Synthesis and biological evaluation of some novel polysubstituted pyrimidine derivatives as potential antimicrobial and anticancer agents

Archiv der Pharmazie

Volumn 342, Issue 5, 2009, Pages 299-310

  Rostom, Sherif A F ^a   Ashour, Hayam M A ^b   Abd El Razik, Heba A ^b  

^a KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^b Alexandria University Faculty of Pharmacy   (Egypt)

Author keywords

Antibacterial; Anticancer activity; Antifungal; Pyrimidines; Thioether

Indexed keywords

2 [4 (4 BENZYLOXY 3 METHOXYPHENYL) 5 CYANO 6 OXO 1,6 DIHYDROPYRIMIDIN 2 YLSULFANYL]ACETIC ACID HYDRAZIDE; 2 BENZYLAMINO 4 (4 BENZYLOXY 3 METHOXYPHENYL) 6 CHLOROPYRIMIDINE 5 CARBONITRILE; 2 BENZYLAMINO 4 (4 BENZYLOXY 3 METHOXYPHENYL) 6 PHENYLSULFANYLPYRIMIDINE 5 CARBONITRILE; 3 AMINO 6 BENZYLAMINO 4 (4 BENZYLOXY 3 METHOXYPHENYL) 1 PHENYLPYRAZOLO[3,4 D]PYRIMIDINE; 4 (4 BENZYLOXY 3 METHOXYPHENYL) 1 METHYL 2 METHYLSULFANYL 6 OXO 1,6 DIHYDROPYRIMIDINE 5 CARBONITRILE; 4 (4 BENZYLOXY 3 METHOXYPHENYL) 2 BENZYLSULFANYL 6 OXO 1,6 DIHYDRO PYRIMIDINE 5 CARBONITRILE; 4 (4 BENZYLOXY 3 METHOXYPHENYL) 2 CYANOMETHYLSULFANYL 6 OXO 1,6 DIHYDROPYRIMIDINE 5 CARBONITRILE; 4 (4 BENZYLOXY 3 METHOXYPHENYL) 2 HYDRAZINO 6 OXO 1,6 DIHYDROPYRIMIDINE 5 CARBONITRILE; 4 (4 BENZYLOXY 3 METHOXYPHENYL) 2 METHYLSULFANYL 6 OXO 1,6 DIHYDRO PYRIMIDINE 5 CARBONITRILE; 4 [3 AMINO 6 BENZYLAMINO 4 (4 BENZYLOXY 3 METHOXYPHENYL)PYRAZOLO[3,4 D]PYRIMIDIN 1 YL]BENZENESULFONAMIDE; 6 (4 BENZYLOXY 3 METHOXYPHENYL) 4 OXO 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBONITRILE; AMPICILLIN; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; ETHYL 2 [4 (4 BENZYLOXY 3 METHOXYPHENYL) 5 CYANO 6 OXO 1,6 DIHYDROPYRIMIDIN 2 YL SULFANYL]ACETATE; N' (4 CHLOROBENZYLIDENE) 2 [4 (4 BENZYLOXY 3 METHOXYPHENYL) 5 CYANO 6 OXO 1,6 DIHYDROPYRIMIDIN 2 YLSULFANYL]ACETIC ACID HYDRAZIDE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BACTERIAL STRAIN; CANCER CELL CULTURE; CANDIDA ALBICANS; CELL STRAIN HT29; CELL STRAIN MCF 7; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; HUMAN CELL; IN VITRO STUDY; LC 50; LIVER CELL CARCINOMA; MICROCOCCUS LUTEUS; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA;

ANTI-BACTERIAL AGENTS; ANTIFUNGAL AGENTS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HUMANS; MICROBIAL SENSITIVITY TESTS; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 66349091952     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.200800223     Document Type: Article

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