Thermal unfolding of a mammalian pentameric ligand-gated ion channel proceeds at consecutive, distinct steps

Journal of Biological Chemistry

Volumn 288, Issue 8, 2013, Pages 5756-5769

  Tol, Menno B ^a   Deluz, Cédric ^a   Hassaine, Gherici ^a   Graff, Alexandra ^b   Stahlberg, Henning ^b   Vogel, Horst ^a  

^a EPFL   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DETERGENT SOLUTION; LIGAND-GATED ION CHANNELS; STRUCTURAL TRANSITIONS; THERMAL UNFOLDING;

CELL MEMBRANES; LIPID BILAYERS; MAMMALS;

HYDRAULIC GATES;

ION CHANNEL; SEROTONIN 3 RECEPTOR; SEROTONIN RECEPTOR;

ANIMAL CELL; ARTICLE; BETA SHEET; BINDING AFFINITY; CELL MEMBRANE; CONTROLLED STUDY; LIGAND BINDING; LIPID BILAYER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN REFOLDING; PROTEIN SECONDARY STRUCTURE; PROTEIN UNFOLDING; TEMPERATURE DEPENDENCE; THERMOSTABILITY;

ANIMALS; CELL MEMBRANE; CHO CELLS; CRICETINAE; DETERGENTS; DNA, COMPLEMENTARY; HOT TEMPERATURE; LIGAND-GATED ION CHANNELS; LIGANDS; LIPID BILAYERS; MICE; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; PROTEIN DENATURATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, SEROTONIN, 5-HT2; SPECTROMETRY, FLUORESCENCE; TEMPERATURE;

EID: 84874329192     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.422287     Document Type: Article

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