Azole antimicrobial pharmacophore-based tetrazoles: Synthesis and biological evaluation as potential antimicrobial and anticonvulsant agents

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 6, 2009, Pages 2410-2422

  Rostom, Sherif A F ^a   Ashour, Hayam M A ^b   Razik, Heba A Abd El ^b   Fattah, Abd El Fattah H Abd El ^c   El Din, Nagwa N ^d  

^a KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^b Alexandria University Faculty of Pharmacy   (Egypt)

^c High Institute of Public Health Egypt   (Egypt)

^d ALEXANDRIA UNIVERSITY   (Egypt)

Author keywords

1,3,4 Oxadiazoles; 1,3,4 Triazoles; 1H Tetrazoles; Antibacterial activity; Anticonvulsant activity; Antifungal activity; Azoles; Pyrazoles

Indexed keywords

2 (5 BENZYL 1H TETRAZOL 1 YL) 1 (4 CHLOROPHENYL)ETHANOL; 2 (5 BENZYL 1H TETRAZOL 1 YL) 1 (4 CHLOROPHENYL)ETHANONE; 2 [1 (4 CHLOROPHENYL) 2 (5 PHENYL 2H TETRAZOL 2 YL)ETHOXY] 1 (3,5 DIMETHYL 1H PYRAZOL 1 YL)ETHANONE; 2 [2 (5 BENZYL 1H TETRAZOL 1 YL) 1 (4 CHLOROPHENYL)ETHOXY] N1 (4 CHLOROBENZYLIDENE)ACETOHYDRAZIDE; 2 [[1 (4 CHLOROPHENYL) 2 (5 PHENYL 2H TETRAZOL 2 YL)ETHOXY]METHYL] 5 PHENYLAMINO 1,3,4 OXADIAZOLE; 5 [[1 (4 CHLOROPHENYL) 2 (5 PHENYL 2H TETRAZOL 2 YL)ETHOXY]METHYL] 1,3,4 OXADIAZOLE 2 THIOL; 5 [[1 (4 CHLOROPHENYL) 2 (5 PHENYL 2H TETRAZOL 2 YL)ETHOXY]METHYL] 4 PHENYL 4H 1,2,4 TRIAZOLE 2 THIOL; 5 [[1 (4 CHLOROPHENYL) 2 (5 PHENYL 2H TETRAZOL 2 YL)ETHOXY]METHYL] 4 PHENYL 4H 1,2,4 TRIAZOLE 3 THIOL; 6 (4 CHLOROPHENYL) 5,6 DIHYDRO 11H TETRAZOLO[1,5 A]BENZ[D]AZEPINE; AMPICILLIN; N4 PHENYL N1 [[2 (5 PHENYL 2H TETRAZOL 2 YL) 1 (4 CHLOROPHENYL)ETHOXY]ACETYL]THIOSEMICARBAZIDE; TETRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ANTICONVULSANT ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; BACTERIAL STRAIN; CANDIDA ALBICANS; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; MALE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PHARMACOPHORE; REACTION ANALYSIS; SEIZURE; STAPHYLOCOCCUS AUREUS; STRUCTURE ANALYSIS;

ANTI-INFECTIVE AGENTS; ANTICONVULSANTS; DRUG EVALUATION, PRECLINICAL; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; TETRAZOLES;

ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; MUS; NEGIBACTERIA; POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

EID: 62149117985     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.02.004     Document Type: Article

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