-
1
-
-
0036635291
-
Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug
-
Capdevilel R., Buchdunger E., Zimmermann J., and Matter A. Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug. Nat. Rev., Drug. Discov. 7 (2002) 493-502
-
(2002)
Nat. Rev., Drug. Discov.
, vol.7
, pp. 493-502
-
-
Capdevilel, R.1
Buchdunger, E.2
Zimmermann, J.3
Matter, A.4
-
2
-
-
33747840618
-
Polymer conjugates as anticancer nanomedicines
-
Duncan R. Polymer conjugates as anticancer nanomedicines. Nat. Rev., Cancer 6 (2006) 688-701
-
(2006)
Nat. Rev., Cancer
, vol.6
, pp. 688-701
-
-
Duncan, R.1
-
3
-
-
12744269417
-
CT-2103: a novel macromolecular taxane with potential advantages compared with conventional taxanes
-
Langer C.J. CT-2103: a novel macromolecular taxane with potential advantages compared with conventional taxanes. Clin. Lung Cancer 6 Suppl. 2 (2004) S85-S88
-
(2004)
Clin. Lung Cancer
, vol.6
, Issue.SUPPL. 2
-
-
Langer, C.J.1
-
4
-
-
0032895235
-
Trastuzumab, a recombinant DNA-derived humanized monoclonal antibody, a novel agent for the treatment of metastatic breast cancer
-
Goldenberg M.M. Trastuzumab, a recombinant DNA-derived humanized monoclonal antibody, a novel agent for the treatment of metastatic breast cancer. Clin. Ther. 21 (1999) 309-318
-
(1999)
Clin. Ther.
, vol.21
, pp. 309-318
-
-
Goldenberg, M.M.1
-
5
-
-
0017701219
-
Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol
-
Abuchowski A., van Es T., Palczuk N.C., and Davis F.F. Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol. J. Biol. Chem. 252 (1977) 3578-3581
-
(1977)
J. Biol. Chem.
, vol.252
, pp. 3578-3581
-
-
Abuchowski, A.1
van Es, T.2
Palczuk, N.C.3
Davis, F.F.4
-
6
-
-
0037124473
-
-
Veronese F.M., and Harris J.M. (Eds)
-
In: Veronese F.M., and Harris J.M. (Eds). Theme issue on "Peptide and Protein Pegylation I". Ad. Drug Del. Rev vol. 54 (2002) 453-609
-
(2002)
Ad. Drug Del. Rev
, vol.54
, pp. 453-609
-
-
-
7
-
-
0345714812
-
-
Veronese F.M., and Harris J.M. Theme issue on "Pegylation of peptides and proteins II - Clinical Evaluation". Ad. Drug Del. Rev vol. 55 (2003) 1259-1350
-
(2003)
Ad. Drug Del. Rev
, vol.55
, pp. 1259-1350
-
-
Veronese, F.M.1
Harris, J.M.2
-
8
-
-
26944452043
-
PEGylation, successful approach to drug delivery
-
Veronese F.M., and Pasut G. PEGylation, successful approach to drug delivery. Drug Discov. Today 10 (2005) 1451-1457
-
(2005)
Drug Discov. Today
, vol.10
, pp. 1451-1457
-
-
Veronese, F.M.1
Pasut, G.2
-
9
-
-
0041931084
-
The enzyme as drug: application of enzymes as pharmaceuticals
-
Vellard M. The enzyme as drug: application of enzymes as pharmaceuticals. Curr. Opin. Biotechnol. 14 (2003) 444-450
-
(2003)
Curr. Opin. Biotechnol.
, vol.14
, pp. 444-450
-
-
Vellard, M.1
-
10
-
-
0141958659
-
Prevention and treatment of hyperuricemia in hematological malignancies
-
Cairo M.S. Prevention and treatment of hyperuricemia in hematological malignancies. Clin. Lymphoma 3 Suppl 1 (2002) S26-S31
-
(2002)
Clin. Lymphoma
, vol.3
, Issue.SUPPL. 1
-
-
Cairo, M.S.1
-
11
-
-
0036240985
-
Rasburicase: a potent uricolytic agent
-
Pu C.H. Rasburicase: a potent uricolytic agent. Expert Opin. Pharmacother. 3 (2002) 433-442
-
(2002)
Expert Opin. Pharmacother.
, vol.3
, pp. 433-442
-
-
Pu, C.H.1
-
12
-
-
84965111634
-
Regression of transplanted lymphomas induced in vivo by means of normal guinea pig serum. I. Course of transplanted cancers of various kinds in mice and rats given guinea pig serum, horse serum, or rabbit serum
-
Kidd J.G. Regression of transplanted lymphomas induced in vivo by means of normal guinea pig serum. I. Course of transplanted cancers of various kinds in mice and rats given guinea pig serum, horse serum, or rabbit serum. J. Exp. Med. 98 (1953) 565-582
-
(1953)
J. Exp. Med.
, vol.98
, pp. 565-582
-
-
Kidd, J.G.1
-
13
-
-
75449142384
-
Evidence that the l-asparaginase of guinea pig serum is responsible for its antilymphoma effects. I. Properties of the l-asparaginase of guinea pig serum in relation to those of the antilymphoma substance
-
Broome J.D. Evidence that the l-asparaginase of guinea pig serum is responsible for its antilymphoma effects. I. Properties of the l-asparaginase of guinea pig serum in relation to those of the antilymphoma substance. J. Exp. Med. 118 (1963) 99-120
-
(1963)
