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Volumn 38, Issue 3-4, 2013, Pages 421-444

Current drug research on PEGylation with small molecular agents

Author keywords

Anti inflammatory; Anti tumor; Anti virus; Antimicrobial; Immunosuppressant; PEGylation; Small molecules drugs

Indexed keywords

FUNCTIONAL POLYMERS; MACROMOLECULES; MEDICAL APPLICATIONS; TUMORS; VIRUSES;

EID: 84874391961     PISSN: 00796700     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.progpolymsci.2012.07.006     Document Type: Review
Times cited : (202)

References (112)
  • 1
    • 36549004553 scopus 로고    scopus 로고
    • Anti-cancer PEG-enzymes: 30 years old, but still a current approach
    • G. Pasut, M. Sergi, and F.M. Veronese Anti-cancer PEG-enzymes: 30 years old, but still a current approach Advanced Drug Delivery Reviews 60 2008 69 78
    • (2008) Advanced Drug Delivery Reviews , vol.60 , pp. 69-78
    • Pasut, G.1    Sergi, M.2    Veronese, F.M.3
  • 4
    • 84855322653 scopus 로고    scopus 로고
    • Computational approaches to the rational design of nanoemulsions, polymeric micelles, and dendrimers for drug delivery
    • L. Huynh, C. Neale, R. Pomès, and C. Allen Computational approaches to the rational design of nanoemulsions, polymeric micelles, and dendrimers for drug delivery Nanomedicine 8 2012 20 36
    • (2012) Nanomedicine , vol.8 , pp. 20-36
    • Huynh, L.1    Neale, C.2    Pomès, R.3    Allen, C.4
  • 6
    • 0017701219 scopus 로고
    • Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol
    • A. Abuchowski, T. Van Es, N.C. Palczuk, and F.F. Davis Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol Journal of Biological Chemistry 252 1977 3578 3581
    • (1977) Journal of Biological Chemistry , vol.252 , pp. 3578-3581
    • Abuchowski, A.1    Van Es, T.2    Palczuk, N.C.3    Davis, F.F.4
  • 7
    • 0017388651 scopus 로고
    • Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase
    • A. Abuchowski, J.R. McCoy, N.C. Palczuk, T. van Es, and F.F. Davis Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase Journal of Biological Chemistry 252 1977 3582 3586
    • (1977) Journal of Biological Chemistry , vol.252 , pp. 3582-3586
    • Abuchowski, A.1    McCoy, J.R.2    Palczuk, N.C.3    Van Es, T.4    Davis, F.F.5
  • 8
    • 42749091133 scopus 로고    scopus 로고
    • Polymer-drug conjugates: Recent development in clinical oncology
    • C. Li, and S. Wallace Polymer-drug conjugates: recent development in clinical oncology Advanced Drug Delivery Reviews 60 2008 886 898
    • (2008) Advanced Drug Delivery Reviews , vol.60 , pp. 886-898
    • Li, C.1    Wallace, S.2
  • 9
    • 34547607522 scopus 로고    scopus 로고
    • Polymer-drug conjugation, recent achievements and general strategies
    • G. Pasut, and F.M. Veronese Polymer-drug conjugation, recent achievements and general strategies Progress in Polymer Science 32 2007 933 961
    • (2007) Progress in Polymer Science , vol.32 , pp. 933-961
    • Pasut, G.1    Veronese, F.M.2
  • 10
    • 58149494371 scopus 로고    scopus 로고
    • Quantitation of free polyethylene glycol in PEGylated protein conjugate by size exclusion HPLC with refractive index (RI) detection
    • N. Li, D. Ziegemeier, L. Bass, and W. Wang Quantitation of free polyethylene glycol in PEGylated protein conjugate by size exclusion HPLC with refractive index (RI) detection Journal of Pharmaceutical and Biomedical Analysis 48 2008 1332 1338
    • (2008) Journal of Pharmaceutical and Biomedical Analysis , vol.48 , pp. 1332-1338
    • Li, N.1    Ziegemeier, D.2    Bass, L.3    Wang, W.4
  • 11
    • 0037124398 scopus 로고    scopus 로고
    • Structural and biological characterization of pegylated recombinant interferon alpha-2b and its therapeutic implications
    • Y.S. Wang, S. Youngster, M. Grace, J. Bausch, R. Bordens, and D.F. Wyss Structural and biological characterization of pegylated recombinant interferon alpha-2b and its therapeutic implications Advanced Drug Delivery Reviews 54 2002 547 570
