Quantitation of free polyethylene glycol in PEGylated protein conjugate by size exclusion HPLC with refractive index (RI) detection

Journal of Pharmaceutical and Biomedical Analysis

Volumn 48, Issue 5, 2008, Pages 1332-1338

  Li, Ning ^a   Ziegemeier, Daisy ^a   Bass, Laura ^a   Wang, Wei ^a  

^a PFIZER INC   (United States)

Author keywords

Polyethylene glycol; Protein PEGylation; Size exclusion high performance liquid chromatography (SE HPLC)

Indexed keywords

MACROGOL; PROTEIN;

ACCURACY; ARTICLE; ASSAY; CONJUGATE; FLOW RATE; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IONIC STRENGTH; PH; PRIORITY JOURNAL; REFRACTION INDEX; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

BUFFERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HEPES; HYDROGEN-ION CONCENTRATION; MOLECULAR WEIGHT; OSMOLAR CONCENTRATION; POLYETHYLENE GLYCOLS; PROTEINS; REFRACTOMETRY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TIME FACTORS;

EID: 58149494371     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2008.09.027     Document Type: Article

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