J. Exp. Med.
, vol.118
, pp. 99-120
-
-
Broome, J.D.1
-
14
-
-
0014572988
-
l-Asparaginase EC-2 from Escherichia coli. Some substrate specificity characteristics
-
Campbell H.A., and Mashburn L.T. l-Asparaginase EC-2 from Escherichia coli. Some substrate specificity characteristics. Biochemistry 8 (1969) 3768-3775
-
(1969)
Biochemistry
, vol.8
, pp. 3768-3775
-
-
Campbell, H.A.1
Mashburn, L.T.2
-
15
-
-
0014528541
-
Purification and properties of asparaginase from Escherichia coli B
-
Whelan H.A., and Wriston Jr. J.C. Purification and properties of asparaginase from Escherichia coli B. Biochemistry 8 (1969) 2386-2393
-
(1969)
Biochemistry
, vol.8
, pp. 2386-2393
-
-
Whelan, H.A.1
Wriston Jr., J.C.2
-
16
-
-
0034924041
-
A phase I and pharmacodynamic evaluation of polyethylene glycol-conjugated l-asparaginase in patients with advanced solid tumors
-
Taylor C.W., Dorr R.T., Fanta P., Hersh E.M., and Salmon S.E. A phase I and pharmacodynamic evaluation of polyethylene glycol-conjugated l-asparaginase in patients with advanced solid tumors. Cancer Chemother. Pharmacol. 47 (2001) 83-88
-
(2001)
Cancer Chemother. Pharmacol.
, vol.47
, pp. 83-88
-
-
Taylor, C.W.1
Dorr, R.T.2
Fanta, P.3
Hersh, E.M.4
Salmon, S.E.5
-
17
-
-
0037664982
-
A Phase I-II trial of polyethylene glycol-conjugated l-asparaginase in patients with multiple myeloma
-
Agrawal N.R., Bukowski R.M., Rybicki L.A., Kurtzberg J., Cohen L.J., and Hussein M.A. A Phase I-II trial of polyethylene glycol-conjugated l-asparaginase in patients with multiple myeloma. Cancer 98 (2003) 94-99
-
(2003)
Cancer
, vol.98
, pp. 94-99
-
-
Agrawal, N.R.1
Bukowski, R.M.2
Rybicki, L.A.3
Kurtzberg, J.4
Cohen, L.J.5
Hussein, M.A.6
-
18
-
-
0018487381
-
Treatment of L5178Y tumor-bearing BDF1 mice with a nonimmunogenic l-glutaminase-l-asparaginase
-
Abuchowski A., van Es T., Palczuk N.C., McCoy J.R., and Davis F.F. Treatment of L5178Y tumor-bearing BDF1 mice with a nonimmunogenic l-glutaminase-l-asparaginase. Cancer Treat. Rep. 63 (1979) 1127-1132
-
(1979)
Cancer Treat. Rep.
, vol.63
, pp. 1127-1132
-
-
Abuchowski, A.1
van Es, T.2
Palczuk, N.C.3
McCoy, J.R.4
Davis, F.F.5
-
19
-
-
0019809191
-
Pharmacology of Escherichia coli-l-asparaginase polyethylene glycol adduct
-
Park Y.K., Abuchowski A., Davis S., and Davis F. Pharmacology of Escherichia coli-l-asparaginase polyethylene glycol adduct. Anticancer Res. 1 (1981) 373-376
-
(1981)
Anticancer Res.
, vol.1
, pp. 373-376
-
-
Park, Y.K.1
Abuchowski, A.2
Davis, S.3
Davis, F.4
-
20
-
-
0021248339
-
Cancer therapy with chemically modified enzymes. I. Antitumor properties of polyethylene glycol-asparaginase conjugates
-
Abuchowski A., Kazo G.M., Verhoest Jr. C.R., Van Es T., Kafkewitz D., Nucci M.L., Viau A.T., and Davis F.F. Cancer therapy with chemically modified enzymes. I. Antitumor properties of polyethylene glycol-asparaginase conjugates. Cancer Biochem. Biophys. 7 (1984) 175-186
-
(1984)
Cancer Biochem. Biophys.
, vol.7
, pp. 175-186
-
-
Abuchowski, A.1
Kazo, G.M.2
Verhoest Jr., C.R.3
Van Es, T.4
Kafkewitz, D.5
Nucci, M.L.6
Viau, A.T.7
Davis, F.F.8
-
21
-
-
0022922655
-
Clinical pharmacology of polyethylene glycol-l-asparaginase
-
Ho D.H., Brown N.S., Yen A., Holmes R., Keating M., Abuchowski A., Newman R.A., and Krakoff I.H. Clinical pharmacology of polyethylene glycol-l-asparaginase. Drug Metab. Dispos. 14 (1986) 349-352
-
(1986)
Drug Metab. Dispos.
, vol.14
, pp. 349-352
-
-
Ho, D.H.1
Brown, N.S.2
Yen, A.3
Holmes, R.4
Keating, M.5
Abuchowski, A.6
Newman, R.A.7
Krakoff, I.H.8
-
22
-
-
0037177490
-
Effects of polyethylene glycol attachment on physicochemical and biological stability of E. coli l-asparaginase
-
Soares A.L., Guimaraes G.M., Polakiewicz B., de Moraes Pitombo R.N., and Abrahao-Neto J. Effects of polyethylene glycol attachment on physicochemical and biological stability of E. coli l-asparaginase. Int. J. Pharm. 237 (2002) 163-170
-
(2002)
Int. J. Pharm.
, vol.237
, pp. 163-170
-
-
Soares, A.L.1
Guimaraes, G.M.2
Polakiewicz, B.3
de Moraes Pitombo, R.N.4
Abrahao-Neto, J.5
-
24
-
-
18644364984
-
Pharmacokinetic/pharmacodynamic relationships of asparaginase formulations: the past, the present and recommendations for the future
-
Avramis V.I., and Panosyan E.H. Pharmacokinetic/pharmacodynamic relationships of asparaginase formulations: the past, the present and recommendations for the future. Clin. Pharmacokinet. 44 (2005) 93-367
-
(2005)
Clin. Pharmacokinet.
, vol.44
, pp. 93-367
-
-
Avramis, V.I.1
Panosyan, E.H.2
-
25
-
-
0037957209
-
PEG-adenosine deaminase and PEG-asparaginase
-
Davis F.F. PEG-adenosine deaminase and PEG-asparaginase. Adv. Exp. Med. Biol. 519 (2003) 51-58
-
(2003)
Adv. Exp. Med. Biol.
