메뉴 건너뛰기




Volumn 3, Issue DEC, 2012, Pages

Understanding natural killer cell regulation by mathematical approaches

Author keywords

Activating receptors; Inhibitory receptors; Mathematical modeling; Natural killer cells; Proliferation; Signaling pathways; Systems biology

Indexed keywords


EID: 84874273255     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2012.00359     Document Type: Short Survey
Times cited : (11)

References (65)
  • 1
    • 80052910202 scopus 로고    scopus 로고
    • Human NK cells differ more in their KIR2DL1-dependent thresholds for HLA-Cw6-mediated inhibition than in their maximal killing capacity
    • doi: 10.1371/journal. pone.0024927
    • Almeida, C. R., Ashkenazi, A., Sha-haf, G., Kaplan, D., Davis, D. M., and Mehr, R. (2011). Human NK cells differ more in their KIR2DL1-dependent thresholds for HLA-Cw6-mediated inhibition than in their maximal killing capacity. PLoS ONE 6:e24927. doi: 10.1371/journal. pone.0024927
    • (2011) PLoS ONE , vol.6
    • Almeida, C.R.1    Ashkenazi, A.2    Sha-haf, G.3    Kaplan, D.4    Davis, D.M.5    Mehr, R.6
  • 2
    • 27844541328 scopus 로고    scopus 로고
    • Modeling T cell antigen discrimination based on feedback control of digital ERK responses
    • doi: 10.1371/journal. pbio.0030356
    • Altan-Bonnet, G., and Germain, R. N. (2005). Modeling T cell antigen discrimination based on feedback control of digital ERK responses. PLoS Biol. 3:e356. doi: 10.1371/journal. pbio.0030356
    • (2005) PLoS Biol , vol.3
    • Altan-Bonnet, G.1    Germain, R.N.2
  • 3
    • 79957671415 scopus 로고    scopus 로고
    • B cells within germinal centers migrate preferentially from dark to light zone
    • Beltman, J. B., Allen, C. D., Cyster, J. G., and De Boer, R. J. (2011). B cells within germinal centers migrate preferentially from dark to light zone. Proc. Natl. Acad. Sci. U.S.A. 108, 8755-8760.
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 8755-8760
    • Beltman, J.B.1    Allen, C.D.2    Cyster, J.G.3    De Boer, R.J.4
  • 4
    • 84857478196 scopus 로고    scopus 로고
    • Skewing of the NK cell repertoire by MHC class I via quantitatively controlled enrichment and contraction of specific Ly49 subsets
    • Brodin, P., Lakshmikanth, T., Karre, K., and Hoglund, P. (2012). Skewing of the NK cell repertoire by MHC class I via quantitatively controlled enrichment and contraction of specific Ly49 subsets. J. Immunol. 188, 2218-2226.
    • (2012) J. Immunol. , vol.188 , pp. 2218-2226
    • Brodin, P.1    Lakshmikanth, T.2    Karre, K.3    Hoglund, P.4
  • 5
    • 78049273728 scopus 로고    scopus 로고
    • Natural killer cell tolerance persists despite significant reduction of self MHC class I on normal target cells in mice
    • doi: 10.1371/journal.pone.0013174
    • Brodin, P., Lakshmikanth, T., Mehr, R., Johansson, M. H., Duru, A. D., Achour, A., et al. (2010). Natural killer cell tolerance persists despite significant reduction of self MHC class I on normal target cells in mice. PLoS ONE 5:e13174. doi: 10.1371/journal.pone.0013174
    • (2010) PLoS ONE , vol.5
    • Brodin, P.1    Lakshmikanth, T.2    Mehr, R.3    Johansson, M.H.4    Duru, A.D.5    Achour, A.6
  • 6
    • 30144443832 scopus 로고    scopus 로고
    • Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion
    • Bryceson, Y. T., March, M. E., Ljung-gren, H. G., and Long, E. O. (2006). Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion. Blood 107, 159-166.