    • (2002) Advanced Drug Delivery Reviews , vol.54 , pp. 547-570
    • Wang, Y.S.1    Youngster, S.2    Grace, M.3    Bausch, J.4    Bordens, R.5    Wyss, D.F.6
  • 13
    • 79960942844 scopus 로고    scopus 로고
    • Polymer therapeutics as nanomedicines: New perspectives
    • R. Duncan Polymer therapeutics as nanomedicines: new perspectives Current Opinion in Biotechnology 22 2011 492 501
    • (2011) Current Opinion in Biotechnology , vol.22 , pp. 492-501
    • Duncan, R.1
  • 15
    • 70349999917 scopus 로고    scopus 로고
    • Polymeric carriers: Preclinical safety and the regulatory implications for design and development of polymer therapeutics
    • R. Gaspar, and R. Duncan Polymeric carriers: preclinical safety and the regulatory implications for design and development of polymer therapeutics Advanced Drug Delivery Reviews 61 2009 1220 1231
    • (2009) Advanced Drug Delivery Reviews , vol.61 , pp. 1220-1231
    • Gaspar, R.1    Duncan, R.2
  • 16
    • 26944452043 scopus 로고    scopus 로고
    • PEGylation, successful approach to drug delivery
    • F.M. Veronese, and G. Pasut PEGylation, successful approach to drug delivery Drug Discovery Today 10 2005 1451 1458
    • (2005) Drug Discovery Today , vol.10 , pp. 1451-1458
    • Veronese, F.M.1    Pasut, G.2
  • 17
    • 70349979533 scopus 로고    scopus 로고
    • Polymer therapeutics: Clinical applications and challenges for development
    • M.J. Vicent, H. Ringsdorf, and R. Duncan Polymer therapeutics: clinical applications and challenges for development Advanced Drug Delivery Reviews 61 2009 1117 1120
    • (2009) Advanced Drug Delivery Reviews , vol.61 , pp. 1117-1120
    • Vicent, M.J.1    Ringsdorf, H.2    Duncan, R.3
  • 22
    • 36549050782 scopus 로고    scopus 로고
    • Releasable PEGylation of proteins with customized linkers
    • D. Filpula, and H. Zhao Releasable PEGylation of proteins with customized linkers Advanced Drug Delivery Reviews 60 2008 29 49
    • (2008) Advanced Drug Delivery Reviews , vol.60 , pp. 29-49
    • Filpula, D.1    Zhao, H.2
  • 24
    • 21744456395 scopus 로고    scopus 로고
    • Soluble polymer conjugates for drug delivery
    • T. Minko Soluble polymer conjugates for drug delivery Drug Discovery Today: Technologies 2 2005 15 20
    • (2005) Drug Discovery Today: Technologies , vol.2 , pp. 15-20
    • Minko, T.1
  • 25
    • 78349234664 scopus 로고    scopus 로고
    • Synthesis, in vitro and in vivo release kinetics, and anti-HIV activity of a sustained-release prodrug (mPEG-AZT) of 3′-azido-3′- deoxythymidine (AZT, zidovudine)
    • W. Li, Y. Chang, P. Zhan, N. Zhang, X. Liu, C. Pannecouque, and E. De Clercq Synthesis, in vitro and in vivo release kinetics, and anti-HIV activity of a sustained-release prodrug (mPEG-AZT) of 3′-azido-3′- deoxythymidine (AZT, zidovudine) ChemMedChem 5 2010 1893 1898
    • (2010) ChemMedChem , vol.5 , pp. 1893-1898
    • Li, W.1    Chang, Y.2    Zhan, P.3    Zhang, N.4    Liu, X.5    Pannecouque, C.6    De Clercq, E.7
  • 26
    • 56749098212 scopus 로고    scopus 로고
    • Designing PEGylated therapeutic molecules: Advantages in ADMET properties
    • M. Hamidi, P. Rafiei, and A. Azadi Designing PEGylated therapeutic molecules: advantages in ADMET properties Expert Opinion on Drug Delivery 3 2008 1293 1307
    • (2008) Expert Opinion on Drug Delivery , vol.3 , pp. 1293-1307
    • Hamidi, M.1    Rafiei, P.2    Azadi, A.3
  • 27
    • 27844515221 scopus 로고    scopus 로고
    • PEG-proteins: Reaction engineering and separation issues
    • C.J. Fee, and J.M. Van Alstine PEG-proteins: reaction engineering and separation issues Chemical Engineering Science 61 2005 924 939
    • (2005) Chemical Engineering Science , vol.61 , pp. 924-939
    • Fee, C.J.1    Van Alstine, J.M.2
  • 28
    • 0016622773 scopus 로고
    • Structure and properties of pharmacologically active polymers
    • H. Ringsdorf Structure and properties of pharmacologically active polymers Journal of Polymer Science: Polymer Symposia 51 1975 135 153