, vol.519
, pp. 51-58
-
-
Davis, F.F.1
-
26
-
-
0042999388
-
Pegaspargase: a review of clinical studies
-
Graham M.L. Pegaspargase: a review of clinical studies. Adv. Drug Deliv. Rev. 55 (2003) 1293-1302
-
(2003)
Adv. Drug Deliv. Rev.
, vol.55
, pp. 1293-1302
-
-
Graham, M.L.1
-
27
-
-
0036214409
-
A pharmacoeconomic analysis of PEG-aspargase versus native Escherichia coli l-asparaginase for the treatment of children with standard-risk, acute lymphoblastic leukemia: the children's cancer group study (CCG-1962)
-
Kurre H.A., Ettinger A.G., Veenstra D.L., Gaynon P.S., Franklin J., Sencer S.F., Reaman G.H., Lange B.J., and Holcenberg J.S. A pharmacoeconomic analysis of PEG-aspargase versus native Escherichia coli l-asparaginase for the treatment of children with standard-risk, acute lymphoblastic leukemia: the children's cancer group study (CCG-1962). J. Pediatr. Hematol./Oncol. 24 (2002) 175-181
-
(2002)
J. Pediatr. Hematol./Oncol.
, vol.24
, pp. 175-181
-
-
Kurre, H.A.1
Ettinger, A.G.2
Veenstra, D.L.3
Gaynon, P.S.4
Franklin, J.5
Sencer, S.F.6
Reaman, G.H.7
Lange, B.J.8
Holcenberg, J.S.9
-
28
-
-
4143063669
-
Asparaginase pharmacokinetics after intensive polyethylene glycol-conjugated l-asparaginase therapy for children with relapsed acute lymphoblastic leukemia
-
Hawkins D.S., Park J.R., Thomson B.G., Felgenhauer J.L., Holcenberg J.S., Panosyan E.H., and Avramis V.I. Asparaginase pharmacokinetics after intensive polyethylene glycol-conjugated l-asparaginase therapy for children with relapsed acute lymphoblastic leukemia. Clin. Cancer Res. 10 (2004) 5335-5341
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 5335-5341
-
-
Hawkins, D.S.1
Park, J.R.2
Thomson, B.G.3
Felgenhauer, J.L.4
Holcenberg, J.S.5
Panosyan, E.H.6
Avramis, V.I.7
-
29
-
-
2442496750
-
Asparaginase antibody and asparaginase activity in children with higher-risk acute lymphoblastic leukemia: children's cancer group study CCG-1961
-
Panosyan E.H., Seibel N.L., Martin-Aragon S., Gaynon P.S., Avramis I.A., Sather H., Franklin J., Nachman J., Ettinger L.J., La M., Steinherz P., Cohen L.J., Siegel S.E., and Avramis V.I. Asparaginase antibody and asparaginase activity in children with higher-risk acute lymphoblastic leukemia: children's cancer group study CCG-1961. J. Pediatr. Hematol./Oncol. 26 (2004) 217-226
-
(2004)
J. Pediatr. Hematol./Oncol.
, vol.26
, pp. 217-226
-
-
Panosyan, E.H.1
Seibel, N.L.2
Martin-Aragon, S.3
Gaynon, P.S.4
Avramis, I.A.5
Sather, H.6
Franklin, J.7
Nachman, J.8
Ettinger, L.J.9
La, M.10
Steinherz, P.11
Cohen, L.J.12
Siegel, S.E.13
Avramis, V.I.14
-
30
-
-
34250800861
-
Antibody against poly(ethylene glycol) adversely affects PEG-asparaginase therapy in acute lymphoblastic leukemia patients
-
Armstrong J.K., Hempel G., Koling S., Chan L.S., Fisher T., Meiselman H.J., and Garratty G. Antibody against poly(ethylene glycol) adversely affects PEG-asparaginase therapy in acute lymphoblastic leukemia patients. Cancer 110 (2007) 103-111
-
(2007)
Cancer
, vol.110
, pp. 103-111
-
-
Armstrong, J.K.1
Hempel, G.2
Koling, S.3
Chan, L.S.4
Fisher, T.5
Meiselman, H.J.6
Garratty, G.7
-
31
-
-
0019123361
-
Reversible growth arrest in simian virus 40-transformed human fibroblasts
-
Hoffman R.M., and Jacobsen S.J. Reversible growth arrest in simian virus 40-transformed human fibroblasts. Proc. Natl. Acad. Sci. U. S. A. 77 (1980) 7306-7310
-
(1980)
Proc. Natl. Acad. Sci. U. S. A.
, vol.77
, pp. 7306-7310
-
-
Hoffman, R.M.1
Jacobsen, S.J.2
-
32
-
-
0027316296
-
Expression of the biochemical defect of methionine dependence in fresh patient tumors in primary histoculture
-
Guo H., Herrera H., Groce A., and Hoffman R.M. Expression of the biochemical defect of methionine dependence in fresh patient tumors in primary histoculture. Cancer Res. 53 (1993) 2479-2483
-
(1993)
Cancer Res.
, vol.53
, pp. 2479-2483
-
-
Guo, H.1
Herrera, H.2
Groce, A.3
Hoffman, R.M.4
-
34
-
-
0027527220
-
Therapeutic tumor-specific cell cycle block induced by methionine starvation in vivo
-
Guo H., Lishko V.K., Herrera H., Groce A., Kubota T., and Hoffman R.M. Therapeutic tumor-specific cell cycle block induced by methionine starvation in vivo. Cancer Res. 53 (1993) 5676-5679
-
(1993)
Cancer Res.
, vol.53
, pp. 5676-5679
-
-
Guo, H.1
Lishko, V.K.2
Herrera, H.3
Groce, A.4
Kubota, T.5
Hoffman, R.M.6
-
36
-
-
0031106365
-
Overexpression and large-scale production of recombinant l-methionine-alpha-deamino-gamma-mercaptomethane-lyase for novel anticancer therapy
-
Tan Y., Xu M., Tan X., Wang X., Saikawa Y., Nagahama T., Sun X., Lenz M., and Hoffman R.M. Overexpression and large-scale production of recombinant l-methionine-alpha-deamino-gamma-mercaptomethane-lyase for novel anticancer therapy. Protein Expr. Purif. 9 (1997) 233-245
-
(1997)
Protein Expr. Purif.