    • (2006) Blood , vol.107 , pp. 159-166
    • Bryceson, Y.T.1    March, M.E.2    Ljung-gren, H.G.3    Long, E.O.4
  • 7
    • 80052314133 scopus 로고    scopus 로고
    • Boltzmann energy-based image analysis demonstrates that extracellular domain size differences explain protein segregation at immune synapses
    • doi: 10.1371/journal.pcbi.1002076
    • Burroughs, N. J., Kohler, K., Miloser-dov, V., Dustin, M. L., Van Der Merwe,P.A.,and Davis,D.M. (2011). Boltzmann energy-based image analysis demonstrates that extracellular domain size differences explain protein segregation at immune synapses. PLoS Comput. Biol. 7:e1002076. doi: 10.1371/journal.pcbi.1002076
    • (2011) PLoS Comput. Biol. , vol.7
    • Burroughs, N.J.1    Kohler, K.2    Miloser-dov, V.3    Dustin, M.L.4    Van Der Merwe, P.A.5    Davis, D.M.6
  • 8
    • 33746918946 scopus 로고    scopus 로고
    • Cancer immunotherapy by interleukin-21: potential treatment strategies evaluated in a mathematical model
    • Cappuccio, A., Elishmereni, M., and Agur, Z. (2006). Cancer immunotherapy by interleukin-21: potential treatment strategies evaluated in a mathematical model. Cancer Res. 66, 7293-7300.
    • (2006) Cancer Res , vol.66 , pp. 7293-7300
    • Cappuccio, A.1    Elishmereni, M.2    Agur, Z.3
  • 9
    • 56249123996 scopus 로고    scopus 로고
    • Characterizing emergent properties of immunological systems with multi-cellular rule-based computational modeling
    • Chavali, A. K., Gianchandani, E. P., Tung, K. S., Lawrence, M. B., Peirce, S. M., and Papin, J. A. (2008). Characterizing emergent properties of immunological systems with multi-cellular rule-based computational modeling. Trends Immunol. 29, 589-599.
    • (2008) Trends Immunol , vol.29 , pp. 589-599
    • Chavali, A.K.1    Gianchandani, E.P.2    Tung, K.S.3    Lawrence, M.B.4    Peirce, S.M.5    Papin, J.A.6
  • 10
    • 77958488363 scopus 로고    scopus 로고
    • Activation or tolerance of natural killer cells is modulated by ligand quality in a nonmonotonic manner
    • Das, J. (2010). Activation or tolerance of natural killer cells is modulated by ligand quality in a nonmonotonic manner. Biophys. J. 99, 2028-2037.
    • (2010) Biophys. J. , vol.99 , pp. 2028-2037
    • Das, J.1
  • 11
    • 58249092059 scopus 로고    scopus 로고
    • Digital signaling and hysteresis characterize Ras activation in lymphoid cells
    • Das, J., Ho, M., Zikherman, J., Govern, C., Yang, M., Weiss, A., et al. (2009). Digital signaling and hysteresis characterize Ras activation in lymphoid cells. Cell 136, 337-351.
    • (2009) Cell , vol.136 , pp. 337-351
    • Das, J.1    Ho, M.2    Zikherman, J.3    Govern, C.4    Yang, M.5    Weiss, A.6
  • 12
    • 84865607726 scopus 로고    scopus 로고
    • Intracellular competition for fates in the immune system
    • Duffy, K. R., and Hodgkin, P. D. (2012). Intracellular competition for fates in the immune system. Trends Cell Biol. 22, 457-464.
    • (2012) Trends Cell Biol , vol.22 , pp. 457-464
    • Duffy, K.R.1    Hodgkin, P.D.2
  • 13
    • 84856072934 scopus 로고    scopus 로고
    • Activation-induced B cell fates are selected by intracellular stochastic competition
    • Duffy, K. R., Wellard, C. J., Markham, J. F., Zhou, J. H., Holmberg, R., Hawkins, E. D., et al. (2012). Activation-induced B cell fates are selected by intracellular stochastic competition. Science 335, 338-341.
