Reconciling repertoire shift with affinity maturation: The role of deleterious mutations

Journal of Immunology

Volumn 162, Issue 7, 1999, Pages 3950-3956

  Shannon, Michele ^a   Mehr, Ramit ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY PRODUCTION; ANTIGEN ANTIBODY REACTION; ARTICLE; B LYMPHOCYTE; CELL DIFFERENTIATION; CELL MATURATION; CELL SELECTION; COMPUTER SIMULATION; GENE MUTATION; MATHEMATICAL MODEL; MEMORY CELL; PRIORITY JOURNAL;

EID: 0033120054     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Reth, M., G. J. Hammerling, and K. Rajewsky. 1978. Analysis of the repertoire of anti-NP antibodies in C57BL/6 mice by cell fusion. I. Characterization of antibody families in the primary and hyperimmune response. Eur. J. Immunol. 8:393.
2. Allen, D., T. Simon, F. Sablitzky, K. Rajewsky, and A. Cumano. 1988. Antibody engineering for the analysis of affinity maturation of an anti-hapten response. EMBO J. 7:1995.
3. Jacob, J., R. Kassir, and G. Kelsoe. 1991. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations. J. Exp. Med. 173:1165.
4. Jacob, J., and G. Kelsoe. 1992. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers. J. Exp. Med. 176:679.
5. Jacob, J., J. Przylepa, C. Miller, and G. Kelsoe. 1993. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells. J. Exp. Med. 178:1293.
6. Han, S., B. Zheng-B, J. Dal-Porto, and G. Kelsoe. 1995. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance. J. Exp. Med. 182:1635.
7. Takahashi, Y., P. R. Dutta, D. M. Cerasoli, and G. Kelsoe. 1998. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection. J. Exp. Med. 187:885.
8. Berek, C., and C. Milstein. 1987. Mutation drift and repertoire shift in the maturation of the immune response. Immunol. Rev. 96:23.
9. Griffiths, G. M., C. Berek, M. Kaartinen, and C. Milstein. 1984. Somatic mutation and the maturation of immune response to 2-phenyl oxazolone. Nature 312:271.
10. Berek, C., G. M. Griffiths, and C. Milstein. 1985. Molecular events during maturation of the immune response to oxazolone. Nature 316:412.
11. Foote, J., and C. Milstein. 1991. Kinetic maturation of an immune response. Nature 352:530.
12. Clarke, S. H., L. M. Staudt, J. Kavaler, D. Schwartz, W. U. Gerhard, and M. G. Weigert. 1990. V region gene usage and somatic mutation in the primary and secondary responses to influenza virus hemagglutinin. J. Immunol. 144:2795.
13. Kavaler, J., A. J. Caton, L. M. Staudt, and W. U. Gerhard. 1991. A B cell population that dominates the primary response to influenza virus hemagglutinin does not participate in the memory response. Eur. J. Immunol. 21:2687.
14. Randen, I., V. Pascual, K. Victor, K. M. Thompson, Ø. Førre, J. D. Capra, and J. B. Natvig. 1993. Synovial IgG rheumatoid factors show evidence of an antigen-driven immune response and a shift in the V gene repertoire compared to IgM rheumatoid factors. Eur. J. Immunol. 23:1220.
15. Press, J. L., and C. A. Giorgetti. 1993. Molecular and kinetic analysis of an epitope-specific shift in the B cell memory response to a multide-terminant antigen. J. Immunol. 151:1998.
16. Kalinke, U., E. M. Bucher, B. Ernst, A. Oxenius, H.-P. Roost, S. Geley, R. Kofier, R. M. Zinkernagel, and H. Hengartner. 1996. The role of somatic mutation in the generation of the protective humoral immune response against vesicular stomatitis virus. Immunity 5:639.
17. Ashton-Rickardt, P. G., and S. Tonegawa. 1994. A differential-avidity model for T-cell selection. Immunol. Today 15:362.
18. Arpin, C., J. Banchereau and Y.-J. Liu. 1997. Memory B cells are biased toward terminal differentiation: A strategy that may prevent repertoire freezing. J. Exp. Med. 186:931.
19. Perelson, A. S., and S. A. Kauffman, eds. 1991. Molecular Evolution on Rugged Landscapes: Proteins. RNA and the Immune System. Vol. 9 of Santa Fe Institute Studies in the Sciences of Complexity. Addison-Wesley, Redwood City, CA. p. 73.
20. Kelsoe, G. 1996. Life and death in germinal centers (redux). Immunity 4:107.
21. MacLennan, I., and E. Chan. 1993. The dynamic relationship between B-cell populations in adults. Immunol. Today 14:29.
22. Osmond. D. G. 1993. The turnover of B-cell populations. Immunol. Today 14:34.
23. Coutinho, A. 1993. Lymphocyte survival and V-region repertoire selection. Immunol. Today 14:38.
24. Rajewsky. K. 1989. Evolutionary and somatic immunological memory. In Progress in Immunology, Vol. 7, F. Melchers, ed. Springer-Verlag, Berlin, p. 397-403.
25. Agenes, F., M. M. Rosado, and A. A. Freitas. 1997. Independent homeostatic regulation of B cell compartments. Eur. J. Immunol. 27:1801.
26. Sulzer, B., L. van Hemmen, A. U. Neumann, and U. Behn. 1993. Memory in idiotypic networks due to competition between proliferation and differentiation. Bull. Math. Biol. 55:1133.
27. Oprea, M., and A. S. Perelson. 1996. Exploring the mechanisms of primary antibody response to T cell-dependent antigens. J. Theor. Biol. 181:215.
28. Kosco-Vilbois, M. H., H. Zentgraf, J. Gerdes, and J. Bonnefoy. 1997. To "B" or not to "B" a germinal center? Immunol. Today 18:225.
29. Shlomchik, M., P. Watts, M. Weigert, and S. Litwin. 1998. Clone: a Monte-Carlo computer simulation of B cell clonal expansion, somatic mutation, and antigen-driven selection. Curr. Top. Microbiol. Immunol. 229:173.
30. Oprea, M., and A. S. Perelson. 1997. Somatic mutation leads to efficient affinity maturation when cenlroeytes recycle back to centroblasts. J. Immunol. 158:5155.
31. Kepler, T. B., and A. S. Perelson. 1993. Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation. Immunol. Today 14:412.
32. Celada, F., and P. E. Seiden. 1996. Affinity maturation and hypermutation in a simulation of the humoral immune response. Eur. J. Immunol. 26:13508.
33. Slifka, M. K., and R. Ahmed. 1998. Long-lived plasma cells: a mechanism for maintaining persistent antibody production. Curr. Opin. Immunol. 10:252.
34. Ahmed, R., and D. Gray. 1996. Immunological memory and protective immunity: understanding their relation. Science 272:54.