, vol.9
, pp. 233-245
-
-
Tan, Y.1
Xu, M.2
Tan, X.3
Wang, X.4
Saikawa, Y.5
Nagahama, T.6
Sun, X.7
Lenz, M.8
Hoffman, R.M.9
-
37
-
-
0030485699
-
Serum methionine depletion without side effects by methioninase in metastatic breast cancer patients
-
Tan Y., Zavala Sr J., Xu M., Zavala Jr. J., and Hoffman R.M. Serum methionine depletion without side effects by methioninase in metastatic breast cancer patients. Anticancer Res. 16 (1996) 3937-3942
-
(1996)
Anticancer Res.
, vol.16
, pp. 3937-3942
-
-
Tan, Y.1
Zavala Sr, J.2
Xu, M.3
Zavala Jr., J.4
Hoffman, R.M.5
-
38
-
-
0031469067
-
Recombinant methioninase infusion reduces the biochemical endpoint of serum methionine with minimal toxicity in high-stage cancer patients
-
Tan Y., Zavala Sr J., Han Q., Xu M., Sun X., Tan X., Magana R., Geller J., and Hoffman R.M. Recombinant methioninase infusion reduces the biochemical endpoint of serum methionine with minimal toxicity in high-stage cancer patients. Anticancer Res. 17 (1997) 3857-3860
-
(1997)
Anticancer Res.
, vol.17
, pp. 3857-3860
-
-
Tan, Y.1
Zavala Sr, J.2
Han, Q.3
Xu, M.4
Sun, X.5
Tan, X.6
Magana, R.7
Geller, J.8
Hoffman, R.M.9
-
39
-
-
10744223928
-
In vivo efficacy of recombinant methioninase is enhanced by the combination of polyethylene glycol conjugation and pyridoxal 5-phosphate supplementation
-
Sun X., Yang Z., Li S., Tan Y., Zhang N., Wang X., Yagi S., Yoshioka T., Takimoto A., Mitsushima K., Suginaka A., Frenkel E.P., and Hoffman R.M. In vivo efficacy of recombinant methioninase is enhanced by the combination of polyethylene glycol conjugation and pyridoxal 5-phosphate supplementation. Cancer Res. 63 (2003) 8377-8383
-
(2003)
Cancer Res.
, vol.63
, pp. 8377-8383
-
-
Sun, X.1
Yang, Z.2
Li, S.3
Tan, Y.4
Zhang, N.5
Wang, X.6
Yagi, S.7
Yoshioka, T.8
Takimoto, A.9
Mitsushima, K.10
Suginaka, A.11
Frenkel, E.P.12
Hoffman, R.M.13
-
40
-
-
0032007236
-
Polyethylene glycol conjugation of recombinant methioninase for cancer therapy
-
Tan Y., Sun X., Xu M., An Z., Tan X., Han Q., Miljkovic D.A., Yang M., and Hoffman R.M. Polyethylene glycol conjugation of recombinant methioninase for cancer therapy. Protein Expr. Purif. 12 (1998) 45-52
-
(1998)
Protein Expr. Purif.
, vol.12
, pp. 45-52
-
-
Tan, Y.1
Sun, X.2
Xu, M.3
An, Z.4
Tan, X.5
Han, Q.6
Miljkovic, D.A.7
Yang, M.8
Hoffman, R.M.9
-
41
-
-
12144288046
-
Pharmacokinetics, methionine depletion, and antigenicity of recombinant methioninase in primates
-
Yang Z., Wang J., Yoshioka T., Li B., Lu Q., Li S., Sun X., Tan Y., Yagi S., Frenkel E.P., and Hoffman R.M. Pharmacokinetics, methionine depletion, and antigenicity of recombinant methioninase in primates. Clin. Cancer Res. 10 (2004) 2131-2138
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 2131-2138
-
-
Yang, Z.1
Wang, J.2
Yoshioka, T.3
Li, B.4
Lu, Q.5
Li, S.6
Sun, X.7
Tan, Y.8
Yagi, S.9
Frenkel, E.P.10
Hoffman, R.M.11
-
42
-
-
4143076011
-
Circulating half-life of PEGylated recombinant methioninase holoenzyme is highly dose dependent on cofactor pyridoxal-5-phosphate
-
Yang Z., Sun X., Li S., Tan Y., Wang X., Zhang N., Yagi S., Takakura T., Kobayashi Y., Takimoto A., Yoshioka T., Suginaka A., Frenkel E.P., and Hoffman R.M. Circulating half-life of PEGylated recombinant methioninase holoenzyme is highly dose dependent on cofactor pyridoxal-5-phosphate. Cancer Res. 64 (2004) 5775-5778
-
(2004)
Cancer Res.
, vol.64
, pp. 5775-5778
-
-
Yang, Z.1
Sun, X.2
Li, S.3
Tan, Y.4
Wang, X.5
Zhang, N.6
Yagi, S.7
Takakura, T.8
Kobayashi, Y.9
Takimoto, A.10
Yoshioka, T.11
Suginaka, A.12
Frenkel, E.P.13
Hoffman, R.M.14
-
43
-
-
4644323709
-
PEGylation confers greatly extended half-life and attenuated immunogenicity to recombinant methioninase in primates
-
Yang Z., Wang J., Lu Q., Xu J., Kobayashi Y., Takakura T., Takimoto A., Yoshioka T., Lian C., Chen C., Zhang D., Zhang Y., Li S., Sun X., Tan Y., Yagi S., Frenkel E.P., and Hoffman R.M. PEGylation confers greatly extended half-life and attenuated immunogenicity to recombinant methioninase in primates. Cancer Res. 64 (2004) 6673-6678
-
(2004)
Cancer Res.