    • (2012) Science , vol.335 , pp. 338-341
    • Duffy, K.R.1    Wellard, C.J.2    Markham, J.F.3    Zhou, J.H.4    Holmberg, R.5    Hawkins, E.D.6
  • 14
    • 79953665043 scopus 로고    scopus 로고
    • Quantification of the relative importance of CTL, B cell, NK cell, and target cell limitation in the control of primary SIV-infection
    • doi: 10.1371/journal.pcbi.1001103
    • Elemans, M., Thiebaut, R., Kaur, A., and Asquith, B. (2011). Quantification of the relative importance of CTL, B cell, NK cell, and target cell limitation in the control of primary SIV-infection. PLoS Comput. Biol. 7:e1001103. doi: 10.1371/journal.pcbi.1001103
    • (2011) PLoS Comput. Biol. , vol.7
    • Elemans, M.1    Thiebaut, R.2    Kaur, A.3    Asquith, B.4
  • 15
    • 79960914933 scopus 로고    scopus 로고
    • Unifying concepts of MHC-dependent natural killer cell education
    • Elliott, J. M., and Yokoyama, W. M. (2011). Unifying concepts of MHC-dependent natural killer cell education. Trends Immunol. 32, 364-372.
    • (2011) Trends Immunol , vol.32 , pp. 364-372
    • Elliott, J.M.1    Yokoyama, W.M.2
  • 16
    • 34247552223 scopus 로고    scopus 로고
    • Inhibitory receptor signals suppress ligation-induced recruitment of NKG2D to GM1-rich membrane domains at the human NK cell immune synapse
    • Endt, J., Mccann, F. E., Almeida, C. R., Urlaub, D., Leung, R., Pende, D., et al. (2007). Inhibitory receptor signals suppress ligation-induced recruitment of NKG2D to GM1-rich membrane domains at the human NK cell immune synapse. J. Immunol. 178, 5606-5611.
    • (2007) J. Immunol. , vol.178 , pp. 5606-5611
    • Endt, J.1    Mccann, F.E.2    Almeida, C.R.3    Urlaub, D.4    Leung, R.5    Pende, D.6
  • 17
    • 0035807959 scopus 로고    scopus 로고
    • Signaling at the inhibitory natural killer cell immune synapse regulates lipid raft polarization but not class I MHC clustering
    • Fassett, M. S., Davis, D. M., Valter, M. M., Cohen, G. B., and Stro-minger, J. L. (2001). Signaling at the inhibitory natural killer cell immune synapse regulates lipid raft polarization but not class I MHC clustering. Proc. Natl. Acad. Sci. U.S.A. 98, 14547-14552.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 14547-14552
    • Fassett, M.S.1    Davis, D.M.2    Valter, M.M.3    Cohen, G.B.4    Stro-minger, J.L.5
  • 18
    • 50149090966 scopus 로고    scopus 로고
    • Variability and robustness in T cell activation from regulated heterogeneity in protein levels
    • Feinerman, O., Veiga, J., Dorfman, J. R., Germain, R. N., and Altan-Bonnet, G. (2008). Variability and robustness in T cell activation from regulated heterogeneity in protein levels. Science 321, 1081-1084.
    • (2008) Science , vol.321 , pp. 1081-1084
    • Feinerman, O.1    Veiga, J.2    Dorfman, J.R.3    Germain, R.N.4    Altan-Bonnet, G.5
  • 19
    • 79953840956 scopus 로고    scopus 로고
    • Confinement of activating receptors at the plasma membrane controls natural killer cell tolerance
    • Guia, S., Jaeger, B. N., Piatek, S., Mail-fert, S., Trombik, T., Fenis, A., et al. (2011). Confinement of activating receptors at the plasma membrane controls natural killer cell tolerance. Sci. Signal. 4, ra21.
    • (2011) Sci. Signal. , vol.4
    • Guia, S.1    Jaeger, B.N.2    Piatek, S.3    Mail-fert, S.4    Trombik, T.5    Fenis, A.6
  • 20
    • 34147167183 scopus 로고    scopus 로고
    • A dynamical modelof humanimmune response to influenza A virus infection
    • Hancioglu, B., Swigon, D., and Cler-mont, G. (2007). A dynamical modelof humanimmune response to influenza A virus infection. J. Theor. Biol. 246, 70-86.
