Novel quinolines and pyrimido[4,5-b]quinolines bearing biologically active sulfonamide moiety as a new class of antitumor agents

European Journal of Medicinal Chemistry

Volumn 45, Issue 2, 2010, Pages 738-744

  Alqasoumi, Saleh I ^a   Al Taweel, Areej M ^a   Alafeefy, Ahmed M ^a   Noaman, Eman ^b   Ghorab, Mostafa M ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b NATIONAL CENTER FOR RADIATION RESEARCH AND TECHNOLOGY   (Egypt)

Author keywords

Antitumor activity; Pyrimidoquinoline; Quinoline; Sulfonamide

Indexed keywords

4 [2 (3 ALLYLTHIOUREIDO) 3 CYANO 4 (2,4 DICHLOROPHENYL) 5 OXO 5,6,7,8 TETRAHYDROQUINOLIN 1(4H) YL]BENZENESULFONAMIDE; 4 [2 (3 BUTYLTHIOUREIDO) 3 CYANO 4 (2,4 DICHLOROPHENYL) 5 OXO 5,6,7,8 TETRAHYDROQUINOLIN 1(4H) YL]BENZENESULFONAMIDE; 4 [2 (3 PHENYLTHIOUREIDO) 3 CYANO 4 (2,4 DICHLOROPHENYL) 5 OXO 5,6,7,8 TETRAHYDROQUINOLIN 1(4H) YL]BENZENESULFONAMIDE; 4 [2 [3 (4 BROMOPHENYLTHIOUREIDO) 3 CYANO 4 (2,4 DICHLOROPHENYL) 5 OXO 5,6,7,8 TETRAHYDROQUINOLIN 1(4H) YL]]BENZENESULFONAMIDE; 4 [2 [3 (4 CHLOROPHENYLTHIOUREIDO) 3 CYANO 4 (2,4 DICHLOROPHENYL) 5 OXO 5,6,7,8 TETRAHYDROQUINOLIN 1(4H) YL]]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 (2,4 DICHLOROPHENYL) 5 OXO 5,6,7,8 TETRAHYDROQUINOLIN 1(4H) YL]BENZENESULFONAMIDE; 4 [3 (4 ALLYL) 5 (2,4 DICHLOROPHENYL) 4 IMINO 6 OXO 2 THIOXO 1,2,3,4,6,7,8,9 OCTAHYDROPYRIMIDOL[4,5 B]QUINOLIN 10(5H) YL]BENZENESULFONAMIDE; 4 [3 (4 BROMOPHENYL) 5 (2,4 DICHLOROPHENYL) 4 IMINO 6 OXO 2 THIOXO 1,2,3,4,6,7,8,9 OCTAHYDROPYRIMIDO[4,5 B]QUINOLIN 10(5H) YL]BENZENESULFONAMIDE; 4 [3 (4 BUTYL) 5 (2,4 DICHLOROPHENYL) 4 IMINO 6 OXO 2 THIOXO 1,2,3,4,6,7,8,9 OCTAHYDROPYRIMIDOL[4,5 B]QUINOLIN 10(5H) YL]BENZENESULFONAMIDE; 4 [3 (4 CHLOROPHENYL) 5 (2,4 DICHLOROPHENYL) 4 IMINO 6 OXO 2 THIOXO 1,2,3,4,6,7,8,9 OCTAHYDROPYRIMIDO[4,5 B]QUINOLIN 10(5H) YL]BENZENESULFONAMIDE; 4 [3 CYANO 4 (2,4 DICHLOROPHENYL) 2 (2,5 DIOXOPYRROLIDIN 1 YL) 5 OXO 5,6,7,8 TETRAHYDROQUINOLIN 1(4H) YL]BENZENESULFONAMIDE; 4 [3 CYANO 4 (2,4 DICHLOROPHENYL) 5 OXO 1 (4 SULFAMOYLPHENYL) 1,4,5,6,7,8 HEXAHYDROQUINOLIN 2 YLAMINO] 4 OXOBUTANOIC ACID; 4 [3 CYANO 4 (2,4 DICHLOROPHENYL) 5 OXO 2 UREIDO 5,6,7,8 TETRAHYDROQUINOLIN 1(4H) YL]BENZENESULFONAMIDE; 4 [4 AMINO 5 (2,4 DICHLOROPHENYL) 2,6 DIOXO 1,2,6,7,8,9 HEXAHYDROPYRIMIDO[4,5 B]QUINOLIN 10(5H) YL]BENZENESULFONAMIDE; 4 [4 AMINO 5 (2,4 DICHLOROPHENYL) 6 OXO 2 THIOXO 1,2,6,7,8,9 HEXAHYDROPYRIMIDO[4,5 B]QUINOLIN 10(5H) YL]BENZENESULFONAMIDE; 4 [5 (2,4 DICHLOROPHENYL) 6 OXO 2,4 DITHIOXO 1,2,3,4,6,7,8,9 OCTAHYDROPYRIMIDO[4,5 B]QUINOLIN 10(5H) YL]BENZENESULFONAMIDE; 4 BROMO N [3 CYANO 4 (2,4 DICHLOROPHENYL) 5 OXO 1 (4 SULFAMOYLPHENYL) 1,4,5,6,7,8 HEXAHYDROQUINOLIN 2 YL]BENZENESULFONAMIDE; 4 NITRO N [3 CYANO 4 (2,4 DICHLOROPHENYL) 5 OXO 1 (4 SULFAMOYLPHENYL) 1,4,5,6,7,8 HEXAHYDROQUINOLIN 2 YL]BENZENESULFONAMIDE; ANTINEOPLASTIC AGENT; BENZENESULFONAMIDE DERIVATIVE; DOXORUBICIN; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; EHRLICH ASCITES TUMOR CELL; FEMALE; IC 50; IN VITRO STUDY; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, EHRLICH TUMOR; CELL SURVIVAL; DRUG DISCOVERY; FEMALE; INHIBITORY CONCENTRATION 50; MICE; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 73549092916     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.11.021     Document Type: Article

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