, vol.64
, pp. 6673-6678
-
-
Yang, Z.1
Wang, J.2
Lu, Q.3
Xu, J.4
Kobayashi, Y.5
Takakura, T.6
Takimoto, A.7
Yoshioka, T.8
Lian, C.9
Chen, C.10
Zhang, D.11
Zhang, Y.12
Li, S.13
Sun, X.14
Tan, Y.15
Yagi, S.16
Frenkel, E.P.17
Hoffman, R.M.18
-
44
-
-
0026686536
-
High sensitivity of human melanoma cell lines to the growth inhibitory activity of mycoplasmal arginine deiminase in vitro
-
Sugimura K., Ohno T., Kusuyama T., and Azuma I. High sensitivity of human melanoma cell lines to the growth inhibitory activity of mycoplasmal arginine deiminase in vitro. Melanoma Res. 2 (1992) 191-196
-
(1992)
Melanoma Res.
, vol.2
, pp. 191-196
-
-
Sugimura, K.1
Ohno, T.2
Kusuyama, T.3
Azuma, I.4
-
45
-
-
19344365089
-
Remission of hepatocellular carcinoma with arginine depletion induced by systemic release of endogenous hepatic arginase due to transhepatic arterial embolisation, augmented by high-dose insulin: arginase as a potential drug candidate for hepatocellular carcinoma
-
Cheng P.N., Leung Y.C., Lo W.H., Tsui S.M., and Lam K.C. Remission of hepatocellular carcinoma with arginine depletion induced by systemic release of endogenous hepatic arginase due to transhepatic arterial embolisation, augmented by high-dose insulin: arginase as a potential drug candidate for hepatocellular carcinoma. Cancer Lett. 224 (2005) 67-80
-
(2005)
Cancer Lett.
, vol.224
, pp. 67-80
-
-
Cheng, P.N.1
Leung, Y.C.2
Lo, W.H.3
Tsui, S.M.4
Lam, K.C.5
-
46
-
-
0018799136
-
Preparation of a non-immunogenic arginase by the covalent attachment of polyethylene glycol
-
Savoca K.V., Abuchowski A., van Es T., Davis F.F., and Palczuk N.C. Preparation of a non-immunogenic arginase by the covalent attachment of polyethylene glycol. Biochim. Biophys. Acta 578 (1979) 47-53
-
(1979)
Biochim. Biophys. Acta
, vol.578
, pp. 47-53
-
-
Savoca, K.V.1
Abuchowski, A.2
van Es, T.3
Davis, F.F.4
Palczuk, N.C.5
-
47
-
-
0028018129
-
High level expression of Mycoplasma arginine deiminase in Escherichia coli and its efficient renaturation as an anti-tumor enzyme
-
Misawa S., Aoshima M., Takaku H., Matsumoto M., and Hayashi H. High level expression of Mycoplasma arginine deiminase in Escherichia coli and its efficient renaturation as an anti-tumor enzyme. J. Biotechnol. 36 (1994) 145-155
-
(1994)
J. Biotechnol.
, vol.36
, pp. 145-155
-
-
Misawa, S.1
Aoshima, M.2
Takaku, H.3
Matsumoto, M.4
Hayashi, H.5
-
48
-
-
0026608575
-
In vivo antitumor activity of arginine deiminase purified from Mycoplasma arginini
-
Takaku H., Takase M., Abe S., Hayashi H., and Miyazaki K. In vivo antitumor activity of arginine deiminase purified from Mycoplasma arginini. Int. J. Cancer 51 (1992) 244-249
-
(1992)
Int. J. Cancer
, vol.51
, pp. 244-249
-
-
Takaku, H.1
Takase, M.2
Abe, S.3
Hayashi, H.4
Miyazaki, K.5
-
49
-
-
0342748603
-
Arginine deiminase inhibits proliferation of human leukemia cells more potently than asparaginase by inducing cell cycle arrest and apoptosis
-
Gong H., Zolzer F., von Recklinghausen G., Havers W., and Schweigerer L. Arginine deiminase inhibits proliferation of human leukemia cells more potently than asparaginase by inducing cell cycle arrest and apoptosis. Leukemia 14 (2000) 826-829
-
(2000)
Leukemia
, vol.14
, pp. 826-829
-
-
Gong, H.1
Zolzer, F.2
von Recklinghausen, G.3
Havers, W.4
Schweigerer, L.5
-
50
-
-
0036792124
-
PEGylated argininedeiminase (ADI-SS PEG 20,000 MW) inhibits human melanomas and hepatocellularcarcinomas in vitro and in vivo
-
Ensor C.M., Holtsberg F.W., Bomalaski J.S., and Clark M.A. PEGylated argininedeiminase (ADI-SS PEG 20,000 MW) inhibits human melanomas and hepatocellularcarcinomas in vitro and in vivo. Cancer Res. 62 (2002) 5443-5450
-
(2002)
Cancer Res.
, vol.62
, pp. 5443-5450
-
-
Ensor, C.M.1
Holtsberg, F.W.2
Bomalaski, J.S.3
Clark, M.A.4
-
51
-
-
0018870253
-
Comparison of the immunosuppressive effects of asparaginases from Escherichia coli and Vibrio succinogenes
-
Durden D.L., and Distasio J.A. Comparison of the immunosuppressive effects of asparaginases from Escherichia coli and Vibrio succinogenes. Cancer Res. 40 (1980) 1125-1129
-
(1980)
Cancer Res.