    • (2007) J. Theor. Biol. , vol.246 , pp. 70-86
    • Hancioglu, B.1    Swigon, D.2    Clermont, G.3
  • 21
    • 67649479393 scopus 로고    scopus 로고
    • Probing natural killer cell education by Ly49 receptor expression analysis and computational modelling in single MHC class I mice
    • doi: 10.1371/journal. pone.0006046
    • Johansson, S., Salmon-Divon, M., Johansson, M. H., Pickman, Y., Brodin, P., Karre, K., et al. (2009). Probing natural killer cell education by Ly49 receptor expression analysis and computational modelling in single MHC class I mice. PLoS ONE 4:e6046. doi: 10.1371/journal. pone.0006046
    • (2009) PLoS ONE , vol.4
    • Johansson, S.1    Salmon-Divon, M.2    Johansson, M.H.3    Pickman, Y.4    Brodin, P.5    Karre, K.6
  • 22
    • 79960517468 scopus 로고    scopus 로고
    • Simulations of the NK cell immune synapse reveal that activation thresholds can be established by inhibitory receptors acting locally
    • Kaplan, A., Kotzer, S., Almeida, C. R., Kohen, R., Halpert, G., Salmon-Divon, M., et al. (2011). Simulations of the NK cell immune synapse reveal that activation thresholds can be established by inhibitory receptors acting locally. J. Immunol. 187, 760-773.
    • (2011) J. Immunol. , vol.187 , pp. 760-773
    • Kaplan, A.1    Kotzer, S.2    Almeida, C.R.3    Kohen, R.4    Halpert, G.5    Salmon-Divon, M.6
  • 23
    • 42449088897 scopus 로고    scopus 로고
    • Natural killer cell recognition of missing self
    • Kärre, K. (2008). Natural killer cell recognition of missing self. Nat. Immunol. 9, 477-480.
    • (2008) Nat. Immunol. , vol.9 , pp. 477-480
    • Kärre, K.1
  • 24
    • 71549163142 scopus 로고    scopus 로고
    • Modeling and simulation of the immune system as a self-regulating network
    • Kim, P. S., Levy, D., and Lee, P. P. (2009). Modeling and simulation of the immune system as a self-regulating network. Methods Enzy-mol. 467, 79-109.
    • (2009) Methods Enzy-mol , vol.467 , pp. 79-109
    • Kim, P.S.1    Levy, D.2    Lee, P.P.3
  • 26
    • 34948840834 scopus 로고    scopus 로고
    • Ensemble modeling for analysis of cell signaling dynamics
    • Kuepfer, L., Peter, M., Sauer, U., and Stelling, J. (2007). Ensemble modeling for analysis of cell signaling dynamics. Nat. Biotechnol. 25, 1001- 1006.
    • (2007) Nat. Biotechnol. , vol.25 , pp. 1001-1006
    • Kuepfer, L.1    Peter, M.2    Sauer, U.3    Stelling, J.4
  • 27
    • 0030596468 scopus 로고    scopus 로고
    • Harpoon model for cell-cell adhesion and recognition of target cells by the natural killer cells
    • Kuznetsov, V. A. (1996). "Harpoon" model for cell-cell adhesion and recognition of target cells by the natural killer cells. J. Theor. Biol. 180, 321-342.
    • (1996) J. Theor. Biol. , vol.180 , pp. 321-342
    • Kuznetsov, V.A.1
  • 28
    • 42449102990 scopus 로고    scopus 로고
    • Up on the tightrope: natural killer cell activation and inhibition
    • Lanier, L. L. (2008). Up on the tightrope: natural killer cell activation and inhibition. Nat. Immunol. 9, 495-502.
    • (2008) Nat. Immunol. , vol.9 , pp. 495-502
    • Lanier, L.L.1
  • 29
    • 74049093675 scopus 로고    scopus 로고
    • Interpreting CFSE obtained division histories of B cells in vitro with Smith-Martin and cyton type models
    • Lee, H. Y., Hawkins, E., Zand, M. S., Mosmann, T., Wu, H., Hodgkin, P. D., et al. (2009). Interpreting CFSE obtained division histories of B cells in vitro with Smith-Martin and cyton type models. Bull. Math. Biol. 71, 1649-1670.
    • (2009) Bull. Math. Biol. , vol.71 , pp. 1649-1670
    • Lee, H.Y.1    Hawkins, E.2    Zand, M.S.3    Mosmann, T.4    Wu, H.5    Hodgkin, P.D.6
  • 30
    • 0034677175 scopus 로고    scopus 로고
    • A balance between positive and negative signals in cytotoxic lymphocytes regulates the polarization of lipid rafts during the development of cell-mediated killing
    • Lou, Z., Jevremovic, D., Billadeau, D. D., and Leibson, P. J. (2000). A balance between positive and negative signals in cytotoxic lymphocytes regulates the polarization of lipid rafts during the development of cell-mediated killing. J. Exp. Med. 191, 347-354.
