study. Kidney Int 55 : 1945 1951, 1999
6. Ikizler TA, Wingard RL, Sun M, Harvell J, Parker RA, Hakim RM : Increased energy expenditure in hemodialysis patients. J Am Soc Nephrol 7 : 2646 2653, 1996
7. Ikizler T, Flakoll P, Parker R, Hakim R : Amino acid and albumin losses during hemodialysis. Kidney Int 46 : 830 837, 1994
8. Motil KJ, Matthews DE, Bier DM, Burke JF, Munro HN, Young VR : Whole-body leucine and lysine metabolism: response to dietary protein intake in young men. Am J Physiol 240 : E712 E721, 1981
9. Owen WF, Lowrie EG : C-reactive protein as an outcome predictor for maintenance hemodialysis patients. Kidney Int 54 : 627 636, 1998
10. Yeun JY, Levine RA, Mantadilok V, Kaysen GA : C-reactive protein predicts all-cause and cardiovascular mortality in hemodialysis patients. Am J Kidney Dis 35 : 469 476, 2000
11. Zimmermann J, Herrlinger S, Pruy A, Metzger T, Wanner C : Inflammation enhances cardiovascular risk and mortality in hemodialysis patients. Kidney Int 55 : 648 658, 1999
12. Zoccali C, Benedetto FA, Mallamaci F, Tripepi G, Fermo I, Foca A, Paroni R, Malatino LS : Inflammation is associated with carotid atherosclerosis in dialysis patients. Creed Investigators. Cardiovascular Risk Extended Evaluation in Dialysis Patients. J Hypertens 18 : 1207 1213, 2000
13. Iseki K, Tozawa M, Yoshi S, Fukiyama K : Serum C-reactive protein (CRP) and risk of death in chronic dialysis patients. Nephrol Dial Transplant 14 : 1956 1960, 1999
14. Noh H, Lee SW, Kang SW, Shin SK, Choi KH, Lee HY, Han DS : Serum C-reactive protein: a predictor of mortality in continuous ambulatory peritoneal dialysis patients. Perit Dial Int 18 : 387 394, 1998
15. Kimmel PL, Phillips TM, Simmens SJ, Peterson RA, Weihs KL, Alleyne S, Cruz I, Yanovski JA, Veis JH : Immunologic function and survival in hemodialysis patients. Kidney Int 54 : 236 244, 1998
16. Stenvinkel P, Heimburger O, Paultre F, Diczfalusy U, Wang T, Berglund L, Jogestrand T : Strong association between malnutrition, inflammation, and atherosclerosis in chronic renal failure. Kidney Int 55 : 1899 1911, 1999 (Pubitemid 29197978)
17. Eustace JA, Astor B, Muntner PM, Ikizler TA, Coresh J : Prevalence of acidosis and inflammation and their association with low serum albumin in chronic kidney disease. Kidney Int 65 : 1031 1040, 2004
18. Ramos LF, Shintani A, Ikizler TA, Himmelfarb J : Oxidative stress and inflammation are associated with adiposity in moderate to severe CKD. J Am Soc Nephrol 19 : 593 599, 2008
19. Kaysen GA : The microinflammatory state in uremia: causes and potential consequences. J Am Soc Nephrol 12 : 1549 1557, 2001
20. Caglar K, Peng Y, Pupim LB, Flakoll PJ, Levenhagen D, Hakim RM, Ikizler TA : Inflammatory signals associated with hemodialysis. Kidney Int 62 : 1408 1416, 2002
21. Zubrod CG, Eversole SL, Dana GW : Amelioration of diabetes and striking rarity of acidosis in patients with Kimmelstiel-Wilson lesions. N Engl J Med 245 : 518 528, 1951
22. Rabkin R, Simon NM, Steiner S, Colwell JA : Effect of renal disease on renal uptake and excretion of insulin in man. N Engl J Med 282 : 182 187, 1970
23. DeFronzo RA, Smith D, Alvestrand A : Insulin action in uremia. Kidney Int Suppl 16 : S102 S114, 1983
24. Chen J, Muntner P, Hamm LL, Jones DW, Batuman V, Fonseca V, Whelton PK, He J : The metabolic syndrome and chronic kidney disease in U.S. adults. Ann Intern Med 140 : 167 174, 2004
25. Kurella M, Lo JC, Chertow GM : Metabolic syndrome and the risk for chronic kidney disease among nondiabetic adults. J Am Soc Nephrol 16 : 2134 2140, 2005