    • (1975) Journal of Polymer Science: Polymer Symposia , vol.51 , pp. 135-153
    • Ringsdorf, H.1
  • 29
    • 0344420226 scopus 로고    scopus 로고
    • Pharmacokinetic and biodistribution properties of poly (ethylene glycol)-protein conjugates
    • P. Caliceti, and F.M. Veronese Pharmacokinetic and biodistribution properties of poly (ethylene glycol)-protein conjugates Advanced Drug Delivery Reviews 55 2003 1261 1277
    • (2003) Advanced Drug Delivery Reviews , vol.55 , pp. 1261-1277
    • Caliceti, P.1    Veronese, F.M.2
  • 30
    • 33646255225 scopus 로고    scopus 로고
    • Polymer-drug conjugates: Progress in polymeric prodrugs
    • J. Khandare, and T. Minko Polymer-drug conjugates: progress in polymeric prodrugs Progress in Polymer Science 31 2006 359 397
    • (2006) Progress in Polymer Science , vol.31 , pp. 359-397
    • Khandare, J.1    Minko, T.2
  • 31
    • 15244346848 scopus 로고    scopus 로고
    • Hyperbranched polymer-drug conjugates with high drug payload for enhanced cellular delivery
    • P. Kolhe, J. Khandare, O. Pillai, S. Kannan, M. Lieh-Lai, and R. Kannan Hyperbranched polymer-drug conjugates with high drug payload for enhanced cellular delivery Pharmaceutical Research 21 2004 2185 2195
    • (2004) Pharmaceutical Research , vol.21 , pp. 2185-2195
    • Kolhe, P.1    Khandare, J.2    Pillai, O.3    Kannan, S.4    Lieh-Lai, M.5    Kannan, R.6
  • 33
    • 79959972712 scopus 로고    scopus 로고
    • Prodrugs for improving tumor targetability and efficiency
    • R. Mahato, W. Tai, and K. Cheng Prodrugs for improving tumor targetability and efficiency Advanced Drug Delivery Reviews 63 2011 659 670
    • (2011) Advanced Drug Delivery Reviews , vol.63 , pp. 659-670
    • Mahato, R.1    Tai, W.2    Cheng, K.3
  • 35
    • 12744269417 scopus 로고    scopus 로고
    • CT-2103: A novel macromolecular taxane with potential advantages compared with conventional taxanes
    • C.J. Langer CT-2103: a novel macromolecular taxane with potential advantages compared with conventional taxanes Clinical Lung Cancer 6 Suppl. 2004 85 88
    • (2004) Clinical Lung Cancer , vol.6 , Issue.SUPPL. , pp. 85-88
    • Langer, C.J.1
  • 36
    • 38449087619 scopus 로고    scopus 로고
    • Polymer-drug conjugates: Current status and future trends
    • F. Greco, and M.J. Vicent Polymer-drug conjugates: current status and future trends Frontiers in Bioscience 13 2008 2256 2744
    • (2008) Frontiers in Bioscience , vol.13 , pp. 2256-2744
    • Greco, F.1    Vicent, M.J.2
  • 37
    • 34547596467 scopus 로고    scopus 로고
    • Conjugates of stimuli-responsive polymers and proteins
    • A.S. Hoffman, and P.S. Stayton Conjugates of stimuli-responsive polymers and proteins Progress in Polymer Science 32 2007 922 932
    • (2007) Progress in Polymer Science , vol.32 , pp. 922-932
    • Hoffman, A.S.1    Stayton, P.S.2
  • 38
    • 34848895140 scopus 로고    scopus 로고
    • Targeted sialic acid-Doxorubicin prodrugs for intracellular delivery and cancer treatment
    • S. Jayant, J.J. Khandare, Y. Wang, A.P. Singh, N. Vorsa, and T. Minko Targeted sialic acid-Doxorubicin prodrugs for intracellular delivery and cancer treatment Pharmaceutical Research 24 2007 2120 2130
    • (2007) Pharmaceutical Research , vol.24 , pp. 2120-2130
    • Jayant, S.1    Khandare, J.J.2    Wang, Y.3    Singh, A.P.4    Vorsa, N.5    Minko, T.6
  • 39
    • 33748445091 scopus 로고    scopus 로고
    • Solubilization of single-wall carbon nanohorns using a PEG-doxorubicin conjugate
    • T. Murakami, J. Fan, M. Yudasaka, S. Iijima, and K. Shiba Solubilization of single-wall carbon nanohorns using a PEG-doxorubicin conjugate Molecular Pharmaceutics 3 2006 407 414
    • (2006) Molecular Pharmaceutics , vol.3 , pp. 407-414
    • Murakami, T.1    Fan, J.2    Yudasaka, M.3    Iijima, S.4    Shiba, K.5
  • 41
    • 48049091570 scopus 로고    scopus 로고
    • Doxorubicin conjugated to d-[α]-tocopheryl polyethylene glycol 1000 succinate (TPGS): Conjugation chemistry, characterization, in vitro and in vivo evaluation