    • (2000) J. Exp. Med. , vol.191 , pp. 347-354
    • Lou, Z.1    Jevremovic, D.2    Billadeau, D.D.3    Leibson, P.J.4
  • 31
    • 77954466035 scopus 로고    scopus 로고
    • A minimum of two distinct heritable factors are required to explain correlation structures in proliferating lymphocytes
    • Markham, J. F., Wellard, C. J., Hawkins, E. D., Duffy, K. R., and Hodgkin, P. D. (2010). A minimum of two distinct heritable factors are required to explain correlation structures in proliferating lymphocytes. J. R. Soc. Interface 7, 1049-1059.
    • (2010) J. R. Soc. Interface , vol.7 , pp. 1049-1059
    • Markham, J.F.1    Wellard, C.J.2    Hawkins, E.D.3    Duffy, K.R.4    Hodgkin, P.D.5
  • 32
    • 77952791119 scopus 로고    scopus 로고
    • Computational systems biology in cancer: modeling methods and applications
    • Materi, W., and Wishart, D. S. (2007). Computational systems biology in cancer: modeling methods and applications. Gene Regul. Syst. Biol. 1, 91-110.
    • (2007) Gene Regul. Syst. Biol. , vol.1 , pp. 91-110
    • Materi, W.1    Wishart, D.S.2
  • 33
    • 0040752472 scopus 로고    scopus 로고
    • Modeling the meta-dynamics of lymphocyte repertoires
    • Mehr, R. (2001). Modeling the meta-dynamics of lymphocyte repertoires. Arch. Immunol. Ther. Exp. (Warsz) 49, 111-120.
    • (2001) Arch. Immunol. Ther. Exp. (Warsz) , vol.49 , pp. 111-120
    • Mehr, R.1
  • 34
    • 23344441151 scopus 로고    scopus 로고
    • Modeling and analysis of the meta-population dynamics of lymphocyte repertoires
    • Mehr, R. (2005). Modeling and analysis of the meta-population dynamics of lymphocyte repertoires. J. Comput. Appl. Math. 184, 223-241.
    • (2005) J. Comput. Appl. Math. , vol.184 , pp. 223-241
    • Mehr, R.1
  • 35
    • 0027528460 scopus 로고
    • A mathematical model of the effect of aging on bone marrow cells colonizing the thymus
    • Mehr, R., Abel, L., Ubezio, P., Glober-son, A., and Agur, Z. (1993). A mathematical model of the effect of aging on bone marrow cells colonizing the thymus. Mech. Ageing Dev. 67, 159-172.
    • (1993) Mech. Ageing Dev. , vol.67 , pp. 159-172
    • Mehr, R.1    Abel, L.2    Ubezio, P.3    Globerson, A.4    Agur, Z.5
  • 36
    • 0029617778 scopus 로고
    • Lymphocyte development in irradiated thymuses: dynamics of colonization by progenitor cells and regeneration of resident cells
    • Mehr, R., Fridkis-Hareli, M., Abel, L., Segel, L., and Globerson, A. (1995). Lymphocyte development in irradiated thymuses: dynamics of colonization by progenitor cells and regeneration of resident cells. J. Theor. Biol. 177, 181-192.
    • (1995) J. Theor. Biol. , vol.177 , pp. 181-192
    • Mehr, R.1    Fridkis-Hareli, M.2    Abel, L.3    Segel, L.4    Globerson, A.5
  • 37
    • 0030924884 scopus 로고    scopus 로고
    • Blind T-cell homeostasis and the CD4/CD8 ratio in the thymus and peripheral blood
    • Mehr, R., and Perelson, A. S. (1997). Blind T-cell homeostasis and the CD4/CD8 ratio in the thymus and peripheral blood. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 14, 387-398.
    • (1997) J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. , vol.14 , pp. 387-398
    • Mehr, R.1    Perelson, A.S.2
  • 39
    • 0030582545 scopus 로고    scopus 로고
    • Feedback regulation of T cell development: manifestations in aging
    • Mehr, R., Perelson, A. S., Fridkis-Hareli, M., and Globerson, A. (1996b). Feedback regulation of T cell development: manifestations in aging. Mech. Ageing Dev. 91, 195-210.
