Synthesis and in vitro antiproliferative evaluation of pyrimido[5,4-c] quinoline-4-(3H)-one derivatives

European Journal of Medicinal Chemistry

Volumn 47, Issue 1, 2012, Pages 206-213

  Ai, Yong ^a   Liang, Yong Ju ^b   Liu, Jian Chao ^c   He, Hong Wu ^c   Chen, Yu ^a   Tang, Chu ^a   Yang, Guang Zhong ^a   Fu, Li Wu ^b  

^a SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES   (China)

^b SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^c CENTRAL CHINA NORMAL UNIVERSITY   (China)

Author keywords

Antiproliferative activities; Antitumor agent(s); Pyrimido 5,4 c quinoline 4 (3H) one; Synthesis

Indexed keywords

10 METHYL 3 PHENYL [1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN[5,4 C]QUINOLIN 11 (3H)ONE; 2 (2 CHLORO 4 NITROPHENOXY) 3 (4 CHLOROPHENYL) 5 METHYLPYRIMIDO[5,4 C]QUINOLIN 4 (3H)ONE; 2 (2 CHLOROPHENOXY) 3 (4 FLUOROPHENYL) 5 METHYLPYRIMIDO[5,4 C]QUINOLIN 4 (3H)ONE; 2 (2 METHOXYPHENOXY) 3 (4 CHLOROPHENYL) 5 METHYLPYRIMIDO[5,4 C]QUINOLIN 4 (3H)ONE; 2 (2 METHOXYPHENOXY) 5 METHYL 3 PHENYLPYRIMIDO[5,4 C]QUINOLIN 4 (3H)ONE; 2 (2,4 DICHLOROPHENOXY) 3 PHENYL 5 METHYL 3H PYRIMIDO[5,4 C]QUINOLIN 4 ONE; 2 (4 BROMOPHENOXY) 3 (4 CHLOROPHENYL) 5 METHYLPYRIMIDO[5,4 C]QUINOLIN 4 (3H)ONE; 2 (4 CHLORO 3 METHYLPHENOXY) 3 (4 FLUOROPHENYL) 5 METHYLPYRIMIDO[5,4 C]QUINOLIN 4 (3H)ONE; 2 (4 CHLOROPHENYLAMINO) 5 METHYL 3 AMINOPYRIMIDO[5,4 C]QUINOLIN 4 (3H)ONE; 2 (4 FLUOROPHENOXY) 3 (4 FLUOROPHENYL) 5 METHYLPYRIMIDO[5,4 C]QUINOLIN 4 (3H)ONE; 2 (BENZO[D][1,3]DIOXOL 6 YLOXY) 3 (4 CHLOROPHENYL) 5 METHYLPYRIMIDO[5,4 C]QUINOLIN 4 (3H)ONE; 2 (PHENYLAMINO) 5 METHYL 3 AMINOPYRIMIDO[5,4 C]QUINOLIN 4 (3H)ONE; 2 (TERT BUTYLAMINO) 3 PHENYL 5 METHYL 3H PYRIMIDO[5,4 C]QUINOLIN 4 ONE; 3 (2 AMINOETHYL) 5 METHYLPYRIMIDO[5,4 C]QUINOLIN 4 (3H)ONE; 3 (2 HYDROXYETHYL) 5 METHYLPYRIMIDO[5,4 C]QUINOLIN 4 (3H)ONE; 3 (4 CHLOROPHENYL) 5 METHYL 2 (NAPHTHALEN 1 YLOXY)PYRIMIDO[5,4 C]QUINOLIN 4 (3H)ONE; 3 BENZYL 5 METHYLPYRIMIDO[5,4 C]QUINOLIN 4( 3H)ONE; 3 BUTYL 5 METHYLPYRIMIDO[5,4 C]QUINOLIN 4 (3H ONE; 3 ETHYL 5 METHYLPYRIMIDO[5,4 C]QUINOLIN 4 (3H)ONE; 3 ISOBUTYL 5 METHYLPYRIMIDO[5,4 C]QUINOLIN 4 (3H)ONE; 3 ISOPROPYL 5 METHYLPYRIMIDO[5,4 C]QUINOLIN 4 (3H)ONE; 3 SEC BUTYL 5 METHYLPYRIMIDO[5,4 C]QUINOLIN 4 (3H)ONE; 5 METHYL 3 AMINOPYRIMIDO[5,4 C]QUINOLIN 4 (3H)ONE; 5 METHYL 3 PHENETHYLPYRIMIDO[5,4 C]QUINOLIN 4 (3H)ONE; 5 METHYL 3 PROPYLPYRIMIDO[5,4 C]QUINOLIN 4 (3H)ONE; ANTINEOPLASTIC AGENT; PYRIMIDO[5,4 C]QUINOLINE 4 (3H)ONE DERIVATIVE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; QUINOLONE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BIOASSAY; BREAST ADENOCARCINOMA; BREAST CARCINOMA; CANCER CELL CULTURE; CANCER GROWTH; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG CARCINOMA; MOUTH CARCINOMA; NASOPHARYNX CARCINOMA; STOMACH CARCINOMA; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECT; IC 50; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; INHIBITORY CONCENTRATION 50; QUINOLONES;

EID: 84855809994     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.10.044     Document Type: Article

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