, vol.40
, pp. 1125-1129
-
-
Durden, D.L.1
Distasio, J.A.2
-
52
-
-
0019952110
-
Glutaminase-freeasparaginase from vibrio succinogenes: an antilymphoma enzyme lacking hepatotoxicity
-
Distasio J.A., Salazar A.M., Nadji M., and Durden D.L. Glutaminase-freeasparaginase from vibrio succinogenes: an antilymphoma enzyme lacking hepatotoxicity. Int. J. Cancer 30 (1982) 343-347
-
(1982)
Int. J. Cancer
, vol.30
, pp. 343-347
-
-
Distasio, J.A.1
Salazar, A.M.2
Nadji, M.3
Durden, D.L.4
-
53
-
-
0037161333
-
Poly(ethylene glycol) (PEG) conjugated arginine deiminase: effects of PEG formulations on its pharmacological properties
-
Holtsberg F.W., Ensor C.M., Steiner M.R., Bomalaski J.S., and Clark M.A. Poly(ethylene glycol) (PEG) conjugated arginine deiminase: effects of PEG formulations on its pharmacological properties. J. Control. Release 80 (2002) 259-271
-
(2002)
J. Control. Release
, vol.80
, pp. 259-271
-
-
Holtsberg, F.W.1
Ensor, C.M.2
Steiner, M.R.3
Bomalaski, J.S.4
Clark, M.A.5
-
54
-
-
3042744030
-
PEGylated arginine deiminase treatment of patients with unresectable hepatocellular carcinoma: results from phase I/II studies
-
Izzo F., Marra P., Beneduce G., Castello G., Vallone P., De Rosa V., Cremona F., Ensor C.M., Holtsberg F.W., Bomalaski J.S., Clark M.A., Ng C., and Curley S.A. PEGylated arginine deiminase treatment of patients with unresectable hepatocellular carcinoma: results from phase I/II studies. J. Clin. Oncol. 22 (2004) 1815-1822
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 1815-1822
-
-
Izzo, F.1
Marra, P.2
Beneduce, G.3
Castello, G.4
Vallone, P.5
De Rosa, V.6
Cremona, F.7
Ensor, C.M.8
Holtsberg, F.W.9
Bomalaski, J.S.10
Clark, M.A.11
Ng, C.12
Curley, S.A.13
-
55
-
-
32944469353
-
Pegylated arginine deiminase treatment of patients with metastatic melanoma: results from phase I and II studies
-
(Erratum in: J. Clin. Oncol.24 (2006) 4047)
-
Ascierto P.A., Scala S., Castello G., Daponte A., Simeone E., Ottaiano A., et al. Pegylated arginine deiminase treatment of patients with metastatic melanoma: results from phase I and II studies. J. Clin. Oncol. 23 (2005) 7660-7668 (Erratum in: J. Clin. Oncol.24 (2006) 4047)
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 7660-7668
-
-
Ascierto, P.A.1
Scala, S.2
Castello, G.3
Daponte, A.4
Simeone, E.5
Ottaiano, A.6
-
56
-
-
33845635205
-
Pegylated arginine deiminase lowers hepatitis C viral titers and inhibits nitric oxide synthesis
-
Izzo F., Montella M., Orlando A.P., Nasti G., Beneduce G., Castello G., et al. Pegylated arginine deiminase lowers hepatitis C viral titers and inhibits nitric oxide synthesis. J. Gastroenterol. Hepatol. 22 (2007) 86-91
-
(2007)
J. Gastroenterol. Hepatol.
, vol.22
, pp. 86-91
-
-
Izzo, F.1
Montella, M.2
Orlando, A.P.3
Nasti, G.4
Beneduce, G.5
Castello, G.6
-
57
-
-
33845200825
-
Engineering an arginine catabolizing bioconjugate: biochemical and pharmacological characterization of pegylated derivatives of arginine deiminase from Mycoplasma arthritidis
-
Wang M., Basu A., Palm T., Hua J., Youngster S., Hwang L., et al. Engineering an arginine catabolizing bioconjugate: biochemical and pharmacological characterization of pegylated derivatives of arginine deiminase from Mycoplasma arthritidis. Bioconjug. Chem. 17 (2006) 1447-1459
-
(2006)
Bioconjug. Chem.
, vol.17
, pp. 1447-1459
-
-
Wang, M.1
Basu, A.2
Palm, T.3
Hua, J.4
Youngster, S.5
Hwang, L.6
-
58
-
-
0017725220
-
Arginine deaminase from Mycoplasma arthritidis: evidence for multiple forms
-
Weickmann J.L., and Fahrney D.E. Arginine deaminase from Mycoplasma arthritidis: evidence for multiple forms. J. Biol. Chem. 252 (1977) 2615-2620
-
(1977)
J. Biol. Chem.
, vol.252
, pp. 2615-2620
-
-
Weickmann, J.L.1
Fahrney, D.E.2
-
59
-
-
0018133522
-
Arginine deiminase from Mycoplasma arthritidis: properties of the enzyme from log phase cultures
-
Weickmann J.L., Himmel M.E., Squire P.G., and Fahrney D.E. Arginine deiminase from Mycoplasma arthritidis: properties of the enzyme from log phase cultures. J. Biol. Chem. 253 (1978) 6010-6015
-
(1978)
J. Biol. Chem.
, vol.253
, pp. 6010-6015
-
-
Weickmann, J.L.1
Himmel, M.E.2
Squire, P.G.3
Fahrney, D.E.4
-
60
-
-
0018077228
-
Arginine deiminase from Mycoplasma arthritidis: structure-activity relationships among substrates and competitive inhibitors
-
Smith D.W., Ganaway R.L., and Fahrney D.E. Arginine deiminase from Mycoplasma arthritidis: structure-activity relationships among substrates and competitive inhibitors. J. Biol. Chem. 253 (1978) 6016-6020
-
(1978)
J. Biol. Chem.
, vol.253
, pp. 6016-6020
-
-
Smith, D.W.1
Ganaway, R.L.2
Fahrney, D.E.3
-
61
-
-
0029124788
-
Anti-tumor activity of arginine deiminase from Mycoplasma arginini and its growth-inhibitory mechanism
-
Takaku H., Matsumoto M., Misawa S., and Miyazaki K. Anti-tumor activity of arginine deiminase from Mycoplasma arginini and its growth-inhibitory mechanism. Jpn. J. Cancer Res. 86 (1995) 840-846
-
(1995)
Jpn. J. Cancer Res.