    • (1996) Mech. Ageing Dev. , vol.91 , pp. 195-210
    • Mehr, R.1    Perelson, A.S.2    Fridkis-Hareli, M.3    Globerson, A.4
  • 41
    • 0032458142 scopus 로고    scopus 로고
    • MHC-linked syngeneic developmental preference in thymic lobes colonized with bone marrow cells: a mathematical model
    • Mehr, R., Perelson, A. S., Sharp, A., Segel, L., and Globerson, A. (1998). MHC-linked syngeneic developmental preference in thymic lobes colonized with bone marrow cells: a mathematical model. Dev. Immunol. 5, 303-318.
    • (1998) Dev. Immunol. , vol.5 , pp. 303-318
    • Mehr, R.1    Perelson, A.S.2    Sharp, A.3    Segel, L.4    Globerson, A.5
  • 42
    • 0027998139 scopus 로고
    • Colonization of the thymus by T cell progenitors: models for cell-cell interactions
    • Mehr, R., Segel, L., Sharp, A., and Globerson, A. (1994). Colonization of the thymus by T cell progenitors: models for cell-cell interactions. J. Theor. Biol. 170, 247-257.
    • (1994) J. Theor. Biol. , vol.170 , pp. 247-257
    • Mehr, R.1    Segel, L.2    Sharp, A.3    Globerson, A.4
  • 43
    • 0037343136 scopus 로고    scopus 로고
    • Asynchronous differentiation models explain bone marrow labeling kinetics and predict reflux between the pre- and immature B cell pools
    • Mehr, R., Shahaf, G., Sah, A., and Cancro, M. (2003). Asynchronous differentiation models explain bone marrow labeling kinetics and predict reflux between the pre- and immature B cell pools. Int. Immunol. 15, 301-312.
    • (2003) Int. Immunol. , vol.15 , pp. 301-312
    • Mehr, R.1    Shahaf, G.2    Sah, A.3    Cancro, M.4
  • 44
    • 84865412764 scopus 로고    scopus 로고
    • Models and methods for analysis of lymphocyte repertoire generation, development, selection and evolution
    • Mehr, R., Sternberg-Simon, M., Michaeli, M., and Pickman, Y. (2012). Models and methods for analysis of lymphocyte repertoire generation, development, selection and evolution. Immunol. Lett. 148, 11-22.
    • (2012) Immunol. Lett. , vol.148 , pp. 11-22
    • Mehr, R.1    Sternberg-Simon, M.2    Michaeli, M.3    Pickman, Y.4
  • 45
    • 0019797316 scopus 로고
    • A model of the role of natural killer cells in immune surveillance-I
    • Merrill, S. J. (1981). A model of the role of natural killer cells in immune surveillance-I. J. Math. Biol. 12, 363-373.
    • (1981) J. Math. Biol. , vol.12 , pp. 363-373
    • Merrill, S.J.1
  • 46
    • 0020502390 scopus 로고
    • A model of the role of natural killer cells in immune surveillance-II
    • Merrill, S. J. (1983). A model of the role of natural killer cells in immune surveillance-II. J. Math. Biol. 17, 153-162.
    • (1983) J. Math. Biol. , vol.17 , pp. 153-162
    • Merrill, S.J.1
  • 47
    • 79957902683 scopus 로고    scopus 로고
    • Integration of activating and inhibitory receptor signaling by regulated phosphoryla-tion of Vav1 in immune cells
    • Mesecke, S., Urlaub, D., Busch, H., Eils, R., and Watzl, C. (2011). Integration of activating and inhibitory receptor signaling by regulated phosphoryla-tion of Vav1 in immune cells. Sci. Signal. 4, ra36.
    • (2011) Sci. Signal. , vol.4
    • Mesecke, S.1    Urlaub, D.2    Busch, H.3    Eils, R.4    Watzl, C.5
  • 48
    • 77957176660 scopus 로고
    • Modelling and simulation of Rosenberg-type adoptive cellular immunotherapy
    • Nani, F. K., and Oguztoreli, M. N. (1994). Modelling and simulation of Rosenberg-type adoptive cellular immunotherapy. IMA J. Math. Appl. Med. Biol. 11, 107-147.