    • N. Cao, and S.S. Feng Doxorubicin conjugated to d-[α]-tocopheryl polyethylene glycol 1000 succinate (TPGS): conjugation chemistry, characterization, in vitro and in vivo evaluation Biomaterials 29 2008 3856 3865
    • (2008) Biomaterials , vol.29 , pp. 3856-3865
    • Cao, N.1    Feng, S.S.2
  • 42
    • 77954764578 scopus 로고    scopus 로고
    • Doxorubicin conjugated to d-alpha-tocopheryl polyethylene glycol succinate and folic acid as a prodrug for targeted chemotherapy
    • V. Anbharasi, N. Cao, and S.S. Feng Doxorubicin conjugated to d-alpha-tocopheryl polyethylene glycol succinate and folic acid as a prodrug for targeted chemotherapy Journal of Biomedical Materials Research A 94 2010 730 743
    • (2010) Journal of Biomedical Materials Research A , vol.94 , pp. 730-743
    • Anbharasi, V.1    Cao, N.2    Feng, S.S.3
  • 43
    • 79953061635 scopus 로고    scopus 로고
    • RGD-modified PEG-PAMAM-DOX conjugate: In vitro and in vivo targeting to both tumor neovascular endothelial cells and tumor
    • S. Zhu, L. Qian, M. Hong, L. Zhang, Y. Pei, and Y. Jiang RGD-modified PEG-PAMAM-DOX conjugate: in vitro and in vivo targeting to both tumor neovascular endothelial cells and tumor Advanced Materials 23 2011 H84 H89
    • (2011) Advanced Materials , vol.23
    • Zhu, S.1    Qian, L.2    Hong, M.3    Zhang, L.4    Pei, Y.5    Jiang, Y.6
  • 44
    • 72949109319 scopus 로고    scopus 로고
    • PEGylated PAMAM dendrimer-doxorubicin conjugates: In vitro evaluation and in vivo tumor accumulation
    • S. Zhu, M. Hong, L. Zhang, G. Tang, Y. Jiang, and Y. Pei PEGylated PAMAM dendrimer-doxorubicin conjugates: in vitro evaluation and in vivo tumor accumulation Pharmaceutical Research 27 2010 161 174
    • (2010) Pharmaceutical Research , vol.27 , pp. 161-174
    • Zhu, S.1    Hong, M.2    Zhang, L.3    Tang, G.4    Jiang, Y.5    Pei, Y.6
  • 46
    • 84874378011 scopus 로고    scopus 로고
    • NKTR-102 demonstrates nonclinical and phase i clinical anti-tumor activity in ovarian cancer
    • U. Hoch, L. Masuoka, D. Maslyar, and D. Von Hoff NKTR-102 demonstrates nonclinical and phase I clinical anti-tumor activity in ovarian cancer European Journal of Cancer. Supplements 7 2 2009 454
    • (2009) European Journal of Cancer. Supplements , vol.7 , Issue.2 , pp. 454
    • Hoch, U.1    Masuoka, L.2    Maslyar, D.3    Von Hoff, D.4
  • 51
    • 0024324205 scopus 로고
    • On the mechanism of topoisomerase i inhibition by camptothecin: Evidence for binding to an enzyme-DNA complex
    • R.P. Hertzberg, M.J. Caranfa, and S.M. Hecht On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex Biochemistry 28 1989 4629 4638
    • (1989) Biochemistry , vol.28 , pp. 4629-4638
    • Hertzberg, R.P.1    Caranfa, M.J.2    Hecht, S.M.3
  • 54
    • 9244234511 scopus 로고    scopus 로고
    • In vitro cytotoxicity and in vivo distribution after direct delivery of PEG-camptothecin conjugates to the rat brain
    • A.B. Fleming, K. Haverstick, and W.M. Saltzman In vitro cytotoxicity and in vivo distribution after direct delivery of PEG-camptothecin conjugates to the rat brain Bioconjugate Chemistry 15 2004 1364 1375
    • (2004) Bioconjugate Chemistry , vol.15 , pp. 1364-1375
    • Fleming, A.B.1    Haverstick, K.2    Saltzman, W.M.3
  • 57
    • 70349988803 scopus 로고    scopus 로고
    • PEG conjugates in clinical development or use as anticancer agents: An overview
    • G. Pasut, and F.M. Veronese PEG conjugates in clinical development or use as anticancer agents: an overview Advanced Drug Delivery Reviews 61 2009 1177 1188
    • (2009) Advanced Drug Delivery Reviews , vol.61 , pp. 1177-1188
    • Pasut, G.1    Veronese, F.M.2
  • 60
    • 79953112735 scopus 로고    scopus 로고
    • Preclinical and clinical studies of NK012, an SN-38-incorporating polymeric micelles, which is designed based on EPR effect
    • Y. Matsumura Preclinical and clinical studies of NK012, an SN-38-incorporating polymeric micelles, which is designed based on EPR effect Advanced Drug Delivery Reviews 63 2011 184 192