, vol.86
, pp. 840-846
-
-
Takaku, H.1
Matsumoto, M.2
Misawa, S.3
Miyazaki, K.4
-
62
-
-
33846429217
-
Pegylated recombinant human arginase (rhArg-peg 5,000 MW) inhibits the in vitro and in vivo proliferation of human hepatocellular carcinoma through arginine depletion
-
Cheng P.N., Lam T., Lam W., Tsui S., Cheng A.W., Lo W., and Leung Y. Pegylated recombinant human arginase (rhArg-peg 5,000 MW) inhibits the in vitro and in vivo proliferation of human hepatocellular carcinoma through arginine depletion. Cancer Res. 67 (2007) 309-317
-
(2007)
Cancer Res.
, vol.67
, pp. 309-317
-
-
Cheng, P.N.1
Lam, T.2
Lam, W.3
Tsui, S.4
Cheng, A.W.5
Lo, W.6
Leung, Y.7
-
63
-
-
0036402941
-
Regulation of enzymes of the urea cycle and arginine metabolism
-
Morris Jr. S.M. Regulation of enzymes of the urea cycle and arginine metabolism. Annu. Rev. Nutr. 22 (2002) 87-105
-
(2002)
Annu. Rev. Nutr.
, vol.22
, pp. 87-105
-
-
Morris Jr., S.M.1
-
64
-
-
0021132808
-
Cancer therapy with chemically modified enzymes. II. The therapeutic effectiveness of arginase, and arginase modified by the covalent attachment of polyethylene glycol, on the taper liver tumor and the L5178Y murine leukemia
-
Savoca K.V., Davis F.F., van Es T., McCoy J.R., and Palczuk N.C. Cancer therapy with chemically modified enzymes. II. The therapeutic effectiveness of arginase, and arginase modified by the covalent attachment of polyethylene glycol, on the taper liver tumor and the L5178Y murine leukemia. Cancer Biochem. Biophys. 7 (1984) 261-268
-
(1984)
Cancer Biochem. Biophys.
, vol.7
, pp. 261-268
-
-
Savoca, K.V.1
Davis, F.F.2
van Es, T.3
McCoy, J.R.4
Palczuk, N.C.5
-
65
-
-
0036093302
-
Arginine catabolism, liver extracts and cancer
-
Wheatley D.N., and Campbell E. Arginine catabolism, liver extracts and cancer. Pathol. Oncol. Res. 8 (2002) 18-25
-
(2002)
Pathol. Oncol. Res.
, vol.8
, pp. 18-25
-
-
Wheatley, D.N.1
Campbell, E.2
-
66
-
-
36549062828
-
-
N.M. Cheng, Y.C. Leung, W.H. Lo, Pharmaceutical preparation and method of treatment of human malignancies with arginine deprivation. US patent no. 20050244398. 2005 November 3.
-
-
-
-
67
-
-
0036347379
-
Modification of a reactive cysteine explains differences between rasburicase and uricozyme, a natural Aspergillus flavus uricase
-
Bayol A., Capdevielle J., Malazzi P., Buzy A., Claude Bonnet M., Colloc'h N., Mornon J.P., Loyaux D., and Ferrara P. Modification of a reactive cysteine explains differences between rasburicase and uricozyme, a natural Aspergillus flavus uricase. Biotechnol. Appl. Biochem. 36 (2002) 21-31
-
(2002)
Biotechnol. Appl. Biochem.
, vol.36
, pp. 21-31
-
-
Bayol, A.1
Capdevielle, J.2
Malazzi, P.3
Buzy, A.4
Claude Bonnet, M.5
Colloc'h, N.6
Mornon, J.P.7
Loyaux, D.8
Ferrara, P.9
-
68
-
-
0018726718
-
Modification of yeast uricase with polyethylene glycol: disappearance of binding ability towards anti-uricase serum
-
Nishimura H., Ashihara Y., Matsushima A., and Inada Y. Modification of yeast uricase with polyethylene glycol: disappearance of binding ability towards anti-uricase serum. Enzyme 24 (1979) 261-264
-
(1979)
Enzyme
, vol.24
, pp. 261-264
-
-
Nishimura, H.1
Ashihara, Y.2
Matsushima, A.3
Inada, Y.4
-
69
-
-
0019879284
-
Properties of two urate oxidases modified by the covalent attachment of poly(ethylene glycol)
-
Chen R.H., Abuchowski A., Van Es T., Palczuk N.C., and Davis F.F. Properties of two urate oxidases modified by the covalent attachment of poly(ethylene glycol). Biochim. Biophys. Acta 660 (1981) 293-298
-
(1981)
Biochim. Biophys. Acta
, vol.660
, pp. 293-298
-
-
Chen, R.H.1
Abuchowski, A.2
Van Es, T.3
Palczuk, N.C.4
Davis, F.F.5
-
70
-
-
0019415611
-
Hypouricaemic effect of polyethyleneglycol modified urate oxidase
-
Davis S., Park Y.K., Abuchowski A., and Davis F.F. Hypouricaemic effect of polyethyleneglycol modified urate oxidase. Lancet 2 (1981) 281-283
-
(1981)
Lancet
, vol.2
, pp. 281-283
-
-
Davis, S.1
Park, Y.K.2
Abuchowski, A.3
Davis, F.F.4
-
71
-
-
0019491411
-
Improved modification of yeast uricase with polyethylene glycol, accompanied with nonimmunoreactivity towards anti-uricase serum and high enzymic activity
-
Nishimura H., Matsushima A., and Inada Y. Improved modification of yeast uricase with polyethylene glycol, accompanied with nonimmunoreactivity towards anti-uricase serum and high enzymic activity. Enzyme 26 (1981) 49-53
-
(1981)
Enzyme
, vol.26
, pp. 49-53
-
-
Nishimura, H.1
Matsushima, A.2
Inada, Y.3
-
72
-
-
0033167240
-
Biopharmaceutical properties of uricase conjugated to neutral and amphiphilic polymers
-
Caliceti P., Schiavon O., and Veronese F.M. Biopharmaceutical properties of uricase conjugated to neutral and amphiphilic polymers. Bioconjug. Chem. 10 (1999) 638-646
-
(1999)
Bioconjug. Chem.