    • (1994) IMA J. Math. Appl. Med. Biol. , vol.11 , pp. 107-147
    • Nani, F.K.1    Oguztoreli, M.N.2
  • 49
    • 79956151449 scopus 로고    scopus 로고
    • Natural killer cell memory
    • Paust, S., and von Andrian, U. H. (2011). Natural killer cell memory. Nat. Immunol. 12, 500-508.
    • (2011) Nat. Immunol. , vol.12 , pp. 500-508
    • Paust, S.1    Von Andrian, U.H.2
  • 50
    • 0037340174 scopus 로고    scopus 로고
    • Generation of the natural killer cell repertoire: the sequential vs. the two-step selection model
    • Salmon-Divon, M., Hoglund, P., and Mehr, R. (2003a). Generation of the natural killer cell repertoire: the sequential vs. the two-step selection model. Bull. Math. Biol. 65, 199-218.
    • (2003) Bull. Math. Biol. , vol.65 , pp. 199-218
    • Salmon-Divon, M.1    Hoglund, P.2    Mehr, R.3
  • 51
    • 0347133288 scopus 로고    scopus 로고
    • Models for natural killer cell repertoire formation
    • Salmon-Divon, M., Hoglund, P., and Mehr, R. (2003b). Models for natural killer cell repertoire formation. Clin. Dev. Immunol. 10, 183-192.
    • (2003) Clin. Dev. Immunol. , vol.10 , pp. 183-192
    • Salmon-Divon, M.1    Hoglund, P.2    Mehr, R.3
  • 52
    • 4344692259 scopus 로고    scopus 로고
    • Screening of alternative models for transitional B cell maturation
    • Shahaf, G., Allman, D., Cancro, M. P., and Mehr, R. (2004). Screening of alternative models for transitional B cell maturation. Int. Immunol. 16, 1081-1090.
    • (2004) Int. Immunol. , vol.16 , pp. 1081-1090
    • Shahaf, G.1    Allman, D.2    Cancro, M.P.3    Mehr, R.4
  • 53
    • 54249165359 scopus 로고    scopus 로고
    • Antigen-driven selection in germinal centers as reflected by the shape characteristics of immunoglobulin gene lineage trees: a large-scale simulation study
    • Shahaf, G., Barak, M., Zuckerman, N. S., Swerdlin, N., Gorfine, M., and Mehr, R. (2008). Antigen-driven selection in germinal centers as reflected by the shape characteristics of immunoglobulin gene lineage trees: a large-scale simulation study. J. Theor. Biol. 255, 210-222.
    • (2008) J. Theor. Biol. , vol.255 , pp. 210-222
    • Shahaf, G.1    Barak, M.2    Zuckerman, N.S.3    Swerdlin, N.4    Gorfine, M.5    Mehr, R.6
  • 54
    • 77949669230 scopus 로고    scopus 로고
    • Kinetic modeling reveals a common death niche for newly formed and mature B cells
    • doi: 10.1371/journal. pone.0009497
    • Shahaf, G., Cancro, M. P., and Mehr, R. (2010). Kinetic modeling reveals a common death niche for newly formed and mature B cells. PLoS ONE 5:e9497. doi: 10.1371/journal. pone.0009497
    • (2010) PLoS ONE , vol.5
    • Shahaf, G.1    Cancro, M.P.2    Mehr, R.3
  • 55
    • 30344455329 scopus 로고    scopus 로고
    • B cell development in aging mice: lessons from mathematical modeling
    • Shahaf, G., Johnson, K., and Mehr, R. (2006). B cell development in aging mice: lessons from mathematical modeling. Int. Immunol. 18, 31-39.
    • (2006) Int. Immunol. , vol.18 , pp. 31-39
    • Shahaf, G.1    Johnson, K.2    Mehr, R.3
  • 56
    • 0033120054 scopus 로고    scopus 로고
    • Reconciling repertoire shift with affinity maturation: the role of deleterious mutations
    • Shannon, M., and Mehr, R. (1999). Reconciling repertoire shift with affinity maturation: the role of deleterious mutations. J. Immunol. 162, 3950- 3956.
