Packing of the extracellular domain hydrophobic core has evolved to facilitate pentameric ligand-gated ion channel function

Journal of Biological Chemistry

Volumn 286, Issue 5, 2011, Pages 3658-3670

  Dellisanti, Cosma D ^a   Hanson, Sonya M ^b,c   Chen, Lin ^b   Czajkowski, Cynthia ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC MECHANISMS; BIOLOGICAL FUNCTIONS; COMPUTATIONAL APPROACH; CONFORMATIONAL FLEXIBILITY; EVOLUTIONARY STRATEGIES; EXTRACELLULAR DOMAINS; HYDROPHOBIC CORE; LIGAND-GATED ION CHANNELS; OPEN CHANNELS; PROTEIN FUNCTIONS;

EVOLUTIONARY ALGORITHMS; HYDRAULIC GATES; HYDROPHOBICITY; IONS;

LIGANDS;

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR BETA2; ION CHANNEL; ISOLEUCINE; LEUCINE; LIGAND; METHIONINE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA1; PHENYLALANINE; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG; VALINE; LIGAND GATED ION CHANNEL;

ALLOSTERISM; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; HYDROPHILICITY; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN STABILITY; SEQUENCE ALIGNMENT; THERMODYNAMICS; ANIMAL; APLYSIA; CHANNEL GATING; CHEMICAL PHENOMENA; CHEMISTRY; LYMNAEA; METABOLISM; MOLECULAR DYNAMICS; PHYSIOLOGY;

EUKARYOTA;

ALLOSTERIC REGULATION; ANIMALS; APLYSIA; GAMMA-AMINOBUTYRIC ACID; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; ION CHANNEL GATING; LIGAND-GATED ION CHANNELS; LYMNAEA; MOLECULAR DYNAMICS SIMULATION; PROTEIN FOLDING; RECEPTORS, GABA-A; THERMODYNAMICS;

EID: 79952790316     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.156851     Document Type: Article

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