    • (2011) Advanced Drug Delivery Reviews , vol.63 , pp. 184-192
    • Matsumura, Y.1
  • 61
    • 80052691602 scopus 로고    scopus 로고
    • Potent and sustained inhibition of HIF-1α and downstream genes by a polyethyleneglycol-SN38 conjugate EZN-2208, results in anti-angiogenic effects
    • P. Sapra, P. Kraft, F. Pastorino, D. Ribatti, M. Dumble, M. Mehlig, M. Wang, M. Ponzoni, L.M. Greenberger, and I.D. Horak Potent and sustained inhibition of HIF-1α and downstream genes by a polyethyleneglycol-SN38 conjugate EZN-2208, results in anti-angiogenic effects Angiogenesis 14 2011 245 253
    • (2011) Angiogenesis , vol.14 , pp. 245-253
    • Sapra, P.1    Kraft, P.2    Pastorino, F.3    Ribatti, D.4    Dumble, M.5    Mehlig, M.6    Wang, M.7    Ponzoni, M.8    Greenberger, L.M.9    Horak, I.D.10
  • 63
    • 62649086512 scopus 로고    scopus 로고
    • PEG conjugated N-octyl-O-sulfate chitosan micelles for delivery of paclitaxel: In vitro characterization and in vivo evaluation
    • G. Qu, Z. Yao, C. Zhang, X. Wu, and Q. Ping PEG conjugated N-octyl-O-sulfate chitosan micelles for delivery of paclitaxel: in vitro characterization and in vivo evaluation European Journal of Pharmaceutical Sciences 37 2009 98 105
    • (2009) European Journal of Pharmaceutical Sciences , vol.37 , pp. 98-105
    • Qu, G.1    Yao, Z.2    Zhang, C.3    Wu, X.4    Ping, Q.5
  • 64
    • 0030071043 scopus 로고    scopus 로고
    • Drug delivery systems: Water soluble taxol 2′-poly (ethylene glycol) ester prodrugs design and in vivo effectiveness
    • R.B. Greenwald, C.W. Gilbert, A. Pendri, C.D. Conover, J. Xia, and A. Martinez Drug delivery systems: water soluble taxol 2′-poly (ethylene glycol) ester prodrugs design and in vivo effectiveness Journal of Medicinal Chemistry 39 1996 424 431
    • (1996) Journal of Medicinal Chemistry , vol.39 , pp. 424-431
    • Greenwald, R.B.1    Gilbert, C.W.2    Pendri, A.3    Conover, C.D.4    Xia, J.5    Martinez, A.6
  • 66
    • 9644266802 scopus 로고    scopus 로고
    • Synthesis and characterization of the paclitaxel/MPEG-PLA block copolymer conjugate
    • X. Zhang, Y. Li, X. Chen, X. Wang, X. Xu, Q. Liang, J. Hu, and X. Jing Synthesis and characterization of the paclitaxel/MPEG-PLA block copolymer conjugate Biomaterials 26 2005 2121 2128
    • (2005) Biomaterials , vol.26 , pp. 2121-2128
    • Zhang, X.1    Li, Y.2    Chen, X.3    Wang, X.4    Xu, X.5    Liang, Q.6    Hu, J.7    Jing, X.8
  • 67
    • 34547214431 scopus 로고    scopus 로고
    • Triblock poly(lactic acid)-b-poly(ethylene glycol)-b-poly(lactic acid)/Paclitaxel conjugates: Synthesis, micellization, and cytotoxicity
    • Z.G. Xie, T.C. Lu, X.S. Chen, C.H. Lu, Y.H. Zheng, and X.B. Jing Triblock poly(lactic acid)-b-poly(ethylene glycol)-b-poly(lactic acid)/Paclitaxel conjugates: synthesis, micellization, and cytotoxicity Journal of Applied Polymer Science 105 2007 2271 2279
    • (2007) Journal of Applied Polymer Science , vol.105 , pp. 2271-2279
    • Xie, Z.G.1    Lu, T.C.2    Chen, X.S.3    Lu, C.H.4    Zheng, Y.H.5    Jing, X.B.6
  • 69
    • 57449109348 scopus 로고    scopus 로고
    • Synthesis, self-assembly in water, and cytotoxicity of mPEG-block-PLLA/DX conjugates
    • Z. Xie, T. Lu, X. Chen, Y. Zheng, and X. Jing Synthesis, self-assembly in water, and cytotoxicity of mPEG-block-PLLA/DX conjugates Journal of Biomedical Materials Research A 88 2009 238 245
    • (2009) Journal of Biomedical Materials Research A , vol.88 , pp. 238-245
    • Xie, Z.1    Lu, T.2    Chen, X.3    Zheng, Y.4    Jing, X.5
  • 71
    • 79956213164 scopus 로고    scopus 로고
    • Dose-escalation phase i study of NKTR-105, a novel pegylated form of docetaxel
    • abstr TPS160
    • E. Calvo, U. Hoch, D.J. Maslyar, and A.W. Tolcher Dose-escalation phase I study of NKTR-105, a novel pegylated form of docetaxel Journal of Clinical Oncology 28 15 Suppl. 2010 abstr TPS160
    • (2010) Journal of Clinical Oncology , vol.28 , Issue.15 SUPPL.
