Syntheses, chemical and enzymatic stability of new poly(ethylene glycol)-acyclovir prodrugs

Farmaco

Volumn 57, Issue 3, 2002, Pages 207-214

  Zacchigna, M ^a   Di Luca, G ^a   Maurich, V ^a   Boccu E ^a  

^a UNIVERSITY OF TRIESTE   (Italy)

Author keywords

Acyclovir; Macromolecular prodrugs; PEG; Poly(ethylene glycol); Valacyclovir

Indexed keywords

ACICLOVIR; ANTIVIRUS AGENT; BUFFER; MACROGOL; PRODRUG; TALAVIR; VALACICLOVIR; DRUG CARRIER; DRUG DERIVATIVE; MACROGOL DERIVATIVE; VALINE;

ARTICLE; CHEMISTRY; DRUG DEGRADATION; DRUG MONITORING; DRUG RELEASE; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME STABILITY; EVALUATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROLYSIS; IN VITRO STUDY; MACROMOLECULE; PH; PLASMA; PROTEIN DEGRADATION; BLOOD; DRUG EFFECT; INFRARED SPECTROPHOTOMETRY; PARTICLE SIZE; PROTEIN BINDING; SYNTHESIS;

ACYCLOVIR; ANTIVIRAL AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CARRIERS; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; PARTICLE SIZE; POLYETHYLENE GLYCOLS; PRODRUGS; PROTEIN BINDING; SPECTROPHOTOMETRY, INFRARED; VALINE;

EID: 0036516759     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(01)01193-4     Document Type: Article

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