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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 19, 2012, Pages 6103-6107

New derivatives of 11-methyl-6-[2-(dimethylamino)ethyl]-6H-indolo[2,3-b] quinoline as cytotoxic DNA topoisomerase II inhibitors

(7) Luniewski, Wojciech a Wietrzyk, Joanna b Godlewska, Joanna b Switalska, Marta b Piskozub, Malgorzata b Peczynska Czoch, Wanda c Kaczmarek, Lukasz a

a INDUSTRIAL CHEMISTRY RESEARCH INSTITUTE (Poland)

b INSTITUTE OF IMMUNOLOGY AND EXPERIMENTAL THERAPY (Poland)

c WROCLAW UNIVERSITY OF TECHNOLOGY (Poland)

Author keywords

Cytotoxic activity; Indolo 2,3 b quinoline derivatives; Multidrug resistance; Neocryptolepine; Topoisomerase II inhibition

Indexed keywords

11 METHYL 6 [2 (DIMETHYLAMINO)ETHYL]6H INDOLO[2,3 B]QUINOLINE; GYRASE INHIBITOR; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE; CELL LINE; CELL STRAIN HL 60; CONTROLLED STUDY; CYTOTOXICITY; DRUG SCREENING; ENZYME ACTIVITY; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; BALB 3T3 CELLS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DNA TOPOISOMERASES, TYPE II; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; FIBROBLASTS; HL-60 CELLS; HUMANS; INDOLES; JURKAT CELLS; MALE; MCF-7 CELLS; MICE; MOLECULAR STRUCTURE; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE II INHIBITORS;

EID: 84866352328 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.08.032 Document Type: Article

Times cited : (46)

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