    • Calvo, E.1    Hoch, U.2    Maslyar, D.J.3    Tolcher, A.W.4
  • 74
    • 0034959803 scopus 로고    scopus 로고
    • The Swedish council on technology assessment in health care (SBU) report on cancer chemotherapy-project objectives, the working process, key definitions and general aspects on cancer trial methodology and interpretation
    • P. Nygren, and B. Glimelius The Swedish council on technology assessment in health care (SBU) report on cancer chemotherapy-project objectives, the working process, key definitions and general aspects on cancer trial methodology and interpretation Acta Oncologica 40 2001 155 165
    • (2001) Acta Oncologica , vol.40 , pp. 155-165
    • Nygren, P.1    Glimelius, B.2
  • 75
    • 0036335104 scopus 로고    scopus 로고
    • Surgical quality in trials of adjuvant cancer therapy
    • S.A. Hundahl Surgical quality in trials of adjuvant cancer therapy Journal of Surgical Oncology 80 2002 177 180
    • (2002) Journal of Surgical Oncology , vol.80 , pp. 177-180
    • Hundahl, S.A.1
  • 77
    • 0038246506 scopus 로고    scopus 로고
    • Folate-targeted PEG as a potential carrier for carboplatin analogs. Synthesis and in vitro studies
    • O. Aronov, A.T. Horowitz, A. Gabizon, and D. Gibson Folate-targeted PEG as a potential carrier for carboplatin analogs. Synthesis and in vitro studies Bioconjugate Chemistry 14 2003 563 574
    • (2003) Bioconjugate Chemistry , vol.14 , pp. 563-574
    • Aronov, O.1    Horowitz, A.T.2    Gabizon, A.3    Gibson, D.4
  • 84
    • 58149216180 scopus 로고    scopus 로고
    • Water-soluble poly(ethylene glycol) prodrug of pemetrexed: Synthesis, characterization, and preliminary cytotoxicity
    • T. Min, H. Ye, P. Zhang, J. Liu, C. Zhang, W.B. Shen, W. Wang, and L.S. Shen Water-soluble poly(ethylene glycol) prodrug of pemetrexed: synthesis, characterization, and preliminary cytotoxicity Journal of Applied Polymer Science 111 2009 444 451
    • (2009) Journal of Applied Polymer Science , vol.111 , pp. 444-451
    • Min, T.1    Ye, H.2    Zhang, P.3    Liu, J.4    Zhang, C.5    Shen, W.B.6    Wang, W.7    Shen, L.S.8
  • 87
    • 25844475286 scopus 로고    scopus 로고
    • Methotrexate-modified superparamagnetic nanoparticles and their intracellular uptake into human cancer cells
    • N. Kohler, C. Sun, J. Wang, and M. Zhang Methotrexate-modified superparamagnetic nanoparticles and their intracellular uptake into human cancer cells Langmuir 21 2005 8858 8864
    • (2005) Langmuir , vol.21 , pp. 8858-8864
    • Kohler, N.1    Sun, C.2    Wang, J.3    Zhang, M.4
  • 88
    • 0036077673 scopus 로고    scopus 로고
    • Polyethylene glycol conjugates of methotrexate varying in their molecular weight from MW 750 to MW 40,000; Synthesis, characterization, and structure-activity relationships in vitro and in vivo
    • K. Riebeseel, E. Biedermann, R. Löser, N. Breiter, R. Hanselmann, R. Muelhaupt, C. Unger, and F. Kratz Polyethylene glycol conjugates of methotrexate varying in their molecular weight from MW 750 to MW 40,000; synthesis, characterization, and structure-activity relationships in vitro and in vivo Bioconjugate Chemistry 13 2002 773 785
    • (2002) Bioconjugate Chemistry , vol.13 , pp. 773-785
    • Riebeseel, K.1    Biedermann, E.2    Löser, R.3    Breiter, N.4    Hanselmann, R.5    Muelhaupt, R.6    Unger, C.7    Kratz, F.8
  • 89
    • 70449093381 scopus 로고    scopus 로고
    • Modified chitosan derivative micelle system for natural anti-tumor product gambogic acid delivery
    • G. Qu, X. Zhu, C. Zhang, and Q. Ping Modified chitosan derivative micelle system for natural anti-tumor product gambogic acid delivery Drug Delivery 16 2009 363 370
    • (2009) Drug Delivery , vol.16 , pp. 363-370
    • Qu, G.1    Zhu, X.2    Zhang, C.3    Ping, Q.4
  • 90
    • 54149096519 scopus 로고    scopus 로고