26. Price SR, Du JD, Bailey JL, Mitch WE : Molecular mechanisms regulating protein turnover in muscle. Am J Kidney Dis 37 : S112 S114, 2001
27. Lee SW, Dai G, Hu Z, Wang X, Du J, Mitch WE : Regulation of muscle protein degradation: coordinated control of apoptotic and ubiquitin-proteasome systems by phosphatidylinositol 3 kinase. J Am Soc Nephrol 15 : 1537 1545, 2004
28. Wolf M, Thadhani R : Beyond minerals and parathyroid hormone: role of active vitamin D in end-stage renal disease. Semin Dial 18 : 302 306, 2005
29. Mak RH : 1,25-Dihydroxyvitamin D3 corrects insulin and lipid abnormalities in uremia. Kidney Int 53 : 1353 1357, 1998
30. Cade C, Norman AW : Vitamin D3 improves impaired glucose tolerance and insulin secretion in the vitamin D-deficient rat in vivo. Endocrinology 119 : 84 90, 1986
31. Mak RH : Effect of metabolic acidosis on insulin action and secretion in uremia. Kidney Int 54 : 603 607, 1998
32. Siew ED, Pupim LB, Majchrzak KM, Shintani A, Flakoll PJ, Ikizler TA : Insulin resistance is associated with skeletal muscle protein breakdown in non-diabetic chronic hemodialysis patients. Kidney Int 71 : 71, 2007
33. Ikizler TA : Nutrition, inflammation and chronic kidney disease. Curr Opin Nephrol Hypertens 17 : 162 167, 2008
34. Flores EA, Bistrian BR, Pomposelli JJ, Dinarello CA, Blackburn GL, Istfan NW : Infusion of tumor necrosis factor/cachectin promotes muscle catabolism in the rat. A synergistic effect with interleukin 1. J Clin Invest 83 : 1614 1622, 1989
35. Kalantar-Zadeh K, Block G, McAllister CJ, Humphreys MH, Kopple JD : Appetite and inflammation, nutrition, anemia, and clinical outcome in hemodialysis patients. Am J Clin Nutr 80 : 299 307, 2004
36. Chen Y, Sun D, Krishnamurthy VM, Rabkin R : Endotoxin attenuates growth hormone-induced hepatic insulin-like growth factor I expression by inhibiting JAK2/STAT5 signal transduction and STAT5b DNA binding. Am J Physiol Endocrinol Metab 292 : E1856 E1862, 2007
37. Flakoll PJ, Carlson M, Cherrington AC : Physiological action of insulin. In : Leroith DTS, Olefsky J (eds). Diabetes Mellitus: A Fundamental and Clinical Text, 2nd edn. Philadelphia, PA : Williams & Wilkins, 2000 : 148 161
38. Biolo G, Inchiostro S, Tiengo A, Tessari P : Regulation of postprandial whole-body proteolysis in insulin-deprived IDDM. Diabetes 44 : 203 209, 1995
39. Bohe J, Rennie MJ : Muscle protein metabolism during hemodialysis. J Ren Nutr 16 : 3 16, 2006
40. Pupim LB, Flakoll PJ, Majchrzak KM, Aftab Guy DL, Stenvinkel P, Ikizler TA : Increased muscle protein breakdown in chronic hemodialysis patients with type 2 diabetes mellitus. Kidney Int 68 : 1857 1865, 2005
41. Pupim LB, Heimburger O, Qureshi AR, Ikizler TA, Stenvinkel P : Accelerated lean body mass loss in incident chronic dialysis patients with diabetes mellitus. Kidney Int 68 : 2368 2374, 2005
42. Du J, Wang X, Miereles C, Bailey JL, Debigare R, Zheng B, Price SR, Mitch WE : Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions. J Clin Invest 113 : 115 123, 2004
43. Plomgaard P, Bouzakri K, Krogh-Madsen R, Mittendorfer B, Zierath JR, Pedersen BK : Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation. Diabetes 54 : 2939 2945, 2005.
44. Larsen CM, Faulenbach M, Vaag A, Volund A, Ehses JA, Seifert B, Mandrup-Poulsen T, Donath MY : Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N Engl J Med 356 : 1517 1526, 2007
45. Lecker SH, Goldberg AL, Mitch WE : Protein degradation by the ubiquitin-proteasome pathway in normal and disease states. J Am Soc Nephrol 17 : 1807 1818, 2006