Integration of activating and inhibitory receptor signaling by regulated phosphorylation of Vav1 in immune cells

Science Signaling

Volumn 4, Issue 175, 2011, Pages

  Mesecke, Sven ^a,b   Urlaub, Doris ^b   Busch, Hauke ^a,c   Eils, Roland ^a,b   Watzl, Carsten ^b,d  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

^d LEIBNIZ RESEARCH CENTRE FOR WORKING ENVIRONMENT AND HUMAN FACTORS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; NATURAL KILLER CELL RECEPTOR; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; VAV PROTEIN; VAV1 PROTEIN; PROTEIN TYROSINE PHOSPHATASE SHP 1; PTPN6 PROTEIN, HUMAN; VAV1 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; LYMPHOCYTOTOXICITY; MATHEMATICAL MODEL; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION; T LYMPHOCYTE ACTIVATION; ANIMAL; BIOLOGICAL MODEL; IMMUNOLOGY; IMMUNOPRECIPITATION; KINETICS; LYMPHOCYTE ACTIVATION; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; HUMANS; IMMUNOPRECIPITATION; KILLER CELLS, NATURAL; KINETICS; LYMPHOCYTE ACTIVATION; MICE; MODELS, BIOLOGICAL; PHOSPHORYLATION; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 6; PROTO-ONCOGENE PROTEINS C-VAV; SIGNAL TRANSDUCTION;

EID: 79957902683     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2001325     Document Type: Article

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36. Acknowledgments: We thank B. Messmer, S. Wingert, and I. Cado for experimental support; Y. Samstag and A. Veillette for sharing reagents; and E. Long for critical reading of the manuscript. Funding: This work was supported by the Initiative and Networking Fund of the Helmholtz Association within the Helmholtz Alliance on Systems Biology/ SBCancer by ForSys [Bundesministerium für Bildung und Forschung (BMBF)] and by the BioFuture funding of the BMBF. Author contributions: S.M., D.U., H.B., R.E., and C.W. designed the research; S.M. and D.U. performed the experiments; S.M., D.U., H.B., R.E., and C.W. analyzed the data; and S.M., D.U., and C.W. wrote the paper. Competing interests: The authors declare that they have no competing interests.