    • Water-soluble gambogic acid PEGylated prodrugs: Synthesis, characterization, physicochemical properties and in vitro hydrolysis
    • X. Tang, P. Zhang, H. Ye, C. Zhang, W. Shen, and Q. Ping Water-soluble gambogic acid PEGylated prodrugs: synthesis, characterization, physicochemical properties and in vitro hydrolysis Pharmazie 63 2008 711 717
    • (2008) Pharmazie , vol.63 , pp. 711-717
    • Tang, X.1    Zhang, P.2    Ye, H.3    Zhang, C.4    Shen, W.5    Ping, Q.6
  • 92
    • 9244261964 scopus 로고    scopus 로고
    • Synthesis of poly (ethylene glycol)-based saquinavir prodrug conjugates and assessment of release and anti-HIV-1 bioactivity using a novel protease inhibition assay
    • S. Gunaseelan, O. Debrah, L. Wan, M.J. Leibowitz, A.B. Rabson, S. Stein, and P.J. Sinko Synthesis of poly (ethylene glycol)-based saquinavir prodrug conjugates and assessment of release and anti-HIV-1 bioactivity using a novel protease inhibition assay Bioconjugate Chemistry 15 2004 1322 1333
    • (2004) Bioconjugate Chemistry , vol.15 , pp. 1322-1333
    • Gunaseelan, S.1    Debrah, O.2    Wan, L.3    Leibowitz, M.J.4    Rabson, A.B.5    Stein, S.6    Sinko, P.J.7
  • 93
    • 0035090503 scopus 로고    scopus 로고
    • Ocular tolerability and in vivo bioavailability of poly(ethylene glycol) (PEG)-coated polyethyl-2-cyanoacrylate nanosphere-encapsulated acyclovir
    • M. Fresta, G. Fontana, C. Bucolo, G. Cavallaro, G. Giammona, and G. Puglisi Ocular tolerability and in vivo bioavailability of poly(ethylene glycol) (PEG)-coated polyethyl-2-cyanoacrylate nanosphere-encapsulated acyclovir Journal of Pharmaceutical Sciences 90 2001 288 297
    • (2001) Journal of Pharmaceutical Sciences , vol.90 , pp. 288-297
    • Fresta, M.1    Fontana, G.2    Bucolo, C.3    Cavallaro, G.4    Giammona, G.5    Puglisi, G.6
  • 94
    • 0036516759 scopus 로고    scopus 로고
    • Syntheses, chemical and enzymatic stability of new poly (ethylene glycol)-acyclovir prodrugs
    • M. Zacchigna, G. Di Luca, V. Maurich, and Boccù E Syntheses, chemical and enzymatic stability of new poly (ethylene glycol)-acyclovir prodrugs Il Farmaco 57 2002 207 214
    • (2002) Il Farmaco , vol.57 , pp. 207-214
    • Zacchigna, M.1    Di Luca, G.2    Maurich, V.3    Boccù, E.4
  • 96
    • 0033039160 scopus 로고    scopus 로고
    • Sterically stabilized liposomes containing gentamicin: Limitations to gentamicin encapsulation
    • E.J. Ruijgrok, A.G. Vulto, and E.W.M. van Etten Sterically stabilized liposomes containing gentamicin: limitations to gentamicin encapsulation Journal of Liposome Research 9 1999 291 300
    • (1999) Journal of Liposome Research , vol.9 , pp. 291-300
    • Ruijgrok, E.J.1    Vulto, A.G.2    Van Etten, E.W.M.3
  • 97
    • 47749127296 scopus 로고    scopus 로고
    • Turning low-molecular-weight drugs into prolonged acting prodrugs by reversible pegylation: A study with gentamicin
    • Y. Marcus, K. Sasson, M. Fridkin, and Y. Shechter Turning low-molecular-weight drugs into prolonged acting prodrugs by reversible pegylation: a study with gentamicin Journal of Medicinal Chemistry 51 2008 4300 4305
    • (2008) Journal of Medicinal Chemistry , vol.51 , pp. 4300-4305
    • Marcus, Y.1    Sasson, K.2    Fridkin, M.3    Shechter, Y.4
  • 98
    • 0002596434 scopus 로고    scopus 로고
    • Amphotericin B toxicity and lethality: A tale of two channels
    • B.E. Cohen Amphotericin B toxicity and lethality: a tale of two channels International Journal of Pharmaceutics 162 1998 95 106
    • (1998) International Journal of Pharmaceutics , vol.162 , pp. 95-106
    • Cohen, B.E.1
  • 100
    • 34247568837 scopus 로고    scopus 로고
    • Synthesis of pH-sensitive amphotericin B-poly (ethylene glycol) conjugates and study of their controlled release in vitro
    • M. Sedlák, M. Pravda, F. Staud, L. Kubicová, K. Týcová, and K. Ventura Synthesis of pH-sensitive amphotericin B-poly (ethylene glycol) conjugates and study of their controlled release in vitro Bioorganic and Medicinal Chemistry 15 2007 4069 4076