, vol.10
, pp. 638-646
-
-
Caliceti, P.1
Schiavon, O.2
Veronese, F.M.3
-
73
-
-
0034918665
-
Immunological properties of uricase conjugated to neutral soluble polymers
-
Caliceti P., Schiavon O., and Veronese F.M. Immunological properties of uricase conjugated to neutral soluble polymers. Bioconjug. Chem. 12 (2001) 515-522
-
(2001)
Bioconjug. Chem.
, vol.12
, pp. 515-522
-
-
Caliceti, P.1
Schiavon, O.2
Veronese, F.M.3
-
74
-
-
0036735357
-
Uricase formulated with polyethylene glycol (uricase-PEG 20): biochemical rationale and preclinical studies
-
Bomalaski J.S., Holtsberg F.W., Ensor C.M., and Clark M.A. Uricase formulated with polyethylene glycol (uricase-PEG 20): biochemical rationale and preclinical studies. J. Rheumatol. 29 (2002) 1942-1949
-
(2002)
J. Rheumatol.
, vol.29
, pp. 1942-1949
-
-
Bomalaski, J.S.1
Holtsberg, F.W.2
Ensor, C.M.3
Clark, M.A.4
-
75
-
-
0023755426
-
Use of polyethylene glycol-modified uricase (PEG-uricase) to treat hyperuricemia in a patient with non-Hodgkin lymphoma
-
Chua C.C., Greenberg M.L., Viau A.T., Nucci M., Brenckman Jr. W.D., and Hershfield M.S. Use of polyethylene glycol-modified uricase (PEG-uricase) to treat hyperuricemia in a patient with non-Hodgkin lymphoma. Ann. Int. Med. 109 (1988) 114-117
-
(1988)
Ann. Int. Med.
, vol.109
, pp. 114-117
-
-
Chua, C.C.1
Greenberg, M.L.2
Viau, A.T.3
Nucci, M.4
Brenckman Jr., W.D.5
Hershfield, M.S.6
-
76
-
-
0033841450
-
Therapeutic proteins: a comparison of chemical and biological properties of uricase conjugated to linear or branched poly(ethylene glycol) and poly(N-acryloylmorpholine)
-
Schiavon O., Caliceti P., Ferruti P., and Veronese F.M. Therapeutic proteins: a comparison of chemical and biological properties of uricase conjugated to linear or branched poly(ethylene glycol) and poly(N-acryloylmorpholine). Farmaco 55 (2000) 264-269
-
(2000)
Farmaco
, vol.55
, pp. 264-269
-
-
Schiavon, O.1
Caliceti, P.2
Ferruti, P.3
Veronese, F.M.4
-
77
-
-
36549003487
-
-
M. Sherman, M. Saifer, L. Williams, Aggregate-free urate oxidase for preparation of non-immunogenic polymer-conjugates. US Patent no. 783,965 (2004).
-
-
-
-
78
-
-
4644275038
-
Serum uric acid-lowering therapies: where are we heading in management of hyperuricemia and the potential role of uricase
-
Bomalaski J.S., and Clark M.A. Serum uric acid-lowering therapies: where are we heading in management of hyperuricemia and the potential role of uricase. Curr. Rheumatol. Rep. 6 (2004) 240-247
-
(2004)
Curr. Rheumatol. Rep.
, vol.6
, pp. 240-247
-
-
Bomalaski, J.S.1
Clark, M.A.2
-
79
-
-
0036817580
-
l-Lysine a-oxidase: physicochemical and biological properties
-
Lukasheva E.V., and Berezov T.T. l-Lysine a-oxidase: physicochemical and biological properties. Biochemistry (Moscow) 67 10 (2002) 1394-1402
-
(2002)
Biochemistry (Moscow)
, vol.67
, Issue.10
, pp. 1394-1402
-
-
Lukasheva, E.V.1
Berezov, T.T.2
-
80
-
-
0019151796
-
A new antitumor enzyme, l-lysine alpha-oxidase from Trichoderma viride. Purification and enzymological properties
-
Kusakabe H., Kodama K., Kuninaka A., Yoshino H., and Soda K. A new antitumor enzyme, l-lysine alpha-oxidase from Trichoderma viride. Purification and enzymological properties. J. Biol. Chem. 255 (1980) 976-981
-
(1980)
J. Biol. Chem.
, vol.255
, pp. 976-981
-
-
Kusakabe, H.1
Kodama, K.2
Kuninaka, A.3
Yoshino, H.4
Soda, K.5
-
81
-
-
0034649626
-
Phosphoglycerate kinase acts in tumor angiogenesis as a disulphide reductase
-
Lay A.J., Jiang X., Kisker O., Flynn E., Underwood A., Condron R., and Hogg P.J. Phosphoglycerate kinase acts in tumor angiogenesis as a disulphide reductase. Nature 408 (2000) 869-873
-
(2000)
Nature
, vol.408
, pp. 869-873
-
-
Lay, A.J.1
Jiang, X.2
Kisker, O.3
Flynn, E.4
Underwood, A.5
Condron, R.6
Hogg, P.J.7
-
82
-
-
0027970092
-
Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma
-
O'Reilly M.S., et al. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 79 (1994) 315-328
-
(1994)
Cell
, vol.79
, pp. 315-328
-
-
O'Reilly, M.S.1
-
83
-
-
33644870699
-
New enzyme for reductive cancer chemotherapy, YieF, and its improvement by directed evolution
-
Barak Y., Thorne S.H., Ackerley D.F., Lynch S.V., Contag C.H., and Matin A. New enzyme for reductive cancer chemotherapy, YieF, and its improvement by directed evolution. Mol. Cancer Ther. 5 (2006) 97-103
-
(2006)
Mol. Cancer Ther.
, vol.5
, pp. 97-103
-
-
Barak, Y.1
Thorne, S.H.2
Ackerley, D.F.3
Lynch, S.V.4
Contag, C.H.5
Matin, A.6
|