    • (1999) J. Immunol. , vol.162 , pp. 3950-3956
    • Shannon, M.1    Mehr, R.2
  • 57
    • 0041534399 scopus 로고    scopus 로고
    • Vav1 dephospho-rylation by the tyrosine phosphatase SHP-1 as a mechanism for inhibition of cellular cytotoxicity
    • Stebbins, C. C., Watzl, C., Billadeau, D. D., Leibson, P. J., Burshtyn, D. N., and Long, E. O. (2003). Vav1 dephospho-rylation by the tyrosine phosphatase SHP-1 as a mechanism for inhibition of cellular cytotoxicity. Mol. Cell. Biol. 23, 6291-6299.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 6291-6299
    • Stebbins, C.C.1    Watzl, C.2    Billadeau, D.D.3    Leibson, P.J.4    Burshtyn, D.N.5    Long, E.O.6
  • 58
    • 84920297611 scopus 로고    scopus 로고
    • Toward a quantitative analysis of the repertoire of class I MHC-specific inhibitory receptors on natural killer cells
    • Vance, R. E., and Raulet, D. H. (1998). Toward a quantitative analysis of the repertoire of class I MHC-specific inhibitory receptors on natural killer cells. Curr. Top. Microbiol. Immunol. 230, 135-160.
    • (1998) Curr. Top. Microbiol. Immunol. , vol.230 , pp. 135-160
    • Vance, R.E.1    Raulet, D.H.2
  • 60
    • 34247621734 scopus 로고    scopus 로고
    • Natural killer cells: from CD3(-)NKp46(+) to post-genomics meta-analyses
    • Walzer, T., Jaeger, S., Chaix, J., and Vivier, E. (2007). Natural killer cells: from CD3(-)NKp46(+) to post-genomics meta-analyses. Curr. Opin. Immunol. 19, 365-372.
    • (2007) Curr. Opin. Immunol. , vol.19 , pp. 365-372
    • Walzer, T.1    Jaeger, S.2    Chaix, J.3    Vivier, E.4
  • 61
    • 0037244127 scopus 로고    scopus 로고
    • Natural killer cell inhibitory receptors block actin cytoskeleton-dependent recruitment of 2B4 (CD244) to lipid rafts
    • Watzl, C., and Long, E. O. (2003). Natural killer cell inhibitory receptors block actin cytoskeleton-dependent recruitment of 2B4 (CD244) to lipid rafts. J. Exp. Med. 197, 77-85.
    • (2003) J. Exp. Med. , vol.197 , pp. 77-85
    • Watzl, C.1    Long, E.O.2
  • 62
    • 77956481004 scopus 로고    scopus 로고
    • Signal transduction during activation and inhibition of natural killer cells
    • Chapter 11 Unit 11.9B
    • Watzl, C., and Long, E. O. (2010). Signal transduction during activation and inhibition of natural killer cells. Curr. Protoc. Immunol. Chapter 11, Unit 11.9B.
    • (2010) Curr. Protoc. Immunol.
    • Watzl, C.1    Long, E.O.2
  • 63
    • 34249812675 scopus 로고    scopus 로고
    • Dynamics of killer T cell inflation in viral infections
    • Wodarz, D., Sierro, S., and Klenerman, P. (2007). Dynamics of killer T cell inflation in viral infections. J. R. Soc. Interface 4, 533-543.
    • (2007) J. R. Soc. Interface , vol.4 , pp. 533-543
    • Wodarz, D.1    Sierro, S.2    Klenerman, P.3
  • 64
    • 34247538298 scopus 로고    scopus 로고
    • In vivo kinetics of human natural killer cells: the effects of ageing and acute and chronic viral infection
    • Zhang, Y., Wallace, D. L., De Lara, C. M., Ghattas, H., Asquith, B., Worth, A., et al. (2007). In vivo kinetics of human natural killer cells: the effects of ageing and acute and chronic viral infection. Immunology 121, 258-265.
    • (2007) Immunology , vol.121 , pp. 258-265
    • Zhang, Y.1    Wallace, D.L.2    De Lara, C.M.3    Ghattas, H.4    Asquith, B.5    Worth, A.6
  • 65
    • 84859400886 scopus 로고    scopus 로고
    • Two-compartment model of NK cell proliferation: insights from population response to IL-15 stimulation
    • Zhao, Y. M., and French, A. R. (2012). Two-compartment model of NK cell proliferation: insights from population response to IL-15 stimulation. J. Immunol. 188, 2981-2990.
    • (2012) J. Immunol. , vol.188 , pp. 2981-2990
    • Zhao, Y.M.1    French, A.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.