    • (2007) Bioorganic and Medicinal Chemistry , vol.15 , pp. 4069-4076
    • Sedlák, M.1    Pravda, M.2    Staud, F.3    Kubicová, L.4    Týcová, K.5    Ventura, K.6
  • 102
    • 77957772731 scopus 로고    scopus 로고
    • Chapter 9-opioid receptor antagonists for gastrointestinal dysfunction
    • J.C. Barrish, D. Weinstein, Bristol-Myers Squibb R&D Princeton, NJ
    • W.R. Hipkin, and R.E. Dolle Chapter 9-opioid receptor antagonists for gastrointestinal dysfunction J.C. Barrish, D. Weinstein, Annu Rep Med Chem Part III: inflammation/pulmonary/gastrointestinal diseases vol. 45 2010 Bristol-Myers Squibb R&D Princeton, NJ 142 155
    • (2010) Annu Rep Med Chem Part III: Inflammation/pulmonary/gastrointestinal Diseases , vol.45 VOL. , pp. 142-155
    • Hipkin, W.R.1    Dolle, R.E.2
  • 103
    • 77957905102 scopus 로고    scopus 로고
    • Efficacy, safety and pharmacokinetics of oral NKTR-118 in patients with opioid-induced constipation: Results of a randomized, double-blind. Placebo-controlled phase 2 study
    • L. Webster, E.R. Blonsky, P. Matz, D. Levinsky, R. Martz, S. Dhar, T. Neumann, M. Eldon, and T. Patrick Efficacy, safety and pharmacokinetics of oral NKTR-118 in patients with opioid-induced constipation: results of a randomized, double-blind. Placebo-controlled phase 2 study American Journal of Gastroenterology 104 2009 S174
    • (2009) American Journal of Gastroenterology , vol.104 , pp. 174
    • Webster, L.1    Blonsky, E.R.2    Matz, P.3    Levinsky, D.4    Martz, R.5    Dhar, S.6    Neumann, T.7    Eldon, M.8    Patrick, T.9
  • 105
    • 77749264641 scopus 로고    scopus 로고
    • 28th annual JPMorgan healthcare conference - Exelixis and nektar therapeutics
    • S. Gale, and G. Croasdell 28th annual JPMorgan healthcare conference - exelixis and nektar therapeutics IDrugs 13 2010 139 141
    • (2010) IDrugs , vol.13 , pp. 139-141
    • Gale, S.1    Croasdell, G.2
  • 106
    • 55749111387 scopus 로고    scopus 로고
    • The pharmacology of PEGylation: Balancing PD with PK to generate novel therapeutics
    • C.S. Fishburn The pharmacology of PEGylation: balancing PD with PK to generate novel therapeutics Journal of Pharmaceutical Sciences 97 2008 4167 4183
    • (2008) Journal of Pharmaceutical Sciences , vol.97 , pp. 4167-4183
    • Fishburn, C.S.1
  • 108
    • 16644382776 scopus 로고    scopus 로고
    • Preparation of highly water soluble tacrolimus derivatives: Poly (ethylene glycol) esters as potential prodrugs
    • Y. Chung, and H. Cho Preparation of highly water soluble tacrolimus derivatives: poly (ethylene glycol) esters as potential prodrugs Archives of Pharmacal Research 27 2004 878 883
    • (2004) Archives of Pharmacal Research , vol.27 , pp. 878-883
    • Chung, Y.1    Cho, H.2
  • 109
    • 28844433357 scopus 로고    scopus 로고
    • The preparation of silybin-phospholipid complex and the study on its pharmacokinetics in rats
    • X. Yanyu, S. Yunmei, C. Zhipeng, and P. Qineng The preparation of silybin-phospholipid complex and the study on its pharmacokinetics in rats International Journal of Pharmaceutics 307 2006 77 82
    • (2006) International Journal of Pharmaceutics , vol.307 , pp. 77-82
    • Yanyu, X.1    Yunmei, S.2    Zhipeng, C.3    Qineng, P.4
  • 110
    • 39049135836 scopus 로고    scopus 로고
    • Water soluble poly (ethylene glycol) prodrug of silybin: Design, synthesis, and characterization
    • P. Zhang, H. Ye, T. Min, and C. Zhang Water soluble poly (ethylene glycol) prodrug of silybin: design, synthesis, and characterization Journal of Applied Polymer Science 107 2008 3230 3235
    • (2008) Journal of Applied Polymer Science , vol.107 , pp. 3230-3235
    • Zhang, P.1    Ye, H.2    Min, T.3    Zhang, C.4


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