Synthesis, in vitro antitumor evaluation and DNA-binding study of novel tetrahydroquinolines and some derived tricyclic and tetracyclic ring systems

European Journal of Medicinal Chemistry

Volumn 63, Issue , 2013, Pages 133-143

  Faidallah, Hassan M ^a   Rostom, Sherif A F ^a,b  

^a KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^b Alexandria University Faculty of Pharmacy   (Egypt)

Author keywords

Antitumor activity; DNA binding; Tetrahydropyrimido 4,5 b quinolines; Tetrahydroquinolines

Indexed keywords

1 BENZOYL 3 (3 CYANO 8 METHYL 4 (4 CHLOROPHENYL) 5,6,7,8 TETRAHYDROQUINOLIN 2 YL) THIOUREA; 1 BENZOYL 3 (3 CYANO 8 METHYL 4 (4 METHOXYPHENYL) 5,6,7,8 TETRAHYDROQUINOLIN 2 YL) THIOUREA; 2 (4 AMINO 9 METHYL 5 (4 CHLOROPHENYL) 6,7,8,9 TETRAHYDRO 1H PYRIMIDO[4,5 B]QUINOLIN 2 YLTHIO) 1 PHENYLETHANONE; 2 (4 AMINO 9 METHYL 5 (4 METHOXYPHENYL) 6,7,8,9 TETRAHYDRO 1H PYRIMIDO[4,5 B]QUINOLIN 2 YLTHIO) 1 PHENYLETHANONE; 2 AMINO 3 CYANO 8 METHYL 4 (4 CHLOROPHENYL) 5,6,7,8 TETRAHYDROQUINOLINE; 2 AMINO 3 CYANO 8 METHYL 4 (4 METHOXYPHENYL) 5,6,7,8 TETRAHYDROQUINOLINE; 2 ETHOXYMETHYLIDINEAMINO 3 CYANO 8 METHYL 4 (4 CHLOROPHENYL) 5,6,7,8 TETRAHYDROQUINOLINE; 2 ETHOXYMETHYLIDINEAMINO 3 CYANO 8 METHYL 4 (4 ETHOXYPHENYL) 5,6,7,8 TETRAHYDROQUINOLINE; 2 ETHYLTHIO 4 AMINO 9 METHYL 5 (4 CHLOROPHENYL) 6,7,8,9 TETRAHYDRO 1H PYRIMIDO [4,5 B]QUINOLINE; 2 ETHYLTHIO 4 AMINO 9 METHYL 5 (4 METHOXYPHENYL) 6,7,8,9 TETRAHYDRO 1H PYRIMIDO [4,5 B]QUINOLINE; 2,9 DIMETHYL 5 (4 CHLOROPHENYL) 6,7,8,9 TETRAHYDRO 3H PYRIMIDO[4,5 B]QUINOLIN 4 ONE; 2,9 DIMETHYL 5 (4 METHOXYPHENYL) 6,7,8,9 TETRAHYDRO 3H PYRIMIDO[4,5 B]QUINOLIN 4 ONE; 3 AMINO 4 IMINO 9 METHYL 5(4 CHLOROPHENYL) 6,7,8,9 TETRAHYDRO 4H PYRIMIDO[4,5 B] QUINOLINE; 3 AMINO 4 IMINO 9 METHYL 5(4 METHOXYPHENYL) 6,7,8,9 TETRAHYDRO 4H PYRIMIDO[4,5 B] QUINOLINE; 4 AMINO 9 METHYL 5 (4 CHLOROPHENYL) 6,7,8,9 TETRAHYDRO 1H PYRIMIDO[4,5 B] QUINOLINE 2 ONE; 4 AMINO 9 METHYL 5 (4 CHLOROPHENYL) 6,7,8,9 TETRAHYDRO 1H PYRIMIDO[4,5 B] QUINOLINE 2 THIONE; 4 AMINO 9 METHYL 5 (4 CHLOROPHENYL) 6,7,8,9 TETRAHYDROPYRIMIDO[4,5 B] QUINOLINE; 4 AMINO 9 METHYL 5 (4 METHOXYPHENYL) 6,7,8,9 TETRAHYDRO 1H PYRIMIDO[4,5 B] QUINOLINE 2 ONE; 4 AMINO 9 METHYL 5 (4 METHOXYPHENYL) 6,7,8,9 TETRAHYDRO 1H PYRIMIDO[4,5 B] QUINOLINE 2 THIONE; 4 AMINO 9 METHYL 5 (4 METHOXYPHENYL) 6,7,8,9 TETRAHYDROPYRIMIDO[4,5 B] QUINOLINE; 4 IMINO 9 METHYL 3 PHENYL 5 (4 CHLOROPHENYL) 3,4,6,7,8,9 HEXAHYDRO 1H PYRIMIDO [4,5 B]QUINOLINE 2 THIONE; 4 IMINO 9 METHYL 3 PHENYL 5 (4 METHOXYPHENYL) 3,4,6,7,8,9 HEXAHYDRO 1H PYRIMIDO [4,5 B]QUINOLINE 2 THIONE; 7 METHYL 11 (4 CHLOROPHENYL) 7,8,9,10 TETRAHYDRO 1,3,3A,5,6 PENTAAZACYCLOPENTA[A]ANTHRACENE; 7 METHYL 11 (4 METHOXYPHENYL) 7,8,9,10 TETRAHYDRO 1,3,3A,5,6 PENTAAZACYCLOPENTA[A]ANTHRACENE; 9 METHYL 5 (4 CHLOROPHENYL) 6,7,8,9 TETRAHYDRO 3H PYRIMIDO[4,5 B]QUINOLIN 4 ONE; 9 METHYL 5 (4 METHOXYPHENYL) 6,7,8,9 TETRAHYDRO 3H PYRIMIDO[4,5 B]QUINOLIN 4 ONE; ANTINEOPLASTIC AGENT; FLUOROURACIL; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; COLON CANCER; CONTROLLED STUDY; DNA BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; KIDNEY CANCER; LEUKEMIA; LUNG NON SMALL CELL CANCER; MELANOMA; OVARY CANCER; PROSTATE CANCER;

ANTINEOPLASTIC AGENTS; BINDING, COMPETITIVE; CELL LINE, TUMOR; CELL SURVIVAL; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HCT116 CELLS; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HETEROCYCLIC COMPOUNDS, 3-RING; HL-60 CELLS; HT29 CELLS; HUMANS; K562 CELLS; MCF-7 CELLS; MOLECULAR STRUCTURE; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84874536553     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.02.006     Document Type: Article

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